| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan Cornett, Lauren Smith, Meyer Friedman, Ji-Yeon Shin, Xiao-Jiang Li, Shi-Hua L. Context-dependent dysregulation of transcription by mutant huntingtin. The Journal of biological chemistry. vol 281. issue 47. 2007-01-09. PMID:17012230. |
huntington disease (hd) is an adult-onset neurodegenerative disease caused by expansion of a polyglutamine (poly(q) tract in the n-terminal region of huntingtin (htt). |
2007-01-09 |
2023-08-12 |
Not clear |
| Jeremy M Van Raamsdonk, Jacqueline Pearson, Daniel A Rogers, Nagat Bissada, A Wayne Vogl, Michael R Hayden, Blair R Leavit. Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease. Human molecular genetics. vol 14. issue 10. 2005-09-26. PMID:15829505. |
huntington disease (hd) is an adult-onset neurodegenerative disease caused by a toxic gain of function in the huntingtin (htt) protein. |
2005-09-26 |
2023-08-12 |
mouse |
| Hideyuki Mukai, Takayuki Isagawa, Emiko Goyama, Shuhei Tanaka, Neil F Bence, Atsuo Tamura, Yoshitaka Ono, Ron R Kopit. Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 31. 2005-09-20. PMID:16040812. |
because small nonfibrillar oligomers, not mature fibrils, recently have been suggested to be the principal cytotoxic species in neurodegenerative disease, these htt globular aggregates formed in cells may represent the pathogenic form of mutant htt. |
2005-09-20 |
2023-08-12 |
Not clear |
| Bin Huang, Stefan Kochane. Adenovirus-mediated silencing of huntingtin expression by shRNA. Human gene therapy. vol 16. issue 5. 2005-08-08. PMID:15916486. |
huntington's disease (hd) is an inherited autosomal dominant, neurodegenerative disease that is caused by a gain of function mutation characterized by the expansion of a cag trinucleotide repeat in exon 1 of the huntingtin (htt) gene. |
2005-08-08 |
2023-08-12 |
Not clear |
| Ming-Chang Chiang, Yi-Chao Lee, Chuen-Lin Huang, Yijuang Cher. cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues. The Journal of biological chemistry. vol 280. issue 14. 2005-06-21. PMID:15689617. |
huntington's disease is a neurodegenerative disease resulting from a cag (glutamine) trinucleotide expansion in exon 1 of the huntingtin (htt) gene. |
2005-06-21 |
2023-08-12 |
Not clear |
| Szu-Yi Chou, Yi-Chao Lee, Hui-Mei Chen, Ming-Chang Chiang, Hsing-Lin Lai, Hao-Hung Chang, Yi-Chih Wu, Chung-Nan Sun, Chen-Li Chien, Yow-Sien Lin, Shyi-Chyi Wang, Yu-Ying Tung, Chen Chang, Yijuang Cher. CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. Journal of neurochemistry. vol 93. issue 2. 2005-05-20. PMID:15816854. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a cag trinucleotide expansion in exon 1 of the huntingtin (htt) gene. |
2005-05-20 |
2023-08-12 |
mouse |
| Mariarosa A B Melone, Francesco P Jori, Gianfranco Pelus. Huntington's disease: new frontiers for molecular and cell therapy. Current drug targets. vol 6. issue 1. 2005-05-19. PMID:15720212. |
huntington's disease (hd) is an incurable, adult-onset, dominantly inherited neurodegenerative disease, caused by a cag expansion in the 5' coding region of the gene hd [encoding huntingtin (htt), which is ubiquitously expressed in all tissues]. |
2005-05-19 |
2023-08-12 |
human |
| Haibing Jiang, Frederick C Nucifora, Christopher A Ross, Donald B DeFranc. Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein. Human molecular genetics. vol 12. issue 1. 2003-07-03. PMID:12490527. |
huntington's disease belongs to the cag repeat family of neurodegenerative diseases and is characterized by the presence of an expanded polyglutamine (polyq) repeat in the huntingtin (htt) gene product. |
2003-07-03 |
2023-08-12 |
Not clear |
| Sébastien Holbert, Alpaslan Dedeoglu, Sandrine Humbert, Frédéric Saudou, Robert J Ferrante, Christian Nér. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12604778. |
huntington's disease (hd) is a neurodegenerative disease caused by polyglutamine (polyq) expansion in the protein huntingtin (htt). |
2003-05-13 |
2023-08-12 |
human |
| J A Parker, J B Connolly, C Wellington, M Hayden, J Dausset, C Ner. Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 23. 2001-12-07. PMID:11687635. |
huntington's disease (hd) is a dominant neurodegenerative disease caused by polyglutamine (polyq) expansion in the protein huntingtin (htt). |
2001-12-07 |
2023-08-12 |
human |
| S Holbert, I Denghien, T Kiechle, A Rosenblatt, C Wellington, M R Hayden, R L Margolis, C A Ross, J Dausset, R J Ferrante, C Nér. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172033. |
huntington's disease (hd) is a neurodegenerative disease caused by polyglutamine expansion in the protein huntingtin (htt). |
2001-04-19 |
2023-08-12 |
human |