| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shouyu Wang, Zilin Wang, Lin Li, Lifang Zou, Yingxin Gong, Tianyu Jia, Shanhong Zhao, Huilong Yuan, Liran Shi, Shuangmei Liu, Bing Wu, Zhihua Yi, Hui Liu, Yun Gao, Guilin Li, Jan M Deussing, Man Li, Chunping Zhang, Shangdong Lian. P2Y12 shRNA treatment decreases SGC activation to relieve diabetic neuropathic pain in type 2 diabetes mellitus rats. Journal of cellular physiology. vol 233. issue 12. 2019-09-30. PMID:29943819. |
targeting the p2y12 receptor by short hairpin rna (shrna) decreased the upregulated expression of p2y12 mrna and protein, coexpression of p2y12 and gfap, the expression of gfap, il-1β, and tumor necrosis factor-receptor 1 in the drg of dm rats, and relieved mechanical and thermal hyperalgesia in dm rats. |
2019-09-30 |
2023-08-13 |
rat |
| Hai-Ju Sun, Si-Si Wang, Xiao-Yu Li, Jun-Ying Du, Jian-Qiao Fang, Jun-Fan Fan. [Advances of researches on peripheral PKCε pathway during transformation from acute to chronic pain and possibility of application of electroacupuncture intervention]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 7. 2019-08-05. PMID:31368289. |
results indicated that prostaglandin e2 (pge2) / ep1 receptor-gq-pkcε is an important signaling pathway to modulate chronic pain in peripheral dorsal root ganglion (drg) neurons, and also plays a role in the later stage of hyperalgesia during transformation from acute to chronic pain. |
2019-08-05 |
2023-08-13 |
Not clear |
| Ezgi Bektur, Erhan Şahin, Emre Ceyhan, Dilek Burukoglu Donmez, Mediha Canbek, Cengiz Baycu, Ozgur Devrim Ca. Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion. Neurological research. vol 41. issue 6. 2019-07-09. PMID:30822229. |
beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of trpv1 and asic1 channels in the spinal cord and dorsal root ganglion. |
2019-07-09 |
2023-08-13 |
Not clear |
| Fang Hu, Huai-Cun Liu, Dong-Qiang Su, Hai-Jing Chen, Sun-On Chan, Yun Wang, Jun Wan. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-07-08. PMID:30024789. |
nogo-a promotes inflammatory heat hyperalgesia by maintaining trpv-1 function in the rat dorsal root ganglion neuron. |
2019-07-08 |
2023-08-13 |
rat |
| Fang Hu, Huai-Cun Liu, Dong-Qiang Su, Hai-Jing Chen, Sun-On Chan, Yun Wang, Jun Wan. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-07-08. PMID:30024789. |
these findings support a therapeutic potential of modulating nogo-a signaling in pain management.-hu, f., liu, h.-c., su, d.-q., chen, h.-j., chan, s.-o., wang, y., wang, j. nogo-a promotes inflammatory heat hyperalgesia by maintaining trpv-1 function in the rat dorsal root ganglion neuron. |
2019-07-08 |
2023-08-13 |
rat |
| Jingjing Yuan, Jing Wen, Shaogen Wu, Yuanyuan Mao, Kai Mo, Zhisong Li, Songxue Su, Hanwen Gu, Yanqiu Ai, Alex Bekker, Wei Zhang, Yuan-Xiang Ta. Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury. Pain. vol 160. issue 2. 2019-06-26. PMID:30247265. |
blocking this increase through microinjection of oct1 sirna into the ipsilateral l4/5 drg attenuated the initiation and maintenance of cci-induced mechanical allodynia, heat hyperalgesia, and cold allodynia and improved morphine analgesia after cci, without affecting basal responses to acute mechanical, heat, and cold stimuli as well as locomotor functions. |
2019-06-26 |
2023-08-13 |
rat |
| Jingjing Yuan, Jing Wen, Shaogen Wu, Yuanyuan Mao, Kai Mo, Zhisong Li, Songxue Su, Hanwen Gu, Yanqiu Ai, Alex Bekker, Wei Zhang, Yuan-Xiang Ta. Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury. Pain. vol 160. issue 2. 2019-06-26. PMID:30247265. |
mimicking this increase through microinjection of recombinant adeno-associated virus 5 harboring full-length oct1 into the unilateral l4/5 drg led to marked mechanical allodynia, heat hyperalgesia, and cold allodynia in naive rats. |
2019-06-26 |
2023-08-13 |
rat |
| Iryna A Khasabova, Sergey G Khasabov, Julie K Olson, Megan L Uhelski, Amy H Kim, Alejandra M Albino-Ramírez, Chad L Wagner, Virginia S Seybold, Donald A Simon. Pioglitazone, a PPARγ agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress. Pain. vol 160. issue 3. 2019-06-26. PMID:30507781. |
oxidative stress in drg neurons was considered a significant contributor to cisplatin-evoked hyperalgesia because a ros scavenger attenuated hyperalgesia and normalized the evoked calcium responses when cotreated with cisplatin. |
2019-06-26 |
2023-08-13 |
mouse |
| Xiumei Zhang, Wenpin Zhao, Xingfang Liu, Zhihua Huang, Reai Shan, Cheng Huan. Celastrol ameliorates inflammatory pain and modulates HMGB1/NF-κB signaling pathway in dorsal root ganglion. Neuroscience letters. vol 692. 2019-06-21. PMID:30395883. |
these results showed that celastrol significantly suppressed hmgb1, nf-κb and il-1β mrna and protein expression in drg and alleviated cfa-evoked thermal hyperalgesia. |
2019-06-21 |
2023-08-13 |
rat |
| Ying Wan, Yi Yu, Xinxin Pan, Xiaoqiang Mo, Weifan Gong, Xiangming Liu, Su Che. Inhibition on acid-sensing ion channels and analgesic activities of flavonoids isolated from dragon's blood resin. Phytotherapy research : PTR. vol 33. issue 3. 2019-06-17. PMID:30618119. |
cfa-induced hyperalgesia was accompanied by c-fos up-regulation in drg neurons, and the combination rescued thermal hyperalgesia through down-regulation of c-fos and asic3 expression in cfa-induced inflammation. |
2019-06-17 |
2023-08-13 |
rat |
| Malgorzata Zaremba, Victor Ruiz-Velasc. Opioid-Mediated Modulation of Acid-Sensing Ion Channel Currents in Adult Rat Sensory Neurons. Molecular pharmacology. vol 95. issue 5. 2019-06-17. PMID:30808671. |
however, we previously reported that sustained asic currents in dorsal root ganglion (drg) neurons were enhanced by naturally occurring endomorphin-1 and -2 opioid peptides, indicating a role of opioid involvement in hyperalgesia. |
2019-06-17 |
2023-08-13 |
rat |
| Hai-Yu Hu, Jia-Wei Ding, Ye-Qi Wu, Ya-Nan Xiang, Jian-Qiao Fang, Li-Hua Xuan, Jun-Ying Du, Jun-Fan Fan. [Effect of Electroacupuncture on Pain Reaction and Content of Proteinase-activated Receptors 2 in Dorsal Root Ganglion in Hyperalgesia Rats]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 1. 2019-04-03. PMID:29383888. |
[effect of electroacupuncture on pain reaction and content of proteinase-activated receptors 2 in dorsal root ganglion in hyperalgesia rats]. |
2019-04-03 |
2023-08-13 |
rat |
| Hai-Yu Hu, Jia-Wei Ding, Ye-Qi Wu, Ya-Nan Xiang, Jian-Qiao Fang, Li-Hua Xuan, Jun-Ying Du, Jun-Fan Fan. [Effect of Electroacupuncture on Pain Reaction and Content of Proteinase-activated Receptors 2 in Dorsal Root Ganglion in Hyperalgesia Rats]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 1. 2019-04-03. PMID:29383888. |
to observe the effect of electroacupuncture (ea) on mechanical hyperalgesia threshold (mhts) and thermal hyperalgesia threshold (thts) and content of proteinase-activated receptors 2 (par 2) in dorsal root ganglia (drg) in rats with inflammatory pain, so as to explore its peripheral mechanism underlying improvement of inflammatory pain. |
2019-04-03 |
2023-08-13 |
rat |
| Juliana Maia Teixeira, Gilson Gonçalves Dos Santos, Amanda Ferreira Neves, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Catarine Massucato Nishijima, Felipe Hertzing Farias, Jozi Godoy Figueiredo, Victor Hernandez-Olmos, Samer Alshaibani, Cláudia Herrera Tambeli, Christa E Müller, Carlos Amílcar Parad. Diabetes-induced Neuropathic Mechanical Hyperalgesia Depends on P2X4 Receptor Activation in Dorsal Root Ganglia. Neuroscience. vol 398. 2019-03-18. PMID:30537520. |
to answer this question, this study verified the involvement of p2x4r expressed in drg cells on diabetes-induced neuropathic mechanical hyperalgesia in rats. |
2019-03-18 |
2023-08-13 |
rat |
| Juliana Maia Teixeira, Gilson Gonçalves Dos Santos, Amanda Ferreira Neves, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Catarine Massucato Nishijima, Felipe Hertzing Farias, Jozi Godoy Figueiredo, Victor Hernandez-Olmos, Samer Alshaibani, Cláudia Herrera Tambeli, Christa E Müller, Carlos Amílcar Parad. Diabetes-induced Neuropathic Mechanical Hyperalgesia Depends on P2X4 Receptor Activation in Dorsal Root Ganglia. Neuroscience. vol 398. 2019-03-18. PMID:30537520. |
these findings indicate that p2x4r activation in drg is essential to diabetes-induced neuropathic mechanical hyperalgesia. |
2019-03-18 |
2023-08-13 |
rat |
| Zhihua Yi, Lihui Xie, Congfa Zhou, Huilong Yuan, Shuai Ouyang, Zhi Fang, Shanhong Zhao, Tianyu Jia, Lifang Zou, Shouyu Wang, Yun Xue, Bing Wu, Yun Gao, Guilin Li, Shuangmei Liu, Hong Xu, Changshui Xu, Chunping Zhang, Shangdong Lian. P2Y Purinergic signalling. vol 14. issue 1. 2019-01-14. PMID:29159762. |
activation of satellite glial cells (sgcs) in the dorsal root ganglia (drg) plays a crucial role in mechanical and thermal hyperalgesia. |
2019-01-14 |
2023-08-13 |
Not clear |
| Fei Xing, Wei Zhang, Jing Wen, Liying Bai, Hanwen Gu, Zhisong Li, Jian Zhang, Yuan-Xiang Tao, Ji-Tian X. TLR4/NF-κB signaling activation in plantar tissue and dorsal root ganglion involves in the development of postoperative pain. Molecular pain. vol 14. 2019-01-14. PMID:30270727. |
injections of tak-242 (a tlr4-specific antagonist) or 4',6-diamidino-2-phenylindole-dihydrochloride (pdtc, a nuclear factor-kappa b activation inhibitor) dose dependently alleviated plantar incision-induced mechanical allodynia and thermal hyperalgesia and inhibited the increased expressions of p-p65, tumor necrosis factor-alpha, and interleukin-1 beta in drg. |
2019-01-14 |
2023-08-13 |
rat |
| Chang-Cheng Lv, Man-Li Xia, Shu-Juan Shu, Fei Chen, Li-Shan Jian. Attenuation of Remifentanil-Induced Hyperalgesia by Betulinic Acid Associates with Inhibiting Oxidative Stress and Inflammation in Spinal Dorsal Horn. Pharmacology. vol 102. issue 5-6. 2018-12-19. PMID:30253391. |
intraoperative remifentanil infusion induced postoperative hyperalgesia, as evidenced by the significant decrease in pwmt and pwtl (p < 0.01), and the significant increase in oxidative stress and inflammation evidenced by up-regulations of malondialdehyde, 3-nitrotyrosine, interleukin-1β and tumour necrosis factor-α (p < 0.01) in spinal dorsal horn and matrix metalloproteinase-9 (mmp-9) activity (p < 0.01) in dorsal root ganglion, as well as a decrease in manganese superoxide -dismutase activity (p < 0.01) compared with control and -incision groups. |
2018-12-19 |
2023-08-13 |
rat |
| Yan Wang, Yingwei Gao, Quan Tian, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao, Tian-Le Xu, Michael X Zhu, Yong L. TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nature communications. vol 9. issue 1. 2018-12-18. PMID:29670121. |
we report here that conditional knockout of desumoylation enzyme, senp1, in mouse dorsal root ganglion (drg) neurons exacerbated thermal hyperalgesia in both carrageenan- and complete freund's adjuvant-induced inflammation models. |
2018-12-18 |
2023-08-13 |
mouse |
| Yan Wang, Yingwei Gao, Quan Tian, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao, Tian-Le Xu, Michael X Zhu, Yong L. TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nature communications. vol 9. issue 1. 2018-12-18. PMID:29670121. |
more importantly, the reduced ability of trpv1 knockout mice to develop inflammatory thermal hyperalgesia was rescued by viral infection of lumbar 3/4 drg neurons of wild-type trpv1, but not its sumoylation-deficient mutant, k822r. |
2018-12-18 |
2023-08-13 |
mouse |