| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi-Jiang Huang, Xue-Jun Son. Differing alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury. Molecular pain. vol 4. 2008-08-07. PMID:18513405. |
voltage-gated sodium channels play important roles in modulating dorsal root ganglion (drg) neuron hyperexcitability and hyperalgesia after peripheral nerve injury or inflammation. |
2008-08-07 |
2023-08-12 |
Not clear |
| Zhi-Jiang Huang, Xue-Jun Son. Differing alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury. Molecular pain. vol 4. 2008-08-07. PMID:18513405. |
these findings provide a possible sodium channel mechanism underlying ccd-induced drg neuron hyperexcitability and hyperalgesia and demonstrate a differential effect in the na+ currents of small drg neurons after somata compression and peripheral nerve injury. |
2008-08-07 |
2023-08-12 |
Not clear |
| Meng-Ling Chen, Chun Cheng, Qing-Shan Lv, Zhi-Qin Guo, Ying Gao, Shang-Feng Gao, Xin Li, Shu-Qiong Niu, Shu-Xian Shi, Ai-Guo She. Altered gene expression of NIDD in dorsal root ganglia and spinal cord of rats with neuropathic or inflammatory pain. Journal of molecular histology. vol 39. issue 2. 2008-07-03. PMID:17899403. |
it was found that nidd mrna was predominantly expressed in nociceptive primary neurons and in neurons of the spinal dorsal horn (dh) and the number of nidd-positive neurons in the corresponding drg or sc increased significantly following induction of chronic hyperalgesia. |
2008-07-03 |
2023-08-12 |
rat |
| Yong Chen, Christian Geis, Claudia Somme. Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 22. 2008-07-01. PMID:18509045. |
intrathecal administration of the selective p38, erk, or jnk inhibitors not only reduced morphine tolerance and associated thermal hyperalgesia but also suppressed the morphine-induced increase of trpv1-ir in drg neurons, spinal cord, and sciatic nerve and of mrna levels in spinal cord and sciatic nerve. |
2008-07-01 |
2023-08-12 |
Not clear |
| Irina G Obrosova, Weizheng Xu, Valeriy V Lyzogubov, Olga Ilnytska, Nazar Mashtalir, Igor Vareniuk, Ivan A Pavlov, Jie Zhang, Barbara Slusher, Viktor R Dre. PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. Free radical biology & medicine. vol 44. issue 6. 2008-05-21. PMID:17976390. |
the orally active parp inhibitor 10-(4-methylpiperazin-1-ylmethyl)-2h-7-oxa-1,2-diaza-benzo[de]anthracen-3-one (gpi-15427; formulated as a mesilate salt, 30 mg kg(-1) day(-1) in the drinking water for 10 weeks after the first 2 weeks without treatment) at least partially prevented parp activation in peripheral nerve and drg neurons, as well as thermal hypoalgesia, mechanical hyperalgesia, tactile allodynia, exaggerated response to formalin, and, most importantly, intraepidermal nerve fiber degeneration in streptozotocin-diabetic rats. |
2008-05-21 |
2023-08-12 |
mouse |
| Weiguo Zhu, Pin Xu, Fernando X Cuascut, Alison K Hall, Gerry S Oxfor. Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 50. 2008-01-22. PMID:18077689. |
activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via pkc-mediated potentiation of transient receptor potential vanilloid i. |
2008-01-22 |
2023-08-12 |
mouse |
| Hsiu-Ying T Yang, Kendall Mitchell, Jason M Keller, Michael J Iadarol. Peripheral inflammation increases Scya2 expression in sensory ganglia and cytokine and endothelial related gene expression in inflamed tissue. Journal of neurochemistry. vol 103. issue 4. 2007-12-13. PMID:17883394. |
our results are consistent with the idea that monocyte chemoattractant protein-1 at the site of peripheral injury and/or in drg is involved in inflammatory hyperalgesia. |
2007-12-13 |
2023-08-12 |
rat |
| Elizabeth K Joseph, Oliver Bogen, Nicole Alessandri-Haber, Jon D Levin. PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia. Pain. vol 132. issue 1-2. 2007-10-30. PMID:17350763. |
antisense to plc-beta 3 isoform, which was found in small-diameter dorsal root ganglion neurons, also attenuated carrageenan-induced acute and chronic-latent hyperalgesia. |
2007-10-30 |
2023-08-12 |
rat |
| Susumu Kasama, Masatomo Kawakubo, Takefumi Suzuki, Tomoko Nishizawa, Akiko Ishida, Jun Nakayam. RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17509082. |
trpv1 plays an essential role in development of inflammatory thermal hyperalgesia after tissue injury and its expression in rat lumbar drg is increased after hindpaw inflammation. |
2007-08-17 |
2023-08-12 |
rat |
| Susumu Kasama, Masatomo Kawakubo, Takefumi Suzuki, Tomoko Nishizawa, Akiko Ishida, Jun Nakayam. RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17509082. |
paratracheal injection of short interfering rna targeting trpv1 blocked trpv1 up-regulation in cervical drg and abolished inflammation-mediated hpl reductions seen at 50 degrees c. however, thermal hyperalgesia previously established by inflammation was not reversed by short interfering rna injection. |
2007-08-17 |
2023-08-12 |
rat |
| Susumu Kasama, Masatomo Kawakubo, Takefumi Suzuki, Tomoko Nishizawa, Akiko Ishida, Jun Nakayam. RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17509082. |
these results indicate that: (i) enhanced trpv1 expression in cervical drg is closely associated with development of inflammatory thermal hyperalgesia in the forepaw after tissue injury and (ii) rna interference targeting trpv1 prevents inflammatory thermal hyperalgesia after forepaw injuries but does not ameliorate it when already established in a rat model of nociceptive pain representing upper limb injury in humans. |
2007-08-17 |
2023-08-12 |
rat |
| Ahmed Kayssi, Silvia Amadesi, Francisco Bautista, Nigel W Bunnett, Stephen Vanne. Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon. The Journal of physiology. vol 580. issue Pt.3. 2007-06-06. PMID:17289784. |
we examined the cellular mechanisms underlying par(2)-evoked hyperexcitability of mouse colonic drg neurons to determine their potential role in pain syndromes such as visceral hyperalgesia. |
2007-06-06 |
2023-08-12 |
mouse |
| Gisela Segond von Banchet, Jonny Richter, Marion Hückel, Christina Rose, Rolf Bräuer, Hans-Georg Schaibl. Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study. Arthritis research & therapy. vol 9. issue 1. 2007-04-30. PMID:17254343. |
in addition, the expression of the transient receptor potential v1 (trpv1) receptor, which is involved in inflammation-evoked thermal hyperalgesia, was mainly upregulated by co-culturing drg neurones with fls cells from chronically inflamed joints. |
2007-04-30 |
2023-08-12 |
rat |
| Ji-Hong Zheng, Edgar T Walters, Xue-Jun Son. Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increased responsiveness to cAMP and cGMP. Journal of neurophysiology. vol 97. issue 1. 2007-03-09. PMID:17021029. |
recent results indicate that after chronic compression of drg (ccd treatment), both hyperexcitability of neurons in intact drg and behaviorally expressed hyperalgesia are maintained by concurrent activity in camp-protein kinase a (pka) and cgmp-protein kinase g (pkg) signaling pathways. |
2007-03-09 |
2023-08-12 |
Not clear |
| Koichi Obata, Hirokazu Katsura, Jun Sakurai, Kimiko Kobayashi, Hiroki Yamanaka, Yi Dai, Tetsuo Fukuoka, Koichi Noguch. Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 46. 2006-12-26. PMID:17108171. |
our results show that p75ntr induced in undamaged drg neurons facilitates trka signaling and contributes to heat and cold hyperalgesia. |
2006-12-26 |
2023-08-12 |
Not clear |
| Laurence Daulhac, Christophe Mallet, Christine Courteix, Monique Etienne, Eliane Duroux, Anne-Marie Privat, Alain Eschalier, Joseph Fiali. Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-D-aspartate-dependent mechanisms. Molecular pharmacology. vol 70. issue 4. 2006-11-29. PMID:16868181. |
we have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (erk), p38, and c-jun n-terminal kinase (jnk) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes. |
2006-11-29 |
2023-08-12 |
rat |
| C Ma, K W Greenquist, R H Lamott. Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons. Journal of neurophysiology. vol 95. issue 4. 2006-09-25. PMID:16381809. |
inflammatory mediators, by increasing the excitability of drg somata, may contribute to ccd-induced neuronal hyperexcitability and to hyperalgesia and tactile allodynia. |
2006-09-25 |
2023-08-12 |
rat |
| Fumimasa Amaya, Goshun Shimosato, Yasuhiko Kawasaki, Satoru Hashimoto, Yoshifumi Tanaka, Ru-Rong Ji, Masaki Tanak. Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist. Pain. vol 124. issue 1-2. 2006-09-21. PMID:16709443. |
here, we investigated cb1 receptor expression in primary afferent neurons in the dorsal root ganglion (drg) and the efficacy of a local (intraplantar) application of the selective cb1 agonist, 2-arachidonyl-2-chloroethylamide (acea), on inflammatory thermal hyperalgesia. |
2006-09-21 |
2023-08-12 |
Not clear |
| Atsuko Inoue, Mikiko Iwasa, Yumi Nishikura, Shinya Ogawa, Ayaka Nakasuka, Yoshihiro Nakat. The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin E2 by the activation of cyclooxygenase-2. Neuroscience letters. vol 401. issue 3. 2006-09-14. PMID:16580130. |
thus, bk has been shown to induce cox-2 protein by b2 receptor, which may cause prostanoid generation in rat drg cells, which may play an important role in the pathogenesis of inflammatory pain and hyperalgesia around the primary sensory neurons. |
2006-09-14 |
2023-08-12 |
rat |
| Hirokazu Katsura, Koichi Obata, Toshiyuki Mizushima, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Tetsuo Fukuoka, Atsushi Tokunaga, Masafumi Sakagami, Koichi Noguch. Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Experimental neurology. vol 200. issue 1. 2006-09-05. PMID:16546170. |
in the present study, we precisely examined the incidence of cold hyperalgesia and the changes of trpa1 and trpm8 expression in the l4 and l5 drg following l5 spinal nerve ligation (snl), because it is likely that the activation of two distinct populations of trpa1- and trpm8-expressing small neurons underlie the sensation of cold. |
2006-09-05 |
2023-08-12 |
rat |