| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Chen, Yu-wei Liu, Kai Yue, Qin Ru, Qi Xiong, Bao-miao Ma, Xiang Tian, Chao-ying L. Differential expression of ATP-gated P2X receptors in DRG between chronic neuropathic pain and visceralgia rat models. Purinergic signalling. vol 12. issue 1. 2016-10-31. PMID:26531254. |
in order to explore the different expressions of p2x1-7 receptors in these two hyperalgesia models, the lumbosacral dorsal root ganglion (drg) neurons from rat sciatic nerve chronic constriction injury (cci) model and neonatal colorectal distention (ncrd) model were studied (both the primary nociceptive neuron afferents of those two models projected to the same segment of spinal cord). |
2016-10-31 |
2023-08-13 |
rat |
| Pin Ye, Liming Hua, Yunlu Jiao, Zhenwei Li, Shichao Qin, Jin Fu, Feng Jiang, Tong Liu, Yonghua J. Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain. Acta biochimica et biophysica Sinica. vol 48. issue 2. 2016-10-31. PMID:26764239. |
furthermore, spontaneous pain and mechanical allodynia, but not thermal hyperalgesia induced by bmk i, are significantly alleviated through either blockade of the nav1.8 sodium channel by its selective blocker a-803467 or knockdown of the nav1.8 expression in drg by antisense oligodeoxynucleotide (as-odn) targeting nav1.8 in rats. |
2016-10-31 |
2023-08-13 |
rat |
| Xiu-Chao Wang, Shan Wang, Ming Zhang, Fang Gao, Chun Yin, Hao Li, Ying Zhang, San-Jue Hu, Jian-Hong Dua. Α-Dendrotoxin-sensitive Kv1 channels contribute to conduction failure of polymodal nociceptive C-fibers from rat coccygeal nerve. Journal of neurophysiology. vol 115. issue 2. 2016-10-20. PMID:26609114. |
previously, we demonstrated that reduced conduction failure of polymodal nociceptive c-fibers and enhanced voltage-dependent sodium currents of small dorsal root ganglion (drg) neurons contribute to diabetic hyperalgesia. |
2016-10-20 |
2023-08-13 |
rat |
| Zipu Jia, Hao Ren, Qian Li, Nan Ji, Fang Lu. Pulsed Radiofrequency Reduced Neuropathic Pain Behavior in Rats Associated with Upregulation of GDNF Expression. Pain physician. vol 19. issue 2. 2016-09-20. PMID:26815249. |
historically, most studies have reported that prf can relieve reduce hyperalgesia in multiple np animal models by acting on the dorsal root ganglion. |
2016-09-20 |
2023-08-13 |
rat |
| Wan-You He, Bin Zhang, Qing-Ming Xiong, Cheng-Xiang Yang, Wei-Cheng Zhao, Jian He, Jun Zhou, Han-Bing Wan. Intrathecal administration of rapamycin inhibits the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats. Neuroscience letters. vol 619. 2016-08-24. PMID:26946108. |
of rapamycin inhibited the phosphorylation and enhanced the functional availability of drg nav1.8 attenuated stz-induced hyperalgesia. |
2016-08-24 |
2023-08-13 |
rat |
| You-Lang Zhou, Guo-Qin Jiang, Jinrong Wei, Hong-Hong Zhang, Wei Chen, Hongyan Zhu, Shufen Hu, Xinghong Jiang, Guang-Yin X. Enhanced binding capability of nuclear factor-κB with demethylated P2X3 receptor gene contributes to cancer pain in rats. Pain. vol 156. issue 10. 2016-06-27. PMID:26049406. |
we showed here that tumor cell injection produced mechanical and thermal hyperalgesia, and an enhanced body weight-bearing difference, which was correlated with an upregulation of p65 and p2x3r expression in lumber drgs and a potentiation of atp-evoked responses of tibia-innervating drg neurons. |
2016-06-27 |
2023-08-13 |
rat |
| Yajun Chen, Hongguang Chen, Keliang Xie, Lingling Liu, Yuan Li, Yonghao Yu, Guolin Wan. H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation. vol 38. issue 5. 2016-06-24. PMID:25820467. |
hyperalgesia and allodynia were tested, pro-inflammatory factors of dorsal root ganglia (drg) and the spinal cord were measured by enzyme-linked immunosorbent assay (elisa) during days 1-14 after the operation, and heme oxygenase (ho)-1 messenger rna (mrna) and protein expression and activities were measured at day 14 after sciatic nerve injury in rats. |
2016-06-24 |
2023-08-13 |
rat |
| Yajun Chen, Hongguang Chen, Keliang Xie, Lingling Liu, Yuan Li, Yonghao Yu, Guolin Wan. H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation. vol 38. issue 5. 2016-06-24. PMID:25820467. |
snpp-ix reversed the inhibitory effect of h2 on hyperalgesia and allodynia and on pro-inflammatory cytokines in drg and the spinal cord. |
2016-06-24 |
2023-08-13 |
rat |
| Yiming Liu, Yi Feng, Tingjie Zhan. Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain. Journal of molecular neuroscience : MN. vol 57. issue 1. 2016-06-17. PMID:26018936. |
the results showed that thermal hyperalgesia, mechano-allodynia, and mechano-hyperalgesia were lower, and drg expression levels of hcn1 and hcn2 higher, in the prf group compared with sham control animals (all p < 0.05 at d14). |
2016-06-17 |
2023-08-13 |
rat |
| Wendy M Walwyn, Wenling Chen, Hyeyoung Kim, Ani Minasyan, Helena S Ennes, James A McRoberts, Juan Carlos G Marvizó. Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 1. 2016-05-09. PMID:26740662. |
we further demonstrated that suppression of hyperalgesia by mors was due to their constitutive activity because of the following: (1) cfa-induced hyperalgesia was reinstated by the mor inverse agonist naltrexone (ntx), but not by its neutral antagonist 6β-naltrexol; (2) pro-enkephalin, pro-opiomelanocortin, and pro-dynorphin ko mice showed recovery from hyperalgesia and reinstatement by ntx; (3) there was no mor internalization during remission; (4) mors immunoprecipitated from the spinal cord during remission had increased ser(375) phosphorylation; and (5) electrophysiology recordings from dorsal root ganglion neurons collected during remission showed constitutive mor inhibition of calcium channels. |
2016-05-09 |
2023-08-13 |
mouse |
| Jaung-Geng Lin, Ching-Liang Hsieh, Yi-Wen Li. Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK. PloS one. vol 10. issue 6. 2016-05-02. PMID:26043006. |
the increase in mechanical hyperalgesia was also accompanied by upregulation of trpv1 expression and phosphoactivation of extracellular signal regulated kinase (perk) in the drg, whereas drg expression levels of trpv4, p-p38, and p-jnk were unaltered. |
2016-05-02 |
2023-08-13 |
mouse |
| Jaung-Geng Lin, Ching-Liang Hsieh, Yi-Wen Li. Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK. PloS one. vol 10. issue 6. 2016-05-02. PMID:26043006. |
this study strongly suggests that drg trpv1 overexpression and perk signaling, as well as sc trpv1 and trpv4 overexpression, mediate hyperalgesia in a mouse fm pain model. |
2016-05-02 |
2023-08-13 |
mouse |
| Takayoshi Masuoka, Makiko Kudo, Junko Yoshida, Takaharu Ishibashi, Ikunobu Muramatsu, Nobuo Kato, Noriko Imaizumi, Matomo Nishi. Long-Term Activation of Group I Metabotropic Glutamate Receptors Increases Functional TRPV1-Expressing Neurons in Mouse Dorsal Root Ganglia. Frontiers in cellular neuroscience. vol 10. 2016-04-12. PMID:27064319. |
these results suggest that long-term activation of mglur1/5 by peripherally released glutamate may increase the number of neurons expressing functional trpv1 in drg, which may be strongly associated with chronic hyperalgesia. |
2016-04-12 |
2023-08-13 |
mouse |
| André Luiz de Souza Grava, Luiz Fernando Ferrari, Carlos Amílcar Parada, Helton Luiz Aparecido Defin. PHARMACOLOGIC TREATMENT OF HYPERALGESIA EXPERIMENTALLY INDUCED BY NUCLEUS PULPOSUS. Revista brasileira de ortopedia. vol 45. issue 6. 2016-03-30. PMID:27026966. |
to evaluate the effect of anti-inflammatory drugs (dexamethasone, indomethacin, atenolol and indomethacin plus atenolol) and analgesic drugs (morphine) on hyperalgesia experimentally induced by the nucleus pulposus (np) in contact with the l5 dorsal root ganglion (drg). |
2016-03-30 |
2023-08-13 |
Not clear |
| Juyong Wang, Ruixin Zhang, Changsheng Dong, Lijing Jiao, Ling Xu, Jiyong Liu, Zhengtao Wang, Lixing La. Transient Receptor Potential Channel and Interleukin-17A Involvement in LTTL Gel Inhibition of Bone Cancer Pain in a Rat Model. Integrative cancer therapies. vol 14. issue 4. 2016-03-29. PMID:26100378. |
the gel significantly (p < .05) alleviated cancer-induced mechanical allodynia and thermal hyperalgesia and inhibited cancer-enhanced expression of il-17a in spinal astrocytes and the trp subfamily members v1, a1, and v4 in lumbar drg. |
2016-03-29 |
2023-08-13 |
rat |
| André Luiz de Souza Grava, Luiz Fernando Ferrari, Carlos Amílcar Parada, Helton Luiz Aparecido Defin. EVALUATION OF HYPERALGESIA AND HISTOLOGICAL CHANGES OF DORSAL ROOT GANGLION INDUCED BY NUCLEUS PULPOSUS. Revista brasileira de ortopedia. vol 45. issue 5. 2016-03-29. PMID:27022595. |
evaluation of hyperalgesia and histological changes of dorsal root ganglion induced by nucleus pulposus. |
2016-03-29 |
2023-08-13 |
Not clear |
| André Luiz de Souza Grava, Luiz Fernando Ferrari, Carlos Amílcar Parada, Helton Luiz Aparecido Defin. EVALUATION OF HYPERALGESIA AND HISTOLOGICAL CHANGES OF DORSAL ROOT GANGLION INDUCED BY NUCLEUS PULPOSUS. Revista brasileira de ortopedia. vol 45. issue 5. 2016-03-29. PMID:27022595. |
to evaluate the hyperalgesia and histological abnormalities induced by contact between the dorsal root ganglion and the nucleus pulposus. |
2016-03-29 |
2023-08-13 |
Not clear |
| Marina G M Castor, Robson A S Santos, Igor D G Duarte, Thiago R L Romer. Angiotensin-(1-7) through Mas receptor activation induces peripheral antinociception by interaction with adrenoreceptors. Peptides. vol 69. 2016-02-29. PMID:25895850. |
mas receptor was recently identified in the drg and its activation by ang-(1-7) resulted in peripheral antinociception against pge2 hyperalgesia in an opioid-independent pathway. |
2016-02-29 |
2023-08-13 |
Not clear |
| Masaya Watanabe, Takashi Ueda, Yasuhiro Shibata, Natsuko Kumamoto, Shoichi Shimada, Shinya Ugaw. Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons. PloS one. vol 10. issue 5. 2016-02-23. PMID:25974104. |
expression and regulation of cav3.2 t-type calcium channels during inflammatory hyperalgesia in mouse dorsal root ganglion neurons. |
2016-02-23 |
2023-08-13 |
mouse |
| Masaya Watanabe, Takashi Ueda, Yasuhiro Shibata, Natsuko Kumamoto, Shoichi Shimada, Shinya Ugaw. Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons. PloS one. vol 10. issue 5. 2016-02-23. PMID:25974104. |
we performed behavioral and comprehensive histochemical analyses to characterize cav3.2-expressing drg neurons and examined the regulation of t-type channels in drgs from c57bl/6 mice with carrageenan-induced inflammatory hyperalgesia. |
2016-02-23 |
2023-08-13 |
mouse |