| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna-Lena Frey, Ciara McCab. Effects of serotonin and dopamine depletion on neural prediction computations during social learning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32330925. |
interestingly, the behavioral and neural responses observed after 5-ht depletion in the current study closely resemble our previous findings in individuals with high depression scores using the same task. |
2021-06-23 |
2023-08-13 |
human |
| Anna-Lena Frey, Ciara McCab. Effects of serotonin and dopamine depletion on neural prediction computations during social learning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32330925. |
it may thus be the case that decreased 5-ht levels contribute to social learning deficits in depression. |
2021-06-23 |
2023-08-13 |
human |
| Auriel A Willette, Colleen Pappas, Nathan Hoth, Qian Wang, Brandon Klinedinst, Sara A Willette, Brittany Larsen, Amy Pollpeter, Tianqi Li, Scott Le, Ana D Collazo-Martinez, Jonathan P Mochel, Karin Allenspach, Robert Dantze. Inflammation, negative affect, and amyloid burden in Alzheimer's disease: Insights from the kynurenine pathway. Brain, behavior, and immunity. vol 95. 2021-06-23. PMID:33775832. |
both ad and major depression inflammatory processes are characterized by shunted tryptophan metabolism away from serotonin (5-ht) and toward the neuroinflammatory kynurenine (kyn) pathway. |
2021-06-23 |
2023-08-13 |
Not clear |
| Michelle R Brajcich, Mauricio A Palau, Ricka D Messer, Michael E Murphy, Jill Mark. Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures. Pediatrics. vol 147. issue 2. 2021-06-21. PMID:33504611. |
bupropion, a norepinephrine-dopamine reuptake inhibitor, is often used as an adjunctive agent to selective serotonin reuptake inhibitors or snris for refractory depression. |
2021-06-21 |
2023-08-13 |
Not clear |
| Xiangdong Du, Ming Yin, Lian Yuan, Guangya Zhang, Yan Fan, Zhe Li, Nian Yuan, Xiaoli Lv, Xueli Zhao, Siyun Zou, Wei Deng, Thomas R Kosten, Xiang Yang Zhan. Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32366842. |
depression may be associated with reduced monoamine neurotransmission, particularly serotonin and norepinephrine (ne). |
2021-06-18 |
2023-08-13 |
rat |
| Amin Zahrai, Faranak Vahid-Ansari, Mireille Daigle, Paul R Alber. Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32999279. |
fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression. |
2021-06-18 |
2023-08-13 |
mouse |
| Xianan Sun, Yi Zu, Xiang Li, Shulei Zhao, Xiao Sun, Lu Li, Xinjing Zhang, Wei Wang, Yuezhu Liang, Wenyao Wang, Xuankai Liang, Mingqi Gao, Chi Sun, Xue Guan, Man Tan. Corticosterone-induced Hippocampal 5-HT Responses were Muted in Depressive-like State. ACS chemical neuroscience. vol 12. issue 5. 2021-06-18. PMID:33586968. |
the present study investigated corticosterone (cort) regulations of extracellular 5-ht in the hippocampal ca3 in a mouse model of depression. |
2021-06-18 |
2023-08-13 |
mouse |
| Mo Xian Chen, Shu Cheng, Lei Lei, Xiao Fan Zhang, Qiang Liu, Aijin Lin, Chloe U Wallis, Michael James Lukowicz, Pak C Sham, Qi Li, Li Juan A. The effects of maternal SSRI exposure on the serotonin system, prefrontal protein expression and behavioral development in male and female offspring rats. Neurochemistry international. vol 146. 2021-06-18. PMID:33836218. |
fluoxetine (flx), a commonly used selective serotonin reuptake inhibitor, is often used to treat depression during pregnancy. |
2021-06-18 |
2023-08-13 |
rat |
| Mariacristina Siotto, Marco Germanotta, Massimo Santoro, Valeria Cipollini, Giulia Guardati, Dionysia Papadopoulou, Elisa Bray, Alessia Mastrorosa, Irene April. Serotonin Levels and Cognitive Recovery in Patients with Subacute Stroke after Rehabilitation Treatment. Brain sciences. vol 11. issue 5. 2021-06-15. PMID:34063444. |
sub-optimal serotonin activity may be in part responsible for cognitive deficits seen in depression. |
2021-06-15 |
2023-08-13 |
Not clear |
| Joana Santos, Maria Fernanda Proença, Ana Joao Rodrigues, Patricia Patrício, Helena Sofia Domingue. Recent Advances in the Synthesis of the Antidepressant Paroxetine. Current medicinal chemistry. vol 28. issue 15. 2021-06-14. PMID:33106133. |
paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. |
2021-06-14 |
2023-08-13 |
Not clear |
| Peilin Hui, Jun Yang, Jing Wang, Lijun Zhao, Xubin Wang, Xiaoyan Su, Jinfeng Wang, Wei Ma, Jie Fan, Wenjuan Chen, Yuan Zhao, Bin Guo, Yu Liu, Shangli Zhang, Ning Zheng, Liyan Zhou, Yuping Xi. Association between 5-hydroxytryptamine gene polymorphism rs140700 and primary insomnia in Chinese population. Internal medicine journal. vol 51. issue 5. 2021-06-11. PMID:32149434. |
previous studies have shown that 5-ht polymorphism (rs140700) is related to depression, and insomnia is often accompanied by depression and anxiety. |
2021-06-11 |
2023-08-13 |
Not clear |
| Ying Yang, Xuping Li, Sixuan Chen, Mingzhu Xiao, Zhongqiu Liu, Jingyan Li, Yuanyuan Chen. Mechanism and therapeutic strategies of depression after myocardial infarction. Psychopharmacology. vol 238. issue 6. 2021-06-01. PMID:33594503. |
although the issue of depression after mi has become a matter of clinical concern, the molecular mechanism underlying depression after mi remains unclear, whereby several strategies suggested have not got ideal effects, such as selective serotonin reuptake inhibitors. |
2021-06-01 |
2023-08-13 |
Not clear |
| Ying Yang, Xuping Li, Sixuan Chen, Mingzhu Xiao, Zhongqiu Liu, Jingyan Li, Yuanyuan Chen. Mechanism and therapeutic strategies of depression after myocardial infarction. Psychopharmacology. vol 238. issue 6. 2021-06-01. PMID:33594503. |
in this review, we summarized and discussed the occurrence mechanism of depression after mi, such as 5-hydroxytryptamine (5-ht) dysfunction, altered hypothalamus-pituitary-adrenal (hpa) axis function, gut microbiota imbalance, exosomal signal transduction, and inflammation. |
2021-06-01 |
2023-08-13 |
Not clear |
| Gilciane Ceolin, Giulia Pipolo Rodrigues Mano, Natália Schmitt Hames, Luciana da Conceição Antunes, Elisa Brietzke, Débora Kurrle Rieger, Júlia Dubois Moreir. Vitamin D, Depressive Symptoms, and Covid-19 Pandemic. Frontiers in neuroscience. vol 15. 2021-06-01. PMID:34054418. |
vitamin d was found to contribute to improved serotonergic neurotransmission in the experimental model of depression by regulating serotonin metabolism. |
2021-06-01 |
2023-08-13 |
Not clear |
| Yi-Jen Fang, Tien-Yuan Wu, Jung-Nien Lai, Cheng-Li Lin, Ni Tien, Yun-Ping Li. Association between Depression, Antidepression Medications, and the Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study in Taiwan. BioMed research international. vol 2021. 2021-05-28. PMID:33506043. |
among patients with depression who received adm, 29.71%, 6.29%, 0.05%, 9.65%, and 6.32% received selective serotonin reuptake inhibitors (ssris), tricyclic antidepressants (tcas), monoamine oxidase inhibitors (maois), heterocyclic antidepressants, and other medications, respectively. |
2021-05-28 |
2023-08-13 |
Not clear |
| Christoph U Correll, Samuele Cortese, Giovanni Croatto, Francesco Monaco, Damir Krinitski, Gonzalo Arrondo, Edoardo G Ostinelli, Caroline Zangani, Michele Fornaro, Andrés Estradé, Paolo Fusar-Poli, Andre F Carvalho, Marco Solm. Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review. World psychiatry : official journal of the World Psychiatric Association (WPA). vol 20. issue 2. 2021-05-27. PMID:34002501. |
based on the meta-analytic evidence, the most convincing efficacy profile emerged for amphetamines, methylphenidate and, to a smaller extent, behavioral therapy in attention-deficit/hyperactivity disorder; aripiprazole, risperidone and several psychosocial interventions in autism; risperidone and behavioral interventions in disruptive behavior disorders; several antipsychotics in schizophrenia spectrum disorders; fluoxetine, the combination of fluoxetine and cognitive behavioral therapy (cbt), and interpersonal therapy in depression; aripiprazole in mania; fluoxetine and group cbt in anxiety disorders; fluoxetine/selective serotonin reuptake inhibitors, cbt, and behavioral therapy with exposure and response prevention in obsessive-compulsive disorder; cbt in post-traumatic stress disorder; imipramine and alarm behavioral intervention in enuresis; behavioral therapy in encopresis; and family therapy in anorexia nervosa. |
2021-05-27 |
2023-08-13 |
Not clear |
| Andrew Salzwedel, Gang Chen, Yuanyuan Chen, Karen Grewen, Wei Ga. Functional dissection of prenatal drug effects on baby brain and behavioral development. Human brain mapping. vol 41. issue 17. 2021-05-17. PMID:32779835. |
in this study, based on a large sample of 133 human neonates and leveraging a novel linear mixed-effect model designed for intersubject variability analyses, we studied the effects of six prenatally exposed drugs (i.e., nicotine, alcohol, selective serotonin reuptake inhibitor, marijuana, cocaine, and opioids) on neonatal whole-brain functional organization and compared them with five other critical nondrug variables (i.e., gestational age at birth/scan, sex, birth weight, and maternal depression). |
2021-05-17 |
2023-08-13 |
human |
| Irene Gonzalez, Rocio Polvillo, Maximiliano Ruiz-Galdon, Armando Reyes-Engel, Jose Luis Roy. MAOB rs3027452 Modifies Mood Improvement After Tryptophan Supplementation. International journal of general medicine. vol 14. 2021-05-16. PMID:33986613. |
proposals have been put forward to co-administer tryptophan supplementation together with serotonin reuptake inhibitors in major depression patients, and also to exploit the sub-therapeutic depressive status in healthy populations. |
2021-05-16 |
2023-08-13 |
human |
| Mala Ananth, Elizabeth A Bartlett, Christine DeLorenzo, Xuejing Lin, Laura Kunkel, Nehal P Vadhan, Greg Perlman, Michala Godstrey, Daniel Holzmacher, R Todd Ogden, Ramin V Parsey, Chuan Huan. Prediction of lithium treatment response in bipolar depression using 5-HTT and 5-HT European journal of nuclear medicine and molecular imaging. vol 47. issue 10. 2021-05-14. PMID:32055965. |
prediction of lithium treatment response in bipolar depression using 5-htt and 5-ht lithium, one of the few effective treatments for bipolar depression (bpd), has been hypothesized to work by enhancing serotonergic transmission. |
2021-05-14 |
2023-08-13 |
Not clear |
| Xiaotao Li, Shanping Chen, Haiyang Yang, Xiang Li, Kwok-Fai So, Liping Wan. GABAergic Neurons in the Dorsal Raphe Nucleus that Express 5-HT3A Receptors Participate in Responses to Stress Hormones. Neuroscience. vol 441. 2021-05-14. PMID:32512137. |
furthermore, corticosterone administration into male rats as a rodent model of depression induced significantly higher c-fos expression in 5-ht3ar-positive gabaergic neurons compared to that in 5-ht neurons within the drn. |
2021-05-14 |
2023-08-13 |
rat |