| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Wirz-Justice, W Pühringe. Increased platelet serotonin in bipolar depression and hypomania. Journal of neural transmission. vol 42. issue 1. 1978-06-28. PMID:565391. |
a longitudinal study of a bipolar ii patient throughout three hospitalizations for depression followed by the switch into hypomania, indicated that 5-ht was state independent, remaining constantly high in all clinical conditions and upon remission, reduced only during and after treatment with clomipramine, a 5-ht uptakt dysfunction of indoleamines underlying bipolar illness. |
1978-06-28 |
2023-08-11 |
Not clear |
| C M Bank. 5-Hydroxytryptamine content of the whole blood in psychiatric illness and alcoholism. Acta psychiatrica Scandinavica. vol 57. issue 3. 1978-06-12. PMID:645413. |
neuroleptic drugs in mania did not alter the blood 5ht levels, but in depression tricyclic antidepressants caused an elevation after 3 weeks of treatment. |
1978-06-12 |
2023-08-11 |
Not clear |
| K Mitsunob. [Depression and serotonin metabolism]. Nihon rinsho. Japanese journal of clinical medicine. vol 36. issue 1. 1978-05-24. PMID:416250. |
[depression and serotonin metabolism]. |
1978-05-24 |
2023-08-11 |
Not clear |
| A R Green, D G Grahame-Smit. Processes regulating the functional activity of brain 5-hydroxytryptamine: results of animal experimentation and their relevance to the understanding and treatment of depression. Pharmakopsychiatrie, Neuro-Psychopharmakologie. vol 11. issue 1. 1978-05-08. PMID:565059. |
processes regulating the functional activity of brain 5-hydroxytryptamine: results of animal experimentation and their relevance to the understanding and treatment of depression. |
1978-05-08 |
2023-08-11 |
rat |
| A R Green, D G Grahame-Smit. Processes regulating the functional activity of brain 5-hydroxytryptamine: results of animal experimentation and their relevance to the understanding and treatment of depression. Pharmakopsychiatrie, Neuro-Psychopharmakologie. vol 11. issue 1. 1978-05-08. PMID:565059. |
investigation has been made into the processes regulating the function activity of rat brain 5-hydroxytryptamine (5-ht) and the way that drugs used to treat depression act on these processes. |
1978-05-08 |
2023-08-11 |
rat |
| D A Cook, K M Macleo. Responses of rabbit portal vein to histamine. British journal of pharmacology. vol 62. issue 2. 1978-04-17. PMID:23880. |
4 desensitization to high doses of 5-hydroxytryptamine caused a concomitant depression in the response to histamine but not to noradrenaline or acetylcholine. |
1978-04-17 |
2023-08-11 |
rabbit |
| M Smialowsk. Nomifensine and central monoamine neurons: histofluorescence studies. Polish journal of pharmacology and pharmacy. vol 29. issue 5. 1978-02-18. PMID:145591. |
the effect of nomifensine (nf) on the content of serotonin (5-ht) and catecholamines (ca) in discrete regions of rat brain was studied with the histofluorescence technique of falck, nf, 20 and 40 mg/kg ip, produced, after 30 min, a depression of 5-ht content in the neurocytes of dorsal and median raphe nuclei (ndr and nmr). |
1978-02-18 |
2023-08-11 |
rat |
| P L Nola. The effects of serotonin precursors on the pressor response to intravenous clonidine in conscious rats. Clinical and experimental pharmacology & physiology. vol 4. issue 6. 1978-02-18. PMID:303969. |
the depression by l-tryptophan of the clonidine-induced pressor response could be prevented by pretreatment with either the l-aromatic amino acid decarboxylase inhibitor rö44602 or the serotonin antagonist methysergide. |
1978-02-18 |
2023-08-11 |
rat |
| D N Franz, R J Neumayr, B D Har. L-dopa-induced hypotension: depression of spinal sympathetic neurons by release of 5-hydroxytryptamine. Advances in experimental medicine and biology. vol 90. 1978-01-27. PMID:201160. |
l-dopa-induced hypotension: depression of spinal sympathetic neurons by release of 5-hydroxytryptamine. |
1978-01-27 |
2023-08-11 |
Not clear |
| R G Schaub, K M Meyers, R D Sand. Serotonin as a factor in depression of collateral blood flow following experimental arterial thrombosis. The Journal of laboratory and clinical medicine. vol 90. issue 4. 1977-11-25. PMID:143502. |
serotonin as a factor in depression of collateral blood flow following experimental arterial thrombosis. |
1977-11-25 |
2023-08-11 |
Not clear |
| A Randrup, C Braestru. Uptake inhibition of biogenic amines by newer antidepressant drugs: relevance to the dopamine hypothesis of depression. Psychopharmacology. vol 53. issue 3. 1977-10-31. PMID:408861. |
the dopamine theory of depression was studied by assessing the effect of antidepressant drugs on uptake of dopamine, noradrenaline, and serotonin in synaptosomes from rat brain. |
1977-10-31 |
2023-08-11 |
rat |
| A Dray, N R Oakle. Methiothepin and a 5-HT pathway to rat substantia nigra. Experientia. vol 33. issue 9. 1977-10-31. PMID:891876. |
methiothepin reduced both median-raphe evoked and exogenous 5-ht depression of single substantia nigra neurones. |
1977-10-31 |
2023-08-11 |
rat |
| E R Block, A B Fishe. Effect of hyperbaric oxygen exposure on pulmonary clearance of 5-hydroxytryptamine. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 43. issue 2. 1977-10-28. PMID:893279. |
these results indicate that depression of pulmonary 5-ht clearance occurs in rats due to hyperoxia and is potentiated by vitamin e deficiency. |
1977-10-28 |
2023-08-11 |
rat |
| E R Block, A B Fishe. Prevention of hyperoxic-induced depression of pulmonary serotonin clearance by pretreatment with superoxide dismutase. The American review of respiratory disease. vol 116. issue 3. 1977-10-20. PMID:900632. |
prevention of hyperoxic-induced depression of pulmonary serotonin clearance by pretreatment with superoxide dismutase. |
1977-10-20 |
2023-08-11 |
Not clear |
| P Teerapong, A L Harve. The effect of 5-hydroxytryptamine on the chick biventer cervicis muscle. European journal of pharmacology. vol 44. issue 2. 1977-09-29. PMID:885170. |
at higher concentrations, 5ht produced a reversible depression of twitches, which was much more marked in indirectly than in directly stimulated preparations. |
1977-09-29 |
2023-08-11 |
chicken |
| A S Tadepalli, E Mills, S M Schanber. Central depression of carotid baroreceptor pressor response, arterial pressure and heart rate by 5-hydroxytryptophan: influence of supracollicular areas of the brain. The Journal of pharmacology and experimental therapeutics. vol 202. issue 2. 1977-09-22. PMID:301930. |
prior intracerebroventricular administration of an l-amino acid decarboxylase inhibitor (ro 4-4602) prevented the effects of 5-htp, indicating that depression is mediated via conversion to serotonin. |
1977-09-22 |
2023-08-11 |
Not clear |
| V P Zarcone, P A Berger, K H Brodie, R Sack, J D Barcha. The indoleamine hypothesis of depression: an overview and pilot study. Diseases of the nervous system. vol 38. issue 8. 1977-09-22. PMID:328245. |
this paper reviews the evidence for a specific indoleamine deficiency in depression and the attempts to correct this suspected deficiency with serotonin precursors. |
1977-09-22 |
2023-08-11 |
Not clear |
| B S Sastry, J W Philli. Antagonism of biogenic amine-induced depression of cerebral cortical neurones by Na+, K+-ATPase in inhibitors. Canadian journal of physiology and pharmacology. vol 55. issue 2. 1977-08-12. PMID:141320. |
the effects of iontophoretically applied na+-, k+-dependent adenosinetriphosphatase (na+,k+-atpase) (ec 3.6.1.3) inhibitors (ouabain, digitoxin, digitoxigenin, strophanthin k, strophanthidin, thevetin a and b, ethacrynate, and harmaline) on the depression of rat cerebral cortical neurones by noradrenaline, 5-hydroxytryptamine, and histamine have been studied. |
1977-08-12 |
2023-08-11 |
rat |
| P G Caulford, F Cocean. Microiontophoresis of 5-hydroxytryptamine, epinephrine, and prostaglandin E1 on spinal neurons in the frog. Canadian journal of physiology and pharmacology. vol 55. issue 2. 1977-08-12. PMID:301425. |
5-ht depressed all but two of the responsive cells, whereas the response to epinephrine consisted exclusively of depression. |
1977-08-12 |
2023-08-11 |
Not clear |
| T Amamoto, K Sara. On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression. Hiroshima journal of medical sciences. vol 25. issue 2-3. 1977-07-18. PMID:1088369. |
changes in plasma 5-ht and 5-hiaa levels and urinary 5-hiaa excretion following oral loading of l-5htp in patients with depression. |
1977-07-18 |
2023-08-11 |
Not clear |