| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Preeti Jha, Shubhra Chaturvedi, Ruchika Bhat, Nidhi Jain, Anil K Mishr. Insights of ligand binding in modeled h5-HT Journal of biomolecular structure & dynamics. 2021-08-13. PMID:34387135. |
insights of ligand binding in modeled h5-ht the pharmacologically characterized receptor subtype of the serotonin family, the 5ht1a receptor is implicated in the pathophysiology and treatment of depression and anxiety-related disorders. |
2021-08-13 |
2023-08-13 |
Not clear |
| Rose E Presby, Renee A Rotolo, Erin M Hurley, Sarah M Ferrigno, Cayla E Murphy, Haley P McMullen, Pranally A Desai, Emma M Zorda, Felicita B Kuperwasser, Carla Carratala-Ros, Merce Correa, John D Salamon. Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: Suppression of high effort activity by the serotonin transport inhibitor fluoxetine. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33493546. |
selective serotonin transport (sert) inhibitors such as fluoxetine are the most commonly prescribed treatments for depression. |
2021-08-10 |
2023-08-13 |
rat |
| Pengfei Cheng, Junxiang Zhang, Yu Wu, Wenting Liu, Jiaying Zhu, Ze Chen, Jiarui Zhang, Songwen Guan, Yiming Sun, Jingxia Wan. 5-HTTLPR polymorphism and depression risk in Parkinson's disease: an updated meta-analysis. Acta neurologica Belgica. vol 121. issue 4. 2021-08-09. PMID:32219696. |
the relationship between the 5-hydroxytryptamine transporter gene-linked polymorphic region (5-httlpr) and depression in parkinson's disease (pd) has remained controversial. |
2021-08-09 |
2023-08-13 |
Not clear |
| Ayesha Afzal, Ammara Khan, Asma Khan, Rashida Farooqi, Bushra Tayyaba Khan, Iffat Ar. Effect of paroxetine on intestinal motility in the presence of ondansetron. Pakistan journal of pharmaceutical sciences. vol 33. issue 3. 2021-08-03. PMID:33191244. |
ondansetron acts by blocking serotonin from acting on the receptors and thus is useful in decreasing episodes of nausea and vomiting but when used concomitantly with ssris (selective serotonin reuptake inhibitors) as cancer patient also suffered from depression. |
2021-08-03 |
2023-08-13 |
Not clear |
| Gwenn S Smith, Hiroto Kuwabara, Neda F Gould, Najilla Nassery, Alena Savonenko, Jin Hui Joo, Kristin L Bigos, Michael Kraut, James Brasic, Daniel P Holt, Andrew W Hall, William B Mathews, Robert F Dannals, Ayon Nandi, Clifford I Workma. Molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression. Neuropharmacology. vol 194. 2021-07-28. PMID:33450276. |
molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression. |
2021-07-28 |
2023-08-13 |
Not clear |
| Chao Ciu-Gwok Guo, Michel M M Verheij, Judith R Homber. Knockout of the Serotonin Transporter in the Rat Mildly Modulates Decisional Anhedonia. Neuroscience. vol 469. 2021-07-27. PMID:34182055. |
serotonin transporter gene variance has long been considered an essential factor contributing to depression. |
2021-07-27 |
2023-08-13 |
rat |
| Monika Głuch-Lutwin, Kinga Sałaciak, Alicja Gawalska, Marek Jamrozik, Joanna Sniecikowska, Adrian Newman-Tancredi, Marcin Kołaczkowski, Karolina Pytk. The selective 5-HT Psychopharmacology. vol 238. issue 8. 2021-07-26. PMID:33973045. |
the selective 5-ht the prevalence of depression is ever-increasing throughout the population. |
2021-07-26 |
2023-08-13 |
Not clear |
| Marina Rieder, Nadine Gauchel, Christoph Bode, Daniel Duerschmie. Serotonin: a platelet hormone modulating cardiovascular disease. Journal of thrombosis and thrombolysis. vol 52. issue 1. 2021-07-21. PMID:33155668. |
serotonin 5-hydroxytryptamin (5-ht), a biogenic amine acting as a neurotransmitter and a peripheral hormone, is involved in the pathogenesis of both, cardiovascular disease and depression. |
2021-07-21 |
2023-08-13 |
Not clear |
| A B Cunningham, J A Brinckmann, D E V Harte. From forest to pharmacy: Should we be depressed about a sustainable Griffonia simplicifolia (Fabaceae) seed supply chain? Journal of ethnopharmacology. vol 278. 2021-07-19. PMID:33991640. |
(fabaceae) seeds are unusually high (6-20% wet weight) in 5-htp (5-hydroxytryptophan), a serotonin precursor widely used to treat depression. |
2021-07-19 |
2023-08-13 |
Not clear |
| Magdalena Kowalska, Łukasz Fijałkowski, Alicja Nowaczy. Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters. International journal of molecular sciences. vol 22. issue 12. 2021-07-14. PMID:34208199. |
due to the confirmed dependence of depression on serotonin, norepinephrine, dopamine and γ-aminobutyric acid levels, studies have been undertaken into paroxetine interactions with these primary neurotransmitters using in silico and in vitro methods. |
2021-07-14 |
2023-08-13 |
Not clear |
| Naheed Akhter, Mehir Un Nisa Iqbal, Aliya Maqsood, Safdar Ali Sheikh, Anwar Ali, Taseer Ahmed Kha. Association of BDNF and SERT gene polymorphisms with depression among Pakistani population. Pakistan journal of pharmaceutical sciences. vol 34. issue 1. 2021-07-12. PMID:34248009. |
brain-derived neurotrophic factor (bdnf) and serotonin transporter (sert) is implicated in the adverse life events which lead to depression. |
2021-07-12 |
2023-08-13 |
human |
| Erica Schlichting, Chris Welter, Tammi Schaeffer, Tania D Strou. Serotonin Syndrome Associated With Vilazodone Overdose in a 22-Month-Old Treated With Dexmedetomidine. The Journal of emergency medicine. vol 60. issue 2. 2021-07-08. PMID:33158691. |
vilazodone is a selective serotonin reuptake inhibitor and 5-ht1a agonist used in the treatment of depression in adults. |
2021-07-08 |
2023-08-13 |
Not clear |
| Eman Soliman, Nariman Essmat, Mona F Mahmoud, Amr A A Mahmou. Impact of some oral hypoglycemic agents on type 2 diabetes-associated depression and reserpine-induced depression in rats: the role of brain oxidative stress and inflammation. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 8. 2021-07-06. PMID:32077986. |
antidiabetic agents reduced diabetes-associated depression as indicated by the reduction in the immobility time in the forced swim test, elevation of cortical and hippocampal serotonin and brain-derived neurotrophic factor (bdnf), and the increase in serum β-amyloid 1-42 (aβ1-42) levels. |
2021-07-06 |
2023-08-13 |
rat |
| Jasmin Obermanns, Elena Krawczyk, Georg Juckel, Barbara Emon. Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression. The European journal of neuroscience. vol 53. issue 10. 2021-06-30. PMID:33768559. |
analysis of cytokine levels, t regulatory cells and serotonin content in patients with depression. |
2021-06-30 |
2023-08-13 |
human |
| Jasmin Obermanns, Elena Krawczyk, Georg Juckel, Barbara Emon. Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression. The European journal of neuroscience. vol 53. issue 10. 2021-06-30. PMID:33768559. |
alterations in peripheral serotonin concentrations and an imbalanced immune system have been reported in patients with depression. |
2021-06-30 |
2023-08-13 |
human |
| Jasmin Obermanns, Elena Krawczyk, Georg Juckel, Barbara Emon. Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression. The European journal of neuroscience. vol 53. issue 10. 2021-06-30. PMID:33768559. |
this study investigates the levels of cytokines and treg cells, as well as the concentration of serotonin (5-ht) in the blood of 89 patients suffering from depression and 89 healthy participants between two acquisitions. |
2021-06-30 |
2023-08-13 |
human |
| Weijie Zhang, Wan Qu, Hua Wang, He Ya. Antidepressants fluoxetine and amitriptyline induce alterations in intestinal microbiota and gut microbiome function in rats exposed to chronic unpredictable mild stress. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33602895. |
thus this study assessed the effect of serotonin reuptake inhibitor antidepressant fluoxetine (flu) and tricyclic antidepressant amitriptyline (ami) administration on gut microbiota composition, diversity, and species abundance, along with microbial function in a chronic unpredictable mild stress (cums)-induced depression rat model. |
2021-06-28 |
2023-08-13 |
rat |
| Y V M Lages, A D Rossi, T E Krahe, J Landeira-Fernande. Effect of chronic unpredictable mild stress on the expression profile of serotonin receptors in rats and mice: a meta-analysis. Neuroscience and biobehavioral reviews. vol 124. 2021-06-25. PMID:33524415. |
however, the role of 5-hydroxytryptamine (5-ht) receptor subtypes in stress-induced depression remains unclear. |
2021-06-25 |
2023-08-13 |
mouse |
| Mengyu Li, Man Ki Kwok, Shirley Siu Ming Fong, Catherine Mary Schoolin. Effects of tryptophan, serotonin, and kynurenine on ischemic heart diseases and its risk factors: a Mendelian Randomization study. European journal of clinical nutrition. vol 74. issue 4. 2021-06-24. PMID:32132674. |
this study aimed to obtain less-confounded estimates of the associations of tryptophan and physiologically related factors (serotonin and kynurenine) with ihd, its risk factors and depression. |
2021-06-24 |
2023-08-13 |
Not clear |
| Anna-Lena Frey, Ciara McCab. Effects of serotonin and dopamine depletion on neural prediction computations during social learning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32330925. |
given that depression is associated with altered dopamine (da) and serotonin (5-ht) functioning, the current study aimed to elucidate the role of these neurotransmitters in the social learning process using a dietary depletion manipulation. |
2021-06-23 |
2023-08-13 |
human |