| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eduarda Gomes Ferrarini, Elaine Cristina Dalazen Gonçalves, Jaíne Ferrareis Menegasso, Bruna Daniel Rabelo, Francielly Andressa Felipetti, Rafael Cypriano Dutr. Exercise Reduces Pain and Deleterious Histological Effects in Fibromyalgia-like Model. Neuroscience. vol 465. 2021-06-04. PMID:33945796. |
spontaneous pain, mechanical hyperalgesia, thermal allodynia, depression-related behavior, and locomotor activity were evaluated weekly, as well as the morphological evaluation of the spinal cord and dorsal root ganglion. |
2021-06-04 |
2023-08-13 |
mouse |
| Lubin Chen, Nivanthika K Wimalasena, Jaehoon Shim, Chongyang Han, Seong-Il Lee, Rafael Gonzalez-Cano, Mark Estacion, Catharina G Faber, Giuseppe Lauria, Sulayman D Dib-Hajj, Clifford J Woolf, Stephen G Waxma. Two independent mouse lines carrying the Nav1.7 I228M gain-of-function variant display dorsal root ganglion neuron hyperexcitability but a minimal pain phenotype. Pain. vol 162. issue 6. 2021-05-19. PMID:33323889. |
whole-cell patch-clamp and multielectrode array recordings show that nav1.7 i228m knock-in drg neurons are hyperexcitable compared with wild-type littermate-control neurons, but despite this, nav1.7 i228m mice do not display mechanical or thermal hyperalgesia or intraepidermal nerve fiber loss in vivo. |
2021-05-19 |
2023-08-13 |
mouse |
| Qin Niu, Fei Xing, Han-Wen Gu, Liying Bai, Jian Zhang, Jing-Jing Yuan, Yuan-Yuan Mao, Zhi-Song Li, Wei Zhang, Ji-Tian X. Upregulation of Myeloid Zinc Finger 1 in Dorsal Root Ganglion via Regulating Matrix Metalloproteinase-2/9 and Voltage-gated Potassium 1.2 Expression Contributes to Complete Freund's Adjuvant-induced Inflammatory Pain. Neuroscience. vol 432. 2021-05-14. PMID:32135233. |
pre- and post-microinjection of mzf1 sirna into the ipsi-l5 drg blocked the development of cfa-induced chronic inflammatory pain and alleviated the mechanical allodynia and thermal hyperalgesia in the maintenance phase. |
2021-05-14 |
2023-08-13 |
rat |
| Johannes Leuchtweis, Gisela Segond von Banchet, Annett Eitner, Matthias Ebbinghaus, Hans-Georg Schaibl. Pain-related behaviors associated with persistence of mechanical hyperalgesia after antigen-induced arthritis in rats. Pain. vol 161. issue 7. 2021-05-14. PMID:32149861. |
both clusters showed a persistent upregulation of pcreb in dorsal root ganglion neurons, inversely correlated with mechanical hyperalgesia at the knee. |
2021-05-14 |
2023-08-13 |
rat |
| Yasuhiko Horii, Megumi Matsuda, Hitomi Takemura, Daiki Ishikawa, Teiji Sawa, Fumimasa Amay. Spinal and Peripheral Mechanisms Individually Lead to the Development of Remifentanil-induced Hyperalgesia. Neuroscience. vol 446. 2021-05-14. PMID:32818602. |
phosphorylation of p38 mitogen-activated protein kinase (p38mapk) in the dorsal root ganglion (drg) neurons after remifentanil infusion, and the effect of a p38mapk inhibitor on remifentanil-induced hyperalgesia were analyzed to investigate involvement of p38mapk in the peripheral mechanisms of remifentanil-induced hyperalgesia. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yasuhiko Horii, Megumi Matsuda, Hitomi Takemura, Daiki Ishikawa, Teiji Sawa, Fumimasa Amay. Spinal and Peripheral Mechanisms Individually Lead to the Development of Remifentanil-induced Hyperalgesia. Neuroscience. vol 446. 2021-05-14. PMID:32818602. |
p38mapk phosphorylation was observed in the drg neuron, and the p38mapk inhibitor inhibited hyperalgesia during the early post-infusion period. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yasuhiko Horii, Megumi Matsuda, Hitomi Takemura, Daiki Ishikawa, Teiji Sawa, Fumimasa Amay. Spinal and Peripheral Mechanisms Individually Lead to the Development of Remifentanil-induced Hyperalgesia. Neuroscience. vol 446. 2021-05-14. PMID:32818602. |
p38mapk phosphorylation in the drg neuron leads to peripherally-driven hyperalgesia during the early post-infusion period, while spinal dynorphin-bradykinin signaling promotes hyperalgesia during the late post-infusion period. |
2021-05-14 |
2023-08-13 |
Not clear |
| Manuel Martínez-Laví. Dorsal root ganglia: fibromyalgia pain factory? Clinical rheumatology. vol 40. issue 2. 2021-05-14. PMID:33409721. |
drg neurons have pseudo-unipolar structure making them able to generate pain signals; additionally, they can sequester antigen-specific antibodies thus inducing immune-mediated hyperalgesia. |
2021-05-14 |
2023-08-13 |
Not clear |
| Manuel Martínez-Laví. Dorsal root ganglia: fibromyalgia pain factory? Clinical rheumatology. vol 40. issue 2. 2021-05-14. PMID:33409721. |
in rodents, diverse physical and/or environmental stressors induce drg phenotypic changes and hyperalgesia. |
2021-05-14 |
2023-08-13 |
Not clear |
| Tao Li, Chen Gao, Shuhua Shu, Xiaoqing Chai, Yanhu Xi. Acid-sensing ion channel 3 expression is increased in dorsal root ganglion, hippocampus and hypothalamus in remifentanil-induced hyperalgesia in rats. Neuroscience letters. vol 721. 2021-04-19. PMID:31734291. |
acid-sensing ion channel 3 expression is increased in dorsal root ganglion, hippocampus and hypothalamus in remifentanil-induced hyperalgesia in rats. |
2021-04-19 |
2023-08-13 |
rat |
| Jingjing Zhang, Lina Rong, Jinping Shao, Yidan Zhang, Yaping Liu, Sen Zhao, Lei Li, Wenli Yu, Mengya Zhang, Xiuhua Ren, Qingzan Zhao, Changlian Zhu, Huan Luo, Weidong Zang, Jing Ca. Epigenetic restoration of voltage-gated potassium channel Kv1.2 alleviates nerve injury-induced neuropathic pain. Journal of neurochemistry. vol 156. issue 3. 2021-04-12. PMID:32621322. |
furthermore, rescuing the expression of kv1.2 in cci rats, achieved through inhibiting mir-137, restored the abnormal kv currents and excitability in drg neurons, and alleviated mechanical allodynia and thermal hyperalgesia. |
2021-04-12 |
2023-08-13 |
rat |
| Li Zhao, Congzhong Song, Yaqin Huang, Weiping Lei, Jianliang Su. MMP-9 regulates CX3CL1/CX3CR1 in the early phase of neuropathic pain in chronic sciatic nerve constriction injury (CCI) rats. Annals of palliative medicine. vol 9. issue 4. 2021-02-24. PMID:32692220. |
to observe the effects of mmp-9 (matrix metalloproteases-9) on the mechanical allodynia and thermal hyperalgesia and the expression of cx3cl1 (cx3c chemokine ligand 1) protein in the spinal dorsal root ganglion (drg) in rats with chronic sciatic nerve constriction injury (cci). |
2021-02-24 |
2023-08-13 |
rat |
| J L Podratz, J J Tang, M J Polzin, A M Schmeichel, J J Nesbitt, A J Windebank, N N Madiga. Mechano growth factor interacts with nucleolin to protect against cisplatin-induced neurotoxicity. Experimental neurology. vol 331. 2021-02-11. PMID:32511954. |
expression of endogenous mgf in adult drg neurons in vivo ameliorated cisplatin-induced thermal hyperalgesia. |
2021-02-11 |
2023-08-13 |
mouse |
| Hiroki Wakabayashi, Gaku Miyamura, Nobuto Nagao, Sho Kato, Yohei Naito, Akihiro Sud. Functional Block of Interleukin-6 Reduces a Bone Pain Marker but Not Bone Loss in Hindlimb-Unloaded Mice. International journal of molecular sciences. vol 21. issue 10. 2021-02-10. PMID:32429268. |
the hu mice showed mechanical hyperalgesia in the hindlimbs and increased cgrp immunoreactive neurons in the l3-5 drg. |
2021-02-10 |
2023-08-13 |
mouse |
| Hiroki Wakabayashi, Gaku Miyamura, Nobuto Nagao, Sho Kato, Yohei Naito, Akihiro Sud. Functional Block of Interleukin-6 Reduces a Bone Pain Marker but Not Bone Loss in Hindlimb-Unloaded Mice. International journal of molecular sciences. vol 21. issue 10. 2021-02-10. PMID:32429268. |
treatment with il-6i and aln prevented hu-induced mechanical hyperalgesia and upregulation of cgrp expressions in drg neurons. |
2021-02-10 |
2023-08-13 |
mouse |
| Hiroki Wakabayashi, Gaku Miyamura, Nobuto Nagao, Sho Kato, Yohei Naito, Akihiro Sud. Functional Block of Interleukin-6 Reduces a Bone Pain Marker but Not Bone Loss in Hindlimb-Unloaded Mice. International journal of molecular sciences. vol 21. issue 10. 2021-02-10. PMID:32429268. |
in summary, treatment with il-6i prevented mechanical hyperalgesia in hindlimbs and suppressed cgrp expressions in drg neurons of osteoporotic models. |
2021-02-10 |
2023-08-13 |
mouse |
| Increased Hyperalgesia and Proinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion After Surgery and/or Fentanyl Administration in Rats: Erratum. Anesthesia and analgesia. vol 131. issue 3. 2021-01-26. PMID:33035041. |
increased hyperalgesia and proinflammatory cytokines in the spinal cord and dorsal root ganglion after surgery and/or fentanyl administration in rats: erratum. |
2021-01-26 |
2023-08-13 |
rat |
| Lubin Chen, Jianying Huang, Curtis Benson, Karen L Lankford, Peng Zhao, Jennifer Carrara, Andrew M Tan, Jeffery D Kocsis, Stephen G Waxman, Sulayman D Dib-Haj. Sodium channel Nav1.6 in sensory neurons contributes to vincristine-induced allodynia. Brain : a journal of neurology. vol 143. issue 8. 2020-12-30. PMID:32830219. |
accompanying the behavioural hyperalgesia phenotype, voltage-clamp recordings of small and medium dorsal root ganglion neurons from vincristine-treated animals revealed a significant upregulation of ttx-s na+ current in medium but not small neurons. |
2020-12-30 |
2023-08-13 |
mouse |
| William Antonio Gonçalves, Barbara Maximino Rezende, Marcos Paulo Esteves de Oliveira, Lucas Secchim Ribeiro, Victor Fattori, Walison Nunes da Silva, Pedro Henrique Dias Moura Prazeres, Celso Martins Queiroz-Junior, Karina Talita de Oliveira Santana, Walyson Coelho Costa, Vinícius Amorim Beltrami, Vivian Vasconcelos Costa, Alexander Birbrair, Waldiceu A Verri, Fernando Lopes, Thiago Mattar Cunha, Mauro Martins Teixeira, Flávio Almeida Amaral, Vanessa Pinh. Sensory Ganglia-Specific TNF Expression Is Associated With Persistent Nociception After Resolution of Inflammation. Frontiers in immunology. vol 10. 2020-11-16. PMID:32038637. |
intrathecal or systemic injection of etanercept, an agent clinically utilized for tnf neutralization, at day 7 post arthritis induction, alleviated the persistent joint hyperalgesia by specific action in drg. |
2020-11-16 |
2023-08-13 |
Not clear |
| Yi-Mei Zhou, Lei Wu, Shuang Wei, Ying Jin, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping H. Enhancement of acid-sensing ion channel activity by prostaglandin E2 in rat dorsal root ganglion neurons. Brain research. vol 1724. 2020-10-29. PMID:31513790. |
our results indicate that pge2 enhanced the electrophysiological activity of asics in drg neurons and contributed to acidosis-evoked pain, which revealed a novel peripheral mechanism underlying pge2 involvement in hyperalgesia by sensitizing asics in primary sensory neurons. |
2020-10-29 |
2023-08-13 |
rat |