| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengfei Xu, Yahui Wang, Chaobo Ni, Miao Xu, Chengyu Yin, Qiuli He, Bing Ma, Jie Fu, Baoxia Zhao, Liping Chen, Tong Zhi, Shirong Wei, Liang Cheng, Hui Xu, Jiajun Xiao, Lei Yang, Qingqing Xu, Jiao Kuang, Boyi Liu, Qinghe Zhou, Xuewu Lin, Ming Yao, Huadong N. Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models. EMBO reports. 2024-10-25. PMID:39448865. |
targeted interventions, including drg microinjection of sirna or aav delivery, mitigate mechanical allodynia, cold, and heat hyperalgesia induced by the tumor. |
2024-10-25 |
2024-10-28 |
mouse |
| Nan Lian, Fangzhou Li, Cheng Zhou, Yan Yin, Yi Kang, Kaiteng Luo, Su Lui, Tao Li, Peilin L. Protein phosphatase 2Cm-regulated branched-chain amino acid catabolic defect in dorsal root ganglion neurons drives pain sensitization. Acta neuropathologica communications. vol 12. issue 1. 2024-09-11. PMID:39256776. |
the accumulation of branched-chain amino acids (bcaas) in drg has been implicated in mechanical allodynia and thermal hyperalgesia, but the exact mechanism is not fully understood. |
2024-09-11 |
2024-09-13 |
mouse |
| Kyra Sohns, Anna Kostenko, Marc Behrendt, Martin Schmelz, Roman Rukwied, Richard Car. Depolarization of mouse DRG neurons by GABA does not translate into acute pain or hyperalgesia in healthy human volunteers. PloS one. vol 19. issue 8. 2024-08-26. PMID:39186592. |
depolarization of mouse drg neurons by gaba does not translate into acute pain or hyperalgesia in healthy human volunteers. |
2024-08-26 |
2024-08-30 |
mouse |
| Kanglu Li, Wenbo Yang, Xuanzuo Chen, Yihan Yu, Yiran Liu, Feifei Ni, Yan Xiao, Xiangcheng Qing, Sheng Liu, YuXin He, Baichuan Wang, Li Xu, Zengwu Shao, Lei Zhao, Yizhong Peng, Hui Li. A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain. Journal of nanobiotechnology. vol 22. issue 1. 2024-08-14. PMID:39143545. |
in addition, tmnp@sr relieved mechanical and thermal hyperalgesia, reduced calcitonin gene-related peptide (cgrp) and substance p (sp) expression in the dorsal root ganglion, and downregulated gfap and c-fos signaling in the spinal cord in the rat idd model. |
2024-08-14 |
2024-08-17 |
rat |
| Chen Tu, Yun-Biao Chen, Si-Qi Lai, Yong-Peng Yu, Zhi-Wei Huang, Hong-Zhou Li, Rui-Feng Ao, Dong Han, Jia-Wen Gao, Guo-Zheng Zhu, Di-Zheng Wu, Yu-Sheng Huang, Kai Zhao, Ting-Ting Meng, Zhao-Ming Zhon. Accumulation of β-aminoisobutyric acid mediates hyperalgesia in ovariectomized mice through Mas-related G protein-coupled receptor D signaling. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 6. 2024-05-31. PMID:38810919. |
knockout of mrgprd markedly suppressed the effects of baiba on hyperalgesia and excitability of drg neurons. |
2024-05-31 |
2024-06-02 |
mouse |
| Li-Ge Zhang, Jing Cheng, Meng-Qi An, Cheng-Jie Li, Li-Guo Dong, Jian-Min Wang, Chun-Feng Liu, Fen Wang, Cheng-Jie Ma. Safinamide alleviates hyperalgesia via inhibiting hyperexcitability of DRG neurons in a mouse model of Parkinson's disease. Behavioural brain research. 2023-12-02. PMID:38042302. |
safinamide alleviates hyperalgesia via inhibiting hyperexcitability of drg neurons in a mouse model of parkinson's disease. |
2023-12-02 |
2023-12-10 |
mouse |
| Li-Ge Zhang, Jing Cheng, Meng-Qi An, Cheng-Jie Li, Li-Guo Dong, Jian-Min Wang, Chun-Feng Liu, Fen Wang, Cheng-Jie Ma. Safinamide alleviates hyperalgesia via inhibiting hyperexcitability of DRG neurons in a mouse model of Parkinson's disease. Behavioural brain research. 2023-12-02. PMID:38042302. |
our results suggest that safinamide could relieve hyperalgesia by inhibiting drg neuron hyperexcitability in mptp mice. |
2023-12-02 |
2023-12-10 |
mouse |
| Vikram Thakur, Mayra A Gonzalez, Maria Parada, Robert D Martinez, Munmun Chattopadhya. Role of Histone Deacetylase Inhibitor in Diabetic Painful Neuropathy. Molecular neurobiology. 2023-10-24. PMID:37875708. |
the results demonstrate that fk228 treatment can alleviate thermal hyperalgesia and mechanical allodynia significantly along with changes in the expression of hdacs in the dorsal root ganglia (drg) and spinal cord dorsal horn neurons of diabetic animals. |
2023-10-24 |
2023-11-08 |
mouse |
| Yizhong Peng, Xuanzuo Chen, Zilong Rao, Wei Wu, Huiyin Zuo, Kaibin Chen, Kanglu Li, Hui Lin, Sheng Liu, Yan Xiao, BaiChuan Wang, Daping Quan, Xiangcheng Qing, Ying Bai, Zengwu Sha. Multifunctional annulus fibrosus matrix prevents disc-related pain via inhibiting neuroinflammation and sensitization. Acta biomaterialia. 2023-08-20. PMID:37598791. |
besides, ti-cnp-daf relieved mechanical hyperalgesia, reduced cgrp and substance p expression in the dorsal root ganglion, and downregulated gfap and c-fos signaling in the spinal cord in the rat disc herniation model. |
2023-08-20 |
2023-09-07 |
rat |
| b' Daozhong Jin \\xe9\\x87\\x91\\xe9\\x81\\x93\\xe5\\xbf\\xa0, Hong Chen \\xe9\\x99\\x88\\xe7\\xba\\xa2, Meng-Hua Zhou \\xe5\\x91\\xa8\\xe5\\xad\\x9f\\xe5\\x8d\\x8e, Shao-Rui Chen \\xe9\\x99\\x88\\xe5\\xb0\\x91\\xe7\\x91\\x9e, Hui-Lin Pan \\xe6\\xbd\\x98\\xe6\\x83\\xa0\\xe9\\xba\\x9. mGluR5 from primary sensory neurons promotes opioid-induced hyperalgesia and tolerance by interacting with and potentiating synaptic NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-14. PMID:37451981.' |
correspondingly, intrathecal injection of mpep or conditional mglur5 knockdown in drg neurons not only potentiated the acute analgesic effect of morphine but also attenuated morphine treatment-induced hyperalgesia and tolerance. |
2023-07-14 |
2023-08-14 |
mouse |
| Yan Zhang, Hao Gong, Ji-Shuai Wang, Meng-Na Li, De-Li Cao, Jun Gu, Lin-Xia Zhao, Xin-Dan Zhang, Yu-Tao Deng, Fu-Lu Dong, Yong-Jing Gao, Wen-Xing Sun, Bao-Chun Jian. Nerve Injury-Induced γH2AX Reduction in Primary Sensory Neurons Is Involved in Neuropathic Pain Processing. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373296. |
the intrathecal injection of ku55933 down-regulated drg γh2ax expression and significantly induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. |
2023-06-28 |
2023-08-14 |
mouse |
| Shunsuke Yamakita, Daisuke Fujita, Kazuki Sudo, Daiki Ishikawa, Kohsuke Kushimoto, Yasuhiko Horii, Fumimasa Amay. Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia. Molecular pain. 2023-05-31. PMID:37254240. |
activation of neurons and satellite glial cells in the drg produces morphine-induced hyperalgesia. |
2023-05-31 |
2023-08-14 |
rat |
| Shunsuke Yamakita, Daisuke Fujita, Kazuki Sudo, Daiki Ishikawa, Kohsuke Kushimoto, Yasuhiko Horii, Fumimasa Amay. Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia. Molecular pain. 2023-05-31. PMID:37254240. |
activation of neurons and glial cells in the dorsal root ganglion is one of the key mechanisms for the development of hyperalgesia. |
2023-05-31 |
2023-08-14 |
rat |
| Songbin Wu, Shaomin Yang, Rongzhen Li, Xiyuan Ba, Changyu Jiang, Donglin Xiong, Lizu Xiao, Wuping Su. HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism. Journal of medical virology. vol 95. issue 4. 2023-05-16. PMID:37185840. |
hsv-1 inoculation in mice resulted in mechanical allodynia, thermal hyperalgesia, and cold allodynia, following the infection of hsv-1 in both drg and spinal cord. |
2023-05-16 |
2023-08-14 |
mouse |
| Lai Wang, Shingo Ishihara, Jun Li, Rachel E Miller, Anne-Marie Malfai. Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain. Arthritis research & therapy. vol 25. issue 1. 2023-04-15. PMID:37061736. |
we aimed to explore activation of the notch signaling pathway in knee-innervating lumbar dorsal root ganglia (drg) in the course of experimental osteoarthritis (oa) in mice, and its role in knee hyperalgesia. |
2023-04-15 |
2023-08-14 |
mouse |
| Junying Du, Min Yi, Danning Xi, Sisi Wang, Boyi Liu, Xiaomei Shao, Yi Liang, Xiaofen He, Jianqiao Fang, Junfan Fan. Satellite glial cells drive the transition from acute to chronic pain in a rat model of hyperalgesic priming. Frontiers in molecular neuroscience. vol 16. 2023-02-23. PMID:36818653. |
in this study, hp model rats developed prolonged hyperalgesia in the hind paw after carrageenan (car) and pge2 injection, accompanied by obvious satellite glial cell (sgc) activation in the dorsal root ganglion (drg), as indicated by upregulation of gfap. |
2023-02-23 |
2023-08-14 |
rat |
| Junying Du, Min Yi, Danning Xi, Sisi Wang, Boyi Liu, Xiaomei Shao, Yi Liang, Xiaofen He, Jianqiao Fang, Junfan Fan. Satellite glial cells drive the transition from acute to chronic pain in a rat model of hyperalgesic priming. Frontiers in molecular neuroscience. vol 16. 2023-02-23. PMID:36818653. |
pharmacological blockade of cxcl1 reduced protein kinase c epsilon overproduction as well as hyperalgesia in hp rats but did not prevent the upregulation of gfap in the drg. |
2023-02-23 |
2023-08-14 |
rat |
| Yi-Qi Ma, Qun-Qi Hu, Yu Rong Kang, Li-Qian Ma, Si-Ying Qu, Han-Zhi Wang, Yin-Mu Zheng, Si-Yi Li, Xiao-Mei Shao, Xiao-Yu Li, Han-Tong Hu, Yong-Liang Jiang, Jian-Qiao Fang, Xiao-Fen H. Electroacupuncture Alleviates Diabetic Neuropathic Pain and Downregulates p-PKC and TRPV1 in Dorsal Root Ganglions and Spinal Cord Dorsal Horn. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-02-13. PMID:36777630. |
ea reversed thermal hyperalgesia in dnp rats and downregulated the expression of p-pkc, trpv1, sp, and cgrp in drg and scdh. |
2023-02-13 |
2023-08-14 |
rat |
| InSug O-Sullivan, Ranjan Kc, Gurjit Singh, Vaskar Das, Kaige Ma, Xin Li, Fackson Mwale, Gina Votta-Velis, Benjamin Bruce, Arivarasu Natarajan Anbazhagan, Andre J van Wijnen, Hee-Jeong I. Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A ( International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36292950. |
we investigated the mechanisms of pain transmission as to whether peripheral sensory neurons are linked to the cellular plasticity in the dorsal root ganglia (drg) and are critical for oa hyperalgesia. |
2022-10-27 |
2023-08-14 |
Not clear |
| Ying-Yi Lu, Chun-Ching Lu, Chao-Lan Huang, Hung-Pei Tsai, Wei-Ting Wang, Zi-Hao Zhang, Chieh-Hsin W. Article Type: Original Article Title: Linalyl Acetate Ameliorates Mechanical Hyperalgesia Through Suppressing Inflammation by TSLP/IL-33 Signaling. Neurochemical research. 2022-10-26. PMID:36287299. |
sni rats were more sensitive to hyperalgesia response to mechanical stimulus since operation, which was accompanied by spinal cord glial cells reactions and drg neuro-glial interaction. |
2022-10-26 |
2023-08-14 |
rat |