| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Fozard, A T Mobarok Ali, G Newgros. Blockade of serotonin receptors on autonomic neurones by (-)-cocaine and some related compounds. European journal of pharmacology. vol 59. issue 3-4. 1980-04-26. PMID:527645. |
low concentrations of (--)-cocaine or its stereoisomer, (4)-pseudococaine, produced shifts to the right of the 5-ht dose-response curves on heart and ileum with no depression of the maximum responses to electrical stimulation or dimethylphenylpiperazinium remained unaffected. |
1980-04-26 |
2023-08-11 |
rabbit |
| J Vetulani, B Byrska, K Reichenber. Head twitches produced by serotonergic drugs and opiates after lesion of the mesostriatal serotonergic system of the rat. Polish journal of pharmacology and pharmacy. vol 31. issue 4. 1980-03-17. PMID:316525. |
there was a good correlation between the extent of lesion, measured by the depression of the level of prosencephalic serotonin, and the depression of head twitch frequency produced by 5-hydroxytryptophan and quipazine, while the correlation was not significant for the action of lsd. |
1980-03-17 |
2023-08-11 |
rat |
| J Tuomisto, E Tukiainen, U G Ahlfor. Decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression. Psychopharmacology. vol 65. issue 2. 1980-02-15. PMID:117482. |
decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression. |
1980-02-15 |
2023-08-11 |
human |
| J Tuomisto, E Tukiainen, U G Ahlfor. Decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression. Psychopharmacology. vol 65. issue 2. 1980-02-15. PMID:117482. |
5-hydroxytryptamine (5-ht) uptake was studied by using blood platelets from 13 patients with endogenous depression (hamilton rating scale 33 +/- 7) and 13 healthy volunteers. |
1980-02-15 |
2023-08-11 |
human |
| S O Ogren, K Fuxe, L F Agnati, J A Gustafsson, G Jonsson, A C Hol. Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs. Journal of neural transmission. vol 46. issue 2. 1980-02-15. PMID:574536. |
thus, a new indoleamine hypothesis of depression is presented: the therapeutic action of antidepressant drugs may in part be due to a reduced functional acitivity of some central 5-ht systems. |
1980-02-15 |
2023-08-11 |
mouse |
| G F Oxenkru. The content and uptake of 5-HT by blood platelets in depressive patients. Journal of neural transmission. vol 45. issue 4. 1979-12-20. PMID:490151. |
these data suggest that the acceleration of 5-ht reuptake in neurones may be one of the reasons of insufficiency of 5-ht-ergic processes in depression of 5-ht type (asberg, 1976). |
1979-12-20 |
2023-08-11 |
Not clear |
| R L Carasso, S Yehuda, M Streifle. Clomipramine and amitriptyline in the treatment of severe pain. The International journal of neuroscience. vol 9. issue 3. 1979-12-18. PMID:489262. |
the results support the hypothesis that in certain pain situations, clomipramine exerts a beneficial effect, not only because of its effect on the depression and anxiety level of the patient, but also via its effects on the 5-ht brain system. |
1979-12-18 |
2023-08-11 |
Not clear |
| D N Franz, B D Hare, R J Neumay. Depression of sympathetic preganglionic neurons by clonidine: evidence for stimulation of 5-HT receptors. Clinical and experimental hypertension. vol 1. issue 1. 1979-12-18. PMID:755644. |
depression of sympathetic preganglionic neurons by clonidine: evidence for stimulation of 5-ht receptors. |
1979-12-18 |
2023-08-11 |
Not clear |
| F R Bell, D E Webbe. Gastric emptying and secretion in the calf on duodenal infusion of tryptophan, tryptamine and 5-hydroxytryptamine. The Journal of physiology. vol 291. 1979-11-29. PMID:480233. |
tryptamine and 5-hydroxytryptamine (5-ht) incorporated in low concentration into isotonic nahco(3) also produced depression of gastric emptying, acid and pepsinogen levels comparable to the response initiated by acid infusate. |
1979-11-29 |
2023-08-11 |
Not clear |
| O Benker. [Biochemical research in depression (author's transl)]. Klinische Wochenschrift. vol 57. issue 13. 1979-11-29. PMID:480857. |
the noradrenalin and serotonin-hypothesis was propounded postulating a disturbance in noradrenalin, or serotonin regulation, respectively at the receptor in depression. |
1979-11-29 |
2023-08-11 |
Not clear |
| J A Armijo, A Mediavilla, J Flóre. Inhibition of the activity of the respiratory and vasomotor centers by centrally administered 5-hydroxytryptamine in cats. Revista espanola de fisiologia. vol 35. issue 2. 1979-11-21. PMID:582627. |
50 mu g of 5-ht injected into the fourth ventricle induced a depression of respiration similar to that observed in the lateral ventricle studies, with the exception that the early stimulation was abolished. |
1979-11-21 |
2023-08-11 |
Not clear |
| C Sangdee, D N Fran. Enhancement of central norepinephrine and 5-hydroxytryptamine transmission by tricyclic antidepressants. A comparison. Psychopharmacology. vol 62. issue 1. 1979-07-28. PMID:220658. |
effects on 5-ht transmission were assessed on 5-ht-mediated depression of spinal sympathetic reflexes produced by 30 mg/kg of 5-htp. |
1979-07-28 |
2023-08-11 |
Not clear |
| C Sangdee, D N Fran. Enhancement of central norepinephrine and 5-hydroxytryptamine transmission by tricyclic antidepressants. A comparison. Psychopharmacology. vol 62. issue 1. 1979-07-28. PMID:220658. |
each of the four drugs also enhanced the 5-htp-induced depression of spinal sympathetic reflexes, but their relative potencies on 5-ht transmission were just the opposite to those found on ne transmission. |
1979-07-28 |
2023-08-11 |
Not clear |
| G Curzo. Study of disturbed tryptophan metabolism in depressive illness. Annales de biologie clinique. vol 37. issue 1. 1979-07-16. PMID:443610. |
the evidence for disturbances of tryptophan and 5-hydroxytryptamine in depression and for various mechanisms by which such disturbances could occur is discussed. |
1979-07-16 |
2023-08-11 |
human |
| P E Garfinkel, J J Warsh, H C Stance. Depression: new evidence in support of biological differentiation. The American journal of psychiatry. vol 136. issue 4B. 1979-05-23. PMID:426139. |
the authors state that their research design reveals changes in serotonin and nonrepinephrine metabolism in unipolar depressed subjects that distinguish this group from normal and bipolar depressed subjects, suggesting a reduced cns uptake of tryptophan in unipolar depression. |
1979-05-23 |
2023-08-11 |
human |
| T A Reader, A Ferron, L Descarries, H H Jaspe. Modulatory role for biogenic amines in the cerebral cortex. Microiontophoretic studies. Brain research. vol 160. issue 2. 1979-04-28. PMID:761065. |
most units inhibited by da, na and 5-ht also showed marked depression of their excitatory response to ach when pretreated with these biogenic amines. |
1979-04-28 |
2023-08-11 |
rat |
| A Aberg, G Holmber. Preliminary clinical test of zimelidine (H 102/09), a new 5-HT uptake inhibitor. Acta psychiatrica Scandinavica. vol 59. issue 1. 1979-04-25. PMID:369299. |
zimelidine, a bicyclic compound, which in animal experiments causes specific inhibition of the uptake of 5-ht, was tried on 15 patients with depression of endogenous type. |
1979-04-25 |
2023-08-11 |
rat |
| S C Brooks, J J Linn, N Disne. Serotonin, folic acid, and uric acid metabolism in the diagnosis of neuropsychiatric disorders. Biological psychiatry. vol 13. issue 6. 1979-04-25. PMID:737255. |
conversely, deficient serotonin, induced by a psychological loss or transport deficit, could be compensated by raising the folate ratio, which would normalize the beta-carboline index and prevent further depression. |
1979-04-25 |
2023-08-11 |
Not clear |
| A Akintonwa, J V Auditor. Reversal of adenine-induced depression of mouse locomotor activity by amphetamine. Archives internationales de pharmacodynamie et de therapie. vol 235. issue 2. 1979-03-24. PMID:736702. |
mice treated with adenine showed marked depletion of brain norepinephrine, dopamine and serotonin, irrespective of whether or not they had been treated with d- or l-amphetamine, and whether or not these agents were capable of reversing adenine-induced depression of locomotor activity. |
1979-03-24 |
2023-08-11 |
mouse |
| K Krnjević, Y Lamour, J F MacDonald, A Nistr. Intracellular actions of monoamine transmitters. Canadian journal of physiology and pharmacology. vol 56. issue 5. 1979-01-26. PMID:30529. |
intracellular injections of 5-hydroxytryptamine have some depolarizing action and increased input resistance, but they produced no comparable depression of the action potential and tended to enhance the after-potentials and increase excitability. |
1979-01-26 |
2023-08-11 |
Not clear |