| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Spencer U McKinstry, Yonca B Karadeniz, Atesh K Worthington, Volodya Y Hayrapetyan, M Ilcim Ozlu, Karol Serafin-Molina, W Christopher Risher, Tuna Ustunkaya, Ioannis Dragatsis, Scott Zeitlin, Henry H Yin, Cagla Erogl. Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009276. |
huntington's disease (hd) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-q) stretch in the huntingtin (htt) protein. |
2014-09-09 |
2023-08-13 |
mouse |
| Hiroko Yano, Sergei V Baranov, Oxana V Baranova, Jinho Kim, Yanchun Pan, Svitlana Yablonska, Diane L Carlisle, Robert J Ferrante, Albert H Kim, Robert M Friedlande. Inhibition of mitochondrial protein import by mutant huntingtin. Nature neuroscience. vol 17. issue 6. 2014-08-04. PMID:24836077. |
mitochondrial dysfunction is associated with neuronal loss in huntington's disease (hd), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (htt). |
2014-08-04 |
2023-08-13 |
mouse |
| Paul G Unschuld, Xinyang Liu, Megan Shanahan, Russell L Margolis, Susan S Bassett, Jason Brandt, David J Schretlen, Graham W Redgrave, Jun Hua, Christoph Hock, Sarah A Reading, Peter C M van Zijl, James J Pekar, Christopher A Ros. Prefrontal executive function associated coupling relates to Huntington's disease stage. Cortex; a journal devoted to the study of the nervous system and behavior. vol 49. issue 10. 2014-07-30. PMID:23906595. |
huntington's disease (hd) is a neurodegenerative disease caused by cytosine-adenine-guanine (cag)-repeat expansion in the huntingtin (htt) gene. |
2014-07-30 |
2023-08-12 |
human |
| Lara Moumné, Sandrine Betuing, Jocelyne Caboch. Multiple Aspects of Gene Dysregulation in Huntington's Disease. Frontiers in neurology. vol 4. 2014-06-24. PMID:24167500. |
huntington's disease (hd) is a genetic neurodegenerative disease caused by a cag expansion in the gene encoding huntingtin (htt). |
2014-06-24 |
2023-08-12 |
mouse |
| Cendrine Tourette, Biao Li, Russell Bell, Shannon O'Hare, Linda S Kaltenbach, Sean D Mooney, Robert E Hughe. A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease. The Journal of biological chemistry. vol 289. issue 10. 2014-06-24. PMID:24407293. |
huntington disease (hd) is an inherited neurodegenerative disease caused by a cag expansion in the htt gene. |
2014-06-24 |
2023-08-12 |
Not clear |
| Juan I Sbodio, Bindu D Paul, Carolyn E Machamer, Solomon H Snyde. Golgi protein ACBD3 mediates neurotoxicity associated with Huntington's disease. Cell reports. vol 4. issue 5. 2014-06-12. PMID:24012756. |
huntington's disease (hd) is an autosomal-dominant neurodegenerative disease caused by the expansion of polyglutamine repeats in the gene for huntingtin (htt). |
2014-06-12 |
2023-08-12 |
mouse |
| Maxmore Chaibva, Kathleen A Burke, Justin Legleite. Curvature enhances binding and aggregation of huntingtin at lipid membranes. Biochemistry. vol 53. issue 14. 2014-06-03. PMID:24670006. |
huntington disease (hd) is a genetic neurodegenerative disease caused by an expanded polyglutamine (polyq) domain in the first exon of the huntingtin (htt) protein, facilitating its aggregation. |
2014-06-03 |
2023-08-12 |
Not clear |
| Giang D Nguyen, Aldrin E Molero, Solen Gokhan, Mark F Mehle. Functions of huntingtin in germ layer specification and organogenesis. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967334. |
huntington's disease (hd) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (htt). |
2014-05-14 |
2023-08-12 |
mouse |
| Magdalena Czeredys, Joanna Gruszczynska-Biegala, Teresa Schacht, Axel Methner, Jacek Kuznick. Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. Frontiers in molecular neuroscience. vol 6. 2013-12-10. PMID:24324398. |
huntington's disease (hd) is a hereditary neurodegenerative disease caused by the expansion of a polyglutamine stretch in the huntingtin (htt) protein and characterized by dysregulated calcium homeostasis. |
2013-12-10 |
2023-08-12 |
mouse |
| Youngnam N Jin, Yanxun V Yu, Soner Gundemir, Chulman Jo, Mei Cui, Kim Tieu, Gail V W Johnso. Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin. PloS one. vol 8. issue 3. 2013-08-27. PMID:23469253. |
huntington disease (hd) is an inherited neurodegenerative disease resulting from an abnormal expansion of polyglutamine in huntingtin (htt). |
2013-08-27 |
2023-08-12 |
Not clear |
| Bruno M D C Godinho, Julien R Ogier, Raphael Darcy, Caitriona M O'Driscoll, John F Crya. Self-assembling modified β-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease. Molecular pharmaceutics. vol 10. issue 2. 2013-08-20. PMID:23116281. |
huntington's disease (hd) is a rare autosomal dominant neurodegenerative disease caused by the expression of a toxic huntingtin (htt) protein. |
2013-08-20 |
2023-08-12 |
mouse |
| Liza M Sutton, Shaun S Sanders, Stefanie L Butland, Roshni R Singaraja, Sonia Franciosi, Amber L Southwell, Crystal N Doty, Mandi E Schmidt, Katherine K N Mui, Vlad Kovalik, Fiona B Young, Weining Zhang, Michael R Hayde. Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease. Human molecular genetics. vol 22. issue 3. 2013-07-01. PMID:23077216. |
huntingtin-interacting protein 14 (hip14), a well-characterized neuronal pat, has been implicated in the pathogenesis of huntington disease (hd), a fatal neurodegenerative disease associated with motor, psychiatric and cognitive symptoms, caused by a cag expansion in the huntingtin gene (htt). |
2013-07-01 |
2023-08-12 |
mouse |
| Shuqiu Zheng, Nima Ghitani, Jessica S Blackburn, Jeh-Ping Liu, Scott O Zeitli. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis. Molecular brain. vol 5. 2013-06-21. PMID:22892315. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease that is caused by the expansion of a polyglutamine (polyq) stretch within huntingtin (htt), the protein product of the hd gene. |
2013-06-21 |
2023-08-12 |
mouse |
| Jing Jin, Jennifer Albertz, Zhihong Guo, Qi Peng, Gay Rudow, Juan C Troncoso, Christopher A Ross, Wenzhen Dua. Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease. Journal of neurochemistry. vol 125. issue 3. 2013-06-20. PMID:23373812. |
the peroxisome proliferator-activated receptor gamma (ppar-γ) is a transcriptional factor that plays a key role in regulating genes involved in energy metabolism; recent studies demonstrated that ppar-γ activation prevented mitochondrial depolarization in cells expressing mutant htt and attenuated neurodegeneration in various models of neurodegenerative diseases. |
2013-06-20 |
2023-08-12 |
mouse |
| Peter O Bauer, Roman Hudec, Anand Goswami, Masaru Kurosawa, Gen Matsumoto, Katsuhiko Mikoshiba, Nobuyuki Nukin. ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT. Molecular neurodegeneration. vol 7. 2013-06-19. PMID:22929228. |
huntington's disease (hd) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (htt) containing an expanded polyglutamine (polyq) tract. |
2013-06-19 |
2023-08-12 |
Not clear |
| Rebecca K Lehman, Martha Nanc. Family history in juvenile Huntington disease: do the signs point to "yes" or "very doubtful"? Neurology. vol 80. issue 11. 2013-04-30. PMID:23390171. |
like the adult form of the disorder, jhd is a hereditary neurodegenerative disease characterized by dementia and behavioral changes, caused by an expanded cag repeat within the first exon of the huntingtin (htt) gene on chromosome 4. |
2013-04-30 |
2023-08-12 |
Not clear |
| Jiun-Tsai Lin, Wei-Cheng Chang, Hui-Mei Chen, Hsing-Lin Lai, Chih-Yeh Chen, Mi-Hua Tao, Yijuang Cher. Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease. Molecular and cellular biology. vol 33. issue 5. 2013-04-09. PMID:23275441. |
huntington's disease (hd) is a neurodegenerative disease caused by the expansion of a cag repeat in the huntingtin (htt) gene. |
2013-04-09 |
2023-08-12 |
mouse |
| Tz-Chuen Ju, Yow-Sien Lin, Yijuang Cher. Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB. Cellular and molecular life sciences : CMLS. vol 69. issue 24. 2013-02-18. PMID:22627493. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a cag trinucleotide expansion in the huntingtin (htt) gene. |
2013-02-18 |
2023-08-12 |
Not clear |
| Laura Ciarlo, Valeria Manganelli, Paola Matarrese, Tina Garofalo, Antonella Tinari, Lucrezia Gambardella, Matteo Marconi, Maria Grasso, Roberta Misasi, Maurizio Sorice, Walter Malorn. Raft-like microdomains play a key role in mitochondrial impairment in lymphoid cells from patients with Huntington's disease. Journal of lipid research. vol 53. issue 10. 2013-01-29. PMID:22773688. |
huntington's disease (hd) is a genetic neurodegenerative disease characterized by an exceedingly high number of contiguous glutamine residues in the translated protein, huntingtin (htt). |
2013-01-29 |
2023-08-12 |
human |
| James J Ritch, Antonio Valencia, Jonathan Alexander, Ellen Sapp, Leah Gatune, Gavin R Sangrey, Saurabh Sinha, Cally M Scherber, Scott Zeitlin, Ghazaleh Sadri-Vakili, Daniel Irimia, Marian Difiglia, Kimberly B Kege. Multiple phenotypes in Huntington disease mouse neural stem cells. Molecular and cellular neurosciences. vol 50. issue 1. 2012-11-09. PMID:22508027. |
hd is a heritable neurodegenerative disease caused by a mutation resulting in an increased number of glutamines (q) within a polyglutamine tract in huntingtin (htt). |
2012-11-09 |
2023-08-12 |
mouse |