| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kara Y Chan, Xueying Li, Janice Ortega, Liya Gu, Guo-Min L. DNA polymerase θ promotes CAG•CTG repeat expansions in Huntington's disease via insertion sequences of its catalytic domain. The Journal of biological chemistry. vol 297. issue 4. 2021-11-24. PMID:34473992. |
huntington's disease (hd), a neurodegenerative disease characterized by progressive dementia, psychiatric problems, and chorea, is known to be caused by cag repeat expansions in the hd gene htt. |
2021-11-24 |
2023-08-13 |
Not clear |
| Adewale Adegbuyiro, Faezeh Sedighi, Pranav Jain, Mark V Pinti, Chathuranga Siriwardhana, John M Hollander, Justin Legleite. Mitochondrial membranes modify mutant huntingtin aggregation. Biochimica et biophysica acta. Biomembranes. vol 1863. issue 10. 2021-11-23. PMID:34089719. |
huntington's disease (hd) is a neurodegenerative disease caused by the expansion of a polyglutamine (polyq) tract near the n-terminus of the huntingtin (htt) protein. |
2021-11-23 |
2023-08-13 |
Not clear |
| Wiebke Frank, Katrin S Lindenberg, Alzbeta Mühlbäck, Jan Lewerenz, G Bernhard Landwehrmeye. [Disease-modifying treatment approaches in Huntington disease : Past and future]. Der Nervenarzt. 2021-11-11. PMID:34762178. |
huntington disease (hd) is the most frequent monogenetic neurodegenerative disease and can be unequivocally diagnosed even in the preclinical stage, at least in all individuals in whom the cag expansion mutation in the huntingtin gene (htt) is in the range of full penetrance. |
2021-11-11 |
2023-08-13 |
Not clear |
| Mandi Gandelman, Warunee Dansithong, Karla P Figueroa, Sharan Paul, Daniel R Scoles, Stefan M Puls. Staufen 1 amplifies proapoptotic activation of the unfolded protein response. Cell death and differentiation. vol 27. issue 10. 2021-11-08. PMID:32415281. |
staufen-1 (stau1) is an rna-binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (psen1), microtubule-associated protein tau (mapt), huntingtin (htt), tar dna-binding protein-43 gene (tardbp), or c9orf72. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xiang Li, Jianbin Wan. Maintenance of chaperone-mediated autophagy activity in cultured cells expressing mutant huntingtin. Biomedical reports. vol 2. issue 4. 2021-10-21. PMID:24944802. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by mutant huntingtin (htt) with an expanded polyglutamine tract. |
2021-10-21 |
2023-08-13 |
Not clear |
| X Zhao, A Chen, Z Wang, Xiao-Han Xu, Y Ta. Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2021-09-26. PMID:34564830. |
huntington disease (hd) is a single-gene autosomal dominant inherited neurodegenerative disease caused by a polyglutamine expansion of the protein huntingtin (htt). |
2021-09-26 |
2023-08-13 |
Not clear |
| Sharon E Groover, Adewale Adegbuyiro, Caleb K Fan, Breanna L Hodges, Maryssa Beasley, Katelyn Taylor, Alyssa R Stonebraker, Chathuranga Siriwardhana, Justin Legleite. Macromolecular crowding in solution alters huntingtin interaction and aggregation at interfaces. Colloids and surfaces. B, Biointerfaces. vol 206. 2021-09-07. PMID:34246856. |
huntington's disease (hd) is a fatal neurodegenerative disease caused by an extended polyglutamine (polyq) domain within the first exon of the huntingtin protein (htt). |
2021-09-07 |
2023-08-13 |
Not clear |
| Sarah R Oikemus, Edith Pfister, Ellen Sapp, Kathryn O Chase, Lori A Kennington, Edward Hudgens, Rachael Miller, Lihua Julie Zhu, Akanksh Chaudhary, Eric O Mick, Miguel Sena-Esteves, Scot A Wolfe, Marian DiFiglia, Neil Aronin, Michael H Brodsk. Allele-specific knockdown of mutant HTT protein via editing at coding region SNP heterozygosities. Human gene therapy. 2021-08-11. PMID:34376056. |
huntington's disease (hd) is a devasting, autosomal dominant neurodegenerative disease caused by a trinucleotide repeat expansion in the htt gene. |
2021-08-11 |
2023-08-13 |
mouse |
| Heather Dahlenburg, David Cameron, Sheng Yang, Angelica Bachman, Kari Pollock, Whitney Cary, Missy Pham, Kyle Hendrix, Jeannine White, Haley Nelson, Peter Deng, Joseph S Anderson, Kyle Fink, Jan Nolt. A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies. Stem cells translational medicine. vol 10. issue 7. 2021-07-01. PMID:33710799. |
huntington's disease (hd) is a fatal autosomal-dominant neurodegenerative disease caused by a trinucleotide cag repeat expansion of the huntingtin gene (htt) that affects 1 in every 10 000 individuals in the united states. |
2021-07-01 |
2023-08-13 |
mouse |
| Sarah J Tabrizi, Michael D Flower, Christopher A Ross, Edward J Wil. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities. Nature reviews. Neurology. vol 16. issue 10. 2021-06-24. PMID:32796930. |
huntington disease (hd) is a neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt) and involves a complex web of pathogenic mechanisms. |
2021-06-24 |
2023-08-13 |
human |
| Chia-Lung Chuang, Fabio Demonti. Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis. Ageing research reviews. vol 69. 2021-06-24. PMID:33979693. |
huntington disease (hd) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (htt) gene, which leads to a toxic, aggregation-prone, mutant htt-polyq protein. |
2021-06-24 |
2023-08-13 |
Not clear |
| A A Malakhova, E V Grigor'eva, T B Malankhanova, S V Pavlova, K R Valetdinova, N Yu Abramycheva, A S Vetchinova, S N Illarioshkin, S M Zakia. Generation of induced pluripotent stem cell line ICGi018-A from peripheral blood mononuclear cells of a patient with Huntington's disease. Stem cell research. vol 44. 2021-06-21. PMID:32179492. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by cag repeat expansion in the htt gene. |
2021-06-21 |
2023-08-13 |
Not clear |
| Ronald Wetze. Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington's Disease. Accounts of chemical research. vol 53. issue 10. 2021-06-01. PMID:32975927. |
huntington's disease (hd) is a progressive, familial neurodegenerative disease triggered by the expansion of a polyglutamine (polyq) track in the protein huntingtin (htt). |
2021-06-01 |
2023-08-13 |
Not clear |
| Thays A Apolinário, Iane Dos Santos da Silva, Luciana de Andrade Agostinho, Carmen L A Paiv. Investigation of intermediate CAG alleles of the HTT in the general population of Rio de Janeiro, Brazil, in comparison with a sample of Huntington disease-affected families. Molecular genetics & genomic medicine. vol 8. issue 4. 2021-04-02. PMID:32067426. |
huntington disease (hd) (mim: 143100) is a severe autosomal dominant neurodegenerative disease caused by the expansion of cag trinucleotides (>35) in the htt. |
2021-04-02 |
2023-08-13 |
Not clear |
| Harleen Kohli, Pravir Kumar, Rashmi K Ambast. Heliyon. vol 7. issue 2. 2021-03-05. PMID:33659724. |
huntington's disease is a neurodegenerative disease caused by cag repeat in the first exon of htt (huntingtin) gene, leading to abnormal form of htt protein containing enlarged polyglutamine strands of variable length that stick together to form aggregates and is toxic to brain causing brain damage. |
2021-03-05 |
2023-08-13 |
Not clear |
| Faezeh Sedighi, Adewale Adegbuyiro, Justin Legleite. SUMOylation Prevents Huntingtin Fibrillization and Localization onto Lipid Membranes. ACS chemical neuroscience. vol 11. issue 3. 2021-03-03. PMID:31880908. |
huntington's disease (hd), a genetic neurodegenerative disease, is caused by an expanded polyglutamine (polyq) domain in the first exon of the huntingtin protein (htt). |
2021-03-03 |
2023-08-13 |
Not clear |
| Karolina Pierzynowska, Magdalena Podlacha, Dorota Łuszczek, Estera Rintz, Lidia Gaffke, Zuzanna Szczudło, Marta Tomczyk, Ryszard T Smoleński, Grzegorz Węgrzy. Hair dysmorphology in the R6/1 and R6/2 mouse models of Huntington's disease. Gene. vol 765. 2020-12-16. PMID:32898606. |
although it is described as a neurodegenerative disease, due to expression of htt in all types of cells, peripheral symptoms also occur. |
2020-12-16 |
2023-08-13 |
mouse |
| Endan Li, Hee Ra Park, Chang Pyo Hong, Younghoon Kim, Jiwoo Choi, Suji Lee, Hyun Jung Park, Bomi Lee, Tae Aug Kim, Seong Jin Kim, Hyun Sook Kim, Jihwan Son. Neural stem cells derived from the developing forebrain of YAC128 mice exhibit pathological features of Huntington's disease. Cell proliferation. vol 53. issue 10. 2020-10-29. PMID:32865873. |
huntington's disease (hd) is a devastating neurodegenerative disease caused by polyglutamine (polyq) expansion in the huntingtin (htt) gene. |
2020-10-29 |
2023-08-13 |
mouse |
| Martin L Duennwal. Cellular stress responses in protein misfolding diseases. Future science OA. vol 1. issue 2. 2020-10-01. PMID:28031871. |
huntington's disease is an inherited neurodegenerative disease caused by the misfolding of an abnormally expanded polyglutamine (polyq) region in the protein huntingtin (htt), polyqhtt. |
2020-10-01 |
2023-08-13 |
human |
| Magdalena Czeredys, Vladimir A Vigont, Vasilisa A Boeva, Katsuhiko Mikoshiba, Elena V Kaznacheyeva, Jacek Kuznick. Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington's Disease. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30455632. |
huntington's disease (hd) is a hereditary neurodegenerative disease that is caused by polyglutamine expansion within the huntingtin (htt) gene. |
2020-09-30 |
2023-08-13 |
mouse |