| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J N Hingtgen, H C Hendrie, M H Apriso. Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 20. issue 3. 1984-05-24. PMID:6608737. |
the potency of trazodone in relation to other antidepressant drugs in our behavioral model of depression paralleled their potency in displacing radioligand binding to 5-ht receptors, and gives additional support for the new hypersensitive postsynaptic serotonin receptor theory of depression. |
1984-05-24 |
2023-08-12 |
rat |
| K Wood, C Swade, M T Abou-Saleh, A Coppe. Headaches, depression and 5-hydroxytryptamine. The British journal of psychiatry : the journal of mental science. vol 144. 1984-05-24. PMID:6704628. |
headaches, depression and 5-hydroxytryptamine. |
1984-05-24 |
2023-08-12 |
Not clear |
| R Mayeux, Y Stern, L Cote, J B William. Altered serotonin metabolism in depressed patients with parkinson's disease. Neurology. vol 34. issue 5. 1984-05-23. PMID:6200801. |
alterations in serotonin metabolism are found in primary (endogenous) depression. |
1984-05-23 |
2023-08-12 |
Not clear |
| R Mayeux, Y Stern, L Cote, J B William. Altered serotonin metabolism in depressed patients with parkinson's disease. Neurology. vol 34. issue 5. 1984-05-23. PMID:6200801. |
the data suggest that the alterations in serotonin metabolism in parkinson's disease identify a subgroup of patients who are prone to depression. |
1984-05-23 |
2023-08-12 |
Not clear |
| Recent advances with zimeldine, the 5-HT reuptake blocker, in the treatment of depression. Proceedings of a symposium. Laxenburg, Austria, July 9, 1983. Acta psychiatrica Scandinavica. Supplementum. vol 308. 1984-04-17. PMID:6230882. |
recent advances with zimeldine, the 5-ht reuptake blocker, in the treatment of depression. |
1984-04-17 |
2023-08-12 |
Not clear |
| T G Waldrop, F L Eldridge, D E Millhor. Inhibition of breathing after stimulation of muscle is mediated by endogenous opiates and GABA. Respiration physiology. vol 54. issue 2. 1984-03-22. PMID:6665335. |
we conclude that endogenous opiates and possibly gaba, but not serotonin, dopamine or norepinephrine, are involved in the neural mechanism responsible for the prolonged depression of breathing. |
1984-03-22 |
2023-08-12 |
Not clear |
| C de Montign. Electroconvulsive shock treatments enhance responsiveness of forebrain neurons to serotonin. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6319668. |
inasmuch as long-term tricyclic antidepressant drug administration has been shown to produce a similar sensitization to serotonin, the present results suggest that enhancement of serotonergic neurotransmission might mediate the therapeutic effect of both types of treatment in major depression. |
1984-02-29 |
2023-08-12 |
rat |
| V Fuchs, E Burbes, H Coper, N Wagne. Significance of biogenic amines for opioid-induced locomotor activity in rats. Drug and alcohol dependence. vol 12. issue 3. 1984-02-22. PMID:6228415. |
in 5-hydroxytryptamine (5-ht)-deficient rats, the first excitation of motility is enhanced and its subsequent depression intensified. |
1984-02-22 |
2023-08-12 |
rat |
| J Ong, D I Ker. Interactions between GABA and 5-hydroxytryptamine in the guinea-pig ileum. European journal of pharmacology. vol 94. issue 3-4. 1984-02-14. PMID:6317404. |
in isolated segments of the guinea-pig ileum, there was: (a) an early, short-lived (less than 20 s) depression by gamma-aminobutyric acid (gaba) of contractile responses to 5-hydroxytryptamine (5-ht), acetylcholine(ach), or nicotine, also seen with 3-amino-1-propanesulphonic acid (3aps) or muscimol in place of gaba, and sensitive to bicuculline, picrotoxinin or piretanide, and (b) a delayed, longer-lasting (30 s-1 min) depression of responses to 5-ht and nicotine, but not exogenously applied ach, also seen with baclofen and only antagonised by delta-aminovaleric acid (dava). |
1984-02-14 |
2023-08-12 |
Not clear |
| A Cardona, P Rudomi. Activation of brainstem serotoninergic pathways decreases homosynaptic depression of monosynaptic responses of frog spinal motoneurons. Brain research. vol 280. issue 2. 1984-02-14. PMID:6652498. |
serotonin (10 mumol/liter) added to the bath, or stimulation of the brain-stem midline raphe nuclei, but not of the lateral reticular formation, reduced the magnitude of the low frequency depression of the responses. |
1984-02-14 |
2023-08-12 |
Not clear |
| T Kimura, S Sato. Presynaptic inhibition by serotonin of cardiac sympathetic transmission in dogs. Clinical and experimental pharmacology & physiology. vol 10. issue 5. 1984-01-27. PMID:6315283. |
the present results suggest that serotonin-induced depression of heart rate during sympathetic nerve stimulation is due to presynaptic inhibition by serotonin of cardiac sympathetic transmission which is not mediated via 'classic' tryptaminergic receptors. |
1984-01-27 |
2023-08-12 |
Not clear |
| H Y Meltzer, B Uberkoman-Wiita, A Robertson, B J Tricou, M Low. Enhanced serum cortisol response to 5-hydroxytryptophan in depression and mania. Life sciences. vol 33. issue 25. 1984-01-26. PMID:6645813. |
in view of evidence for decreased brain serotonergic activity in depression and perhaps mania, the results suggest at least some serotonin receptors may be supersensitive in some patients with affective disorders. |
1984-01-26 |
2023-08-12 |
Not clear |
| C W Coen, M C Coomb. Effects of manipulating catecholamines on the incidence of the preovulatory surge of of luteinizing hormone and ovulation in the rat: evidence for a necessary involvement of hypothalamic adrenaline in the normal or 'midnight' surge. Neuroscience. vol 10. issue 1. 1984-01-07. PMID:6358942. |
in terms of the hypothalamic concentration of dopamine, noradrenaline, adrenaline and 5-hydroxytryptamine at 18.00 h on pro-oestrus, the only common effect of diethyldithiocarbamate and skf 64139, given in a dose which blocks the surge, was a severe depletion of adrenaline; alpha-methyl-p-tyrosine failed to produce this effect despite inducing a marked depression of dopamine and a moderate loss of noradrenaline. |
1984-01-07 |
2023-08-12 |
rat |
| J M Lakoski, G K Aghajania. Effects of histamine, H1- and H2-receptor antagonists on the activity of serotonergic neurons in the dorsal raphe nucleus. The Journal of pharmacology and experimental therapeutics. vol 227. issue 2. 1983-12-17. PMID:6138428. |
histamine's effects may, in part, be mediated at a gamma-aminobutyric acid receptor complex as the gamma-aminobutyric acid antagonists bicuculline and picrotoxin rapidly and reversibly antagonized both the histamine- and the cimetidine-induced depression of serotonin cell firing; the glycine antagonist strychnine selectively blocked the inhibitory effect of glycine without altering the histamine-induced response. |
1983-12-17 |
2023-08-12 |
rat |
| D H Burke, J C Brooks, S B Trem. Cobaltous chloride-induced hypothermia in mice III: effect of pretreatment with 5-hydroxytryptaminergic agents. Journal of pharmaceutical sciences. vol 72. issue 7. 1983-10-28. PMID:6224927. |
elevation rather than depletion of brain serotonin by p-iodoamphetamine and failure of uptake inhibitors to modify p-chloroamphetamine antagonism of cobalt hypothermia lend further support for a nonserotonergic role of these amines in their ability to antagonize body-temperature depression by cobaltous chloride in mice. |
1983-10-28 |
2023-08-12 |
mouse |
| K Tika. Brain serotonin and 5 hydroxyindolacetic acid and blood magnesium cation levels after cortical spreading depression. Physiologia Bohemoslovaca. vol 32. issue 3. 1983-10-08. PMID:6193546. |
brain serotonin and 5 hydroxyindolacetic acid and blood magnesium cation levels after cortical spreading depression. |
1983-10-08 |
2023-08-12 |
Not clear |
| H Beckmann, S Kaspe. [Serotonin precursors as antidepressive agents: a review]. Fortschritte der Neurologie-Psychiatrie. vol 51. issue 5. 1983-09-23. PMID:6603403. |
however, the possibility exists that a serotonin deficient subgroup of depressed patients responds to this substance and further, that it has depression prophylactic properties. |
1983-09-23 |
2023-08-12 |
Not clear |
| D G Saintsing, D H Hwang, T H Diet. Production of prostaglandins E2 and F2 alpha in the freshwater mussel Ligumia subrostrata: relation to sodium transport. The Journal of pharmacology and experimental therapeutics. vol 226. issue 2. 1983-09-20. PMID:6410045. |
stimulation of na transport by serotonin and cyclic amp results in a depression of blood pge2 with no effect on circulating pgf2 alpha. |
1983-09-20 |
2023-08-12 |
Not clear |
| J L Costa, J M Launay, K L Kir. Exploration of the role of phenolsulfotransferase in the disposition of serotonin in human platelets: implications for a novel therapeutic strategy against depression. Medical hypotheses. vol 10. issue 3. 1983-09-09. PMID:6576226. |
exploration of the role of phenolsulfotransferase in the disposition of serotonin in human platelets: implications for a novel therapeutic strategy against depression. |
1983-09-09 |
2023-08-12 |
human |
| F K Goodwin, R M Pos. 5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology. British journal of clinical pharmacology. vol 15 Suppl 3. 1983-08-11. PMID:6190490. |
5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology. |
1983-08-11 |
2023-08-12 |
human |