| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M H Mohajeri, J Wittwer, K Vargas, E Hogan, A Holmes, P J Rogers, R Goralczyk, E L Gibso. Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women. The British journal of nutrition. vol 113. issue 2. 2016-08-15. PMID:25572038. |
common pharmacological treatments of mood disorders aim to modulate serotonergic neurotransmission and enhance serotonin levels in the brain. |
2016-08-15 |
2023-08-13 |
human |
| Alberto Montalbano, Renato Corradetti, Boris Mlina. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PloS one. vol 10. issue 10. 2016-06-06. PMID:26460748. |
distinct pharmacological properties of girk channels in 5-ht neurons should be explored for the development of new therapeutic agents for mood disorders. |
2016-06-06 |
2023-08-13 |
rat |
| Sarah J Judge, Claire Y Savy, Matthew Campbell, Rebecca Dodds, Larissa Kruger Gomes, Grace Laws, Anna Watson, Peter G Blain, Christopher M Morris, Sarah E Gartsid. Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system. Chemico-biological interactions. vol 245. 2016-05-26. PMID:26721196. |
the neurotransmitter serotonin (5-ht) is involved in mood disorder aetiology and it has been reported that (organophosphate) op exposure affects 5-ht turnover. |
2016-05-26 |
2023-08-13 |
rat |
| Man Luo, Terry-Elinor Reid, Xiang Simon Wan. Discovery of Natural Product-Derived 5-HT1A Receptor Binders by Cheminfomatics Modeling of Known Binders, High Throughput Screening and Experimental Validation. Combinatorial chemistry & high throughput screening. vol 18. issue 7. 2016-05-13. PMID:26138565. |
the human 5-hydroxytryptamine receptor subtype 1a (5-ht1a) is highly expressed in the raphe nuclei region and limbic structures; for that reason 5-ht1a has served as a promising target for treating human mood disorders and neurodegenerative diseases. |
2016-05-13 |
2023-08-13 |
human |
| M Bellani, M Nobile, V Bianchi, J van Os, P Brambill. G × E interaction and neurodevelopment II. Focus on adversities in paediatric depression: the moderating role of serotonin transporter. Epidemiology and psychiatric sciences. vol 22. issue 1. 2016-04-23. PMID:23114056. |
this article aims to review the studies exploring the moderating role of serotonin transporter on the effect of environmental adversities over time, particularly during childhood and adolescence, which is when level of internalizing symptoms and prevalence of mood disorders change substantially. |
2016-04-23 |
2023-08-12 |
Not clear |
| Yue Pei, Aman Asif-Malik, Juan J Canale. Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications. Frontiers in neuroscience. vol 10. 2016-04-19. PMID:27092049. |
taar1 is uniquely positioned to exert direct control over da and 5-ht neuronal firing and release, which has profound implications for understanding the pathophysiology of, and therefore designing more efficacious therapeutic interventions for, a range of neuropsychiatric disorders that involve aminergic dysregulation, including parkinson's disease, schizophrenia, mood disorders, and addiction. |
2016-04-19 |
2023-08-13 |
Not clear |
| Hayato Terayama, Takahiro Takimoto, Isao Fukunishi, Masahiro Itoh, Kazuhiko Iwahash. The serotonin-2A receptor polymorphism and clinical symptoms in mood disorders, schizophrenia and alcohol dependence in Japan. Acta neuropsychiatrica. vol 15. issue 3. 2016-03-18. PMID:26983355. |
in the past, there have been many epidemiological and genetic studies of mood disorders, schizophrenia, and alcohol dependence, and in this study, the human serotonin 2a receptor (5-htr2a) polymorphism was examined in 80 patients with mood disorders, 50 patients with schizophrenia and 41 patients with alcohol dependence. |
2016-03-18 |
2023-08-13 |
human |
| W M Verhoeven, S Tuinie. Biological and psychopharmacological aspects of impulse-control disorders. Acta neuropsychiatrica. vol 9. issue 2. 2016-03-14. PMID:26972136. |
subsequent investigations revealed that altered 5-ht metabolism is not related to mood disorder per se, but to components of the depressive syndrome and more specifically to increased anxiety and/or signs of dysregulated aggression, including violent suicidal attempts. |
2016-03-14 |
2023-08-13 |
Not clear |
| Tae Kyung Eun, Seong Hoon Jeong, Kyu Young Lee, Se Hyun Kim, Yong Min Ahn, Yang Weon Bang, Eun-Jeong Jo. Association between the 5-HTTLPR Genotype and Childhood Characteristics in Mood Disorders. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 14. issue 1. 2016-01-21. PMID:26792045. |
the present study aimed to determine whether a genetic role may be played by the serotonin transporter-linked polymorphic region (5-httlpr) in the childhood adhd features of adult patients with mood disorders. |
2016-01-21 |
2023-08-13 |
Not clear |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Asenapine alters the activity of monoaminergic systems following its subacute and long-term administration: an in vivo electrophysiological characterization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25656272. |
taken together, asenapine had profound effects on both catecholamine systems, potently blocked 5-ht2a receptors, and enhanced 5-ht tone, effects that could be important in treatment of mood disorders and schizophrenia. |
2016-01-11 |
2023-08-13 |
Not clear |
| Yann S Mineur, Emily B Einstein, Matthew P Bentham, Mattis B Wigestrand, Sam Blakeman, Sylvia A Newbold, Marina R Picciott. Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25288485. |
this study suggests that serotonin signaling through postsynaptic 5-ht1a receptors in the hippocampus is critical for the antidepressant-like effects of a cholinergic drug and begins to elucidate the molecular mechanisms underlying interactions between the serotonergic and cholinergic systems related to mood disorders. |
2016-01-05 |
2023-08-13 |
mouse |
| Raffaele Cozzolongo, Piero Porcelli, Filomena Cariola, Vito Giannuzzi, Elsa Lanzilotta, Mattia Gentile, Gabriella Sonnante, Gioacchino Leandr. Serotonin gene polymorphisms and lifetime mood disorders in predicting interferon-induced depression in chronic hepatitis C. Journal of affective disorders. vol 183. 2015-12-31. PMID:26001668. |
serotonin gene polymorphisms and lifetime mood disorders in predicting interferon-induced depression in chronic hepatitis c. ifn-induced depression is a suitable model for investigating vulnerability to depression. |
2015-12-31 |
2023-08-13 |
Not clear |
| Z M Ignácio, G Z Réus, H M Abelaira, J Queved. Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression. Neuroscience. vol 275. 2015-10-15. PMID:24972302. |
epidemiological studies have shown significant results in the interaction between the functions of brain-derived neurotrophic factor (bdnf) and 5-ht in mood disorders, such as major depressive disorder (mdd). |
2015-10-15 |
2023-08-13 |
Not clear |
| Lara-Jane Kepser, Judith R Homber. The neurodevelopmental effects of serotonin: a behavioural perspective. Behavioural brain research. vol 277. 2015-09-08. PMID:24859172. |
the studies together demonstrate that risk for mood disorders (including social deficits) is related to serotonergic perturbations during the prenatal and postnatal phases, whereas risk for autism-like features and sexual abnormalities increases when serotonin levels are increased during the postnatal period. |
2015-09-08 |
2023-08-13 |
Not clear |
| Luisa Rocha, Mario Alonso-Vanegas, Sandra Orozco-Suárez, David Alcántara-González, Humberto Cruzblanca, Elena Castr. Do certain signal transduction mechanisms explain the comorbidity of epilepsy and mood disorders? Epilepsy & behavior : E&B. vol 38. 2015-09-03. PMID:24472685. |
here, we described some changes at the biochemical level involving serotonin, dopamine, and γ-aminobutyric acid (gaba) receptors as well as signal transduction mechanisms that may explain the coexistence of both epilepsy and mood disorders. |
2015-09-03 |
2023-08-12 |
Not clear |
| Hristina Jovanovic, Ljiljana Kocoska-Maras, Angelique Flöter Rådestad, Christer Halldin, Jacqueline Borg, Angelica Lindén Hirschberg, Anna-Lena Nordströ. Effects of estrogen and testosterone treatment on serotonin transporter binding in the brain of surgically postmenopausal women--a PET study. NeuroImage. vol 106. 2015-09-03. PMID:25462800. |
although the mechanism still needs further exploration, the study supports the view that gonadal hormones play a role in serotonin regulated mood disorders. |
2015-09-03 |
2023-08-13 |
Not clear |
| Sandra Odebrecht Vargas Nunes, Márcia Regina Pizzo de Castro, Estefania Gastaldello Moreira, Roberta Losi Guembarovski, Decio Sabbatini Barbosa, Heber Odebrecht Vargas, Luiz Gustavo Piccoli de Melo, Chiara Cristina Bortolasci, Maria Angelica Ehara Watanabe, Seetal Dodd, Michael Berk, Michael Mae. Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders. Neuroscience letters. vol 585. 2015-08-19. PMID:25445355. |
this study was carried out to examine whether both tud and mood disorders are associated with genetic biomarkers particularly paraoxonase 1 (pon1) status, polymorphisms of glutathione s-transferases (gsts), such as gstm1 and gstt1, and the stin 2 polymorphism of the serotonin transporter. |
2015-08-19 |
2023-08-13 |
Not clear |
| Sandra Odebrecht Vargas Nunes, Márcia Regina Pizzo de Castro, Estefania Gastaldello Moreira, Roberta Losi Guembarovski, Decio Sabbatini Barbosa, Heber Odebrecht Vargas, Luiz Gustavo Piccoli de Melo, Chiara Cristina Bortolasci, Maria Angelica Ehara Watanabe, Seetal Dodd, Michael Berk, Michael Mae. Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders. Neuroscience letters. vol 585. 2015-08-19. PMID:25445355. |
these results show that comorbid mood disorders and tud are associated with specific biomarkers related to oxidative stress and serotonin pathways. |
2015-08-19 |
2023-08-13 |
Not clear |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
here, we examined several aspects of 5-ht1a receptor function in the 5-ht transporter knockout mouse (sert-ko), a model of vulnerability to stress and mood disorders. |
2015-07-24 |
2023-08-13 |
mouse |
| Nitasha Agrawal, Sergio Marco-Peiró, Josep Esteve-Romero, Abhilasha Durgbanshi, Devasish Bose, Juan Peris-Vicente, Samuel Carda-Broc. Determination of paroxetine in blood and urine using micellar liquid chromatography with electrochemical detection. Journal of chromatographic science. vol 52. issue 10. 2015-07-02. PMID:24448669. |
paroxetine is a potent selective serotonin reuptake inhibitor used for the treatment of depression and related mood disorders. |
2015-07-02 |
2023-08-12 |
human |