| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine E Brandao, Mark L Dell'Acqua, S Rock Levinso. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons. The Journal of comparative neurology. vol 520. issue 1. 2012-02-29. PMID:21674494. |
thus akap150 is expressed in small, nociceptive drg neurons, where it is targeted to membrane regions and where it may play a role in the modulation of ion channel phosphorylation states required for hyperalgesia. |
2012-02-29 |
2023-08-12 |
rat |
| Hiroshi Ued. Lysophosphatidic acid as the initiator of neuropathic pain. Biological & pharmaceutical bulletin. vol 34. issue 8. 2012-02-27. PMID:21804198. |
the lpa(1) signal also initiates the up-regulation of ca(v)α2δ1 in dorsal root ganglion and pkcγ in the dorsal horn, underlying mechanisms for characteristic neuropathic hyperalgesia in myelinated sensory (a-type) fibers. |
2012-02-27 |
2023-08-12 |
Not clear |
| V A Carozzi, C P Zoia, D Maggioni, E Verga, P Marmiroli, C Ferrarese, G Cavalett. Expression, distribution and glutamate uptake activity of high affinity-excitatory aminoacid transporters in in vitro cultures of embryonic rat dorsal root ganglia. Neuroscience. vol 192. 2012-01-18. PMID:21726604. |
new advances in research have demonstrated that rat peripheral sensory terminals and dorsal root ganglia (drg) express molecules involved in glutamate signalling, including high-affinity membrane-bound glutamate transporters (glast [glutamate aspartate transporter], glt1 [glutamate transporter 1], eaac1 [excitatory aminoacid transporter 1]) and that alterations in their expression and/or functionality can be implicated in several models of peripheral neuropathy, neuropathic pain and hyperalgesia. |
2012-01-18 |
2023-08-12 |
rat |
| Rong-Gui Chen, Wei-Wei Kong, Da-Long Ge, Ceng Luo, San-Jue H. Bilateral mechanical and thermal hyperalgesia and tactile allodynia after chronic compression of dorsal root ganglion in mice. Neuroscience bulletin. vol 27. issue 4. 2011-12-06. PMID:21788994. |
bilateral mechanical and thermal hyperalgesia and tactile allodynia after chronic compression of dorsal root ganglion in mice. |
2011-12-06 |
2023-08-12 |
mouse |
| Rong-Gui Chen, Wei-Wei Kong, Da-Long Ge, Ceng Luo, San-Jue H. Bilateral mechanical and thermal hyperalgesia and tactile allodynia after chronic compression of dorsal root ganglion in mice. Neuroscience bulletin. vol 27. issue 4. 2011-12-06. PMID:21788994. |
it also favors the development of new treatment strategies for pain and hyperalgesia after spinal injury and other disorders which affect the dorsal root ganglion in humans. |
2011-12-06 |
2023-08-12 |
mouse |
| Carissa Chu, Emma Levine, Robert W Gear, Oliver Bogen, Jon D Levin. Mitochondrial dependence of nerve growth factor-induced mechanical hyperalgesia. Pain. vol 152. issue 8. 2011-11-23. PMID:21570183. |
because nerve growth factor (ngf), which induces nociceptor sensitization by acting on the high-affinity tropomyosin receptor kinase a (trka) receptor, also produces local recruitment of mitochondria in drg neurons, we evaluated the role of mitochondria in ngf-induced mechanical hyperalgesia. |
2011-11-23 |
2023-08-12 |
rat |
| Friederike Mahn, Philipp Hüllemann, Ulrich Gockel, Mathias Brosz, Rainer Freynhagen, Thomas R Tölle, Ralf Baro. Sensory symptom profiles and co-morbidities in painful radiculopathy. PloS one. vol 6. issue 5. 2011-10-24. PMID:21573064. |
despite similarities in sensory symptoms there are two important differences between rad and other neuropathic pain disorders: (1) the paucity of mechanical allodynia and thermal hyperalgesia might be explained by the fact that the site of the nerve lesion in rad is often located proximal to the dorsal root ganglion. |
2011-10-24 |
2023-08-12 |
Not clear |
| Catherine Chu, Kathryn Zavala, Atefeh Fahimi, Jessica Lee, Qing Xue, Helge Eilers, Mark A Schumache. Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons. Molecular pain. vol 7. 2011-09-12. PMID:21645329. |
under pathophysiologic conditions, trpv1 mrna and receptor protein expression are elevated in dorsal root ganglion (drg) neurons for weeks to months and is associated with hyperalgesia. |
2011-09-12 |
2023-08-12 |
rat |
| Chao Wang, Li-Ping Ning, Yong-Hui Wang, Yang Zhang, Xin-Li Ding, Hong-You Ge, Lars Arendt-Nielsen, Shou-Wei Yu. Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. Behavioural brain research. vol 221. issue 1. 2011-09-06. PMID:21356247. |
nuclear factor-kappa b mediates trpv4-no pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. |
2011-09-06 |
2023-08-12 |
rat |
| Chao Wang, Li-Ping Ning, Yong-Hui Wang, Yang Zhang, Xin-Li Ding, Hong-You Ge, Lars Arendt-Nielsen, Shou-Wei Yu. Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. Behavioural brain research. vol 221. issue 1. 2011-09-06. PMID:21356247. |
the aim of this study was to test the hypothesis that nuclear factor-kappa b (nf-κb) is involved in trpv4-no pathway in thermal hyperalgesia following chronic compression of the dorsal root ganglion (drg) (the procedure hereafter termed ccd) in rat. |
2011-09-06 |
2023-08-12 |
rat |
| Yun Gao, Han Liu, Libin Deng, Gaochun Zhu, Changshui Xu, Guilin Li, Shuangmei Liu, Jinyan Xie, Jun Liu, Fanjun Kong, Raoping Wu, Guodong Li, Shangdong Lian. Effect of emodin on neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons. Brain research bulletin. vol 84. issue 6. 2011-07-18. PMID:21303687. |
the results showed that the application of emodin alleviated the hyperalgesia of cci rats and significantly decreased the p2x(2/3) expression of l4/l5 drg in cci+emodin group compared with that in cci+vehicle group (p<0.05). |
2011-07-18 |
2023-08-12 |
rat |
| Christine L Weisshaar, Ling Dong, Alex S Bowman, Federico M Perez, Benjamin B Guarino, Sarah M Sweitzer, Beth A Winkelstei. Metabotropic glutamate receptor-5 and protein kinase C-epsilon increase in dorsal root ganglion neurons and spinal glial activation in an adolescent rat model of painful neck injury. Journal of neurotrauma. vol 27. issue 12. 2011-03-18. PMID:20925479. |
following injury, forepaw mechanical hyperalgesia was measured, and protein kinase c-epsilon (pkcɛ) and metabotropic glutamate receptor-5 (mglur5) expression in the dorsal root ganglion and markers of spinal glial activation were assessed. |
2011-03-18 |
2023-08-12 |
rat |
| E K Joseph, J D Levin. Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20457222. |
thus, while pkcepsilon is present in most dorsal root ganglion neurons, where it can contribute to acute mechanical hyperalgesia, priming is restricted to ib4(+)-nociceptors, including those that are trka(+). |
2011-03-04 |
2023-08-12 |
rat |
| Feng Sui, Hai-Ru Huo, Chang-Bin Zhang, Na Yang, Jian-You Guo, Xin-Liang Du, Bao-Sheng Zhao, Hong-Bin Liu, Lan-Fang Li, Shu-Ying Guo, Ting-Liang Jian. Emodin down-regulates expression of TRPV1 mRNA and its function in DRG neurons in vitro. The American journal of Chinese medicine. vol 38. issue 4. 2011-01-19. PMID:20626063. |
in conclusion, we established that the mrna expression level of trpv1 and its calcium-mediating function in naive drg neurons could be down-regulated by emodin through perhaps the non-trpv1 channel pathways, and this might be the molecular mechanisms for rhubarb to inhibit hyperalgesia induced by inflammatory stimuli. |
2011-01-19 |
2023-08-12 |
Not clear |
| Jing Zhao, Guanglu Yuan, Cruz M Cendan, Mohammed A Nassar, Malin C Lagerström, Klas Kullander, Isabella Gavazzi, John N Woo. Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain. Molecular pain. vol 6. 2011-01-03. PMID:21059214. |
recent studies show that intrathecal treatment with ephb-receptor activator ephrinb2-fc induced thermal hyperalgesia and mechanical allodynia in rat, indicating that ephrin-b2 in small dorsal root ganglia (drg) neurons and ephb receptors in the spinal cord modulate pain processing. |
2011-01-03 |
2023-08-12 |
mouse |
| Tomoko Takahashi, Yuka Aoki, Kazumasa Okubo, Yumi Maeda, Fumiko Sekiguchi, Kenji Mitani, Hiroyuki Nishikawa, Atsufumi Kawabat. Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain. Pain. vol 150. issue 1. 2010-11-22. PMID:20546998. |
finally, silencing of ca(v)3.2 in drg by repeated intrathecal administration of ca(v)3.2-targeting sirna significantly attenuated the neuropathic hyperalgesia in the l5snc rat. |
2010-11-22 |
2023-08-12 |
rat |
| Masako Nakanishi, Kenji Hata, Tomotaka Nagayama, Teruhisa Sakurai, Toshihiko Nishisho, Hiroki Wakabayashi, Toru Hiraga, Shigeyuki Ebisu, Toshiyuki Yoned. Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain. Molecular biology of the cell. vol 21. issue 15. 2010-11-16. PMID:20534813. |
chemically induced inflammation was associated with thermal hyperalgesia and increased cgrp expression in dorsal root ganglion (drg) in rats. |
2010-11-16 |
2023-08-12 |
rat |
| Youmin Hu, Qihai Gu, Ruei-Lung Lin, Richard Kryscio, Lu-Yuan Le. Calcium transient evoked by TRPV1 activators is enhanced by tumor necrosis factor-{alpha} in rat pulmonary sensory neurons. American journal of physiology. Lung cellular and molecular physiology. vol 299. issue 4. 2010-10-19. PMID:20639352. |
tnfα, a proinflammatory cytokine known to be involved in the pathogenesis of allergic asthma, has been shown to induce hyperalgesia in somatic tissue via a sensitizing effect on dorsal root ganglion neurons expressing transient receptor potential vanilloid type 1 receptor (trpv1). |
2010-10-19 |
2023-08-12 |
rat |
| Ying Wang, Xiang Zhang, Qu-Lian Guo, Wang-Yuan Zou, Chang-Sheng Huang, Jian-Qin Ya. Cyclooxygenase inhibitors suppress the expression of P2X(3) receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats. Neuroscience letters. vol 478. issue 2. 2010-09-02. PMID:20450958. |
cyclooxygenase inhibitors suppress the expression of p2x(3) receptors in the drg and attenuate hyperalgesia following chronic constriction injury in rats. |
2010-09-02 |
2023-08-12 |
rat |
| Koyo Ueda, Munetaka Hirose, Eri Murata, Mayumi Takatori, Masashi Ueda, Hiroshi Ikeda, Kenji Shigem. Local administration of a synthetic cell-penetrating peptide antagonizing TrkA function suppresses inflammatory pain in rats. Journal of pharmacological sciences. vol 112. issue 4. 2010-08-12. PMID:20351485. |
local injection of this peptide significantly suppressed both thermal and mechanical hyperalgesia produced by cfa and also significantly reduced trpv1 expression at the drg. |
2010-08-12 |
2023-08-12 |
rat |