| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Aberg-Wistedt, K G Jostell, S B Ross, D Westerlun. Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression. Psychopharmacology. vol 74. issue 4. 1981-12-15. PMID:6457309. |
effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression. |
1981-12-15 |
2023-08-12 |
rat |
| A Aberg-Wistedt, K G Jostell, S B Ross, D Westerlun. Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression. Psychopharmacology. vol 74. issue 4. 1981-12-15. PMID:6457309. |
the selective inhibitors of neuronal 5-hydroxytryptamine (5-ht) and noradrenaline (na) uptake, zimelidine and desipramine, were compared in a double blind crossover study of 40 inpatients with endogenous depression. |
1981-12-15 |
2023-08-12 |
rat |
| H Nagayama, J N Hingtgen, M H Apriso. Postsynaptic action by four antidepressive drugs in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 15. issue 1. 1981-12-15. PMID:6974869. |
to further test the new hypersensitive postsynaptic serotonin (5-ht) receptor theory of depression bases on or animal model, it was necessary to demonstrate that some of the currently used antidepressive drugs can block d,l-5-hydroxytryptophan (5-htp) induced depression acting through postsynaptic rather than presynaptic mechanisms. |
1981-12-15 |
2023-08-12 |
rat |
| H Nagayama, J N Hingtgen, M H Apriso. Postsynaptic action by four antidepressive drugs in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 15. issue 1. 1981-12-15. PMID:6974869. |
since acute pretreatment with comparable clinical doses of the antidepressive drugs, mianserin, amitriptyline, imipramine, or iprindole, resulted in blockade of the 5-htp induced depression by 70, 50, 40, and 20% respectively, these drugs can act as antagonists of 5-ht at the postsynaptic serotonin receptor. |
1981-12-15 |
2023-08-12 |
rat |
| E R Block, S A Stalcu. Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 50. issue 6. 1981-10-25. PMID:7263381. |
depression of serotonin uptake by cultured endothelial cells exposed to high o2 tension. |
1981-10-25 |
2023-08-12 |
Not clear |
| E R Block, S A Stalcu. Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 50. issue 6. 1981-10-25. PMID:7263381. |
to characterized the cellular basis and mechanism for hyperoxic depression of lung 5-ht uptake, we evaluated the effect of high po2 on 5-ht uptake by calf aortic endothelial cells in primary confluent monolayer. |
1981-10-25 |
2023-08-12 |
Not clear |
| E R Block, S A Stalcu. Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 50. issue 6. 1981-10-25. PMID:7263381. |
exposure to 95% o2 for 20 h or 42 h resulted in significant depression of 5-ht uptake by cultured endothelial cells, and uptakes remained significantly depressed 48 h after exposure to 95% o2 had ended. |
1981-10-25 |
2023-08-12 |
Not clear |
| E R Block, S A Stalcu. Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 50. issue 6. 1981-10-25. PMID:7263381. |
these results indicate that 1) high po2 levels depress 5-ht uptake in endothelial cells by direct inhibition of the transcellular transport of 5-ht and 2) hyperoxic depression of 5-ht uptake in cultured endothelial cells is not readily reversible. |
1981-10-25 |
2023-08-12 |
Not clear |
| D Male. Central action of narcotic analgesics. VI. Further studies on the participation of serotonin in the action of analgesics. Polish journal of pharmacology and pharmacy. vol 32. issue 5. 1981-10-14. PMID:6115369. |
depression of the cerebral level of 5-ht usually antagonized the behavioral effects of analgesics, but the effect varied with the agent depressing the 5-ht level. |
1981-10-14 |
2023-08-12 |
rat |
| B Morgan, M Winic. A possible control of food intake during pregnancy in the rat. The British journal of nutrition. vol 46. issue 1. 1981-10-14. PMID:7260030. |
the increase food intake of the dams during gestation and lactation increased to the same extent as elevation in hypothalamic norepinephrine content and depression in serotonin content. |
1981-10-14 |
2023-08-12 |
rat |
| R Philo, R J Reite. The involvement of brain amines in pinealectomy-induced convulsions in the gerbil: I. Serotonin. Behavioural brain research. vol 3. issue 1. 1981-09-15. PMID:6972773. |
serotonin is apparently of little importance in the px-induced convulsion since the artificial elevation by administration of tryptophan and 5-hydroxytryptophan, or depression by treatment with p-chloramphetamine, of telencephalic 5-ht had little effect on the convulsions. |
1981-09-15 |
2023-08-12 |
Not clear |
| S Greenberg, C McGowan, T M Glen. Pulmonary vascular smooth muscle function in porcine splanchnic arterial occlusion shock. The American journal of physiology. vol 241. issue 1. 1981-08-27. PMID:7246787. |
the depression in the sensitivity to 5-ht and maximal tension development to 5-ht and ne was selective, since the responses to potassium ion were not depressed. |
1981-08-27 |
2023-08-12 |
Not clear |
| R S Jone. In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British journal of pharmacology. vol 73. issue 2. 1981-08-20. PMID:6972243. |
4 5-ht or noradrenaline injected intravenously into 5 day-old chicks caused a dose-dependent behavioural depression resembling sleep. |
1981-08-20 |
2023-08-12 |
mouse |
| R S Jone. In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British journal of pharmacology. vol 73. issue 2. 1981-08-20. PMID:6972243. |
tryptamine at low doses had no overt effects but enhanced depression induced by 5-ht. |
1981-08-20 |
2023-08-12 |
mouse |
| R S Jone. In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British journal of pharmacology. vol 73. issue 2. 1981-08-20. PMID:6972243. |
at behaviourally excitatory doses tryptamine reduced the duration of the 5-ht depression. |
1981-08-20 |
2023-08-12 |
mouse |
| M K DeMyer, P A Shea, H C Hendrie, N N Yoshimur. Plasma tryptophan and five other amino acids in depressed and normal subjects. Archives of general psychiatry. vol 38. issue 6. 1981-08-10. PMID:7247626. |
decreases in brain serotonin levels have been implicated in the pathogenesis of human depression. |
1981-08-10 |
2023-08-12 |
human |
| M K DeMyer, P A Shea, H C Hendrie, N N Yoshimur. Plasma tryptophan and five other amino acids in depressed and normal subjects. Archives of general psychiatry. vol 38. issue 6. 1981-08-10. PMID:7247626. |
this finding tends to support the idea that changes in brain serotonin level reflect changes in depression severity. |
1981-08-10 |
2023-08-12 |
human |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
since ethanol may interact with central serotonergic (5ht) neurons, and since 5ht systems have been found to play a role in modulating lh release, we examined the possible role of central serotonergic neurons in the ethanol-induced depression of lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
acute pcpa (400 mg/kg, 20 hr before 2.0 g/kg ethanol) was effective in preventing the ethanol-induced depression of lh, suggesting that ethanol activates 5ht systems to lower lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
x 3 days before ethanol) produced similar reductions in hypothalamic 5ht but did not block the ethanol effect, and because electrolytic lesions of the median raphe nucleus were also ineffective in preventing the post-ethanol depression of lh, we conclude that activation of serotonergic systems does not play a major role in the ethanol induced depression of lh. |
1981-07-23 |
2023-08-12 |
Not clear |