| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen E Abram, Johnny Yi, Andreas Fuchs, Quinn H Hoga. Permeability of injured and intact peripheral nerves and dorsal root ganglia. Anesthesiology. vol 105. issue 1. 2006-08-11. PMID:16810006. |
nerve injury that produces behavioral changes of allodynia and hyperalgesia in animals is associated with electrophysiologic changes in dorsal root ganglion (drg) cells. |
2006-08-11 |
2023-08-12 |
Not clear |
| Jolan M Terner, Andrew C Barrett, Lisa M Lomas, S Stevens Negus, Mitchell J Picke. Influence of low doses of naltrexone on morphine antinociception and morphine tolerance in male and female rats of four strains. Pain. vol 122. issue 1-2. 2006-06-06. PMID:16527399. |
in a recently proposed bimodal opioid receptor model, the inhibitory actions of opioids on action potential duration in dorsal root ganglion neurons have been proposed to produce antinociception, and the excitatory actions of hyperalgesia. |
2006-06-06 |
2023-08-12 |
rat |
| Julia J Inglis, Ahuva Nissim, Delphine M Lees, Stephen P Hunt, Yuti Chernajovsky, Bruce L Kid. The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation. Arthritis research & therapy. vol 7. issue 4. 2006-04-06. PMID:15987482. |
these results highlight the potential for tnf to play a vital role in inflammatory hyperalgesia, both by a direct action on neurons via tnfr1 and by facilitating the accumulation of macrophages in the drg via a tnfr2-mediated pathway. |
2006-04-06 |
2023-08-12 |
rat |
| Z Y Tan, D F Donnelly, R H LaMott. Effects of a chronic compression of the dorsal root ganglion on voltage-gated Na+ and K+ currents in cutaneous afferent neurons. Journal of neurophysiology. vol 95. issue 2. 2006-02-28. PMID:16424456. |
a chronic compression of the dorsal root ganglion (ccd) produces ipsilateral cutaneous hyperalgesia that is associated with an increased excitability of neuronal somata in the compressed ganglion, as evidenced by spontaneous activity and a lower rheobase. |
2006-02-28 |
2023-08-12 |
rat |
| Xue-Jun Song, Zheng-Bei Wang, Qiang Gan, Edgar T Walter. cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression. Journal of neurophysiology. vol 95. issue 1. 2006-01-20. PMID:16120663. |
evidence is presented for roles of both the camp-pka and cgmp-protein kinase g (pkg) pathways in maintaining neuronal hyperexcitability and behavioral hyperalgesia in a neuropathic pain model: chronic compression of the drg (ccd treatment). |
2006-01-20 |
2023-08-12 |
rat |
| Jin Chen, Zhi-Yong Tan, Rong Zhao, Xing-Hua Feng, Jian Shi, Yong-Hua J. The modulation effects of BmK I, an alpha-like scorpion neurotoxin, on voltage-gated Na(+) currents in rat dorsal root ganglion neurons. Neuroscience letters. vol 390. issue 2. 2005-12-15. PMID:16129561. |
it was further suggested that a combined effect of bmk i including inhibiting the inactivation of ttx-s and ttx-r channels, accelerating activation and decreasing the activation threshold of ttx-s channels, might produce a hyperexcitability of small drg neurons, and thus contribute to the bmk i-induced hyperalgesia. |
2005-12-15 |
2023-08-12 |
rat |
| Man Li, Jing Shi, Jun-Rui Tang, Di Chen, Bo Ai, Jun Chen, Li-Na Wang, Fu-Yuan Cao, Ling-Li Li, Chuan-You Lin, Xin-Min Gua. Effects of complete Freund's adjuvant on immunohistochemical distribution of IL-1beta and IL-1R I in neurons and glia cells of dorsal root ganglion. Acta pharmacologica Sinica. vol 26. issue 2. 2005-10-19. PMID:15663898. |
to investigate the effects of complete freund adjuvant (cfa) on inflammatory hyperalgesia and morphological change of the coexistence of interleukin-1 beta (il-1beta) and type i il-1 receptor (il-1ri) in neurons and glia cells of rat dorsal root ganglion (drg). |
2005-10-19 |
2023-08-12 |
rat |
| Hideo Doya, Seiji Ohtori, Masashi Fujitani, Tomoko Saito, Katsuhiko Hata, Hidetoshi Ino, Kazuhisa Takahashi, Hideshige Moriya, Toshihide Yamashit. c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity. Biochemical and biophysical research communications. vol 335. issue 1. 2005-10-11. PMID:16055088. |
we examined the involvement of c-jun n-terminal kinase (jnk) in the dorsal root ganglion (drg) in the early phase of inflammation-induced hyperalgesia. |
2005-10-11 |
2023-08-12 |
rat |
| Chao Ma, Robert H LaMott. Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat. Pain. vol 113. issue 1-2. 2005-04-18. PMID:15621370. |
a chronic compression of the dorsal root ganglion (ccd) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. |
2005-04-18 |
2023-08-12 |
rat |
| Chao Ma, Robert H LaMott. Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat. Pain. vol 113. issue 1-2. 2005-04-18. PMID:15621370. |
enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion. |
2005-04-18 |
2023-08-12 |
rat |
| Koichi Obata, Hiroki Yamanaka, Yi Dai, Toshiyuki Mizushima, Tetsuo Fukuoka, Atsushi Tokunaga, Koichi Noguch. Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats. The European journal of neuroscience. vol 20. issue 11. 2005-02-28. PMID:15579142. |
the p38 inhibitor, sb203580, reversed the cci-induced heat hyperalgesia and also the increase in brain-derived neurotrophic factor (bdnf) expression in intact drg neurons. |
2005-02-28 |
2023-08-12 |
rat |
| J H Chen, H-R Weng, P M Doughert. Sensitization of dorsal root reflexes in vitro and hyperalgesia in neonatal rats produced by capsaicin. Neuroscience. vol 126. issue 3. 2004-09-14. PMID:15183522. |
changes of drrs in rats of increasing age were also tested by administration of capsaicin to the drg and related to spinal mechanisms of hyperalgesia by defining the behavioral responses of neonatal rats to intradermal capsaicin. |
2004-09-14 |
2023-08-12 |
rat |
| Harry J Gould, John D England, R Denis Soignier, Porter Nolan, Lerna D Minor, Z P Liu, S Rock Levinson, Dennis Pau. Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat. The journal of pain. vol 5. issue 5. 2004-09-07. PMID:15219259. |
the cytochemical signal for sodium channel up-regulation in the large drg cells that most closely correlates with inflammatory hyperalgesia is mediated at least in part through products of the cyclooxygenase pathway. |
2004-09-07 |
2023-08-12 |
rat |
| Shuangsong Hong, Thomas J Morrow, Pamela E Paulson, Lori L Isom, John W Wile. Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat. The Journal of biological chemistry. vol 279. issue 28. 2004-08-24. PMID:15123645. |
we investigated the expression and function of ttx-sensitive (ttx-s) and ttx-r sodium channels in dorsal root ganglion (drg) neurons and the responses to thermal hyperalgesia and mechanical allodynia in streptozotocin-treated rats between 4-8 weeks after onset of diabetes. |
2004-08-24 |
2023-08-12 |
rat |
| Koichi Obata, Hiroki Yamanaka, Yi Dai, Toshiyuki Mizushima, Tetsuo Fukuoka, Atsushi Tokunaga, Hideki Yoshikawa, Koichi Noguch. Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion. Experimental neurology. vol 188. issue 1. 2004-08-10. PMID:15191811. |
l5 ventral rhizotomy, producing a selective lesion of motor fibers, produced thermal hyperalgesia and increased bdnf expression in tyrosine kinase a-containing small- and medium-sized neurons in the l5 drg and their central terminations within the spinal cord, but not in the l4 drg. |
2004-08-10 |
2023-08-12 |
rat |
| Hao Luo, Jin Cheng, Ji-Sheng Han, You Wa. Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats. Neuroreport. vol 15. issue 4. 2004-07-13. PMID:15094470. |
hot plate latency (hpl) was used to evaluate resulting thermal hyperalgesia and immunohistochemistry to observe vr1 expression in dorsal root ganglion and spinal cord dorsal horn. |
2004-07-13 |
2023-08-12 |
rat |
| Xue-Jun Song, Jun-Ming Zhang, San-Jue Hu, Robert H LaMott. Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators. Pain. vol 104. issue 3. 2003-10-15. PMID:12927643. |
inflammatory mediators, by increasing the excitability of drg neurons, may contribute to paresthesiae, pain and hyperalgesia after peripheral nerve injury. |
2003-10-15 |
2023-08-12 |
rat |
| Hyoh Kim, Teiji Sasaki, Kengo Maeda, Daisuke Koya, Atsunori Kashiwagi, Hitoshi Yasud. Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons. Diabetes. vol 52. issue 8. 2003-09-15. PMID:12882929. |
protein kinase cbeta selective inhibitor ly333531 attenuates diabetic hyperalgesia through ameliorating cgmp level of dorsal root ganglion neurons. |
2003-09-15 |
2023-08-12 |
rat |
| Hyoh Kim, Teiji Sasaki, Kengo Maeda, Daisuke Koya, Atsunori Kashiwagi, Hitoshi Yasud. Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons. Diabetes. vol 52. issue 8. 2003-09-15. PMID:12882929. |
both attenuated neuronal nitric oxide synthase (nnos)-cgmp system and tetrodotoxin-resistant (ttx-r) na channels in dorsal root ganglion neurons may be involved in diabetic hyperalgesia. |
2003-09-15 |
2023-08-12 |
rat |
| Hyoh Kim, Teiji Sasaki, Kengo Maeda, Daisuke Koya, Atsunori Kashiwagi, Hitoshi Yasud. Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons. Diabetes. vol 52. issue 8. 2003-09-15. PMID:12882929. |
we examined whether pkcbeta inhibition ameliorates diabetic hyperalgesia and, if so, whether the effect is obtained through action on neurons by testing nociceptive threshold in normal and stz-induced diabetic rats treated with or without pkcbeta-selective inhibitor ly333531 (ly) and by assessing the implication of ly in either nnos-cgmp system or ttx-r na channels of isolated dorsal root ganglion neurons. |
2003-09-15 |
2023-08-12 |
rat |