| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergio Domínguez-López, Ian Mahar, Francis Rodriguez Bambico, Benoit Labonté, Rafael Ochoa-Sánchez, Marco Leyton, Gabriella Gobb. Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle. Journal of psychopharmacology (Oxford, England). vol 26. issue 6. 2013-01-15. PMID:21730015. |
melatonin (mlt) and serotonin (5-ht) are two biosynthetically related compounds implicated in several common physiological functions and the etiology of mood disorders. |
2013-01-15 |
2023-08-12 |
rat |
| Sergio Domínguez-López, Ian Mahar, Francis Rodriguez Bambico, Benoit Labonté, Rafael Ochoa-Sánchez, Marco Leyton, Gabriella Gobb. Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle. Journal of psychopharmacology (Oxford, England). vol 26. issue 6. 2013-01-15. PMID:21730015. |
this mlt-induced decrease in 5-ht neurotransmission may represent a biological mechanism underlying mood disorders characterized by increased mlt secretion, such as seasonal affective disorder. |
2013-01-15 |
2023-08-12 |
rat |
| Enza Lacivita, Pantaleo Di Pilato, Paola De Giorgio, Nicola A Colabufo, Francesco Berardi, Roberto Perrone, Marcello Leopold. The therapeutic potential of 5-HT1A receptors: a patent review. Expert opinion on therapeutic patents. vol 22. issue 8. 2012-11-27. PMID:22788968. |
the 5-ht(1a) receptors are implicated in mood disorders (anxiety, depression), in cognition, and in modulation of pain. |
2012-11-27 |
2023-08-12 |
Not clear |
| C E McAllister, R D Creech, P A Kimball, N A Muma, Q L. GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus. Psychoneuroendocrinology. vol 37. issue 8. 2012-11-05. PMID:22265196. |
estrogen therapy used in combination with selective serotonin reuptake inhibitor (ssri) treatment improves ssri efficacy for the treatment of mood disorders. |
2012-11-05 |
2023-08-12 |
rat |
| Ilan A Kerman, René Bernard, William E Bunney, Edward G Jones, Alan F Schatzberg, Richard M Myers, Jack D Barchas, Huda Akil, Stanley J Watson, Robert C Thompso. Evidence for transcriptional factor dysregulation in the dorsal raphe nucleus of patients with major depressive disorder. Frontiers in neuroscience. vol 6. 2012-10-23. PMID:23087602. |
dorsal raphe nucleus (dr) is a major source of serotonin in the brain, and previous studies have reported within it alterations in 5-ht-related gene expression, protein levels, receptor binding, and morphological organization in mood disorders. |
2012-10-23 |
2023-08-12 |
human |
| Olga Chernoloz, Mostafa El Mansari, Pierre Blie. Effects of sustained administration of quetiapine alone and in combination with a serotonin reuptake inhibitor on norepinephrine and serotonin transmission. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 7. 2012-09-21. PMID:22373941. |
the enhancement of ne and 5-ht transmission by hquet may contribute to its antidepressant action in mood disorders. |
2012-09-21 |
2023-08-12 |
rat |
| Brian J Mickey, Benjamin J Sanford, Tiffany M Love, Pei-Hong Shen, Colin A Hodgkinson, Christian S Stohler, David Goldman, Jon-Kar Zubiet. Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 27. 2012-09-18. PMID:22764241. |
in humans, a common missense single-nucleotide change (rs6318, cys23ser) in the 5-ht(2c) receptor gene (htr2c) has been associated with altered activity in vitro and with clinical mood disorders. |
2012-09-18 |
2023-08-12 |
Not clear |
| F Duval, M C Mokrani, P Bailey, H Corrêa, M A Crocq, T Son Diep, J P Mache. Serotonergic and noradrenergic function in depression: clinical correlates. Dialogues in clinical neuroscience. vol 2. issue 3. 2012-09-10. PMID:22033550. |
however, our results also suggest that na and/or 5-ht dysfunction are less likely to be the primary cause of mood disorders but are more indicative of failure of compensatory mechanisms involved in affective homeostatic processes. |
2012-09-10 |
2023-08-12 |
Not clear |
| Carmen Mannucci, Michele Navarra, Antonella Pieratti, Giuseppina A Russo, Achille P Caputi, Gioacchino Calapa. Interactions between endocannabinoid and serotonergic systems in mood disorders caused by nicotine withdrawal. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 13. issue 4. 2012-07-31. PMID:21324836. |
involvement of serotonin in mood disorders occurring after smoking cessation has been observed. |
2012-07-31 |
2023-08-12 |
Not clear |
| Shunske Tanahashi, Satoshi Yamamura, Masanori Nakagawa, Eishi Motomura, Motohiro Okad. Effect of lamotrigine and carbamazepine on corticotropin-releasing factor-associated serotonergic transmission in rat dorsal raphe nucleus. Psychopharmacology. vol 220. issue 3. 2012-07-11. PMID:21947356. |
corticotropin-releasing factor (crf) and serotonin are important transmitters of the pathophysiology of mood disorder. |
2012-07-11 |
2023-08-12 |
rat |
| Quentin J M Huys, Neir Eshel, Elizabeth O'Nions, Luke Sheridan, Peter Dayan, Jonathan P Roise. Bonsai trees in your head: how the pavlovian system sculpts goal-directed choices by pruning decision trees. PLoS computational biology. vol 8. issue 3. 2012-06-25. PMID:22412360. |
we found that the tendency towards pavlovian pruning was selectively predicted by the degree to which subjects exhibited sub-clinical mood disturbance, in accordance with theories that ascribe pavlovian behavioural inhibition, via serotonin, a role in mood disorders. |
2012-06-25 |
2023-08-12 |
human |
| Jodi L Pawluski, Thierry D Charlier, Marianne Fillet, Virginie Houbart, Hilda T Crispin, Harry W Steinbusch, Daniël L van den Hov. Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam. Behavioural brain research. vol 228. issue 1. 2012-05-24. PMID:22173000. |
selective serotonin reuptake inhibitor (ssri) medications are currently the antidepressant of choice to treat maternal mood disorders. |
2012-05-24 |
2023-08-12 |
rat |
| Quentin Rainer, Hai T Nguyen, Gaël Quesseveur, Alain M Gardier, Denis J David, Bruno P Guiar. Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration. Molecular pharmacology. vol 81. issue 2. 2012-05-04. PMID:22031471. |
the serotonin 1a (5-ht(1a)) autoreceptor is known to play a role in mood disorders and their treatments. |
2012-05-04 |
2023-08-12 |
mouse |
| Paul R Matthews, Paul J Harriso. A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide. Journal of affective disorders. vol 137. issue 1-3. 2012-04-27. PMID:22129767. |
several lines of evidence implicate 5-hydroxytryptamine (5-ht, serotonin) in the pathophysiology of mood disorders and suicide. |
2012-04-27 |
2023-08-12 |
Not clear |
| Gabriella A Horvath, Kathryn Selby, Ken Poskitt, Keith Hyland, Paula J Waters, Marion Coulter-Mackie, Sylvia G Stockler-Ipsirogl. Hemiplegic migraine, seizures, progressive spastic paraparesis, mood disorder, and coma in siblings with low systemic serotonin. Cephalalgia : an international journal of headache. vol 31. issue 15. 2012-04-04. PMID:22013141. |
hemiplegic migraine, seizures, progressive spastic paraparesis, mood disorder, and coma in siblings with low systemic serotonin. |
2012-04-04 |
2023-08-12 |
Not clear |
| Crystal Pinto, Renan P Souza, Diane Lioult, Mawahib Semeralul, James L Kennedy, Jerry J Warsh, Albert H Wong, Vincenzo De Luc. Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour. European archives of psychiatry and clinical neuroscience. vol 261. issue 8. 2012-03-25. PMID:21290142. |
the serotonin transporter (5htt) plays an important role in the pathophysiology of mood disorders and may also be involved in suicidal behaviour since 5htt binding is decreased in the brain of suicide completers. |
2012-03-25 |
2023-08-12 |
human |
| E K Sawyer, L L Howel. Pharmacokinetics of fluoxetine in rhesus macaques following multiple routes of administration. Pharmacology. vol 88. issue 1-2. 2012-03-25. PMID:21757974. |
fluoxetine (prozac) is a selective serotonin reuptake inhibitor currently used to treat depression and mood disorders. |
2012-03-25 |
2023-08-12 |
Not clear |
| Nathalie Le Floc'h, Winfried Otten, Elodie Merlo. Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino acids. vol 41. issue 5. 2012-03-12. PMID:20872026. |
serotonin is synthesized from tryptophan in the gut and also in the brain, where tryptophan availability is known to influence the sensitivity to mood disorders. |
2012-03-12 |
2023-08-12 |
Not clear |
| H-C Yan, X Cao, T-M Gao, X-H Zh. Promoting adult hippocampal neurogenesis: a novel strategy for antidepressant drug screening. Current medicinal chemistry. vol 18. issue 28. 2012-02-29. PMID:21861813. |
major depression is a common mood disorder that affects overall health; currently, almost all of the available antidepressants have the same core mechanisms of action through promotion of serotonin or noradrenaline function in the brain. |
2012-02-29 |
2023-08-12 |
Not clear |
| R Crupi, A Marino, S Cuzzocre. New therapeutic strategy for mood disorders. Current medicinal chemistry. vol 18. issue 28. 2012-02-29. PMID:21861822. |
among them selective serotonin reuptake (ssris), monoamine oxidase inhibitors (maois), specific norepinephrine reuptake inhibitors (snris) and tricyclic acids (tca) alleviate symptoms of mood disorders. |
2012-02-29 |
2023-08-12 |
Not clear |