| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qin Zheng, Dong Fang, Min Liu, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xin. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain. vol 154. issue 3. 2013-08-15. PMID:23352759. |
on the contrary, activation of the kcnq/m channels with retigabine not only inhibited the hyperexcitability of these small drg neurons, but also alleviated mechanical allodynia and thermal hyperalgesia in bone cancer rats, and all of these effects of retigabine could be blocked by kcnq/m-channel antagonist xe-991. |
2013-08-15 |
2023-08-12 |
rat |
| Gisela Segond von Banchet, Michael K Boettger, Christian König, Yoichiro Iwakura, Rolf Bräuer, Hans-Georg Schaibl. Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia. Molecular and cellular neurosciences. vol 52. 2013-07-22. PMID:23147107. |
neuronal il-17 receptor upregulates trpv4 but not trpv1 receptors in drg neurons and mediates mechanical but not thermal hyperalgesia. |
2013-07-22 |
2023-08-12 |
mouse |
| Feihu Qi, Youlang Zhou, Ying Xiao, Jin Tao, Jianguo Gu, Xinghong Jiang, Guang-Yin X. Promoter demethylation of cystathionine-β-synthetase gene contributes to inflammatory pain in rats. Pain. vol 154. issue 1. 2013-06-18. PMID:23273102. |
the cbs inhibitors hydroxylamine and aminooxyacetic acid attenuated mechanical hyperalgesia in a dose-dependent manner and reversed hyperexcitability of drg neurons in inflamed rats. |
2013-06-18 |
2023-08-12 |
rat |
| Der-Jang Kao, Allen H Li, Jin-Chung Chen, Ro-Sun Luo, Ying-Ling Chen, Juu-Chin Lu, Hung-Li Wan. CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons. Journal of neuroinflammation. vol 9. 2013-06-17. PMID:22870919. |
inflammation or nerve injury-induced upregulation and release of chemokine cc chemokine ligand 2 (ccl2) within the dorsal root ganglion (drg) is believed to enhance the activity of drg nociceptive neurons and cause hyperalgesia. |
2013-06-17 |
2023-08-12 |
Not clear |
| Jun-Long Zhang, Jan-Ping Yang, Ji-Ru Zhang, Rui-Qin Li, Jing Wang, Jin-Jin Jan, Qing Zhuan. Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons. Brain research. vol 1493. 2013-06-13. PMID:23183040. |
gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of nav1.7 and p-erk1/2 in drg neurons. |
2013-06-13 |
2023-08-12 |
rat |
| Dionéia Araldi, Luiz Fernando Ferrari, Celina Monteiro Lotufo, André Schwambach Vieira, Maria Carolina Pedro Athié, Jozi Godoy Figueiredo, Djane Braz Duarte, Claudia Herrera Tambeli, Sérgio Henrique Ferreira, Carlos Amilcar Parad. Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 9. 2013-05-02. PMID:23401543. |
peripheral inflammatory hyperalgesia depends on the cox increase in the dorsal root ganglion. |
2013-05-02 |
2023-08-12 |
rat |
| Dionéia Araldi, Luiz Fernando Ferrari, Celina Monteiro Lotufo, André Schwambach Vieira, Maria Carolina Pedro Athié, Jozi Godoy Figueiredo, Djane Braz Duarte, Claudia Herrera Tambeli, Sérgio Henrique Ferreira, Carlos Amilcar Parad. Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 9. 2013-05-02. PMID:23401543. |
recently, we have successfully established a technique to inject drugs (3 μl) directly into the l5-drg of rats, allowing in vivo identification of the role that drg cell-derived cox-1 and cox-2 play in the development of inflammatory hyperalgesia of peripheral tissue. |
2013-05-02 |
2023-08-12 |
rat |
| Judith A Strong, Wenrui Xie, Dennis E Coyle, Jun-Ming Zhan. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain. PloS one. vol 7. issue 7. 2013-03-21. PMID:22815815. |
robust mechanical hyperalgesia and allodynia can be induced by locally inflaming the l5 dorsal root ganglion (drg) in rat. |
2013-03-21 |
2023-08-12 |
rat |
| Jian-ping Jiang, Yan Fu, Yan-guo Hon. [Bovine adrenal medulla 22 attenuates hyperalgesia in the early phase of complete Freund's adjuvant-induced inflammation in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 1. 2013-01-31. PMID:21340429. |
the present study suggests that bam22 relieves cfa-induced thermal hyperalgesia in the early phase and resumes antinociceptive effects through down-regulation of nnos and cgrp expressions in drg and spinal cord, which is possibly mediated via snsr. |
2013-01-31 |
2023-08-12 |
rat |
| Zhi-Jiang Huang, Hao-Chuan Li, Ashley A Cowan, Su Liu, Yan-Kai Zhang, Xue-Jun Son. Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2. Pain. vol 153. issue 7. 2012-10-24. PMID:22541444. |
chronic compression (ccd) or dissociation of dorsal root ganglion (drg) can induce cyclic adenosine monophosphate (camp)-dependent drg neuronal hyperexcitability and behaviorally expressed hyperalgesia. |
2012-10-24 |
2023-08-12 |
rat |
| Dae Kee Choi, Jeong Gill Leem, Jin Woo Shin, Jeong Hun Su. Effects of Ethyl Pyruvate on Allodynia, TNF-α Expression, and Apoptosis in the Dorsal Root Ganglion after Spinal Nerve Ligation Injury. The Korean journal of pain. vol 25. issue 4. 2012-10-24. PMID:23091681. |
it has been demonstrated that the expression of tumor necrosis factor-α (tnf-α) and apoptotic cell death in the dorsal root ganglion (drg) following spinal nerve constriction injury play a role in the initiation and continuation of hyperalgesia and allodynia. |
2012-10-24 |
2023-08-12 |
Not clear |
| Milena De Felice, Pietro Melchiorri, Michael H Ossipov, Todd W Vanderah, Frank Porreca, Lucia Negr. Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression. Neuroscience letters. vol 521. issue 1. 2012-10-15. PMID:22641053. |
finally, during the late-phase of hyperalgesia, there was an upregulation of cgrp and substance p immunoreactivity in the rat lumbar dorsal horn and drg. |
2012-10-15 |
2023-08-12 |
mouse |
| Bai Ling Chen, Yi Qiang Li, Deng Hui Xie, Qiu Lan He, Xiao Xi Yan. Blocking TNF-α with infliximab alleviates ovariectomy induced mechanical and thermal hyperalgesia in rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 33. issue 3. 2012-09-25. PMID:21874299. |
in conclusion, tnf-α plays an important role in estrogen deficiency induced mechanical and thermal hyperalgesia, and drg may be one site on which tnf-α acts to cause hyperalgesia. |
2012-09-25 |
2023-08-12 |
rat |
| Maike Kanngiesser, Annett Häussler, Thekla Myrczek, Nele Küsener, Hee-Young Lim, Gerd Geisslinger, Ellen Niederberger, Irmgard Tegede. Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury. The journal of pain. vol 13. issue 5. 2012-09-14. PMID:22564672. |
mice carrying a cre-loxp-mediated deletion of inhibitor kappa b kinase beta (ikkβ) in drg neurons were protected from nerve injury-evoked allodynia and hyperalgesia. |
2012-09-14 |
2023-08-12 |
mouse |
| Xiaofeng Xu, Zhen Liu, Huaxiang Liu, Xiangdong Yang, Zhenzhong L. The effects of galanin on neuropathic pain in streptozotocin-induced diabetic rats. European journal of pharmacology. vol 680. issue 1-3. 2012-09-13. PMID:22306246. |
the results showed that (1) the diabetic rats showed a significant mechanical hyperalgesia between 4 and 12weeks; (2) galanin receptor 1 expression decreased in sdh in diabetic rats; (3) galanin receptor 2 expression decreased in drg and sdh in diabetic rats; (4) intrathecal administration of exogenous galanin attenuated diabetic neuropathic pain, this effect could be blocked by pre-treatment with galanin receptor antagonist m35; and (5) intrathecal administration of galanin receptor 1 agonist m617, but not galanin receptor 2 agonist ar-m1896, attenuated diabetic neuropathic pain. |
2012-09-13 |
2023-08-12 |
rat |
| Elias Utreras, Jason Keller, Anita Terse, Michaela Prochazkova, Michael J Iadarola, Ashok B Kulkarn. Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons. The Journal of biological chemistry. vol 287. issue 20. 2012-07-13. PMID:22451679. |
the decreased cdk5 activity is associated with attenuated thermal hyperalgesia in tgf-β1 receptor conditional knock-out mice, where tgf-β signaling is significantly reduced in trigeminal ganglia and drg. |
2012-07-13 |
2023-08-12 |
mouse |
| Haichen Chu, Jiangling Xia, Zhao Yang, Jie Ga. Melanocortin 4 receptor induces hyperalgesia and allodynia after chronic constriction injury by activation of p38 MAPK in DRG. The International journal of neuroscience. vol 122. issue 2. 2012-05-07. PMID:21985621. |
melanocortin 4 receptor induces hyperalgesia and allodynia after chronic constriction injury by activation of p38 mapk in drg. |
2012-05-07 |
2023-08-12 |
rat |
| XiaoPing Gu, Liangyu Peng, Dong Yang, Qing Ma, YaGuo Zheng, Chenglong Liu, Beibei Zhu, Lihua Song, Xiaofeng Sun, Zhengliang M. The respective and interaction effects of spinal GRs and MRs on radicular pain induced by chronic compression of the dorsal root ganglion in the rat. Brain research. vol 1396. 2012-04-17. PMID:21550593. |
here we show that the nociceptive behaviors induced by chronic compression of the lumbar dorsal root ganglion (ccd) are attenuated by either gr agonist dexamethasone (4=2 μg>vehicle) or mr antagonist spironolactone (3 μg) administered intrathecally twice daily for postoperative days 2-4, whereas the gr antagonist mifepristone (2 μg) significantly exacerbated both mechanical hyperalgesia and thermal allodynia. |
2012-04-17 |
2023-08-12 |
rat |
| Ajit K Naik, Janelle R Latham, Aleksandar Obradovic, Vesna Jevtovic-Todorovi. Dorsal root ganglion application of muscimol prevents hyperalgesia and stimulates myelin protein expression after sciatic nerve injury in rats. Anesthesia and analgesia. vol 114. issue 3. 2012-04-06. PMID:22190549. |
dorsal root ganglion application of muscimol prevents hyperalgesia and stimulates myelin protein expression after sciatic nerve injury in rats. |
2012-04-06 |
2023-08-12 |
rat |
| Ajit K Naik, Janelle R Latham, Aleksandar Obradovic, Vesna Jevtovic-Todorovi. Dorsal root ganglion application of muscimol prevents hyperalgesia and stimulates myelin protein expression after sciatic nerve injury in rats. Anesthesia and analgesia. vol 114. issue 3. 2012-04-06. PMID:22190549. |
it seems that direct application of a potent gaba(a) agonist, muscimol, to the ipsilateral drg prevents the development of hyperalgesia in rats subjected to a sciatic nerve crush injury. |
2012-04-06 |
2023-08-12 |
rat |