| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C M Ciarleglio, H E S Resuehr, D G McMaho. Interactions of the serotonin and circadian systems: nature and nurture in rhythms and blues. Neuroscience. vol 197. 2012-02-27. PMID:21963350. |
the reciprocal connections of the serotonin and circadian systems likely have importance for neurobehavioral disorders, as suggested by their convergent contribution to a similar range of mood disorders including seasonal affective disorder (sad), bipolar disorder, and major depression, and as suggested by their overlapping relationship with the developmental disorder, autism spectrum disorder. |
2012-02-27 |
2023-08-12 |
Not clear |
| Sonali Lokuge, Benicio N Frey, Jane A Foster, Claudio N Soares, Meir Steine. Depression in women: windows of vulnerability and new insights into the link between estrogen and serotonin. The Journal of clinical psychiatry. vol 72. issue 11. 2012-01-18. PMID:22127200. |
the purpose of this commentary is to provide an update on the research in both preclinical and clinical models regarding the cross-talk between estrogen and various serotonin molecular markers and the possible implications this may have on female-related mood disorders. |
2012-01-18 |
2023-08-12 |
Not clear |
| A Pal, S Nayak, P K Sahu, T Swai. Piperine protects epilepsy associated depression: a study on role of monoamines. European review for medical and pharmacological sciences. vol 15. issue 11. 2012-01-17. PMID:22195361. |
elevation in serotonin concentration gives an inhibitory response to epileptic discharge and stabilizes the depressed mood disorder. |
2012-01-17 |
2023-08-12 |
rat |
| Greta Wozniak, Aikaterini Toska, Maria Saridi, Odysseas Mouza. Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis. Medical science monitor : international medical journal of experimental and clinical research. vol 17. issue 9. 2011-12-27. PMID:21873959. |
selective serotonin reuptake inhibitors (ssris) are a class of drug widely used for treatment of mood disorders, including depression and cardiovascular disease. |
2011-12-27 |
2023-08-12 |
Not clear |
| Lee X Blonder, John T Slevi. Emotional dysfunction in Parkinson's disease. Behavioural neurology. vol 24. issue 3. 2011-12-27. PMID:21876260. |
there is also evidence suggesting that the interaction between serotonin and dopamine systems is important in the understanding and treatment of mood disorders in parkinson's disease. |
2011-12-27 |
2023-08-12 |
Not clear |
| Gerald Pail, Wolfgang Huf, Edda Pjrek, Dietmar Winkler, Matthaeus Willeit, Nicole Praschak-Rieder, Siegfried Kaspe. Bright-light therapy in the treatment of mood disorders. Neuropsychobiology. vol 64. issue 3. 2011-12-05. PMID:21811085. |
the first part elucidates the neurobiology of circadian and seasonal adaptive mechanisms focusing on the suprachiasmatic nucleus (scn), the indolamines melatonin and serotonin, and the chronobiology of mood disorders. |
2011-12-05 |
2023-08-12 |
Not clear |
| Lydia Günther, Julia Rothe, André Rex, Jörg-Peter Voigt, Mark J Millan, Heidrun Fink, Bettina Ber. 5-HT(1A)-receptor over-expressing mice: genotype and sex dependent responses to antidepressants in the forced swim-test. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21419787. |
due to its modulatory effect on serotonin (5-ht) release, the 5-ht(1a)-receptor is thought to play a decisive role in the therapy of this mood disorder. |
2011-10-14 |
2023-08-12 |
mouse |
| Lyngine H Calizo, Adaure Akanwa, Xiaohang Ma, Yu-Zhen Pan, Julia C Lemos, Caryne Craige, Lydia A Heemstra, Sheryl G Bec. Raphe serotonin neurons are not homogenous: electrophysiological, morphological and neurochemical evidence. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21530552. |
the median (mr) and dorsal raphe (dr) nuclei contain the majority of the 5-hydroxytryptamine (5-ht, serotonin) neurons that project to limbic forebrain regions, are important in regulating homeostatic functions and are implicated in the etiology and treatment of mood disorders and schizophrenia. |
2011-10-14 |
2023-08-12 |
Not clear |
| Emilie Paul-Savoie, Stéphane Potvin, Kathya Daigle, Edith Normand, Jean-François Corbin, René Gagnon, Serge Marchan. A deficit in peripheral serotonin levels in major depressive disorder but not in chronic widespread pain. The Clinical journal of pain. vol 27. issue 6. 2011-10-07. PMID:21415718. |
it has been proposed that serotonin dysfunctions underlie the pathophysiology of various mood disorders (including major depressive disorder, mdd) and chronic pain conditions characterized by deficient pain inhibition, such as fibromyalgia (fm). |
2011-10-07 |
2023-08-12 |
Not clear |
| Julien Andries, Laetitia Lemoine, Didier Le Bars, Luc Zimmer, Thierry Billar. Synthesis and biological evaluation of potential 5-HT(7) receptor PET radiotracers. European journal of medicinal chemistry. vol 46. issue 8. 2011-09-30. PMID:21620533. |
brain serotonin 7 receptor (5-ht(7)) is involved in several mood disorders and drug candidates targeting this subtype are currently in development. |
2011-09-30 |
2023-08-12 |
rat |
| P C McHugh, P R Joyce, X Deng, M A Kenned. A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. The pharmacogenomics journal. vol 11. issue 3. 2011-09-14. PMID:20351752. |
given the pivotal role of the serotonergic system in mood disorders and selective serotonin reuptake inhibitors (ssris) antidepressant function, we tested the hypothesis that gfrp gene (gchfr) variants would modify response to antidepressants in subjects with major depression. |
2011-09-14 |
2023-08-12 |
human |
| Jason M Dwyer, Brian J Platt, Stacey J Sukoff Rizzo, Claudine M Pulicicchio, Caitlin Wantuch, Mei-Yi Zhang, Terri Cummons, Liza Leventhal, Corey N Bender, Jean Zhang, Dianne Kowal, Shendi Lu, S Johannes R Rajarao, Deborah L Smith, Adam D Shilling, Jianyao Wang, John Butera, Lynn Resnick, Sharon Rosenzweig-Lipson, Lee E Schechter, Chad E Beye. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. The international journal of neuropsychopharmacology. vol 13. issue 9. 2011-09-01. PMID:20047711. |
biogenic amines such as norepinephrine, dopamine, and serotonin play a well-described role in the treatment of mood disorders and some types of pain. |
2011-09-01 |
2023-08-12 |
rat |
| Ann Pakalnis, Mark Splaingard, Deborah Splaingard, Donna Kring, Andrew Colvi. Serotonin effects on sleep and emotional disorders in adolescent migraine. Headache. vol 49. issue 10. 2011-08-04. PMID:19486363. |
to determine the relationship of whole blood serotonin, caffeine consumption, and frequency of sleep and mood disorders. |
2011-08-04 |
2023-08-12 |
Not clear |
| Adam W Oaks, Anita Sidh. Synuclein modulation of monoamine transporters. FEBS letters. vol 585. issue 7. 2011-05-26. PMID:21396366. |
a key regulatory component of monoamine neurotransmission is re-uptake of neurotransmitter by the dopamine transporter, norepinephrine transporter, and serotonin transporter, which are common drug targets in the treatment of depression and other mood disorders. |
2011-05-26 |
2023-08-12 |
Not clear |
| Gregory V Carr, Lee E Schechter, Irwin Luck. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20217056. |
although selective serotonin reuptake inhibitors (ssris) produce clinical therapeutic effects on depression and anxiety through augmentation of serotonergic neurotransmission, there is little known about the potential contributions of the 5-ht(6) receptor in the treatment of mood disorders. |
2011-05-24 |
2023-08-12 |
rat |
| Brent J Thompson, Tammy Jessen, L K Henry, Julie R Field, Karen L Gamble, Paul J Gresch, Ana M Carneiro, Rebecca E Horton, Peter J Chisnell, Yekaterina Belova, Douglas G McMahon, Lynette C Daws, Randy D Blakel. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 9. 2011-05-09. PMID:21282638. |
serotonin [i.e., 5-hydroxytryptamine (5-ht)]-targeted antidepressants are in wide use for the treatment of mood disorders, although many patients do not show a response or experience unpleasant side effects. |
2011-05-09 |
2023-08-12 |
mouse |
| Kirsten X Jacobsen, Margaret Czesak, Mariam Deria, Brice Le François, Paul R Alber. Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21182526. |
serotonin (5-hydroxytryptamine, 5-ht) neurotransmission is negatively regulated by 5-ht1a autoreceptors on raphe neurons, and is implicated in mood disorders. |
2011-04-15 |
2023-08-12 |
mouse |
| Chong-Bin Zhu, Kathryn M Lindler, Anthony W Owens, Lynette C Daws, Randy D Blakely, William A Hewlet. Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 13. 2011-03-03. PMID:20827273. |
medications that block the neuronal 5-ht transporter (sert) are used as major pharmacological treatment for mood disorders. |
2011-03-03 |
2023-08-12 |
mouse |
| Shinji Kusakawa, Kazuaki Nakamura, Yuki Miyamoto, Atsushi Sanbe, Tomohiro Torii, Junji Yamauchi, Akito Tanou. Fluoxetine promotes gliogenesis during neural differentiation in mouse embryonic stem cells. Journal of neuroscience research. vol 88. issue 16. 2011-03-03. PMID:20857517. |
selective serotonin reuptake inhibitors (ssris) are commonly prescribed for treatment of mood disorders and depression, even during pregnancy and lactation. |
2011-03-03 |
2023-08-12 |
mouse |
| Sonali Lokuge, Benicio N Frey, Jane A Foster, Claudio N Soares, Meir Steine. The rapid effects of estrogen: a mini-review. Behavioural pharmacology. vol 21. issue 5-6. 2010-11-24. PMID:20661136. |
the purpose of this mini-review is to outline the recent literature regarding the rapid effects of estrogen, to explore the intracellular signaling pathways that may be involved in this regulation as well as the connection between estrogen and serotonin neurotransmission and finally, to look into the antidepressant role that estrogen may have, with particular emphasis on female-specific mood disorders. |
2010-11-24 |
2023-08-12 |
Not clear |