| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Regina C Caspe. Use of selective serotonin reuptake inhibitor antidepressants in pregnancy does carry risks, but the risks are small. The Journal of nervous and mental disease. vol 203. issue 3. 2015-04-22. PMID:25714254. |
the paper by robinson posits that risks from prenatal exposure to selective serotonin reuptake inhibitor (ssri) antidepressants are not different from the risks encountered in the general population and that untoward effects of ssris are difficult to distinguish from those of the mood disorder. |
2015-04-22 |
2023-08-13 |
Not clear |
| Martin J Lan, R Todd Ogden, Yung-Yu Huang, Maria A Oquendo, Gregory M Sullivan, Jeffrey Miller, Matthew Milak, J John Mann, Ramin V Parse. Genetic variation in brain-derived neurotrophic factor val66met allele is associated with altered serotonin-1A receptor binding in human brain. NeuroImage. vol 94. 2015-02-06. PMID:24607934. |
in mdd, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-ht(1a) receptors in mood disorders. |
2015-02-06 |
2023-08-12 |
human |
| Brian Dean, Nahed Tawadros, Myoung Suk Seo, Won Je Jeon, Ian Everall, Elizabeth Scarr, Andrew Gibbon. Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine. The international journal of neuropsychopharmacology. vol 17. issue 6. 2015-01-22. PMID:24495390. |
we have attempted to replicate studies showing higher levels of serotonin 2a receptors (htr2a) in the cortex of people with mood disorders and to determine the effects of treating rats with antidepressant drugs on levels of that receptor. |
2015-01-22 |
2023-08-12 |
rat |
| Shih-Hsien Lin, Lan-Ting Lee, Yen Kuang Yan. Serotonin and mental disorders: a concise review on molecular neuroimaging evidence. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 12. issue 3. 2015-01-19. PMID:25598822. |
in this concise review, we focus on evidence of the links between serotonin and major depressive disorders, as well as other mood disorders, anxiety disorders, schizophrenia, addiction, attention deficit hyperactivity disorder (adhd), and autism. |
2015-01-19 |
2023-08-13 |
Not clear |
| Tomiki Sumiyoshi, Hiroshi Kunugi, Kazuyuki Nakagom. Serotonin and dopamine receptors in motivational and cognitive disturbances of schizophrenia. Frontiers in neuroscience. vol 8. 2014-12-24. PMID:25538549. |
serotonin (5-ht) receptors may also play a significant role in cognitive and motivational disabilities in psychoses and mood disorders. |
2014-12-24 |
2023-08-13 |
mouse |
| Ali Seven, Beril Yüksel, Sevtap Kılıç, Hasan Esen, Uğur Keskin, Mustafa Ulubay, Murat Ozekinc. Effect of injectable medroxyprogesterone acetate and etonogestrel implants on GABA-A and serotonin receptors in white and gray matter of the brain: experimental study in rats. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 30. issue 4. 2014-12-08. PMID:24460500. |
we also showed that mpa has time-dependent effects on serotonin receptors, which may be a possible mechanism involved in mood disorders during long-term usage of injectable progesterone-only contraceptives. |
2014-12-08 |
2023-08-12 |
rat |
| Allison C Nugent, Paul J Carlson, Earle E Bain, William Eckelman, Peter Herscovitch, Husseini Manji, Carlos A Zarate, Wayne C Drevet. Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression. Journal of psychopharmacology (Oxford, England). vol 27. issue 10. 2014-11-15. PMID:23926239. |
abnormal serotonin type 1a (5-ht1a) receptor function and binding have been implicated in the pathophysiology of mood disorders. |
2014-11-15 |
2023-08-12 |
human |
| Isaac K Sundar, Hongwei Yao, Yadi Huang, Elizabeth Lyda, Patricia J Sime, Michael T Sellix, Irfan Rahma. Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis. PloS one. vol 9. issue 2. 2014-10-13. PMID:24520342. |
since smoking is a contributing factor in the development of copd, we hypothesize that cs can affect circadian rhythms of cort and 5ht secretion leading to sleep and mood disorders in smokers and patients with copd. |
2014-10-13 |
2023-08-12 |
mouse |
| Jodi L Pawluski, Eva van Donkelaar, Zipporah Abrams, Virginie Houbart, Marianne Fillet, Harry W M Steinbusch, Thierry D Charlie. Fluoxetine dose and administration method differentially affect hippocampal plasticity in adult female rats. Neural plasticity. vol 2014. 2014-10-06. PMID:24757568. |
selective serotonin reuptake inhibitor medications are one of the most common treatments for mood disorders. |
2014-10-06 |
2023-08-13 |
rat |
| Hamid Mostafavi Abdolmaleky, Shabnam Nohesara, Mohammad Ghadirivasfi, Arthur W Lambert, Hamidreza Ahmadkhaniha, Sait Ozturk, Chen Khuan Wong, Rahim Shafa, Ashraf Mostafavi, Sam Thiagalinga. DNA hypermethylation of serotonin transporter gene promoter in drug naïve patients with schizophrenia. Schizophrenia research. vol 152. issue 2-3. 2014-09-23. PMID:24411530. |
dysfunctional serotonin signaling has been linked to the pathogenesis of autism, obsessive compulsive disorder, mood disorders and schizophrenia. |
2014-09-23 |
2023-08-12 |
Not clear |
| Bo Xiang, Zhenxing Yang, Yin Lin, Lijie Guan, Xuan Li, Wei Deng, Zeyu Jiang, Guohui Lao, Qiang Wang, Xiaoyu Hao, Xiang Liu, Yingcheng Wang, Liansheng Zhao, Xiaohong Ma, Tao Li, Liping Cao, Xun H. Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population. Neuroscience bulletin. vol 30. issue 1. 2014-09-19. PMID:24136241. |
serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar i disorder (bp-i), a mood disorder, is not clear. |
2014-09-19 |
2023-08-12 |
Not clear |
| Sjoerd Hulsken, Antje Märtin, M Hasan Mohajeri, Judith Regina Homber. Food-derived serotonergic modulators: effects on mood and cognition. Nutrition research reviews. vol 26. issue 2. 2014-08-26. PMID:24134856. |
the most frequently described drugs in the treatment of mood disorders are selective serotonin reuptake and monoamine oxidase (mao) inhibitors, enhancing serotonin levels in the brain. |
2014-08-26 |
2023-08-12 |
human |
| Ian Mahar, Francis Rodriguez Bambico, Naguib Mechawar, José N Nobreg. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience and biobehavioral reviews. vol 38. 2014-08-08. PMID:24300695. |
specifically, chronic stress significantly attenuates 5-ht neurotransmission and 5-ht1a autoreceptor sensitivity, and this effect could represent an endophenotypic hallmark for mood disorders. |
2014-08-08 |
2023-08-12 |
Not clear |
| Adele Stewart, Biswanath Maity, Amanda M Wunsch, Fantao Meng, Qi Wu, John A Wemmie, Rory A Fishe. Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 4. 2014-06-02. PMID:24421401. |
targeting serotonin (5-ht) bioavailability with selective 5-ht reuptake inhibitors (ssris) remains the most widely used treatment for mood disorders. |
2014-06-02 |
2023-08-12 |
mouse |
| Adele Stewart, Biswanath Maity, Amanda M Wunsch, Fantao Meng, Qi Wu, John A Wemmie, Rory A Fishe. Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 4. 2014-06-02. PMID:24421401. |
rgs6 is enriched in hippocampal and cortical neurons, 5-ht(1a)r-expressing cells implicated in mood disorders. |
2014-06-02 |
2023-08-12 |
mouse |
| Niki Antypa, Raffaella Calati, Daniel Souery, Silvia Pellegrini, Othman Sentissi, Daniela Amital, Ulrike Moser, Stuart Montgomery, Siegfried Kasper, Joseph Zohar, Diana De Ronchi, Julien Mendlewicz, Alessandro Serrett. Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients. Journal of affective disorders. vol 150. issue 2. 2014-05-05. PMID:23537781. |
genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders. |
2014-05-05 |
2023-08-12 |
Not clear |
| Alan L Pehrson, Thomas Cremers, Cecile Bétry, Marieke G C van der Hart, Laerke Jørgensen, Mathias Madsen, Nasser Haddjeri, Bjarke Ebert, Connie Sanche. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 2. 2014-04-21. PMID:22612991. |
the monoaminergic network, including serotonin (5-ht), norepinephrine (ne), and dopamine (da) pathways, is highly interconnected and has a well-established role in mood disorders. |
2014-04-21 |
2023-08-12 |
rat |
| Allison C Nugent, Earle E Bain, Paul J Carlson, Alexander Neumeister, Omer Bonne, Richard E Carson, William Eckelman, Peter Herscovitch, Carlos A Zarate, Dennis S Charney, Wayne C Drevet. Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 8. 2014-03-13. PMID:23434290. |
multiple lines of evidence suggest that serotonin type 1a (5-ht(1a)) receptor dysfunction is involved in the pathophysiology of mood disorders, and that alterations in 5-ht(1a) receptor function play a role in the mechanisms of antidepressant and mood stabilizer treatment. |
2014-03-13 |
2023-08-12 |
human |
| Philipp G San. The serotonin 1A receptor gene in mood disorders: a tale of missed opportunities. European archives of psychiatry and clinical neuroscience. vol 263. issue 5. 2014-02-28. PMID:23179998. |
the serotonin 1a receptor gene in mood disorders: a tale of missed opportunities. |
2014-02-28 |
2023-08-12 |
Not clear |
| Jae-Min Kim, Robert Stewart, Hee-Ju Kang, Sung-Wan Kim, Il-Seon Shin, Hye-Ran Kim, Myung-Geun Shin, Joon-Tae Kim, Man-Seok Park, Ki-Hyun Cho, Jin-Sang Yoo. A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression. Journal of psychiatric research. vol 47. issue 9. 2014-02-14. PMID:23702251. |
serotonin transporter gene (slc6a4) has been shown to play an important role in the pathophysiology of mood disorders including poststroke depression (psd). |
2014-02-14 |
2023-08-12 |
Not clear |