| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Aberg-Wistedt, S B Ross, K G Jostell, B Sjöquis. A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. II. Biochemical findings. Acta psychiatrica Scandinavica. vol 66. issue 1. 1982-12-02. PMID:6181652. |
a double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. |
1982-12-02 |
2023-08-12 |
rat |
| A Aberg-Wistedt, S B Ross, K G Jostell, B Sjöquis. A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. II. Biochemical findings. Acta psychiatrica Scandinavica. vol 66. issue 1. 1982-12-02. PMID:6181652. |
in a comparative evaluation of zimelidine, a potent serotonin (5-ht) uptake inhibitor, and desipramine, a potent noradrenaline (na) uptake inhibitor, 65 hospitalized patients with endogenous depression were evaluated for the following biochemical variables: 5-ht uptake in platelets, 5-ht concentration in whole blood, inhibition of the 5-ht and na accumulation in rat hypothalamic synaptosomes incubated in the patients' plasma, the excretion of 4-hydroxy-3-methoxyphenyl glycol (hmpg) in urine and the pretreatment levels of the amine metabolites 5-hydroxyindoleacetic acid (5-hiaa), homovanillic acid (hva) and hmpg in cerebrospinal fluid (csf). |
1982-12-02 |
2023-08-12 |
rat |
| A Uza. [Proserotoninergic agents and depression (author's transl)]. L'Encephale. vol 8. issue 2. 1982-10-21. PMID:6286277. |
the proserotoninergic hypothesis of depression has been for a long time founded on biochemical parameters (brain from suicide patients, csf and plasma from depressed patients) or more recently on measurement of platelets 5-ht uptake or imipramine binding. |
1982-10-21 |
2023-08-12 |
human |
| A Georgotas, M Krakowski, S Gersho. Controlled trial of zimelidine, a 5-HT reuptake inhibitor, for treatment of depression. The American journal of psychiatry. vol 139. issue 8. 1982-08-26. PMID:6211994. |
controlled trial of zimelidine, a 5-ht reuptake inhibitor, for treatment of depression. |
1982-08-26 |
2023-08-12 |
Not clear |
| D R Cook, R E Howell, C N Gilli. Xanthine oxidase-induced lung injury inhibits removal of 5-hydroxytryptamine from the pulmonary circulation. Anesthesia and analgesia. vol 61. issue 8. 1982-08-26. PMID:6283949. |
as uptake of 5-ht is the rate-limiting step in 5-ht removal, these data demonstrate dose (time)-related depression of active 5-ht uptake by free radicals generated in vitro. |
1982-08-26 |
2023-08-12 |
Not clear |
| D R Cook, B W Brando. Enflurane, halothane, and isoflurane inhibit removal of 5-hydroxytryptamine from the pulmonary circulation. Anesthesia and analgesia. vol 61. issue 8. 1982-08-26. PMID:7201270. |
as uptake of 5-ht is the rate-limiting step in 5-ht removal, these data demonstrate a uniform depression of 5-ht uptake by the three potent anesthetics. |
1982-08-26 |
2023-08-12 |
rabbit |
| E R Block, F J Schoe. Depression of serotonin uptake by rat lungs exposed to paraquat. The Journal of pharmacology and experimental therapeutics. vol 221. issue 1. 1982-05-27. PMID:7062288. |
depression of serotonin uptake by rat lungs exposed to paraquat. |
1982-05-27 |
2023-08-12 |
rat |
| E R Block, F J Schoe. Depression of serotonin uptake by rat lungs exposed to paraquat. The Journal of pharmacology and experimental therapeutics. vol 221. issue 1. 1982-05-27. PMID:7062288. |
administration of superoxide dismutase prolonged survival but did not protect against paraquat-induced depression of serotonin uptake. |
1982-05-27 |
2023-08-12 |
rat |
| E R Block, F J Schoe. Depression of serotonin uptake by rat lungs exposed to paraquat. The Journal of pharmacology and experimental therapeutics. vol 221. issue 1. 1982-05-27. PMID:7062288. |
these results indicate that paraquat causes an early and reversible depression of pulmonary endothelial cell uptake of serotonin which antedates morphological alterations in lung and the endothelial cell and which is not prevented by treatment with exogenous superoxide dismutase. |
1982-05-27 |
2023-08-12 |
rat |
| J R Flink, B R Pitt, G L Hammond, C N Gilli. Selective effect of microembolization on pulmonary removal of biogenic amines. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 52. issue 2. 1982-05-21. PMID:7061295. |
the selectivity of the effect of embolization on e(5-[14c]ht), the lack of an effect on imipramine-insensitive e(5-[14c]ht) extraction, and the much smaller changes after progressive lobar ligation indicate that, although derecruitment of vascular surface area secondary to mechanical obstruction may contribute to postembolization depression of e(5-[14c]ht), additional mechanisms such as local saturation of 5-ht uptake or selective damage to endothelial cell transport of 5-ht may underlie these observations. |
1982-05-21 |
2023-08-12 |
Not clear |
| L V Bezrukova, E I Solntsev. [Naloxone-dependent morphine-induced depression of the snail response to serotonin]. Neirofiziologiia = Neurophysiology. vol 13. issue 6. 1982-04-22. PMID:6276796. |
[naloxone-dependent morphine-induced depression of the snail response to serotonin]. |
1982-04-22 |
2023-08-12 |
Not clear |
| M Hamo. [The possible role of neurotransmitter receptors in the mechanisms of action of antidepressants (author's transl)]. L'Encephale. vol 7. issue 4 Suppl. 1982-03-26. PMID:6119200. |
these data further support the "monoamine theory" of depression: since down regulation is generally due to a long lasting overstimulation of receptors, it can be proposed that antidepressants increase ne and 5-ht neurotransmission in the cns, notably in some depressed patients. |
1982-03-26 |
2023-08-12 |
rat |
| S Yehuda, D I Mostofsky, T Brach. Increased serotonin level via augmented tryptophan diet and its effect on escape learning. The International journal of neuroscience. vol 15. issue 4. 1982-03-13. PMID:7319706. |
the results are discussed in relation to brain serotonin effects on escape following shock pretreatment ("learned helplessness") and its relevance to clinical depression. |
1982-03-13 |
2023-08-12 |
rat |
| A V Chandra, M M Ali, D K Saxena, R C Murth. Behavioral and neurochemical changes in rats simultaneously exposed to manganese and lead. Archives of toxicology. vol 49. issue 1. 1982-03-13. PMID:7325800. |
the exact role of depression in the levels of dopamine and 5-hydroxytryptamine in inducing marked impairment in learning ability and increased aggressive behavior in rats after the combined exposure to manganese and lead could not be ascertained. |
1982-03-13 |
2023-08-12 |
rat |
| J N Ghia, R A Mueller, G H Duncan, D S Scott, W Ma. Serotonergic activity in man as a function of pain, pain mechanisms, and depression. Anesthesia and analgesia. vol 60. issue 12. 1982-02-25. PMID:6172060. |
furthermore, the increased depression and continued pain in the presence of elevated 5-ht activity in patients with chronic pain may represent a tolerance or decreased responsiveness to 5-ht. |
1982-02-25 |
2023-08-12 |
Not clear |
| S M Paul, M Rehavi, P Skolnick, J C Ballenger, F K Goodwi. Depressed patients have decreased binding of tritiated imipramine to platelet serotonin "transporter". Archives of general psychiatry. vol 38. issue 12. 1982-02-25. PMID:7316676. |
these results, coupled with previous studies showing a significant decrease in the maximal uptake of serotonin in platelets from depressed patients, suggest that an inherited or acquired deficiency of the serotonin transport protein or proteins may be involved in the pathogenesis of depression. |
1982-02-25 |
2023-08-12 |
human |
| H Y Meltzer, R C Arora, R Baber, B J Trico. Serotonin uptake in blood platelets of psychiatric patients. Archives of general psychiatry. vol 38. issue 12. 1982-02-25. PMID:7316677. |
decreased 5-ht uptake in platelets provides additional evidence for the role of 5-ht in the pathophysiologic process of some forms of depression. |
1982-02-25 |
2023-08-12 |
Not clear |
| R Takahashi, T Tateishi, H Yoshida, H Nagayama, K H Tachik. Serotonin metabolism of animal model of depression. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6172020. |
all results presented here would indicate that serotonin plays an important role in animal behavior such as locomotor depression and that, taking into consideration the effects of antidepressants on 5-ht receptor activity as well as recent biochemical findings of human depression, some forms of human depression could be induced by a cerebral serotonergic receptor hyperactivity contrary to a conventional theory of serotonin deficiency in the synaptic cleft in the brain. |
1982-02-12 |
2023-08-12 |
human |
| R Takahashi, T Tateishi, H Yoshida, H Nagayama, K H Tachik. Serotonin metabolism of animal model of depression. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6172020. |
serotonin metabolism of animal model of depression. |
1982-02-12 |
2023-08-12 |
human |
| J Mendlewicz, J E Vanderheyden, G Noe. Serotonin and dopamine disturbances in patients with unipolar depression and Parkinsonism. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6172024. |
serotonin and dopamine disturbances in patients with unipolar depression and parkinsonism. |
1982-02-12 |
2023-08-12 |
Not clear |