| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongshuai Liu, Ainsley McCollum, Asvini Krishnaprakash, Yuxiao Ouyang, Tianze Shi, Tamara Ratovitski, Mali Jiang, Wenzhen Duan, Christopher A Ross, Jing Ji. Roscovitine, a CDK Inhibitor, Reduced Neuronal Toxicity of mHTT by Targeting HTT Phosphorylation at S1181 and S1201 In Vitro. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596381. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a single mutation in the huntingtin gene (htt). |
2024-11-27 |
2024-11-29 |
mouse |
| Subrata Pradhan, Keegan Bush, Nan Zhang, Raj K Pandita, Chi-Lin Tsai, Charlene Smith, Devon F Pandlebury, Sagar Gaikwad, Francis Leonard, Linghui Nie, Annie Tao, William Russell, Subo Yuan, Sanjeev Choudhary, Kenneth S Ramos, Cornelis Elferink, Yogesh P Wairkar, John A Tainer, Leslie M Thompson, Tej K Pandita, Partha S Sarka. Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345557. |
persistent dna double-strand breaks (dsbs) are enigmatically implicated in neurodegenerative diseases including huntington's disease (hd), the inherited late-onset disorder caused by cag repeat elongations in huntingtin (htt). |
2024-09-30 |
2024-10-02 |
Not clear |
| Anirban Chakraborty, Sravan Gopalkrishnashetty Sreenivasmurthy, Wyatt Miller, Weihan Huai, Tapan Biswas, Santi Mohan Mandal, Lisardo Boscá, Balaji Krishnan, Gourisankar Ghosh, Tapas Hazr. Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 39. 2024-09-19. PMID:39298485. |
huntington's disease (hd) and spinocerebellar ataxia type 3 (sca3) are the two most prevalent polyglutamine (polyq) neurodegenerative diseases, caused by cag (encoding glutamine) repeat expansion in the coding region of the huntingtin (htt) and ataxin-3 (atxn3) proteins, respectively. |
2024-09-19 |
2024-09-22 |
mouse |
| Ankita Deo, Rishita Ghosh, Snehal Ahire, Sayali Marathe, Amitabha Majumdar, Tania Bos. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Scientific reports. vol 14. issue 1. 2024-09-06. PMID:39242711. |
huntington's disease (hd) is a rare neurodegenerative disease caused due to aggregation of huntingtin (htt) protein. |
2024-09-06 |
2024-09-10 |
drosophila_melanogaster |
| Sabrina Montresor, Maria Lucia Pigazzini, Sudarson Baskaran, Mira Sleiman, Govinda Adhikari, Lukas Basilicata, Luca Secker, Natascha Jacob, Yara Ehlert, Anushree Kelkar, Gurleen Kaur Kalsi, Niraj Kulkarni, Paul Spellerberg, Janine Kirstei. HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity. Journal of neurochemistry. 2024-08-24. PMID:39180255. |
interestingly, hsp110 is vital for the hsp70/110/jdp-mediated disaggregation of amyloidogenic proteins implicated in neurodegenerative diseases (i.e., α-synuclein, htt, and tau). |
2024-08-24 |
2024-08-27 |
caenorhabditis_elegans |
| Marina Sogorb-Gonzalez, Christian Landles, Nicholas S Caron, Anouk Stam, Georgina Osborne, Michael R Hayden, David Howland, Sander van Deventer, Gillian P Bates, Astrid Vallès, Melvin Ever. Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington disease models. Brain : a journal of neurology. 2024-08-18. PMID:39155061. |
huntington disease (hd) is a fatal neurodegenerative disease caused by a trinucleotide repeat expansion in exon 1 of the huntingtin gene (htt) resulting in toxic gain-of-function and cell death. |
2024-08-18 |
2024-08-21 |
mouse |
| Mohit Neema, Jordan L Schultz, Douglas R Langbehn, Amy L Conrad, Eric A Epping, Vincent A Magnotta, Peggy C Nopoulo. Mutant Huntingtin Drives Development of an Advantageous Brain Early in Life: Evidence in Support of Antagonistic Pleiotropy. Annals of neurology. 2024-08-08. PMID:39115048. |
huntington's disease (hd) is a neurodegenerative disease caused by a triplet repeat expansion within the gene huntingtin (htt). |
2024-08-08 |
2024-08-10 |
Not clear |
| Harman Sharma, Sushma Koirala, Yee Lian Chew, Anna Konopk. DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration. Molecular neurobiology. 2024-07-08. PMID:38977621. |
this review focused on hallmark proteins involved in various neurodegenerative diseases, such as the microtubule-associated protein tau, tar dna/rna binding protein 43 (tdp-43), superoxide dismutase 1 (sod1), fused in sarcoma (fus), huntingtin (htt), α-synuclein, and β-amyloid precursor protein (app). |
2024-07-08 |
2024-07-12 |
Not clear |
| Lucie Chenain, Rachid Riad, Nicolas Fraisse, Cécilia Jubin, Graça Morgado, Katia Youssov, Marine Lunven, Anne-Catherine Bachoud-Lev. Graph methods to infer spatial disturbances: Application to Huntington's Disease's speech. Cortex; a journal devoted to the study of the nervous system and behavior. vol 176. 2024-05-25. PMID:38795650. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by the mutation of the htt gene, impacting all aspects of living and functioning. |
2024-05-25 |
2024-05-31 |
Not clear |
| Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yan. HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice. Cell death & disease. vol 15. issue 5. 2024-05-14. PMID:38744826. |
huntington's disease (hd) is a monogenic neurodegenerative disease, caused by the cag trinucleotide repeat expansion in exon 1 of the huntingtin (htt) gene. |
2024-05-14 |
2024-05-27 |
mouse |
| Xingyu Lu, Jiongtong Lu, Shengnan Li, Sifan Feng, Yan Wang, Lili Cu. The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases. Aging and disease. 2024-05-13. PMID:38739933. |
in this review, we present an overview of the progress of phase separation research, involving its biological mechanisms and the status of research in neurodegenerative diseases, focusing on five main disease-specific proteins, tau, tdp-43, fus, α-syn and htt, and how exactly these proteins reside within dynamic liquid-like compartments and thus turn into solid deposits. |
2024-05-13 |
2024-05-27 |
Not clear |
| Dale D O Martin, Shaun S Sander. Let's get fat: emergence of S-acylation as a therapeutic target in Huntington disease. Biochemical Society transactions. 2024-05-02. PMID:38695682. |
huntington disease (hd) is a devastating, fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric deficits caused by a cag repeat expansion in the htt gene. |
2024-05-02 |
2024-05-04 |
Not clear |
| Javier Ojalvo-Pacheco, Sokhna M S Yakhine-Diop, José M Fuentes, Marta Paredes-Barquero, Mireia Niso-Santan. Role of TFEB in Huntington's Disease. Biology. vol 13. issue 4. 2024-04-26. PMID:38666850. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by an expansion of the cag trinucleotide repeat in exon 1 of the huntingtin (htt) gene. |
2024-04-26 |
2024-04-28 |
Not clear |
| Adam Skeens, Chathuranga Siriwardhana, Sophia E Massinople, Michelle M Wunder, Zachary L Ellis, Kaitlyn M Keith, Tyler Girman, Shelli L Frey, Justin Legleite. The polyglutamine domain is the primary driver of seeding in huntingtin aggregation. PloS one. vol 19. issue 3. 2024-03-14. PMID:38483973. |
huntington's disease (hd) is a fatal, neurodegenerative disease caused by aggregation of the huntingtin protein (htt) with an expanded polyglutamine (polyq) domain into amyloid fibrils. |
2024-03-14 |
2024-03-17 |
caenorhabditis_elegans |
| Sergio Pérez-Oliveira, Juan Castilla-Silgado, Cèlia Painous, Iban Aldecoa, Manuel Menéndez-González, Marta Blázquez-Estrada, Daniela Corte, Cristina Tomás-Zapico, Yaroslau Compta, Esteban Muñoz, Albert Lladó, Mircea Balasa, Gemma Aragonès, Pablo García-González, Maitée Rosende-Roca, Mercè Boada, Agustín Ruíz, Pau Pastor, Beatriz De la Casa-Fages, Alberto Rabano, Raquel Sánchez-Valle, Laura Molina-Porcel, Victoria Álvare. Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights. Brain pathology (Zurich, Switzerland). 2024-02-28. PMID:38418081. |
previous studies have suggested a relationship between the number of cag triplet repeats in the htt gene and neurodegenerative diseases not related to huntington's disease (hd). |
2024-02-28 |
2024-03-02 |
human |
| Xuanzhuo Liu, Fang Wang, Xinman Fan, Mingyi Chen, Xiaoxin Xu, Qiuhong Xu, Huili Zhu, Anding Xu, Mahmoud A Pouladi, Xiaohong X. CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress. Cell death & disease. vol 15. issue 2. 2024-02-10. PMID:38341417. |
huntington disease (hd) is a neurodegenerative disease caused by the abnormal expansion of a polyglutamine tract resulting from a mutation in the htt gene. |
2024-02-10 |
2024-02-14 |
mouse |
| Francesco D'Egidio, Vanessa Castelli, Giorgia Lombardozzi, Fabrizio Ammannito, Annamaria Cimini, Michele d'Angel. Therapeutic advances in neural regeneration for Huntington's disease. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227527. |
huntington's disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the htt gene which is responsible for the production of the huntingtin (htt) protein. |
2024-01-16 |
2024-01-18 |
Not clear |
| Sonia Podvin, Charles Mosier, William Poon, Enlin Wei, Leigh-Ana Rossotto, Vivian Hoo. Dysregulation of Human Juvenile Huntington's Disease Brain Proteomes in Cortex and Putamen Involves Mitochondrial and Neuropeptide Systems. Journal of Huntington's disease. vol 12. issue 4. 2023-12-19. PMID:38108356. |
huntington's disease (hd) is a genetic neurodegenerative disease caused by trinucleotide repeat cag expansions in the human htt gene. |
2023-12-19 |
2023-12-21 |
human |
| Huichun Tong, Tianqi Yang, Li Liu, Caijuan Li, Yize Sun, Qingqing Jia, Yiyang Qin, Laiqiang Chen, Xianxian Zhao, Gongke Zhou, Sen Yan, Xiao-Jiang Li, Shihua L. Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs. Neurobiology of disease. 2023-09-16. PMID:37716514. |
huntington's disease (hd) is an autosomal-dominant inherited neurodegenerative disease caused by a cag repeat expansion in exon1 of the huntingtin gene (htt). |
2023-09-16 |
2023-10-07 |
mouse |
| Marta Piechota, Ewelina Latoszek, Ewa Liszewska, Hana Hansíková, Jiří Klempíř, Alžbeta Mühlbäck, Georg Bernhard Landwehrmeyer, Jacek Kuźnicki, Magdalena Czeredy. Generation of two human iPSC lines from dermal fibroblasts of adult- and juvenile-onset Huntington's disease patients and two healthy donors. Stem cell research. vol 71. 2023-08-31. PMID:37651831. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a mutation in the htt gene. |
2023-08-31 |
2023-09-07 |
human |