| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R S Jone. In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British journal of pharmacology. vol 73. issue 2. 1981-08-20. PMID:6972243. |
tryptamine at low doses had no overt effects but enhanced depression induced by 5-ht. |
1981-08-20 |
2023-08-12 |
mouse |
| R S Jone. In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British journal of pharmacology. vol 73. issue 2. 1981-08-20. PMID:6972243. |
at behaviourally excitatory doses tryptamine reduced the duration of the 5-ht depression. |
1981-08-20 |
2023-08-12 |
mouse |
| M K DeMyer, P A Shea, H C Hendrie, N N Yoshimur. Plasma tryptophan and five other amino acids in depressed and normal subjects. Archives of general psychiatry. vol 38. issue 6. 1981-08-10. PMID:7247626. |
decreases in brain serotonin levels have been implicated in the pathogenesis of human depression. |
1981-08-10 |
2023-08-12 |
human |
| M K DeMyer, P A Shea, H C Hendrie, N N Yoshimur. Plasma tryptophan and five other amino acids in depressed and normal subjects. Archives of general psychiatry. vol 38. issue 6. 1981-08-10. PMID:7247626. |
this finding tends to support the idea that changes in brain serotonin level reflect changes in depression severity. |
1981-08-10 |
2023-08-12 |
human |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
since ethanol may interact with central serotonergic (5ht) neurons, and since 5ht systems have been found to play a role in modulating lh release, we examined the possible role of central serotonergic neurons in the ethanol-induced depression of lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
acute pcpa (400 mg/kg, 20 hr before 2.0 g/kg ethanol) was effective in preventing the ethanol-induced depression of lh, suggesting that ethanol activates 5ht systems to lower lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
x 3 days before ethanol) produced similar reductions in hypothalamic 5ht but did not block the ethanol effect, and because electrolytic lesions of the median raphe nucleus were also ineffective in preventing the post-ethanol depression of lh, we conclude that activation of serotonergic systems does not play a major role in the ethanol induced depression of lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| N Matusse. [Development of biological psychiatric depression research (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 123. issue 19. 1981-07-20. PMID:6262640. |
the concern with the neurochemical actions of these substances led to putting forth the noradrenaline and serotonin hypothesis of depression in the mid-60s. |
1981-07-20 |
2023-08-12 |
Not clear |
| N Matusse. [Development of biological psychiatric depression research (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 123. issue 19. 1981-07-20. PMID:6262640. |
according to this, there is supposed to be a deficiency of noradrenaline and/or serotonin at the nerve endings in depression. |
1981-07-20 |
2023-08-12 |
Not clear |
| A A Borbély, H U Neuhaus, I Toble. Effect of p-chlorophenylalanine and tryptophan on sleep, EEG and motor activity in the rat. Behavioural brain research. vol 2. issue 1. 1981-07-20. PMID:6452888. |
the experiments show that the depression of sws and rems, and the hyperactivity 1-2 days after pcpa administration, are a consequence of the reduced 5-ht level, whereas the involvement of serotonergic mechanisms in the initial sedative phase and in the recovery phase is less clear. |
1981-07-20 |
2023-08-12 |
rat |
| H M van Praa. Management of depression with serotonin precursors. Biological psychiatry. vol 16. issue 3. 1981-07-09. PMID:6164407. |
management of depression with serotonin precursors. |
1981-07-09 |
2023-08-12 |
Not clear |
| L Träskman-Bendz, M Asberg, L Bertilsso. Serotonin and noradrenaline uptake inhibitors in the treatment of depression--relationship to 5-HIAA in spinal fluid. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6164251. |
serotonin and noradrenaline uptake inhibitors in the treatment of depression--relationship to 5-hiaa in spinal fluid. |
1981-06-13 |
2023-08-12 |
Not clear |
| J Wålinder, A Carlsson, R Persso. 5-HT reuptake inhibitors plus tryptophan in endogenous depression. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6452791. |
5-ht reuptake inhibitors plus tryptophan in endogenous depression. |
1981-06-13 |
2023-08-12 |
Not clear |
| A Aber. Controlled cross-over study of a 5-HT uptake inhibiting and an NA uptake inhibiting antidepressant. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6452794. |
a double-blind comparison of zimelidine, a potent and fairly selective 5-hydroxytryptamine (5-ht) uptake inhibitor, and desipramine, a noradrenaline (na) uptake inhibitor, was carried out in hospitalized patients with endogenous depression. |
1981-06-13 |
2023-08-12 |
rat |
| S Agurel. Biogenic amines and depression (introduction to symposium). Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6939311. |
it has generally been assumed that these "tricyclics" alleviate depression by influencing the neurotransmitters (na, 5-ht) at crucial receptor sites in the brain. |
1981-06-13 |
2023-08-12 |
Not clear |
| H Y Meltzer, M Simonovic, R D Sturgeon, V S Fan. Effect of antidepressants, lithium and electroconvulsive treatment on rat serum prolactin levels. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6971560. |
these results are discussed in light of current theories of the role of 5-ht and da in depression. |
1981-06-13 |
2023-08-12 |
rat |
| J Davie. Selective depression of synaptic excitation in cat spinal neurones by baclofen: an iontophoretic study. British journal of pharmacology. vol 72. issue 2. 1981-06-13. PMID:7214103. |
6 comparison of baclofen with a number of other substances indicates that the depression of noncholinergic, excitatory, synaptic responses is unlikely to involve an interaction of this agent with receptors for monoamines, 5-hydroxytryptamine or the inhibitory amino acids, gamma-aminobutyric acid and glycine. |
1981-06-13 |
2023-08-12 |
cat |
| E R Block, F J Schoe. Effect of alpha naphthylthiourea on uptake of 5-hydroxytryptamine from the pulmonary circulation. The American review of respiratory disease. vol 123. issue 1. 1981-03-27. PMID:6779686. |
depression of 5-ht uptake is an early and reversible alteration of lung endothelial cell function caused by antu. |
1981-03-27 |
2023-08-12 |
rat |
| H Nagayama, J N Hingtgen, M H Apriso. Pre- and postsynaptic serotonergic manipulations in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 13. issue 4. 1981-01-29. PMID:6968915. |
thus, these studies support the hypothesis that some types of human depression may be primarily due to an excess of free 5-ht acting at postsynaptic receptors. |
1981-01-29 |
2023-08-12 |
human |
| A Parbtani, G Frampton, V Yewdall, N Kasai, J S Camero. Platelet and plasma serotonin in glomerulonephritis. III: The nephritis of systemic lupus erythematosus. Clinical nephrology. vol 14. issue 4. 1981-01-26. PMID:7428190. |
there was, however, a correlation between the amount of platelet-aggregating material in the serum and depression of intraplatelet serotonin. |
1981-01-26 |
2023-08-12 |
Not clear |