| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giulia Schillani, Maria Anna Capozzo, Eugenio Aguglia, Maurizio De Vanna, Luigi Grassi, Maria Anna Conte, Tullio Girald. 5-HTTLPR polymorphism of serotonin transporter and effects of sertraline in terminally ill cancer patients: report of eleven cases. Tumori. vol 94. issue 4. 2008-10-09. PMID:18822694. |
selective serotonin reuptake inhibitors (ssris) are the treatment of choice for mood disorders, but they show a highly variable response. |
2008-10-09 |
2023-08-12 |
Not clear |
| Catherine Jonnakuty, Claudia Gragnol. What do we know about serotonin? Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18651566. |
in addition, we summarize the results of large-scale genetic studies on serotonin and serotonin transporter genes, performed in relation to behavioral and mood disorders. |
2008-09-12 |
2023-08-12 |
human |
| Luisella Bocchio-Chiavetto, Carlo Miniussi, Roberta Zanardini, Anna Gazzoli, Stefano Bignotti, Claudia Specchia, Massimo Gennarell. 5-HTTLPR and BDNF Val66Met polymorphisms and response to rTMS treatment in drug resistant depression. Neuroscience letters. vol 437. issue 2. 2008-08-18. PMID:18450378. |
according to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-httlpr) and the brain-derived neurotrophic factor (bdnf val66met), and rtms response in a group of 36 drug resistant patients affected by mood disorders. |
2008-08-18 |
2023-08-12 |
Not clear |
| L F Mohammad-Zadeh, L Moses, S M Gwaltney-Bran. Serotonin: a review. Journal of veterinary pharmacology and therapeutics. vol 31. issue 3. 2008-07-24. PMID:18471139. |
through such research serotonin has been shown to modulate gastrointestinal motility, peripheral vascular tone, cerebral vascular tone, and platelet function and has been implicated in the pathophysiology of mood disorders, emesis, migraine, irritable bowel syndrome (ibs), and pulmonary and systemic hypertension. |
2008-07-24 |
2023-08-12 |
Not clear |
| Michael E Thase, Timothey Denk. Pharmacotherapy of mood disorders. Annual review of clinical psychology. vol 4. 2008-07-01. PMID:18370614. |
this review examines recent developments in the pharmacotherapy of both forms of mood disorder, comparing the newer antidepressants such as the selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors with their predecessors (the monoamine oxidase inhibitors and tricyclic antidepressants) and likewise comparing the older standard for management of bipolar disorder, lithium, with newer classes of medications, such as a selected group of anticonvulsants and the atypical antipsychotics. |
2008-07-01 |
2023-08-12 |
Not clear |
| Marc Cuesta, Jorge Mendoza, Daniel Clesse, Paul Pévet, Etienne Challe. Serotonergic activation potentiates light resetting of the main circadian clock and alters clock gene expression in a diurnal rodent. Experimental neurology. vol 210. issue 2. 2008-06-20. PMID:18190911. |
beside the chronobiotic effects of serotonin, changes of serotonergic activity in humans have been involved in mood disorders, that are often associated with alterations in circadian rhythmicity. |
2008-06-20 |
2023-08-12 |
Not clear |
| Vibe G Frokjaer, Lars H Pinborg, Jacob Madsen, Robin de Nijs, Claus Svarer, Aase Wagner, Gitte M Knudse. Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 2. 2008-03-26. PMID:18199621. |
imaging serotonin transporters in the living human brain is important in several fields, such as normal psychophysiology, mood disorders, eating disorders, and neurodegenerative disorders. |
2008-03-26 |
2023-08-12 |
human |
| James W Crane, Keiko Shimizu, Gonzalo A Carrasco, Francisca Garcia, Cuihong Jia, Nicole R Sullivan, Deborah N D'Souza, Yahong Zhang, Louis D Van de Kar, Nancy A Muma, George Battagli. 5-HT1A receptors mediate (+)8-OH-DPAT-stimulation of extracellular signal-regulated kinase (MAP kinase) in vivo in rat hypothalamus: time dependence and regional differences. Brain research. vol 1183. 2008-03-25. PMID:17976547. |
brain serotonin 1a (5-ht1a) receptors play an important role in mood disorders and can modulate various intracellular signaling mechanisms. |
2008-03-25 |
2023-08-12 |
rat |
| Wayne C Drevets, Michael E Thase, Eydie L Moses-Kolko, Julie Price, Ellen Frank, David J Kupfer, Chester Mathi. Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nuclear medicine and biology. vol 34. issue 7. 2008-02-20. PMID:17921037. |
we have previously assessed 5-ht1ar binding potential (bp) in depression using positron emission tomography (pet) and [carbonyl-(11)c]way-100635, and we have demonstrated reduced 5-ht1ar bp in the mesiotemporal cortex (mtc) and raphe in depressives with primary recurrent familial mood disorders (n=12) versus controls (n=8) [drevets wc, frank e, price jc, kupfer dj, holt d, greer pj, huang y, gautier c, mathis c. pet imaging of serotonin 1a receptor binding in depression. |
2008-02-20 |
2023-08-12 |
human |
| Keri Martinowich, Bai L. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 1. 2008-02-14. PMID:17882234. |
interaction between bdnf and serotonin: role in mood disorders. |
2008-02-14 |
2023-08-12 |
Not clear |
| E Sibille, J Su, S Leman, A M Le Guisquet, Y Ibarguen-Vargas, J Joeyen-Waldorf, C Glorioso, G C Tseng, M Pezzone, R Hen, C Belzun. Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity. Molecular psychiatry. vol 12. issue 11. 2008-01-09. PMID:17420766. |
in addition to its role in the etiology and treatment of mood disorders, altered serotonin (5-ht) signaling is considered a contributing factor to aging; however, no causative role has been identified in aging. |
2008-01-09 |
2023-08-12 |
mouse |
| Ikuko Kishida, Eleni Aklillu, Chiaki Kawanishi, Leif Bertilsson, Hans Agre. Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 10. 2007-11-20. PMID:17299512. |
the serotonin (5-hydroxytryptamine) transporter (5-htt) is considered to affect the pathogenesis of mood disorders. |
2007-11-20 |
2023-08-12 |
human |
| Vesselin M Chorbov, Elizabeth A Lobos, Alexandre A Todorov, Andrew C Heath, Kelly N Botteron, Richard D Tod. Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 6. 2007-11-07. PMID:17455215. |
several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (slc6a4; 5-htt) in the development of mood disorders. |
2007-11-07 |
2023-08-12 |
Not clear |
| Thomas N Wise, David A Fishbain, Vicenzio Holder-Perkin. Painful physical symptoms in depression: a clinical challenge. Pain medicine (Malden, Mass.). vol 8 Suppl 2. 2007-11-05. PMID:17714118. |
antidepressant agents that inhibit both serotonin and norepinephrine reuptake effectively remit mood disorders, thereby providing relief of painful physical symptoms often associated with these disorders. |
2007-11-05 |
2023-08-12 |
Not clear |
| G C Lasiuk, K M Hegadore. The effects of estradiol on central serotonergic systems and its relationship to mood in women. Biological research for nursing. vol 9. issue 2. 2007-10-30. PMID:17909167. |
to shed light on the complex interactions among estrogens, serotonin, and mood, we briefly examine (a) central serotonin systems and their relationship to mood and mood disorders, (b) nonreproductive effects of estrogens on those systems, (c) potential points of intersection between serotonin systems and estrogens, and (d) research into the use of exogenous estrogen in depression in women. |
2007-10-30 |
2023-08-12 |
Not clear |
| Laura Mandelli, Alessandro Serretti, Elena Marino, Adele Pirovano, Raffaella Calati, Cristina Colomb. Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. The international journal of neuropsychopharmacology. vol 10. issue 4. 2007-10-18. PMID:16756688. |
interaction between serotonin transporter gene, catechol-o-methyltransferase gene and stressful life events in mood disorders. |
2007-10-18 |
2023-08-12 |
human |
| Alessandro Serretti, Antonio Drago, Diana De Ronch. HTR2A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies. Current medicinal chemistry. vol 14. issue 19. 2007-09-18. PMID:17691947. |
variants at the gene encoding for the 5-hydrosytryptamine (serotonin) receptor 2a (htr2a) have been associated with many psychiatric disorders such as schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and alzheimer's disease. |
2007-09-18 |
2023-08-12 |
Not clear |
| Ruth Iceta, José E Mesonero, Ana I Alcald. Effect of long-term fluoxetine treatment on the human serotonin transporter in Caco-2 cells. Life sciences. vol 80. issue 16. 2007-06-28. PMID:17289086. |
fluoxetine is a selective serotonin reuptake inhibitor (ssri) broadly used in the treatment of human mood disorders and gastrointestinal diseases involving the serotoninergic system. |
2007-06-28 |
2023-08-12 |
human |
| Pascal Bonaventure, Lisa Kelly, Leah Aluisio, Jonathan Shelton, Brian Lord, Ruggero Galici, Kirsten Miller, John Atack, Timothy W Lovenberg, Christine Dugovi. Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents. The Journal of pharmacology and experimental therapeutics. vol 321. issue 2. 2007-06-06. PMID:17314195. |
evidence has accumulated supporting a role for 5-hydroxytryptamine (5-ht)7 receptors in circadian rhythms, sleep, and mood disorders, presumably as a consequence of the modulation of 5-ht-mediated neuronal activity. |
2007-06-06 |
2023-08-12 |
mouse |
| A Serretti, M Kato, D De Ronchi, T Kinoshit. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Molecular psychiatry. vol 12. issue 3. 2007-04-24. PMID:17146470. |
the serotonin transporter gene promoter polymorphism (5-httlpr) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. |
2007-04-24 |
2023-08-12 |
human |