| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Crystal Li, Juliana Silva, Ezgi Ozturk, Gabriella Dezsi, Terence J O'Brien, Thibault Renoir, Nigel C Jone. Chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-HT Epilepsia. vol 59. issue 7. 2019-01-23. PMID:29858497. |
chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-ht patients with epilepsy often have mood disorders, and these are commonly treated with antidepressant drugs. |
2019-01-23 |
2023-08-13 |
mouse |
| Guoxun Zheng, Fengyuan Yang, Tingting Fu, Gao Tu, Yuzong Chen, Xiaojun Yao, Weiwei Xue, Feng Zh. Computational characterization of the selective inhibition of human norepinephrine and serotonin transporters by an escitalopram scaffold. Physical chemistry chemical physics : PCCP. vol 20. issue 46. 2018-12-11. PMID:30457616. |
human norepinephrine and serotonin transporters (hnet and hsert) are closely related monoamine transporters (mats) that regulate neurotransmitter signaling in neurons and are primary targets for a wide range of therapeutic drugs used in the treatment of mood disorders. |
2018-12-11 |
2023-08-13 |
human |
| Saiful Alom Siddique, Thangavel Tamilselvan, Manikkannan Vishnupriya, Elumalai Balamuruga. Evaluation of Neurotransmitter Alterations in Four Distinct Brain Regions After Rapid Eye Movement Sleep Deprivation (REMSD) Induced Mania-Like Behaviour in Swiss Albino Mice. Neurochemical research. vol 43. issue 6. 2018-10-15. PMID:29671235. |
a number of neurotransmitter systems have been implicated in contributing to the pathology of mood disorders, including those of dopamine (da), serotonin (5-ht), norepinephrine (ne) and γ-aminobutyric acid (gaba). |
2018-10-15 |
2023-08-13 |
mouse |
| Krishna C Vadodaria, Shani Stern, Maria C Marchetto, Fred H Gag. Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. Cell and tissue research. vol 371. issue 1. 2018-08-10. PMID:28812143. |
several lines of evidence implicate serotonin in the etiology of multiple psychiatric disorders, especially mood disorders, such as major depressive disorder (mdd) and bipolar disorder (bd). |
2018-08-10 |
2023-08-13 |
human |
| Naama Rotem-Kohavi, Tim F Oberlande. Variations in Neurodevelopmental Outcomes in Children with Prenatal SSRI Antidepressant Exposure. Birth defects research. vol 109. issue 12. 2018-03-30. PMID:28714603. |
mood disorders and treatment with selective serotonin reuptake inhibitor (ssri) antidepressants during pregnancy are common and both pose neurodevelopmental risks. |
2018-03-30 |
2023-08-13 |
Not clear |
| Lucyna Antkiewicz-Michaluk, Irena Romańska, Agnieszka Wąsik, Jerzy Michalu. Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats. Neurotoxicity research. vol 32. issue 1. 2018-03-27. PMID:28367606. |
biogenic amines such as norepinephrine, dopamine, and serotonin play a well-described role in the treatment of mood disorders especially depression. |
2018-03-27 |
2023-08-13 |
rat |
| Santiago Balla. The unappreciated roles of the cholecystokinin receptor CCK(1) in brain functioning. Reviews in the neurosciences. vol 28. issue 6. 2018-03-05. PMID:28343167. |
the activity of cck(1)r maintains adequate levels of dopamine and regulates the activity of serotonin neurons of raphe nuclei, which makes cck(1)r an interesting therapeutic target for the development of adjuvant treatments for schizophrenia, drug addiction, and mood disorders. |
2018-03-05 |
2023-08-13 |
Not clear |
| Anna Jurczak, Małgorzata Szkup, Anna Grzywacz, Krzysztof Safranow, Elżbieta Grochan. The analysis of anxiety and mood in healthy late-reproductive-stage women with regard to hormonal and genetic factors. Archives of women's mental health. vol 19. issue 6. 2018-01-26. PMID:27614969. |
the purpose of this study was to determine whether anxiety and mood disorders in late-reproductive-stage women are related to the serotonin transporter and monoamine oxidase a gene polymorphisms. |
2018-01-26 |
2023-08-13 |
human |
| Helene Bach, Victoria Arango, Suham A Kassir, Andrew J Dwork, J John Mann, Mark D Underwoo. Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides. Archives of suicide research : official journal of the International Academy for Suicide Research. vol 20. issue 3. 2018-01-24. PMID:26954509. |
cigarette smoking is associated with suicide and mood disorders and stimulates serotonin release. |
2018-01-24 |
2023-08-13 |
Not clear |
| Robin M Hallett, Adele Girgis-Gabardo, William D Gwynne, Andrew O Giacomelli, Jennifer N P Bisson, Jeremy E Jensen, Anna Dvorkin-Gheva, John A Hassel. Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer. Oncotarget. vol 7. issue 33. 2018-01-18. PMID:27447971. |
we found that inhibitors of the serotonin reuptake transporter (sert) and serotonin receptors, which include approved drugs used to treat mood disorders, were potent inhibitors of mouse btic activity as determined by functional sphere-forming assays and the initiation of tumor formation by transplant of drug-exposed tumor cells into syngeneic mice. |
2018-01-18 |
2023-08-13 |
mouse |
| Tae Young Yang, Eun Young Jang, Yeonhee Ryu, Gyu Won Lee, Eun Byeol Lee, Suchan Chang, Jong Han Lee, Jin Suk Koo, Chae Ha Yang, Hee Young Ki. Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus. BMC complementary and alternative medicine. vol 17. issue 1. 2017-12-27. PMID:29228944. |
serotonin transporter (sert) plays an important role in the pathology of anxiety and other mood disorders. |
2017-12-27 |
2023-08-13 |
Not clear |
| Carol A Shively, Marnie Silverstein-Metzler, Jamie Justice, Stephanie L Willar. The impact of treatment with selective serotonin reuptake inhibitors on primate cardiovascular disease, behavior, and neuroanatomy. Neuroscience and biobehavioral reviews. vol 74. issue Pt B. 2017-10-27. PMID:27590831. |
sertraline had no effect on depressive behavior, reduced anxious behavior, increased affiliation, reduced aggression, changed serotonin neurotransmission and volumes of neural areas critical to mood disorders, and exacerbated coronary and carotid atherosclerosis. |
2017-10-27 |
2023-08-13 |
monkey |
| Ayesha Sengupta, Marco Bocchio, David M Bannerman, Trevor Sharp, Marco Capogn. Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 7. 2017-08-18. PMID:28087766. |
several lines of evidence suggest that 5-ht transmission in the amygdala is implicated in the susceptibility and drug treatment of mood disorders. |
2017-08-18 |
2023-08-13 |
mouse |
| Santhanalakshmi Sundaramurthy, Balasubramaniam Annamalai, Devadoss J Samuvel, Toni S Shippenberg, Lankupalle D Jayanthi, Sammanda Ramamoorth. Modulation of serotonin transporter function by kappa-opioid receptor ligands. Neuropharmacology. vol 113. issue Pt A. 2017-07-11. PMID:27743931. |
presynaptic serotonin transporter (sert) activity is critical in the modulation of synaptic 5-ht and, subsequently, in mood disorders. |
2017-07-11 |
2023-08-13 |
Not clear |
| Amy Yang, Jody D Ciolino, Emily Pinheiro, Laura J Rasmussen-Torvik, Dorothy K Y Sit, Katherine L Wisne. Neonatal Discontinuation Syndrome in Serotonergic Antidepressant-Exposed Neonates. The Journal of clinical psychiatry. vol 78. issue 5. 2017-06-16. PMID:28570796. |
to determine whether infants exposed in utero to serotonin reuptake inhibitor (sri) antidepressants or a dsm-iv-tr-defined mood disorder have significantly more neonatal discontinuation signs compared to an unexposed group of infants at 2-4 weeks after birth. |
2017-06-16 |
2023-08-13 |
Not clear |
| Stefano Comai, Antonella Bertazzo, Jeanne Vachon, Marc Daigle, Jean Toupin, Gilles Côté, Gustavo Turecki, Gabriella Gobb. Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression. Progress in neuro-psychopharmacology & biological psychiatry. vol 70. 2017-04-12. PMID:27117820. |
aggressive compared to non-aggressive inmates exhibited lower trp and kyn serum levels but higher levels of 5-ht and 5-ht/trp∗1000, higher levels of impulsivity and adhd indices, lower iq and gaf, higher prevalence of mood disorders, drug abuse/dependence, and borderline, conduct and antisocial behaviors. |
2017-04-12 |
2023-08-13 |
Not clear |
| Yukiori Goto, Young-A Lee, Yoshie Yamaguchi, Emanuel Ja. Biological mechanisms underlying evolutionary origins of psychotic and mood disorders. Neuroscience research. vol 111. 2016-12-29. PMID:27230505. |
we discuss the evolutionary origins of psychotic and mood disorders with specific focuses on the roles of dopamine and serotonin in the conditions of social competitiveness/hierarchy and maternal care and other potential mechanisms, such as social network homophily and symbiosis. |
2016-12-29 |
2023-08-13 |
human |
| Márcia Regina Pizzo de Castro, Sandra Odebrecht Vargas Nunes, Roberta Losi Guembarovski, Carolina Batista Ariza, Julie Massayo Maeda Oda, Heber Odebrecht Vargas, Luiz Gustavo Piccoli de Melo, Maria Angelica Ehara Watanabe, Michael Berk, Michael Mae. STin2 VNTR polymorphism is associated with comorbid tobacco use and mood disorders. Journal of affective disorders. vol 172. 2016-12-13. PMID:25451436. |
gene variants of the 5-ht transporter, such as stin2 vntr (a variable number of tandem repeats in the functional serotonin transporter intron 2) may be associated with mood disorders and tud. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jessica Romero-Reyes, Mario Cárdenas, Pablo Damián-Matsumura, Roberto Domínguez, María Elena Ayal. Inhibition of serotonin reuptake in the prepubertal rat ovary by fluoxetine and effects on ovarian functions. Reproductive toxicology (Elmsford, N.Y.). vol 59. 2016-12-13. PMID:26746107. |
fluoxetine (flx), a selective serotonin reuptake inhibitor is an antidepressant in the treatment of mood disorders. |
2016-12-13 |
2023-08-13 |
rat |
| Rui Zhao, Shoubao Wang, Zhonglin Huang, Li Zhang, Xiuying Yang, Xiaoyu Bai, Dan Zhou, Zhizhen Qin, Guanhua D. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Bioscience trends. vol 9. issue 6. 2016-11-04. PMID:26781794. |
serotonin transporter (sert) is a critical determinant of synaptic serotonin (5-hydroxytryptamine, 5-ht) inactivation which plays a critical role in the pathology of depression and other mood disorders. |
2016-11-04 |
2023-08-13 |
Not clear |