| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Costanza Ferrari Bardile, Carola I Radulescu, Mahmoud A Poulad. Oligodendrocyte pathology in Huntington's disease: from mechanisms to therapeutics. Trends in molecular medicine. 2023-08-17. PMID:37591764. |
there is new recognition of the role of olgs in the pathogenesis of neurodegenerative diseases (ndds), including huntington's disease (hd), a prototypic ndd caused by a polyglutamine tract expansion in huntingtin (htt), which results in gain- and loss-of-function effects. |
2023-08-17 |
2023-09-07 |
Not clear |
| Alyssa R Stonebraker, Maryssa Beasley, Sophia Massinople, Michelle Wunder, Peng Li, Stephen J Valentine, Justin Legleite. Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation. Protein science : a publication of the Protein Society. 2023-04-13. PMID:37052951. |
huntington's disease (hd) is a neurodegenerative disease resulting from an expansion of the polyglutamine (polyq) domain within the huntingtin protein (htt). |
2023-04-13 |
2023-08-14 |
Not clear |
| Kizito-Tshitoko Tshilenge, Carlos Galicia Aguirre, Joanna Bons, Akos A Gerencser, Nathan Basisty, Sicheng Song, Jacob Rose, Alejandro Lopez-Ramirez, Swati Naphade, Ashley Loureiro, Elena Battistoni, Mateus Milani, Cameron Wehrfritz, Anja Holtz, Claudio Hetz, Sean D Mooney, Birgit Schilling, Lisa M Ellerb. Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets. Molecular & cellular proteomics : MCP. 2023-03-23. PMID:36958627. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag repeat expansion in the huntingtin (htt) gene. |
2023-03-23 |
2023-08-14 |
human |
| Christiana C Christodoulou, Eleni Zamba Papanicolao. Integrated Bioinformatics Analysis of Shared Genes, miRNA, Biological Pathways and Their Potential Role as Therapeutic Targets in Huntington's Disease Stages. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902304. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt). |
2023-03-11 |
2023-08-14 |
Not clear |
| Baljit S Khakh, Steven A Goldma. Astrocytic contributions to Huntington's disease pathophysiology. Annals of the New York Academy of Sciences. 2023-03-02. PMID:36864567. |
huntington's disease (hd) is a fatal, monogenic, autosomal dominant neurodegenerative disease caused by a polyglutamine-encoding cag expansion in the huntingtin (htt) gene that results in mutant huntingtin proteins (mhtt) in cells throughout the body. |
2023-03-02 |
2023-08-14 |
mouse |
| Noria Okada, Shinsuke Nakamura, Masamitsu Shimazaw. 3-Nitropropionic Acid Enhances Ferroptotic Cell Death via NOX2-Mediated ROS Generation in STHdhQ111 Striatal Cells Carrying Mutant Huntingtin. Biological & pharmaceutical bulletin. vol 46. issue 2. 2023-02-01. PMID:36724946. |
huntington's disease (hd) is a hereditary neurodegenerative disease that involves an expansion of the cag repeats of the huntingtin (htt) gene, but the disease onset and progression do not necessarily correspond to the extent of cag repeats. |
2023-02-01 |
2023-08-14 |
mouse |
| Sirui Zhang, Yangfan Cheng, Huifang Shan. The updated development of blood-based biomarkers for Huntington's disease. Journal of neurology. 2023-01-24. PMID:36692635. |
huntington's disease is a progressive neurodegenerative disease caused by mutation of the huntingtin (htt) gene. |
2023-01-24 |
2023-08-14 |
Not clear |
| Hyuck Kim, Rocio Gomez-Pasto. HSF1 and Its Role in Huntington's Disease Pathology. Advances in experimental medicine and biology. 2022-11-17. PMID:36396925. |
this review focuses on huntington's disease (hd), a neurodegenerative disease characterized by severe protein aggregation of the huntingtin (htt) protein. |
2022-11-17 |
2023-08-14 |
Not clear |
| Ling Chen, Mingxia Bi, Zhen Zhang, Xixun Du, Xi Chen, Qian Jiao, Hong Jian. The functions of IRE1α in neurodegenerative diseases: Beyond ER stress. Ageing research reviews. 2022-11-04. PMID:36332756. |
furthermore, ire1α is a significant factor in the regulation of neurodegenerative diseases that are caused by the phosphorylation of tau protein, the accumulation of α-synuclein (α-syn) and the toxic effects of mutant htt (mhtt). |
2022-11-04 |
2023-08-14 |
Not clear |
| Yu-Ting Weng, Hui-Mei Chen, Ting Chien, Feng-Lan Chiu, Hung-Chih Kuo, Yijuang Cher. TRAX Provides Neuroprotection for Huntington's Disease Via Modulating a Novel Subset of MicroRNAs. Movement disorders : official journal of the Movement Disorder Society. 2022-08-23. PMID:35997316. |
huntington's disease (hd) is a neurodegenerative disease caused by cag-repeat expansions (>36) in exon 1 of htt, which dysregulates multiple cellular machineries. |
2022-08-23 |
2023-08-14 |
Not clear |
| Yidan Zhang, Yifan Wang, Zhan Zhao, Weixun Peng, Peng Wang, Ximing Xu, Chenyang Zha. Glutaminyl cyclases, the potential targets of cancer and neurodegenerative diseases. European journal of pharmacology. 2022-08-10. PMID:35948163. |
several substrates of sqc involving beta amyloid (aβ), huntington (htt) protein and certain inflammatory mediators such as ccl2 and cx3cl1 have been observed to associate with neurodegenerative diseases and cancers. |
2022-08-10 |
2023-08-14 |
human |
| S M Ayala Mariscal, M L Pigazzini, Y Richter, M Özel, I L Grothaus, J Protze, K Ziege, M Kulke, M ElBediwi, J V Vermaas, L Colombi Ciacchi, S Köppen, F Liu, J Kirstei. Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT. Nature communications. vol 13. issue 1. 2022-08-10. PMID:35948542. |
huntington's disease is a neurodegenerative disease caused by an expanded polyq stretch within huntingtin (htt) that renders the protein aggregation-prone, ultimately resulting in the formation of amyloid fibrils. |
2022-08-10 |
2023-08-14 |
Not clear |
| Elena V Grigor'eva, Anastasia A Malakhova, Diana A Sorogina, Sofia V Pavlova, Tuyana B Malankhanova, Natalia Yu Abramycheva, Sergey A Klyushnikov, Sergey N Illarioshkin, Suren M Zakia. Generation of induced pluripotent stem cell line, ICGi033-A, by reprogramming peripheral blood mononuclear cells from a patient with Huntington's disease. Stem cell research. vol 63. 2022-07-25. PMID:35872525. |
huntington's disease (hd) is a hereditary autosomal dominant neurodegenerative disease caused by the polyglutamine stretch expansion in the huntingtin (htt) protein. |
2022-07-25 |
2023-08-14 |
Not clear |
| Sonia Podvin, Sara Brin Rosenthal, William Poon, Enlin Wei, Kathleen M Fisch, Vivian Hoo. Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease. Journal of Huntington's disease. 2022-07-24. PMID:35871359. |
huntington's disease (hd) is a genetic neurodegenerative disease caused by trinucleotide repeat (cag) expansions in the human htt gene encoding the huntingtin protein (htt) with an expanded polyglutamine tract. |
2022-07-24 |
2023-08-14 |
human |
| Sergio Pérez-Oliveira, Ignacio Álvarez, Irene Rosas, Manuel Menendez-González, Marta Blázquez-Estrada, Miquel Aguilar, Daniela Corte, Mariateresa Buongiorno, Laura Molina-Porcel, Iban Aldecoa, María J Martí, Pascual Sánchez-Juan, Jon Infante, Isabel González-Aramburu, Pablo García-González, Maitée Rosende-Roca, Mercè Boada, Agustín Ruiz, María Teresa Periñán, Daniel Macías-García, Laura Muñoz-Delgado, Pilar Gómez-Garre, Pablo Mir, Jordi Clarimón, Alberto Lleo, Daniel Alcolea, Beatriz De la Casa-Fages, Israel Duarte, Victoria Álvarez, Pau Pasto. Intermediate and Expanded HTT Alleles and the Risk for α-Synucleinopathies. Movement disorders : official journal of the Movement Disorder Society. 2022-07-19. PMID:35852957. |
previous studies suggest a link between cag repeat number in the htt gene and non-huntington neurodegenerative diseases. |
2022-07-19 |
2023-08-14 |
Not clear |
| Yiyang Qin, Shihua Li, Xiao-Jiang Li, Su Yan. CRISPR-Based Genome-Editing Tools for Huntington's Disease Research and Therapy. Neuroscience bulletin. 2022-05-24. PMID:35608753. |
huntington's disease (hd) is an autosomal dominantly-inherited neurodegenerative disease, which is caused by cag trinucleotide expansion in exon 1 of the huntingtin (htt) gene. |
2022-05-24 |
2023-08-13 |
Not clear |
| Nicholas S Caron, Raul Banos, Amirah E Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M Anderson, Benjamin Gordon, Amber L Southwell, Michael R Hayde. Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice. Neurobiology of disease. 2022-02-10. PMID:35143966. |
huntington disease (hd) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the htt gene encoding an elongated polyglutamine tract in the huntingtin (htt) protein. |
2022-02-10 |
2023-08-13 |
mouse |
| Li Zhang, Tengteng Wu, Yangyang Shan, Ge Li, Xue Ni, Xiaorui Chen, Xiuting Hu, Lishan Lin, Yongchao Li, Yalun Guan, Jinfeng Gao, Dingbang Chen, Yu Zhang, Zhong Pei, Xi Che. Therapeutic reversal of Huntington's disease by in vivo self-assembled siRNAs. Brain : a journal of neurology. vol 144. issue 11. 2021-12-17. PMID:34918046. |
huntington's disease is an autosomal-dominant neurodegenerative disease caused by cag expansion in exon 1 of the huntingtin (htt) gene. |
2021-12-17 |
2023-08-13 |
mouse |
| Leah Gottlieb, Lin Guo, James Shorter, Ronen Marmorstei. N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. The Journal of biological chemistry. vol 297. issue 6. 2021-12-11. PMID:34732320. |
these studies represent the first link between n-terminal acetylation and the promotion of a neurodegenerative disease and implicates nata-mediated htt acetylation as a new potential therapeutic target in hd. |
2021-12-11 |
2023-08-13 |
Not clear |
| Olga D Jarosińska, Stefan G D Rüdige. Molecular Strategies to Target Protein Aggregation in Huntington's Disease. Frontiers in molecular biosciences. vol 8. 2021-12-07. PMID:34869596. |
there are currently still no treatments available for hd, but approaches targeting the htt levels offer systematic, mechanism-driven routes towards curing hd and other neurodegenerative diseases. |
2021-12-07 |
2023-08-13 |
Not clear |