| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Bauman. Transport systems and enzymes involved in the metamorphosis of tryptophan into serotonin. Pharmacopsychiatry. vol 18. issue 2. 1985-09-03. PMID:3875108. |
tryptophan (trp), as the precursor of serotonin, has been introduced in the treatment of depression and isomnia, but its clinical effectiveness must be considered with caution. |
1985-09-03 |
2023-08-11 |
Not clear |
| B Müller-Oerlinghause. Lithium long-term treatment--does it act via serotonin? Pharmacopsychiatry. vol 18. issue 2. 1985-09-03. PMID:3927331. |
taking into account that, firstly, lithium possesses antiaggressive effects in animals and men, and secondly, that (auto-)aggression seems to be related to a low concentration of 5-hiaa in csf, and thirdly, that a close relationship exists between depression and aggressive behavior, the proof of 5-ht agonistic effects in humans may enable us to formulate an integrative theory on the mode of action of lithium salts. |
1985-09-03 |
2023-08-11 |
Not clear |
| C J Schmidt, J W Gib. Role of the serotonin uptake carrier in the neurochemical response to methamphetamine: effects of citalopram and chlorimipramine. Neurochemical research. vol 10. issue 5. 1985-08-22. PMID:3859754. |
the role of the serotonin uptake carrier in the methamphetamine-induced depression of serotonin synthesis was examined. |
1985-08-22 |
2023-08-11 |
Not clear |
| C J Schmidt, J W Gib. Role of the serotonin uptake carrier in the neurochemical response to methamphetamine: effects of citalopram and chlorimipramine. Neurochemical research. vol 10. issue 5. 1985-08-22. PMID:3859754. |
furthermore, the methamphetamine-induced depression of serotonin synthesis is dependent upon a functional serotonin uptake system. |
1985-08-22 |
2023-08-11 |
Not clear |
| S W Cadde. The digastric reflex evoked by tooth-pulp stimulation in the cat and its modulation by stimuli applied to the limbs. Brain research. vol 336. issue 1. 1985-08-20. PMID:4005575. |
the serotonin antagonists, methysergide and cinanserin, strongly depressed the digastric reflex but it was not clear whether these drugs also affected the depression of the reflex by the conditioning stimuli. |
1985-08-20 |
2023-08-11 |
cat |
| Y Take, S Narumi, E Kurihara, M Shibota, Y Saji, Y Nagaw. [Pharmacological study of the temporary cerebral ischemic rats produced by bilateral vertebral and carotid artery occlusion. Effects of DN-1417]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 85. issue 3. 1985-08-12. PMID:2861149. |
in addition, dn-1417 (10 mg/kg) recovered the various changes such as decrease of 5-hydroxytryptamine (5-ht) levels, increase of cyclic amp (camp) levels, inhibition of [3h]-choline uptake, depression of choline acetyltransferase (cat) and acetylcholine esterase (ache) activities, and shortened the durations of hyperperfusion and hypoperfusion of rcbf. |
1985-08-12 |
2023-08-11 |
rat |
| B B Domangue, C G Margolis, D Lieberman, H Kaj. Biochemical correlates of hypnoanalgesia in arthritic pain patients. The Journal of clinical psychiatry. vol 46. issue 6. 1985-07-18. PMID:3158643. |
dopamine levels were positively correlated with both depression and epinephrine levels and negatively correlated with levels of serotonin. |
1985-07-18 |
2023-08-11 |
Not clear |
| P Riederer, H Beckmann, T Brück. [Current biochemical hypotheses of endogenous depression]. Wiener klinische Wochenschrift. vol 97. issue 4. 1985-05-23. PMID:2580396. |
anticholinergic properties, co-modulation of various transmitters by different neuropeptides, great variations in the influence on the "re-uptake" mechanism for noradrenaline and serotonin with no effect by novel antidepressants like iprindole, mianserin and clenbuterol and variability to either stimulate or block receptor systems (alpha 1-, alpha 2-, beta-, serotonin-, dopamine-, adenylate cyclase dependent-, histaminergic receptors and possibly others) might further indicate a complex pathobiochemical background to depression. |
1985-05-23 |
2023-08-11 |
Not clear |
| A J Kaumann, M Frenke. A paradox: the 5-HT2-receptor antagonist ketanserin restores the 5-HT-induced contraction depressed by methysergide in large coronary arteries of calf. Allosteric regulation of 5-HT2-receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 328. issue 3. 1985-05-15. PMID:3157064. |
the ic50 of methysergide for depression of the response to 5-ht was (-log mol/l) 9.8. |
1985-05-15 |
2023-08-11 |
cattle |
| A Aberg-Wistedt, M Alvariza, L Bertilsson, R Malmgren, H Wachtmeiste. Alaproclate a novel antidepressant? A biochemical and clinical comparison with zimeldine. Acta psychiatrica Scandinavica. vol 71. issue 3. 1985-05-03. PMID:2580422. |
clinical and biochemical effects of two selective 5-ht uptake inhibitors, zimeldine and alaproclate, were studied in 24 hospitalized patients with endogenous depression. |
1985-05-03 |
2023-08-11 |
Not clear |
| H Beving, L Bjerkenstedt, R Malmgren, P Olsson, G Ung. The effects of citalopram (Lu 10-171) on the serotonin (5-HT) uptake kinetics in platelets from endogenously depressed patients. Journal of neural transmission. vol 61. issue 1-2. 1985-05-03. PMID:3856629. |
the uptake kinetics of serotonin (5-ht) in platelets from eight patients with endogenous depression was determined in platelet rich plasma (prp). |
1985-05-03 |
2023-08-11 |
Not clear |
| C L Bowden, S H Koslow, I Hanin, J W Maas, J M Davis, E Robin. Effects of amitriptyline and imipramine on brain amine neurotransmitter metabolites in cerebrospinal fluid. Clinical pharmacology and therapeutics. vol 37. issue 3. 1985-04-10. PMID:2578912. |
the effects of amitriptyline (ami) or imipramine (imi) on levels of 3-methoxy-4-hydroxyphenylethyleneglycol (mhpg), 5-hydroxyindoleacetic acid (5-hiaa), and homovanillic acid (hva) (the major brain metabolites of the neurotransmitters norepinephrine [ne], serotonin [5-ht], and dopamine [da]) in cerebrospinal fluid were determined in 66 subjects with unipolar and bipolar depression. |
1985-04-10 |
2023-08-11 |
human |
| K H Le Quan-Bui, O Plaisant, M Leboyer, C Gay, L Kamal, M A Devynck, P Meye. Reduced platelet serotonin in depression. Psychiatry research. vol 13. issue 2. 1985-03-21. PMID:6596580. |
reduced platelet serotonin in depression. |
1985-03-21 |
2023-08-12 |
human |
| L L Peterson, T Bartfai, L Ernster, G Wickström, B E Roos, U Wehlin-Ahs, H Agre. Uncoupler-accelerated efflux of 5-hydroxytryptamine from platelets of healthy subjects and patients with unipolar and bipolar depression. Psychiatry research. vol 13. issue 2. 1985-03-21. PMID:6596581. |
uncoupler-accelerated efflux of 5-hydroxytryptamine from platelets of healthy subjects and patients with unipolar and bipolar depression. |
1985-03-21 |
2023-08-12 |
human |
| C W Hughes, T A Kent, J Campbell, A Oke, H Croskell, S H Preskor. Cerebral blood flow and cerebrovascular permeability in an inescapable shock (learned helplessness) animal model of depression. Pharmacology, biochemistry, and behavior. vol 21. issue 6. 1985-03-05. PMID:6441169. |
the effects of a purported animal model of depression (inescapable shock, is) was tested on: (a) escape behavior, (b) regional brain levels of norepinephrine (ne), serotonin (5-ht), and dopamine, and (c), the response of the cerebromicrovasculature to metabolic demand as mimicked by manipulation of arterial co2 content (paco2). |
1985-03-05 |
2023-08-12 |
rat |
| b' C de Montigny, R Elie, G Caill\\xc3\\xa. Rapid response to the addition of lithium in iprindole-resistant unipolar depression: a pilot study. The American journal of psychiatry. vol 142. issue 2. 1985-02-22. PMID:3918468.' |
since iprindole induces in the animal a sensitization of forebrain neurons to serotonin (5-ht), as do other tricyclic antidepressants, and lithium enhances the activity of 5-ht neurons, the authors propose that an enhanced release of 5-ht on sensitized target neurons might underlie the rapid antidepressant effect in tricyclic-refractory depression when lithium is added to the treatment regimen. |
1985-02-22 |
2023-08-11 |
Not clear |
| J C Pérez de los Cobos Peri. [Serotonin metabolism in severe depression. Clinical and biochemical changes and the contribution of precursors]. Actas luso-espanolas de neurologia, psiquiatria y ciencias afines. vol 12. issue 4. 1985-01-31. PMID:6334979. |
[serotonin metabolism in severe depression. |
1985-01-31 |
2023-08-12 |
Not clear |
| N G Lopatina, L Z Dolotovskai. [Effect of tryptophan and its metabolites on the conditioned reflex activity of the honeybee]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 34. issue 5. 1985-01-24. PMID:6506871. |
it was shown that mutations eliciting accumulation of free tryptophane and serotonin in the hemolymph of the bees and creating a deficit of kynurenins accelerate the transformation of conditioned reflexes and aggravate the depression of conditioned activity usually elicited in wild bees by monotonous prolonged presentation of conditioned signal. |
1985-01-24 |
2023-08-12 |
bee |
| R Ropert, H Lôo, C Ga. [Open preliminary study of new antidepressive compound: citalopram]. L'Encephale. vol 10. issue 3. 1984-12-27. PMID:6594229. |
the antidepressant effect of citalopram, a specific inhibitor of the reuptake of serotonin, was explored in an open phase ii study involving twenty-one patients hospitalized for depression. |
1984-12-27 |
2023-08-12 |
Not clear |
| S K Majumdar, G K Shaw, P K Bridge. Relationship between plasma cortisol concentrations and depression in chronic alcoholic patients. Drug and alcohol dependence. vol 14. issue 1. 1984-12-19. PMID:6149109. |
it is further suggested that brain serotonin deficiency known to occur in chronic alcoholics might lead to raised plasma cortisol levels in ethanol-induced depression. |
1984-12-19 |
2023-08-12 |
Not clear |