| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Dray, N R Oakle. Methiothepin and a 5-HT pathway to rat substantia nigra. Experientia. vol 33. issue 9. 1977-10-31. PMID:891876. |
methiothepin reduced both median-raphe evoked and exogenous 5-ht depression of single substantia nigra neurones. |
1977-10-31 |
2023-08-11 |
rat |
| E R Block, A B Fishe. Effect of hyperbaric oxygen exposure on pulmonary clearance of 5-hydroxytryptamine. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 43. issue 2. 1977-10-28. PMID:893279. |
these results indicate that depression of pulmonary 5-ht clearance occurs in rats due to hyperoxia and is potentiated by vitamin e deficiency. |
1977-10-28 |
2023-08-11 |
rat |
| E R Block, A B Fishe. Prevention of hyperoxic-induced depression of pulmonary serotonin clearance by pretreatment with superoxide dismutase. The American review of respiratory disease. vol 116. issue 3. 1977-10-20. PMID:900632. |
prevention of hyperoxic-induced depression of pulmonary serotonin clearance by pretreatment with superoxide dismutase. |
1977-10-20 |
2023-08-11 |
Not clear |
| P Teerapong, A L Harve. The effect of 5-hydroxytryptamine on the chick biventer cervicis muscle. European journal of pharmacology. vol 44. issue 2. 1977-09-29. PMID:885170. |
at higher concentrations, 5ht produced a reversible depression of twitches, which was much more marked in indirectly than in directly stimulated preparations. |
1977-09-29 |
2023-08-11 |
chicken |
| A S Tadepalli, E Mills, S M Schanber. Central depression of carotid baroreceptor pressor response, arterial pressure and heart rate by 5-hydroxytryptophan: influence of supracollicular areas of the brain. The Journal of pharmacology and experimental therapeutics. vol 202. issue 2. 1977-09-22. PMID:301930. |
prior intracerebroventricular administration of an l-amino acid decarboxylase inhibitor (ro 4-4602) prevented the effects of 5-htp, indicating that depression is mediated via conversion to serotonin. |
1977-09-22 |
2023-08-11 |
Not clear |
| V P Zarcone, P A Berger, K H Brodie, R Sack, J D Barcha. The indoleamine hypothesis of depression: an overview and pilot study. Diseases of the nervous system. vol 38. issue 8. 1977-09-22. PMID:328245. |
this paper reviews the evidence for a specific indoleamine deficiency in depression and the attempts to correct this suspected deficiency with serotonin precursors. |
1977-09-22 |
2023-08-11 |
Not clear |
| B S Sastry, J W Philli. Antagonism of biogenic amine-induced depression of cerebral cortical neurones by Na+, K+-ATPase in inhibitors. Canadian journal of physiology and pharmacology. vol 55. issue 2. 1977-08-12. PMID:141320. |
the effects of iontophoretically applied na+-, k+-dependent adenosinetriphosphatase (na+,k+-atpase) (ec 3.6.1.3) inhibitors (ouabain, digitoxin, digitoxigenin, strophanthin k, strophanthidin, thevetin a and b, ethacrynate, and harmaline) on the depression of rat cerebral cortical neurones by noradrenaline, 5-hydroxytryptamine, and histamine have been studied. |
1977-08-12 |
2023-08-11 |
rat |
| P G Caulford, F Cocean. Microiontophoresis of 5-hydroxytryptamine, epinephrine, and prostaglandin E1 on spinal neurons in the frog. Canadian journal of physiology and pharmacology. vol 55. issue 2. 1977-08-12. PMID:301425. |
5-ht depressed all but two of the responsive cells, whereas the response to epinephrine consisted exclusively of depression. |
1977-08-12 |
2023-08-11 |
Not clear |
| T Amamoto, K Sara. On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression. Hiroshima journal of medical sciences. vol 25. issue 2-3. 1977-07-18. PMID:1088369. |
changes in plasma 5-ht and 5-hiaa levels and urinary 5-hiaa excretion following oral loading of l-5htp in patients with depression. |
1977-07-18 |
2023-08-11 |
Not clear |
| S Takahash. Reduction of blood platelet serotonin levels in manic and depressed patients. Folia psychiatrica et neurologica japonica. vol 30. issue 4. 1977-05-12. PMID:1021543. |
unipolar and involutional depressed patients exhibited to have the most pronounced reduced levels of serotonin of various subtypes of depression, while bipolar depressed patients, neurotic and chronic characterological depressed patients as well as patients with first-episode depression had the values which were comparable with those in normal controls. |
1977-05-12 |
2023-08-11 |
human |
| H M Praa. The Harold E. Himwich Memorial Lecture. Significance of biochemical parameters in the diagnosis, treatment, and prevention of depressive disorders. Biological psychiatry. vol 12. issue 1. 1977-04-30. PMID:300032. |
disturbances of central 5-ht metabolism are not typical for any depression but for certain types of vital (endogenous) depression. |
1977-04-30 |
2023-08-11 |
Not clear |
| H M Praa. The Harold E. Himwich Memorial Lecture. Significance of biochemical parameters in the diagnosis, treatment, and prevention of depressive disorders. Biological psychiatry. vol 12. issue 1. 1977-04-30. PMID:300032. |
(ii) there is suggestive evidence that abolition of the 5-ht deficit (by means of 5-htp) exerts a prophylactic effect in uni-and bipolar depression. |
1977-04-30 |
2023-08-11 |
Not clear |
| S Takahash. Reduction of blood platelet serotonin levels in manic and depressed patients. Folia psychiatrica et neurologica japonica. vol 30. issue 4. 1977-04-28. PMID:1087914. |
unipolar and involutional depressed patients exhibited to have the most pronounced reduced levels of serotonin of various subtypes of depression, while bipolar depressed patients, neurotic and chronic characterological depressed patients as well as patients with first-episode depression had the values which were comparable with those in normal controls. |
1977-04-28 |
2023-08-11 |
human |
| E R Block, A B Fishe. Depression of serotonin clearance by rat lungs during oxygen exposure. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 42. issue 1. 1977-03-31. PMID:833074. |
depression of serotonin clearance by rat lungs during oxygen exposure. |
1977-03-31 |
2023-08-11 |
rat |
| E R Block, A B Fishe. Depression of serotonin clearance by rat lungs during oxygen exposure. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 42. issue 1. 1977-03-31. PMID:833074. |
depression of 5ht clearance by the lungs is an early alteration of lung function fue to hyperoxia and is potentiated by vitamin e deficiency. |
1977-03-31 |
2023-08-11 |
rat |
| E R Block, A B Fishe. Depression of serotonin clearance by rat lungs during oxygen exposure. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 42. issue 1. 1977-03-31. PMID:833074. |
the most likely mechanism for the depression of 5-ht clearance is interference with the transport properties of lung endothelium. |
1977-03-31 |
2023-08-11 |
rat |
| M H Aprison, K H Tachiki, R Takahash. [Increased sensitivity of serotonin receptors in depression--a hypothesis]. Nihon rinsho. Japanese journal of clinical medicine. vol 34. issue 9. 1977-01-29. PMID:825669. |
[increased sensitivity of serotonin receptors in depression--a hypothesis]. |
1977-01-29 |
2023-08-11 |
Not clear |
| D W Gallager, G K Aghajania. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. European journal of pharmacology. vol 39. issue 2. 1977-01-03. PMID:10173. |
the depressant effects of certain antipsychotic drugs and piperoxane on 5ht neurons appears to be mediated by a cnetral adrenergic system since (1) the depression could be reversed by the catecholamine releasing agents 1- and d-amphetamine; (2) the depression could be abolished by destruction of adrenergic pathways in the cns by chemical, mechanical, or electrothermic lesions. |
1977-01-03 |
2023-08-11 |
Not clear |
| R Takahashi, K H Tachiki, K Nishiwaki, E Nakamura, T Tateish. Biochemical basis of an animal model of depressive illness--a preliminary report--. Folia psychiatrica et neurologica japonica. vol 30. issue 2. 1976-12-03. PMID:9342. |
biochemical analyses of brain samples of an animal model of depression indicate the state of motionlessness observed in response to a conditioned stimulus was due to an excess in functional activity of serotonin. |
1976-12-03 |
2023-08-11 |
human |
| H M van Praag, J Kor. Central monoamine deficiency in depressions: causative of secondary phenomenon? Pharmakopsychiatrie, Neuro-Psychopharmakologie. vol 8. issue 5. 1976-12-01. PMID:1085937. |
there are indications for a functional deficiency of 5-ht and da in certain kinds of depression. |
1976-12-01 |
2023-08-11 |
Not clear |