| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paulina Nuñez-Badinez, Hugo Sepúlveda, Emilio Diaz, Wolfgang Greffrath, Rolf-Detlef Treede, Jimmy Stehberg, Martin Montecino, Brigitte van Zunder. Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia. Journal of cellular biochemistry. vol 119. issue 5. 2018-12-11. PMID:29219199. |
in this study, we sought to get insights into the molecular mechanisms responsible for inflammatory hyperalgesia by determining p2x3-r expression in drg neurons of juvenile male rats that received a complete freund's adjuvant (cfa) bilateral paw injection. |
2018-12-11 |
2023-08-13 |
rat |
| Paulina Nuñez-Badinez, Hugo Sepúlveda, Emilio Diaz, Wolfgang Greffrath, Rolf-Detlef Treede, Jimmy Stehberg, Martin Montecino, Brigitte van Zunder. Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia. Journal of cellular biochemistry. vol 119. issue 5. 2018-12-11. PMID:29219199. |
immunostaining assays did not reveal significant increases in the percentage of p2x3-positive neurons, indicating that increased p2x3-r at drg somas is not critical for inducing inflammatory hyperalgesia in cfa-treated rats. |
2018-12-11 |
2023-08-13 |
rat |
| Meei-Ling Sheu, Chien-Yi Chiang, Hong-Lin Su, Chun-Jung Chen, Jason Sheehan, Hung-Chuan Pa. Intrathecal Injection of Dual Zipper Kinase shRNA Alleviating the Neuropathic Pain in a Chronic Constrictive Nerve Injury Model. International journal of molecular sciences. vol 19. issue 8. 2018-11-16. PMID:30115872. |
intrathecal injection of dlk shrna attenuates the expression of dlk over the dorsal root ganglion and hippocampus neurons and increased the threshold of mechanical allodynia and decreased thermal hyperalgesia. |
2018-11-16 |
2023-08-13 |
Not clear |
| Aye Aye-Mon, Kiyomi Hori, Yu Kozakai, Tatsuki Nakagawa, Shinichiro Hiraga, Tsuneo Nakamura, Yoshitake Shiraishi, Hiroaki Okuda, Noriyuki Ozak. CCR2 upregulation in DRG neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy. Molecular pain. vol 14. 2018-10-22. PMID:29359616. |
ccr2 upregulation in drg neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy. |
2018-10-22 |
2023-08-13 |
rat |
| Basak Donertas, Cigdem Cengelli Unel, Sule Aydin, Emel Ulupinar, Orhan Ozatik, Bilgin Kaygisiz, Engin Yildirim, Kevser Ero. Agmatine co-treatment attenuates allodynia and structural abnormalities in cisplatin-induced neuropathy in rats. Fundamental & clinical pharmacology. vol 32. issue 3. 2018-10-05. PMID:29377255. |
the mechanical allodynia, thermal hyperalgesia [corrected], and tail clip tests were performed, and drg cells and sciatic nerves were analyzed. |
2018-10-05 |
2023-08-13 |
rat |
| Lu Chang, Fang Ye, Quehua Luo, Zewen Wang, Yimin Wang, Zhengyuan Xia, Haihua Sh. Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia. Bioscience trends. vol 12. issue 2. 2018-10-01. PMID:29657246. |
the aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (il)-1β and il-6 and tumor necrosis factor-α (tnf-α) in the spinal cord and dorsal root ganglion (drg) in a rat model of perioperative fentanyl induced hyperalgesia. |
2018-10-01 |
2023-08-13 |
rat |
| Mingdong Yu, Yong Zhao, Xiaoxia Zhan. Gardenoside combined with ozone inhibits the expression of P2X3 and P2X7 purine receptors in rats with sciatic nerve injury. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620177. |
pain behavior, mechanical hyperalgesia, thermal hyperalgesia, and the protein expression levels of p2x3 and p2x7 purine receptors in l4‑l5 dorsal root ganglion (drg) were determined 15 days post‑surgery. |
2018-09-26 |
2023-08-13 |
rat |
| Marian J Pérez-Rodríguez, Isabel Velazquez-Lagunas, Alejandro Pluma-Pluma, Paulino Barragán-Iglesias, Vinicio Granados-Sot. Anion exchanger 3 in dorsal root ganglion contributes to nerve injury-induced chronic mechanical allodynia and thermal hyperalgesia. The Journal of pharmacy and pharmacology. vol 70. issue 3. 2018-08-21. PMID:29355942. |
anion exchanger 3 in dorsal root ganglion contributes to nerve injury-induced chronic mechanical allodynia and thermal hyperalgesia. |
2018-08-21 |
2023-08-13 |
rat |
| Meng Zhang, Cun-Xiang Gao, Yan-Ping Wang, Ke-Tao Ma, Li Li, Jiang-Wen Yin, Zhi-Gang Dai, Sheng Wang, Jun-Qiang S. The association between the expression of PAR2 and TMEM16A and neuropathic pain. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29257338. |
chronic constriction injury (cci) of the sciatic nerve may induce dorsal root ganglion (drg) neuronal hyperexcitability and behaviorally expressed hyperalgesia. |
2018-08-14 |
2023-08-13 |
rat |
| Yeu-Shiuan Su, Yu-Fen Huang, Jen Wong, Chia-Wei Lee, Wei-Shan Hsieh, Wei-Hsin Su. G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia. Journal of molecular neuroscience : MN. vol 64. issue 1. 2018-08-13. PMID:29159784. |
we previously found increased g2a expression in mouse dorsal root ganglia (drg) at 90 min after complete freund's adjuvant (cfa)-induced inflammatory pain, but whether g2a is involved in the inflammation or hyperalgesia remained unclear. |
2018-08-13 |
2023-08-13 |
mouse |
| Jing Wang, Xin-Sheng Zhang, Rong Tao, Jie Zhang, Lin Liu, Ying-Hai Jiang, Song-He Ma, Lin-Xia Song, Ling-Jie Xi. Upregulation of CX3CL1 mediated by NF-κB activation in dorsal root ganglion contributes to peripheral sensitization and chronic pain induced by oxaliplatin administration. Molecular pain. vol 13. 2018-07-23. PMID:28849713. |
here, we found that intraperitoneal consecutive administration of oxaliplatin significantly increased excitability of small diameter dorsal root ganglion neurons and induced thermal hyperalgesia in rats. |
2018-07-23 |
2023-08-13 |
rat |
| Jing Wang, Xin-Sheng Zhang, Rong Tao, Jie Zhang, Lin Liu, Ying-Hai Jiang, Song-He Ma, Lin-Xia Song, Ling-Jie Xi. Upregulation of CX3CL1 mediated by NF-κB activation in dorsal root ganglion contributes to peripheral sensitization and chronic pain induced by oxaliplatin administration. Molecular pain. vol 13. 2018-07-23. PMID:28849713. |
furthermore, the cx3cl1 expression was significantly increased after oxaliplatin treatment, and intrathecal injection of a neutralizing antibody against cx3cl1 markedly attenuated the enhanced excitability of dorsal root ganglion neurons and thermal hyperalgesia. |
2018-07-23 |
2023-08-13 |
rat |
| Jing Wang, Xin-Sheng Zhang, Rong Tao, Jie Zhang, Lin Liu, Ying-Hai Jiang, Song-He Ma, Lin-Xia Song, Ling-Jie Xi. Upregulation of CX3CL1 mediated by NF-κB activation in dorsal root ganglion contributes to peripheral sensitization and chronic pain induced by oxaliplatin administration. Molecular pain. vol 13. 2018-07-23. PMID:28849713. |
importantly, the upregulated cx3cl1 is mediated by the nf-κb signaling pathway, as inhibition of nf-κb p65 activation with pyrrolidine dithiocarbamate or p65 sirna inhibited the upregulation of cx3cl1, the enhanced excitability of dorsal root ganglion neurons, and thermal hyperalgesia induced by oxaliplatin. |
2018-07-23 |
2023-08-13 |
rat |
| Yong-Yong Li, He Li, Ze-Long Liu, Qiong Li, Hua-Wen Qiu, Li-Jin Zeng, Wen Yang, Xiang-Zhong Zhang, Zhen-Yu L. Activation of STAT3-mediated CXCL12 up-regulation in the dorsal root ganglion contributes to oxaliplatin-induced chronic pain. Molecular pain. vol 13. 2018-07-23. PMID:29166835. |
in the present study, we found that the intraperitoneal administration of oxaliplatin at 4 mg/kg for five consecutive days noticeably upregulated the expression of cxc motif ligand 12 (cxcl12) in the dorsal root ganglion, and the intrathecal injection of an anti-cxcl12 neutralizing antibody or cxcl12 sirna attenuated the mechanical allodynia and thermal hyperalgesia induced by oxaliplatin. |
2018-07-23 |
2023-08-13 |
Not clear |
| Lin Su, Ruichen Shu, Chengcheng Song, Yonghao Yu, Guolin Wang, Yazhuo Li, Changxiao Li. Downregulations of TRPM8 expression and membrane trafficking in dorsal root ganglion mediate the attenuation of cold hyperalgesia in CCI rats induced by GFRα3 knockdown. Brain research bulletin. vol 135. 2018-07-05. PMID:28867384. |
downregulations of trpm8 expression and membrane trafficking in dorsal root ganglion mediate the attenuation of cold hyperalgesia in cci rats induced by gfrα3 knockdown. |
2018-07-05 |
2023-08-13 |
rat |
| Lin Su, Ruichen Shu, Chengcheng Song, Yonghao Yu, Guolin Wang, Yazhuo Li, Changxiao Li. Downregulations of TRPM8 expression and membrane trafficking in dorsal root ganglion mediate the attenuation of cold hyperalgesia in CCI rats induced by GFRα3 knockdown. Brain research bulletin. vol 135. 2018-07-05. PMID:28867384. |
the aim of this study was to investigate whether gfrα3 could influence cold hyperalgesia of cci rats via modulating trpm8 expression and plasma membrane trafficking in dorsal root ganglion (drg). |
2018-07-05 |
2023-08-13 |
rat |
| Ajeet Kumar Singh, Manjula Vinaya. Activation of ERK signalling by Src family kinases (SFKs) in DRG neurons contributes to hydrogen peroxide (H Free radical research. vol 51. issue 9-10. 2018-06-22. PMID:28931335. |
activation of erk signalling by src family kinases (sfks) in drg neurons contributes to hydrogen peroxide (h concomitant generation of reactive oxygen species during tissue inflammation has been recognised as a major factor for the development and the maintenance of hyperalgesia, out of which h |
2018-06-22 |
2023-08-13 |
Not clear |
| Jichan Nie, Xishi Li. Quercetin alleviates generalized hyperalgesia in mice with induced adenomyosis. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849202. |
after 3 weeks of drug treatment, the potential ability of quercetin to improve the generalized hyperalgesia in mice with induced adenomyosis was evaluated by determining the body weight, pain modulation, examining the myometrial infiltration by histology examination of the uterus and detecting the expression of transient receptor potential cation channel subfamily v member 1 (trpv‑1), phospho (p)‑p38 mitogen activated protein kinase p‑extracellular signal‑regulated kinase (p‑erk) in drg neurons via immunohistochemistry. |
2018-05-11 |
2023-08-13 |
mouse |
| Jichan Nie, Xishi Li. Quercetin alleviates generalized hyperalgesia in mice with induced adenomyosis. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849202. |
the results demonstrated that treatment with quercetin improved the generalized hyperalgesia by extending the hotplate response latency, reduced myometrial infiltration and decreased the expression levels trpv‑1, p‑p38 and p‑erk in dorsal root ganglion neurons. |
2018-05-11 |
2023-08-13 |
mouse |
| Bradford D Fischer, Cojen Ho, Igor Kuzin, Andrea Bottaro, Michael E O'Lear. Chronic exposure to tumor necrosis factor in vivo induces hyperalgesia, upregulates sodium channel gene expression and alters the cellular electrophysiology of dorsal root ganglion neurons. Neuroscience letters. vol 653. 2018-04-30. PMID:28558976. |
chronic exposure to tumor necrosis factor in vivo induces hyperalgesia, upregulates sodium channel gene expression and alters the cellular electrophysiology of dorsal root ganglion neurons. |
2018-04-30 |
2023-08-13 |
mouse |