| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue-Jun Song, Carlos Vizcarra, Dong-Sheng Xu, Ronald L Rupert, Zheng-Nan Won. Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. Journal of neurophysiology. vol 89. issue 4. 2003-05-29. PMID:12612043. |
hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. |
2003-05-29 |
2023-08-12 |
rat |
| Xue-Jun Song, Carlos Vizcarra, Dong-Sheng Xu, Ronald L Rupert, Zheng-Nan Won. Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. Journal of neurophysiology. vol 89. issue 4. 2003-05-29. PMID:12612043. |
we examined thermal hyperalgesia, excitability of dorsal root ganglion (drg) neurons, and antinociceptive effects of n-methyl-d-aspartate (nmda) receptor antagonists in rats with injury to different regions of drg neurons. |
2003-05-29 |
2023-08-12 |
rat |
| Xue-Jun Song, Carlos Vizcarra, Dong-Sheng Xu, Ronald L Rupert, Zheng-Nan Won. Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. Journal of neurophysiology. vol 89. issue 4. 2003-05-29. PMID:12612043. |
pretreatment of apv and mk-801 delayed the emergence of hyperalgesia for 48-72 h, while posttreatment inhibited hyperalgesia for 24-36 h; and 4) ccd and cci increased excitability of drg neurons as judged by the significantly lowered threshold currents and action potential voltage thresholds and increased incidence of repetitive discharges. |
2003-05-29 |
2023-08-12 |
rat |
| Xue-Jun Song, Carlos Vizcarra, Dong-Sheng Xu, Ronald L Rupert, Zheng-Nan Won. Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. Journal of neurophysiology. vol 89. issue 4. 2003-05-29. PMID:12612043. |
these findings indicate that injury to the dorsal root, compared with injury to the peripheral nerve or drg somata has different effects on the development of hyperalgesia. |
2003-05-29 |
2023-08-12 |
rat |
| Chao Ma, Yousheng Shu, Zheng Zheng, Yong Chen, Hang Yao, Kenneth W Greenquist, Fletcher A White, Robert H LaMott. Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons. Journal of neurophysiology. vol 89. issue 3. 2003-05-09. PMID:12612024. |
we hypothesize that the changes in the electrophysiological properties of axotomized and intact drg neurons after snl are produced by a mechanism associated with wallerian degeneration and that the hyperexcitability of intact neurons may contribute to snl-induced hyperalgesia and allodynia. |
2003-05-09 |
2023-08-12 |
rat |
| Fumimasa Amaya, Kentaro Oh-hashi, Yoshihisa Naruse, Norio Iijima, Masashi Ueda, Goshun Shimosato, Makoto Tominaga, Yoshifumi Tanaka, Masaki Tanak. Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons. Brain research. vol 963. issue 1-2. 2003-04-28. PMID:12560124. |
local inflammation thus increases in vr1 protein level within distinct subgroups of drg neurons that may participate in the development and maintenance of inflammatory hyperalgesia. |
2003-04-28 |
2023-08-12 |
rat |
| Hang Yao, David F Donnelly, Chao Ma, Robert H LaMott. Upregulation of the hyperpolarization-activated cation current after chronic compression of the dorsal root ganglion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 6. 2003-04-17. PMID:12657665. |
a chronic compression of the drg (ccd) produces cutaneous hyperalgesia and an enhanced excitability of neuronal somata in the compressed ganglion. |
2003-04-17 |
2023-08-12 |
rat |
| Prisca Honore, Karen Kage, Joseph Mikusa, Andrew T Watt, Joseph F Johnston, Jacqueline R Wyatt, Connie R Faltynek, Michael F Jarvis, Kevin Lync. Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain. vol 99. issue 1-2. 2002-12-06. PMID:12237180. |
in contrast, a decrease in p2x(3) receptor protein expression in the drg did not affect nociceptive behavior in the carrageenan model of acute thermal hyperalgesia. |
2002-12-06 |
2023-08-12 |
mouse |
| Tetsuo Fukuoka, Atsushi Tokunaga, Toshiya Tachibana, Yi Dai, Hiroki Yamanaka, Koichi Noguch. VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation. Pain. vol 99. issue 1-2. 2002-12-06. PMID:12237189. |
vr1 mrna expression increased in the small- and medium-sized drg neurons from the first to 28th day after injury, and this up-regulation corresponded well with the development and maintenance of thermal hyperalgesia of the hind paw. |
2002-12-06 |
2023-08-12 |
rat |
| Lindsey J Hudson, Stuart Bevan, Kara McNair, Clive Gentry, Alyson Fox, Rainer Kuhn, Janet Winte. Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 7. 2002-04-08. PMID:11923431. |
therefore, reversal of thermal hyperalgesia by mpep correlates with increased mglur5 in lumbar drg a-fiber somata after nerve injury. |
2002-04-08 |
2023-08-12 |
Not clear |
| X Shu, L M Mendel. Acute sensitization by NGF of the response of small-diameter sensory neurons to capsaicin. Journal of neurophysiology. vol 86. issue 6. 2002-01-28. PMID:11731549. |
we investigated acute sensitization by nerve growth factor (ngf) of the response of small-diameter (<30 microm) dissociated dorsal root ganglion (drg) cells to brief repeated puffs of capsaicin as a model for thermal hyperalgesia induced by ngf. |
2002-01-28 |
2023-08-12 |
Not clear |
| M J Esser, T Chase, G V Allen, J Sawyno. Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. European journal of pharmacology. vol 430. issue 2-3. 2002-01-14. PMID:11711033. |
nerve injury was produced by unilateral spinal nerve ligation of the fifth and sixth lumbar nerves distal to the dorsal root ganglion, and this resulted in stimulus-evoked thermal hyperalgesia and static tactile mechanical allodynia. |
2002-01-14 |
2023-08-12 |
rat |
| M Dobretsov, S L Hastings, J R Stimers, J M Zhan. Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. Journal of neuroscience methods. vol 110. issue 1-2. 2001-12-07. PMID:11564519. |
mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. |
2001-12-07 |
2023-08-12 |
rat |
| M Dobretsov, S L Hastings, J R Stimers, J M Zhan. Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. Journal of neuroscience methods. vol 110. issue 1-2. 2001-12-07. PMID:11564519. |
repetitive tests of foot withdrawal to mechanical stimuli have shown that chronic hyperglycemia localized to the l(5) drg causes hyperalgesia in the hind limb innervated by perfused ganglion but not in the contralateral limb. |
2001-12-07 |
2023-08-12 |
rat |
| M Dobretsov, S L Hastings, J R Stimers, J M Zhan. Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. Journal of neuroscience methods. vol 110. issue 1-2. 2001-12-07. PMID:11564519. |
control experiments (drg perfusion with 5 mm glucose or 5 mm glucose+25 mm mannitol solution) have shown that hyperglycemia-induced hyperalgesia can not be attributed to surgery-related injury or hyperosmolality of the ganglion-perfusing solution. |
2001-12-07 |
2023-08-12 |
rat |
| Y Zhou, Z S Zhou, Z Q Zha. PKC regulates capsaicin-induced currents of dorsal root ganglion neurons in rats. Neuropharmacology. vol 41. issue 5. 2001-12-07. PMID:11587715. |
these data suggest that pkc can directly regulate the capsaicin response in drg neurons, which could increase nociceptive sensory transmission and contribute to hyperalgesia. |
2001-12-07 |
2023-08-12 |
rat |
| K O Aley, A Martin, T McMahon, J Mok, J D Levine, R O Messin. Nociceptor sensitization by extracellular signal-regulated kinases. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517280. |
epinephrine, which induces hyperalgesia by direct action at beta(2)-adrenergic receptors on primary afferent nociceptors, stimulated phosphorylation of erk1/2 in cultured rat dorsal root ganglion cells. |
2001-09-20 |
2023-08-12 |
rat |
| J M Zhang, Y Homma, W E Ackerman, S J Brul. Topical application of acidic bupivacaine to the lumbar ganglion induces mechanical hyperalgesia in the rat. Anesthesia and analgesia. vol 93. issue 2. 2001-08-16. PMID:11473881. |
results indicate that acute single-dose infusion of the drg with bupivacaine (0.5%) at acidic ph (5.5) induced ipsilateral mechanical hyperalgesia that lasted for 7 days. |
2001-08-16 |
2023-08-12 |
rat |
| J M Zhang, Y Homma, W E Ackerman, S J Brul. Topical application of acidic bupivacaine to the lumbar ganglion induces mechanical hyperalgesia in the rat. Anesthesia and analgesia. vol 93. issue 2. 2001-08-16. PMID:11473881. |
in rats receiving chronic treatment of the drg with alkalinized saline, mechanical hyperalgesia lasted for only 3 days. |
2001-08-16 |
2023-08-12 |
rat |
| J M Zhang, Y Homma, W E Ackerman, S J Brul. Topical application of acidic bupivacaine to the lumbar ganglion induces mechanical hyperalgesia in the rat. Anesthesia and analgesia. vol 93. issue 2. 2001-08-16. PMID:11473881. |
the results demonstrated that acidic bupivacaine deposited at the drg causes pain and hyperalgesia when the effects of the local anesthetic have dissipated. |
2001-08-16 |
2023-08-12 |
rat |