| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaya Watanabe, Takashi Ueda, Yasuhiro Shibata, Natsuko Kumamoto, Shoichi Shimada, Shinya Ugaw. Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons. PloS one. vol 10. issue 5. 2016-02-23. PMID:25974104. |
in mice with carrageenan-induced inflammatory hyperalgesia, cav3.2 channels, but not cav3.1 or cav3.3 channels, were upregulated in ipsilateral drg neurons during the sub-acute phase. |
2016-02-23 |
2023-08-13 |
mouse |
| Dmytro E Duzhyy, Viacheslav Y Viatchenko-Karpinski, Eugen V Khomula, Nana V Voitenko, Pavel V Bela. Upregulation of T-type Ca2+ channels in long-term diabetes determines increased excitability of a specific type of capsaicin-insensitive DRG neurons. Molecular pain. vol 11. 2016-02-22. PMID:25986602. |
previous studies have shown that increased excitability of capsaicin-sensitive drg neurons and thermal hyperalgesia in rats with short-term (2-4 weeks) streptozotocin-induced diabetes is mediated by upregulation of t-type ca(2+) current. |
2016-02-22 |
2023-08-13 |
rat |
| Gen Zheng, Shuangsong Hong, John M Hayes, John W Wile. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. Experimental neurology. vol 273. 2016-02-18. PMID:26408049. |
previous studies reported that stress-induced visceral hyperalgesia is associated with reciprocal alterations of endovanilloid and endocannabinoid pain pathways in drg neurons innervating the pelvic viscera. |
2016-02-18 |
2023-08-13 |
rat |
| Angela Dörr, Sandra Pierre, Dong D Zhang, Marina Henke, Sabrina Holland, Klaus Scholic. MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia. The Journal of biological chemistry. vol 290. issue 42. 2016-02-16. PMID:26304119. |
we show that loss of the neuronal e3 ubiquitin ligase mycbp2 caused the up-regulation of ran and rangap1 in dorsal root ganglia (drg) under basal conditions and during inflammatory hyperalgesia. |
2016-02-16 |
2023-08-13 |
Not clear |
| Dong Fang, Ling-Yu Kong, Jie Cai, Song Li, Xiao-Dan Liu, Ji-Sheng Han, Guo-Gang Xin. Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model. Pain. vol 156. issue 6. 2016-02-04. PMID:25775359. |
therefore, suppression of functional upregulation of trpv1 in drg neurons by the inhibition of jak/pi3k pathway, either before surgery or after surgery, reduces the hyperexcitability of drg neurons and pain hyperalgesia in bone cancer rats. |
2016-02-04 |
2023-08-13 |
rat |
| T Smith, M Al Otaibi, J Sathish, L Djouhr. Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats. Neuroscience. vol 295. 2016-01-13. PMID:25813712. |
a hallmark of peripheral neuropathic pain (pnp) is chronic spontaneous pain and/or hypersensitivity to normally painful stimuli (hyperalgesia) or normally nonpainful stimuli (allodynia).this pain results partly from abnormal hyperexcitability of dorsal root ganglion (drg) neurons. |
2016-01-13 |
2023-08-13 |
rat |
| X-L Zhang, K M Albers, M S Gol. Inflammation-induced increase in nicotinic acetylcholine receptor current in cutaneous nociceptive DRG neurons from the adult rat. Neuroscience. vol 284. 2016-01-04. PMID:25453771. |
with the relatively selective distribution of nachr currents in putative nociceptive cutaneous drg neurons, our results suggest that the role of these receptors in inflammatory hyperalgesia is likely to be complex and dependent on the concentration and timing of acetylcholine release in the periphery. |
2016-01-04 |
2023-08-13 |
rat |
| Li-Jun Heng, Rui Qi, Rui-Hua Yang, Guo-Zheng X. Docosahexaenoic acid inhibits mechanical allodynia and thermal hyperalgesia in diabetic rats by decreasing the excitability of DRG neurons. Experimental neurology. vol 271. 2015-12-22. PMID:26118950. |
docosahexaenoic acid inhibits mechanical allodynia and thermal hyperalgesia in diabetic rats by decreasing the excitability of drg neurons. |
2015-12-22 |
2023-08-13 |
human |
| Li-Jun Heng, Rui Qi, Rui-Hua Yang, Guo-Zheng X. Docosahexaenoic acid inhibits mechanical allodynia and thermal hyperalgesia in diabetic rats by decreasing the excitability of DRG neurons. Experimental neurology. vol 271. 2015-12-22. PMID:26118950. |
dha supplementation decreased the excitability of drg neurons by decreasing the sodium currents and increasing potassium currents, which may contribute to the effect of alleviating allodynia and hyperalgesia in diabetic rats. |
2015-12-22 |
2023-08-13 |
human |
| Xing Xiao, Xiao-Tao Zhao, Ling-Chi Xu, Lu-Peng Yue, Feng-Yu Liu, Jie Cai, Fei-Fei Liao, Jin-Ge Kong, Guo-Gang Xing, Ming Yi, You Wa. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats. Pain. vol 156. issue 4. 2015-12-01. PMID:25790452. |
these results suggested that shp-1 dephosphorylated and inhibited trpv1 in drg neurons, contributing to maintain thermal nociceptive thresholds in normal rats, and as a compensatory mechanism, shp-1 increased in drgs of rats with cfa-induced inflammatory pain, which was involved in protecting against excessive thermal hyperalgesia. |
2015-12-01 |
2023-08-13 |
rat |
| Toru Taguchi, Kimiaki Katanosaka, Masaya Yasui, Koei Hayashi, Mai Yamashita, Koji Wakatsuki, Hiroshi Kiyama, Akihiro Yamanaka, Kazue Mizumur. Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. Pain. vol 156. issue 3. 2015-11-02. PMID:25599239. |
a significant increase in mrna expression of the acid-sensing ion channel (asic)-3 was detected in the drg, and the behavioral mechanical hyperalgesia was significantly reversed by subcutaneous injection of apetx2, a selective blocker of asic3. |
2015-11-02 |
2023-08-13 |
rat |
| Jie Wang, Xiao-Wei Wang, Yang Zhang, Cui-Ping Yin, Shou-Wei Yu. Ca(2+) influx mediates the TRPV4-NO pathway in neuropathic hyperalgesia following chronic compression of the dorsal root ganglion. Neuroscience letters. vol 588. 2015-08-24. PMID:25575793. |
ca(2+) influx mediates the trpv4-no pathway in neuropathic hyperalgesia following chronic compression of the dorsal root ganglion. |
2015-08-24 |
2023-08-13 |
rat |
| Ran Ran, Junfeng Gu, Jun Fu, Heying Zhong, Yupeng Zhao, YuChun Gu, Ailian Zhang, Guifeng Li, Lihua Wang, Qingxiu Wan. The role of the GABA-A receptor of the adjacent intact dorsal root ganglion neurons in rats with neuropathic pain. Acta neurobiologiae experimentalis. vol 74. issue 4. 2015-08-19. PMID:25576971. |
in conclusion, the decrease of inhibition signal mediated by gaba-a receptor in the adjacent intact drg neurons may be crucial in the development of hyperalgesia in npp. |
2015-08-19 |
2023-08-13 |
rat |
| Luiz F Ferrari, Dioneia Araldi, Jon D Levin. Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 15. 2015-06-18. PMID:25878283. |
injection of a cell-permeant camp analog, 8-bromo camp, into the dorsal root ganglion induced mechanical hyperalgesia and priming with an onset more rapid than when induced at the peripheral terminal. |
2015-06-18 |
2023-08-13 |
rat |
| Kathryn L Maier Ortmann, Munmun Chattopadhya. Decrease in neuroimmune activation by HSV-mediated gene transfer of TNFα soluble receptor alleviates pain in rats with diabetic neuropathy. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24880032. |
therapeutic approaches by hsv mediated expression of p55 tnf soluble receptor significantly attenuated the diabetes-induced hyperalgesia and decreased the expression of tnfα with reduction in the phosphorylation of p38mapk in the spinal cord dorsal horn and drg. |
2015-06-09 |
2023-08-13 |
rat |
| Robert H LaMotte, Chao M. Hyperexcitable neurons and altered non-neuronal cells in the compressed spinal ganglion. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 5. 2015-05-16. PMID:18958366. |
in a rat model of radicular pain, an intraforaminal implantation of a rod that chronically compressed the lumbar drg ("ccd" model) resulted in neuronal somal hyperexcitability and spontaneous activity that was accompanied by hyperalgesia in the ipsilateral hind paw. |
2015-05-16 |
2023-08-12 |
rat |
| Zhi-Jiang Huang, Hao-Chuan Li, Su Liu, Xue-Jun Son. Activation of cGMP-PKG signaling pathway contributes to neuronal hyperexcitability and hyperalgesia after in vivo prolonged compression or in vitro acute dissociation of dorsal root ganglion in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 5. 2015-05-16. PMID:23090497. |
activation of cgmp-pkg signaling pathway contributes to neuronal hyperexcitability and hyperalgesia after in vivo prolonged compression or in vitro acute dissociation of dorsal root ganglion in rats. |
2015-05-16 |
2023-08-12 |
rat |
| Zhi-Jiang Huang, Hao-Chuan Li, Su Liu, Xue-Jun Son. Activation of cGMP-PKG signaling pathway contributes to neuronal hyperexcitability and hyperalgesia after in vivo prolonged compression or in vitro acute dissociation of dorsal root ganglion in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 5. 2015-05-16. PMID:23090497. |
recent studies have indicated that, following chronic compression of drg (ccd) or acute dissociation of drg (add) treatment, both hyperexcitability of neurons in intact drg and behaviorally expressed hyperalgesia are maintained by activity in cgmp-pkg signaling pathway. |
2015-05-16 |
2023-08-12 |
rat |
| Zhi-Jiang Huang, Hao-Chuan Li, Su Liu, Xue-Jun Son. Activation of cGMP-PKG signaling pathway contributes to neuronal hyperexcitability and hyperalgesia after in vivo prolonged compression or in vitro acute dissociation of dorsal root ganglion in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 5. 2015-05-16. PMID:23090497. |
these findings indicate that the in vivo ccd or in vitro add treatment can activate the cgmp-pkg signaling pathway, and that continuing activation of cgmp-pkg pathway is required to maintain drg neuronal hyperexcitability and/or hyperalgesia after these two dissimilar forms of injury-related stress. |
2015-05-16 |
2023-08-12 |
rat |
| Luiz Fernando Ferrari, Celina Monteiro Lotufo, Dionéia Araldi, Marcos A Rodrigues, Larissa P Macedo, Sérgio H Ferreira, Carlos Amilcar Parad. Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 51. 2015-04-17. PMID:25489099. |
moreover, blockade of drg ampa receptors by the antagonist 6,7-dinitroquinoxaline-2,3-dione had no effect in the pge2-induced hyperalgesia in the paw, showing specific involvement of nmdars in this modulatory effect and suggesting that activation of nmdar in the drg plays an important role in the peripheral inflammatory hyperalgesia. |
2015-04-17 |
2023-08-13 |
rat |