| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luiz Fernando Ferrari, Celina Monteiro Lotufo, Dionéia Araldi, Marcos A Rodrigues, Larissa P Macedo, Sérgio H Ferreira, Carlos Amilcar Parad. Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 51. 2015-04-17. PMID:25489099. |
in following experiments we observed attenuation of pge2-induced hyperalgesia in the paw by the knockdown of nmdar subunits nr1, nr2b, nr2d, and nr3a with antisense-oligodeoxynucleotide treatment in the drg. |
2015-04-17 |
2023-08-13 |
rat |
| Luiz Fernando Ferrari, Celina Monteiro Lotufo, Dionéia Araldi, Marcos A Rodrigues, Larissa P Macedo, Sérgio H Ferreira, Carlos Amilcar Parad. Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 51. 2015-04-17. PMID:25489099. |
also, in vitro experiments showed that the nmda-induced sensitization of cultured drg neurons depends on satellite cell activation and on those same nmdar subunits, suggesting their importance for the pge2-induced hyperalgesia. |
2015-04-17 |
2023-08-13 |
rat |
| Luiz Fernando Ferrari, Celina Monteiro Lotufo, Dionéia Araldi, Marcos A Rodrigues, Larissa P Macedo, Sérgio H Ferreira, Carlos Amilcar Parad. Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 51. 2015-04-17. PMID:25489099. |
together, the present results suggest that the mechanical inflammatory nociceptor sensitization is dependent on glutamate release at the drg and subsequent nmdar activation in satellite glial cells, supporting the idea that the peripheral hyperalgesia is an event modulated by a glutamatergic system in the drg. |
2015-04-17 |
2023-08-13 |
rat |
| Yi Li, Fang Hu, Hai-Jing Chen, Yi-Juan Du, Zhi-Ying Xie, Ying Zhang, Jun Wang, Yun Wan. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Science signaling. vol 7. issue 331. 2015-02-19. PMID:24962708. |
in rats injected with complete freund's adjuvant (cfa), which induces inflammatory heat hyperalgesia, drg neurons showed an increase in limk activity and in the phosphorylation and thus inhibition of the limk substrate cofilin, an actin-severing protein. |
2015-02-19 |
2023-08-13 |
rat |
| Yi Li, Fang Hu, Hai-Jing Chen, Yi-Juan Du, Zhi-Ying Xie, Ying Zhang, Jun Wang, Yun Wan. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Science signaling. vol 7. issue 331. 2015-02-19. PMID:24962708. |
manipulations that reduced limk activity or abundance, prevented the phosphorylation of cofilin, or disrupted actin filaments in drg neurons attenuated cfa-induced heat hyperalgesia. |
2015-02-19 |
2023-08-13 |
rat |
| Jennifer J DeBerry, Erica S Schwartz, Brian M Davi. TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis. Pain. vol 155. issue 7. 2015-02-12. PMID:24704367. |
although many previous studies of visceral hyperalgesia have reported changes in dorsal root ganglion neuron trpv1 expression and/or function, we found no change in bladder afferent trpv1 expression or sensitivity on the basis of the percentage of bladder afferents responsive to capsaicin, including at submaximal concentrations. |
2015-02-12 |
2023-08-13 |
mouse |
| Li Li, Rong Luo, Yuan Guo, Fanrong Yao, Dongyuan Cao, Shaojie Ma, Jun Wang, Huisheng Wang, Yan Zha. The inhibitory effect of somatostatin receptor activation on bee venom-evoked nociceptive behavior and pCREB expression in rats. BioMed research international. vol 2014. 2015-01-14. PMID:24895558. |
subcutaneous injection of bv into the rat unilateral hindpaw pad induced significant spontaneous nociceptive behaviors, primary mechanical allodynia, primary thermal hyperalgesia, and mirror-thermal hyperalgesia, as well as an increase in pcreb expression in the lumbar spinal dorsal horn and drg. |
2015-01-14 |
2023-08-13 |
rat |
| Yanju Bao, Baojin Hua, Wei Hou, Zhan Shi, Weidong Li, Conghuang Li, Cihui Chen, Rui Liu, Yinggang Qi. Involvement of protease-activated receptor 2 in nociceptive behavior in a rat model of bone cancer. Journal of molecular neuroscience : MN. vol 52. issue 4. 2014-11-25. PMID:24057889. |
these results suggest that the increased expression of par2 in the drg may contribute to the development of mechanical allodynia and thermal hyperalgesia associated with bone cancer rats. |
2014-11-25 |
2023-08-12 |
rat |
| Kuan-Hung Chen, Chien-Hui Yang, Sin-Ei Juang, Hui-Wen Huang, Jen-Kun Cheng, Shyr-Ming Sheen-Chen, Jiin-Tsuey Cheng, Chung-Ren Li. Pulsed radiofrequency reduced complete Freund's adjuvant-induced mechanical hyperalgesia via the spinal c-Jun N-terminal kinase pathway. Cellular and molecular neurobiology. vol 34. issue 2. 2014-10-16. PMID:24242210. |
behavioral studies showed that prf applied close to the dorsal root ganglion (drg) significantly attenuated cfa-induced mechanical hyperalgesia compared to no-prf group (p < .05). |
2014-10-16 |
2023-08-12 |
rat |
| Kuan-Hung Chen, Chien-Hui Yang, Sin-Ei Juang, Hui-Wen Huang, Jen-Kun Cheng, Shyr-Ming Sheen-Chen, Jiin-Tsuey Cheng, Chung-Ren Li. Pulsed radiofrequency reduced complete Freund's adjuvant-induced mechanical hyperalgesia via the spinal c-Jun N-terminal kinase pathway. Cellular and molecular neurobiology. vol 34. issue 2. 2014-10-16. PMID:24242210. |
application of prf close to drg provides an effective treatment for cfa-induced persistent mechanical hyperalgesia by attenuating jnk activation in the spinal dorsal horn. |
2014-10-16 |
2023-08-12 |
rat |
| Ping Peng, Qingsong Xi, Shu Xia, Liang Zhuang, Qi Gui, Yu Chen, Yu Huang, Man Zou, Jie Rao, Shiying Y. Pregabalin attenuates docetaxel-induced neuropathy in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 32. issue 4. 2014-09-09. PMID:22886975. |
our results showed that docetaxel induced mechanical allodynia, mechanical hyperalgesia, heat hypoalgesia, cold allodynia, and sciatic nerve impairment and substance p and cgrp release in drg. |
2014-09-09 |
2023-08-12 |
rat |
| Liping Ning, Chuanwei Wang, Xiaohua Fan, Xinli Ding, Yonghui Wang, Yang Zhang, Jie Wang, Shouwei Yu. Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion. Neurological research. vol 36. issue 1. 2014-09-03. PMID:24074178. |
role of colchicine-induced microtubule depolymerization in hyperalgesia via trpv4 in rats with chronic compression of the dorsal root ganglion. |
2014-09-03 |
2023-08-12 |
rat |
| Liping Ning, Chuanwei Wang, Xiaohua Fan, Xinli Ding, Yonghui Wang, Yang Zhang, Jie Wang, Shouwei Yu. Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion. Neurological research. vol 36. issue 1. 2014-09-03. PMID:24074178. |
the aim of this study is to investigate the effect of microtubule depolymerization by colchicine on hyperalgesia mediated by transient receptor potential vanilloid 4 (trpv4) in a neuropathic pain model of chronic compression of the dorsal root ganglion (drg) (hereafter termed ccd) in rat. |
2014-09-03 |
2023-08-12 |
rat |
| Dan-dan Song, Yong Li, Dong Tang, Li-ya Huang, Yao-zong Yua. Neuron-glial communication mediated by TNF-α and glial activation in dorsal root ganglia in visceral inflammatory hypersensitivity. American journal of physiology. Gastrointestinal and liver physiology. vol 306. issue 9. 2014-06-19. PMID:24627565. |
we investigated whether satellite glial cell (sgc) and tumor necrosis factor-α (tnf-α) activation in drg participates in a 2,4,6-trinitrobenzene sulfonic acid (tnbs)-induced rat model of visceral hyperalgesia. |
2014-06-19 |
2023-08-12 |
rat |
| Tomomi Hara, Terumasa Chiba, Kenji Abe, Akiko Makabe, Souichi Ikeno, Kazuyoshi Kawakami, Iku Utsunomiya, Toshihiro Hama, Kyoji Taguch. Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion. Pain. vol 154. issue 6. 2014-01-08. PMID:23602343. |
to analyze the contribution of transient receptor potential vanilloid 1 (trpv1) in the development of paclitaxel-induced thermal hyperalgesia, trpv1 expression in the rat dorsal root ganglion (drg) was analyzed after paclitaxel treatment. |
2014-01-08 |
2023-08-12 |
rat |
| Dagmar Hackel, Diana Pflücke, Annick Neumann, Johannes Viebahn, Shaaban Mousa, Erhard Wischmeyer, Norbert Roewer, Alexander Brack, Heike Lydia Rittne. The connection of monocytes and reactive oxygen species in pain. PloS one. vol 8. issue 5. 2013-12-04. PMID:23658840. |
inflammatory hyperalgesia after complete freund's adjuvant (cfa) as well as capsaicin-induced hyperalgesia and capsaicin-induced current flow in dorsal root ganglion neurons in da were comparable to wistar rats. |
2013-12-04 |
2023-08-12 |
human |
| T Nishigami, Y Osako, M Ikeuchi, K Yuri, T Ushid. Development of heat hyperalgesia and changes of TRPV1 and NGF expression in rat dorsal root ganglion following joint immobilization. Physiological research. vol 62. issue 2. 2013-10-28. PMID:23234417. |
development of heat hyperalgesia and changes of trpv1 and ngf expression in rat dorsal root ganglion following joint immobilization. |
2013-10-28 |
2023-08-12 |
rat |
| T Nishigami, Y Osako, M Ikeuchi, K Yuri, T Ushid. Development of heat hyperalgesia and changes of TRPV1 and NGF expression in rat dorsal root ganglion following joint immobilization. Physiological research. vol 62. issue 2. 2013-10-28. PMID:23234417. |
these drg alterations may involve heat hyperalgesia after long-term limb immobilization. |
2013-10-28 |
2023-08-12 |
rat |
| K Mizukoshi, M Sasaki, Y Izumi, M Miura, M Watanabe, F Amay. Activation of p38 mitogen-activated protein kinase in the dorsal root ganglion contributes to pain hypersensitivity after plantar incision. Neuroscience. vol 234. 2013-10-25. PMID:23298852. |
the role of p38mapk signaling in the drg in the pathogenesis of plantar incision hyperalgesia has not been investigated. |
2013-10-25 |
2023-08-12 |
Not clear |
| Viola Spahn, Oliver Fischer, Jeannette Endres-Becker, Michael Schäfer, Christoph Stein, Christian Zöllne. Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. Pain. vol 154. issue 4. 2013-09-19. PMID:23398938. |
in summary, our results demonstrate an increased activity of trpv1 in drg neurons as a new mechanism contributing to opioid withdrawal-induced hyperalgesia. |
2013-09-19 |
2023-08-12 |
human |