| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuhisa Fukuo, Taro Kishi, Reiji Yoshimura, Tsuyoshi Kitajima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Hiroshi Naitoh, Wakako Umene-Nakano, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Jun Nakamura, Norio Ozaki, Nakao Iwat. Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis. Neuroscience research. vol 67. issue 3. 2010-09-13. PMID:20394784. |
serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis. |
2010-09-13 |
2023-08-12 |
Not clear |
| Yasuhisa Fukuo, Taro Kishi, Reiji Yoshimura, Tsuyoshi Kitajima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Hiroshi Naitoh, Wakako Umene-Nakano, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Jun Nakamura, Norio Ozaki, Nakao Iwat. Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis. Neuroscience research. vol 67. issue 3. 2010-09-13. PMID:20394784. |
several evidence suggests that alterations in serotonin 6 (5-ht6) receptors might be associated with the pathophysiology of mood disorders. |
2010-09-13 |
2023-08-12 |
Not clear |
| Latasha K Crawford, Caryne P Craige, Sheryl G Bec. Increased intrinsic excitability of lateral wing serotonin neurons of the dorsal raphe: a mechanism for selective activation in stress circuits. Journal of neurophysiology. vol 103. issue 5. 2010-08-25. PMID:20237311. |
the membrane properties identified in lwdr recordings may thereby contribute to a unique role of lwdr 5-ht neurons in adaptive responses to stress and in the pathobiology of stress-related mood disorders. |
2010-08-25 |
2023-08-12 |
mouse |
| Lakshmi N Ravindran, Murray B Stei. The pharmacologic treatment of anxiety disorders: a review of progress. The Journal of clinical psychiatry. vol 71. issue 7. 2010-08-23. PMID:20667290. |
findings suggest that both selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors are useful first-line agents for most of the anxiety disorders, particularly given the frequent comorbidity with mood disorders. |
2010-08-23 |
2023-08-12 |
Not clear |
| Elena Marino, Bongiorno Fanny, Cristina Lorenzi, Adele Pirovano, Linda Franchini, Cristina Colombo, Placido Bramanti, Enrico Smerald. Genetic bases of comorbidity between mood disorders and migraine: possible role of serotonin transporter gene. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31. issue 3. 2010-08-18. PMID:19936882. |
genetic bases of comorbidity between mood disorders and migraine: possible role of serotonin transporter gene. |
2010-08-18 |
2023-08-12 |
Not clear |
| Jeffery N Talbot, Emily M Jutkiewicz, Steven M Graves, Crystal F Clemans, Melanie R Nicol, Richard M Mortensen, Xinyan Huang, Richard R Neubig, John R Trayno. RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 24. 2010-07-14. PMID:20534514. |
by selectively enhancing the beneficial effects of serotonin, inhibition of rgs proteins represents a therapeutic approach for the treatment of mood disorders. |
2010-07-14 |
2023-08-12 |
mouse |
| Eric Marvin, Karie Scrogin, Bertalan Dudá. Morphology and distribution of neurons expressing serotonin 5-HT1A receptors in the rat hypothalamus and the surrounding diencephalic and telencephalic areas. Journal of chemical neuroanatomy. vol 39. issue 4. 2010-06-29. PMID:20080175. |
among the serotonin receptors currently recognized, 5-ht(1a) receptors have received considerable attention due to their importance in the etiology of mood disorders. |
2010-06-29 |
2023-08-12 |
rat |
| Vibe G Frokjaer, Maj Vinberg, David Erritzoe, William Baaré, Klaus Kähler Holst, Erik Lykke Mortensen, Haroon Arfan, Jacob Madsen, Terry L Jernigan, Lars Vedel Kessing, Gitte Moos Knudse. Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043006. |
familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2a receptor binding. |
2010-06-21 |
2023-08-12 |
Not clear |
| Francesca Calabrese, Raffaella Molteni, Annamaria Cattaneo, Flavia Macchi, Giorgio Racagni, Massimo Gennarelli, Bart A Ellenbroek, Marco A Riv. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159945. |
major vulnerability genes for mood disorders are also related to the serotonergic system: one of these genes encodes for the serotonin transporter (sert), which represent a major target for the action of antidepressant drugs. |
2010-05-28 |
2023-08-12 |
rat |
| Silke Heinisch, Lynn G Kirb. SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19755127. |
future therapies targeting cxcl12 and other chemokines may treat serotonin related mood disorders, particularly depression experienced by immune-compromised individuals. |
2010-04-13 |
2023-08-12 |
rat |
| Francesca Calabrese, Raffaella Molteni, Giorgio Racagni, Marco A Riv. Neuronal plasticity: a link between stress and mood disorders. Psychoneuroendocrinology. vol 34 Suppl 1. 2010-03-26. PMID:19541429. |
even though decreased levels of norepinephrine and serotonin may underlie depressive symptoms, compelling evidence now suggests that mood disorders are characterized by reduced neuronal plasticity, which can be brought about by exposure to stress at different stages of life. |
2010-03-26 |
2023-08-12 |
human |
| Lihong Wang, O'Dhaniel A Mullette-Gillman, Kishore M Gadde, Cynthia M Kuhn, Gregory McCarthy, Scott A Huette. The effect of acute tryptophan depletion on emotional distraction and subsequent memory. Social cognitive and affective neuroscience. vol 4. issue 4. 2010-03-03. PMID:19628700. |
these findings highlight the importance of serotonin in negative memory with implications for mood disorders. |
2010-03-03 |
2023-08-12 |
human |
| Erica Z McAuley, Janice M Fullerton, Ian P Blair, Jennifer A Donald, Philip B Mitchell, Peter R Schofiel. Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort. Psychiatric genetics. vol 19. issue 5. 2010-02-09. PMID:19584773. |
the serotonin 2a receptor gene (htr2a) is involved in serotonergic neurotransmission, and has been targeted as a functional candidate for mood disorders because of the extensive support for the involvement of serotonin in mood regulation. |
2010-02-09 |
2023-08-12 |
Not clear |
| S Heinisch, L G Kirb. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19748551. |
therapies targeting cx3cl1 may treat serotonin related mood disorders, including depression experienced by patients with compromised immune systems. |
2010-02-08 |
2023-08-12 |
rat |
| Raffaella Molteni, Francesca Calabrese, Paola F Maj, Jocelien D A Olivier, Giorgio Racagni, Bart A Ellenbroek, Marco A Riv. Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 12. 2010-01-25. PMID:19576731. |
a gene variant in the human serotonin transporter (sert) can increase the vulnerability to mood disorders. |
2010-01-25 |
2023-08-12 |
human |
| Atsuko Kimura, Paula L Stevenson, Roderick N Carter, Gavin Maccoll, Karen L French, J Paul Simons, Raya Al-Shawi, Valerie Kelly, Karen E Chapman, Megan C Holme. Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity. The European journal of neuroscience. vol 30. issue 2. 2010-01-08. PMID:19614978. |
therefore, the exact role of 5-ht(2c) receptors in mood disorders remain controversial, some suggesting agonists and others suggesting antagonists may be efficacious antidepressants, while there is general agreement that antagonists are beneficial anxiolytics. |
2010-01-08 |
2023-08-12 |
mouse |
| Atsuko Kimura, Paula L Stevenson, Roderick N Carter, Gavin Maccoll, Karen L French, J Paul Simons, Raya Al-Shawi, Valerie Kelly, Karen E Chapman, Megan C Holme. Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity. The European journal of neuroscience. vol 30. issue 2. 2010-01-08. PMID:19614978. |
in order to test the hypothesis that increased 5-ht(2c) receptor expression, and thus increased 5-ht(2c) receptor signalling, is causative in mood disorders, we have undertaken a transgenic approach, directly altering the 5-ht(2c) receptor number in the forebrain and evaluating the consequences on behaviour. |
2010-01-08 |
2023-08-12 |
mouse |
| Jennifer Joeyen-Waldorf, Nicole Edgar, Etienne Sibill. The roles of sex and serotonin transporter levels in age- and stress-related emotionality in mice. Brain research. vol 1286. 2009-10-20. PMID:19577546. |
this sex-by-sert double dissociation provides a framework to investigate molecular substrates of emotionality regulation in concert with serotonin function and may contribute to the sexually dimorphic features of mood disorders. |
2009-10-20 |
2023-08-12 |
mouse |
| Burak Yulu. Neuroprotective treatment strategies for poststroke mood disorders: A minireview on atypical neuroleptic drugs and selective serotonin re-uptake inhibitors. Brain research bulletin. vol 80. issue 3. 2009-10-14. PMID:19576272. |
neuroprotective treatment strategies for poststroke mood disorders: a minireview on atypical neuroleptic drugs and selective serotonin re-uptake inhibitors. |
2009-10-14 |
2023-08-12 |
Not clear |
| Ari Illi, Eija Setälä-Soikkeli, Merja Viikki, Outi Poutanen, Heini Huhtala, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Olli Kampma. 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. Neuroreport. vol 20. issue 12. 2009-09-29. PMID:19590397. |
genes that regulate the serotonin signalling system are potential targets for research in the aetiology of mood disorders and also in the treatment response of serotonin reuptake inhibitors. |
2009-09-29 |
2023-08-12 |
Not clear |