| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Kaumann, M Frenke. A paradox: the 5-HT2-receptor antagonist ketanserin restores the 5-HT-induced contraction depressed by methysergide in large coronary arteries of calf. Allosteric regulation of 5-HT2-receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 328. issue 3. 1985-05-15. PMID:3157064. |
the ic50 of methysergide for depression of the response to 5-ht was (-log mol/l) 9.8. |
1985-05-15 |
2023-08-11 |
cattle |
| A Aberg-Wistedt, M Alvariza, L Bertilsson, R Malmgren, H Wachtmeiste. Alaproclate a novel antidepressant? A biochemical and clinical comparison with zimeldine. Acta psychiatrica Scandinavica. vol 71. issue 3. 1985-05-03. PMID:2580422. |
clinical and biochemical effects of two selective 5-ht uptake inhibitors, zimeldine and alaproclate, were studied in 24 hospitalized patients with endogenous depression. |
1985-05-03 |
2023-08-11 |
Not clear |
| H Beving, L Bjerkenstedt, R Malmgren, P Olsson, G Ung. The effects of citalopram (Lu 10-171) on the serotonin (5-HT) uptake kinetics in platelets from endogenously depressed patients. Journal of neural transmission. vol 61. issue 1-2. 1985-05-03. PMID:3856629. |
the uptake kinetics of serotonin (5-ht) in platelets from eight patients with endogenous depression was determined in platelet rich plasma (prp). |
1985-05-03 |
2023-08-11 |
Not clear |
| C L Bowden, S H Koslow, I Hanin, J W Maas, J M Davis, E Robin. Effects of amitriptyline and imipramine on brain amine neurotransmitter metabolites in cerebrospinal fluid. Clinical pharmacology and therapeutics. vol 37. issue 3. 1985-04-10. PMID:2578912. |
the effects of amitriptyline (ami) or imipramine (imi) on levels of 3-methoxy-4-hydroxyphenylethyleneglycol (mhpg), 5-hydroxyindoleacetic acid (5-hiaa), and homovanillic acid (hva) (the major brain metabolites of the neurotransmitters norepinephrine [ne], serotonin [5-ht], and dopamine [da]) in cerebrospinal fluid were determined in 66 subjects with unipolar and bipolar depression. |
1985-04-10 |
2023-08-11 |
human |
| K H Le Quan-Bui, O Plaisant, M Leboyer, C Gay, L Kamal, M A Devynck, P Meye. Reduced platelet serotonin in depression. Psychiatry research. vol 13. issue 2. 1985-03-21. PMID:6596580. |
reduced platelet serotonin in depression. |
1985-03-21 |
2023-08-12 |
human |
| L L Peterson, T Bartfai, L Ernster, G Wickström, B E Roos, U Wehlin-Ahs, H Agre. Uncoupler-accelerated efflux of 5-hydroxytryptamine from platelets of healthy subjects and patients with unipolar and bipolar depression. Psychiatry research. vol 13. issue 2. 1985-03-21. PMID:6596581. |
uncoupler-accelerated efflux of 5-hydroxytryptamine from platelets of healthy subjects and patients with unipolar and bipolar depression. |
1985-03-21 |
2023-08-12 |
human |
| C W Hughes, T A Kent, J Campbell, A Oke, H Croskell, S H Preskor. Cerebral blood flow and cerebrovascular permeability in an inescapable shock (learned helplessness) animal model of depression. Pharmacology, biochemistry, and behavior. vol 21. issue 6. 1985-03-05. PMID:6441169. |
the effects of a purported animal model of depression (inescapable shock, is) was tested on: (a) escape behavior, (b) regional brain levels of norepinephrine (ne), serotonin (5-ht), and dopamine, and (c), the response of the cerebromicrovasculature to metabolic demand as mimicked by manipulation of arterial co2 content (paco2). |
1985-03-05 |
2023-08-12 |
rat |
| b' C de Montigny, R Elie, G Caill\\xc3\\xa. Rapid response to the addition of lithium in iprindole-resistant unipolar depression: a pilot study. The American journal of psychiatry. vol 142. issue 2. 1985-02-22. PMID:3918468.' |
since iprindole induces in the animal a sensitization of forebrain neurons to serotonin (5-ht), as do other tricyclic antidepressants, and lithium enhances the activity of 5-ht neurons, the authors propose that an enhanced release of 5-ht on sensitized target neurons might underlie the rapid antidepressant effect in tricyclic-refractory depression when lithium is added to the treatment regimen. |
1985-02-22 |
2023-08-11 |
Not clear |
| J C Pérez de los Cobos Peri. [Serotonin metabolism in severe depression. Clinical and biochemical changes and the contribution of precursors]. Actas luso-espanolas de neurologia, psiquiatria y ciencias afines. vol 12. issue 4. 1985-01-31. PMID:6334979. |
[serotonin metabolism in severe depression. |
1985-01-31 |
2023-08-12 |
Not clear |
| N G Lopatina, L Z Dolotovskai. [Effect of tryptophan and its metabolites on the conditioned reflex activity of the honeybee]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 34. issue 5. 1985-01-24. PMID:6506871. |
it was shown that mutations eliciting accumulation of free tryptophane and serotonin in the hemolymph of the bees and creating a deficit of kynurenins accelerate the transformation of conditioned reflexes and aggravate the depression of conditioned activity usually elicited in wild bees by monotonous prolonged presentation of conditioned signal. |
1985-01-24 |
2023-08-12 |
bee |
| R Ropert, H Lôo, C Ga. [Open preliminary study of new antidepressive compound: citalopram]. L'Encephale. vol 10. issue 3. 1984-12-27. PMID:6594229. |
the antidepressant effect of citalopram, a specific inhibitor of the reuptake of serotonin, was explored in an open phase ii study involving twenty-one patients hospitalized for depression. |
1984-12-27 |
2023-08-12 |
Not clear |
| S K Majumdar, G K Shaw, P K Bridge. Relationship between plasma cortisol concentrations and depression in chronic alcoholic patients. Drug and alcohol dependence. vol 14. issue 1. 1984-12-19. PMID:6149109. |
it is further suggested that brain serotonin deficiency known to occur in chronic alcoholics might lead to raised plasma cortisol levels in ethanol-induced depression. |
1984-12-19 |
2023-08-12 |
Not clear |
| W M Welch, A R Kraska, R Sarges, B K Ko. Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins. Journal of medicinal chemistry. vol 27. issue 11. 1984-12-10. PMID:6492080. |
the potential role of derangements of 5-ht pathways in the etiology of depression has long been suspected and has given impetus to the development of newer compounds that accentuate inhibition of serotonin reuptake. |
1984-12-10 |
2023-08-12 |
Not clear |
| L Branchey, M Branchey, S Shaw, C S Liebe. Depression, suicide, and aggression in alcoholics and their relationship to plasma amino acids. Psychiatry research. vol 12. issue 3. 1984-12-06. PMID:6593754. |
because it has been postulated that altered serotonin metabolism may be a highly significant contributing factor not only to depression but also to aggressive and suicidal behavior, we decided to assess the existence of possible associations between amino acid abnormalities and these behaviors in a population of alcoholics. |
1984-12-06 |
2023-08-12 |
Not clear |
| R A Mueller, E Widerlöv, G R Brees. Attempted antagonism of adenosine analogue induced depression of respiration. Pharmacology, biochemistry, and behavior. vol 21. issue 2. 1984-11-15. PMID:6483940. |
neonatal destruction of brain serotonin or dopamine-containing nerve terminals did not alter the 2ca-induced respiratory depression. |
1984-11-15 |
2023-08-12 |
rat |
| J W Maas, S H Koslow, M M Katz, C L Bowden, R L Gibbons, P E Stokes, E Robins, J M Davi. Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. The American journal of psychiatry. vol 141. issue 10. 1984-11-09. PMID:6207736. |
the authors present hypotheses about the association of alterations in serotonin and norepinephrine systems and definable subtypes of depression. |
1984-11-09 |
2023-08-12 |
Not clear |
| L Branchey, M Branchey, S Shaw, C S Liebe. Relationship between changes in plasma amino acids and depression in alcoholic patients. The American journal of psychiatry. vol 141. issue 10. 1984-11-09. PMID:6486254. |
a decreased tryptophan ratio is known to result in decreased brain tryptophan and may contribute to depression through a deficiency of brain serotonin. |
1984-11-09 |
2023-08-12 |
human |
| N Pomara, K L Coffman, D F Bush, S Gersho. Myalgia and elevation in muscle creatine phosphokinase during zimelidine treatment. Journal of clinical psychopharmacology. vol 4. issue 4. 1984-10-03. PMID:6236235. |
the authors report a case involving a 65-year-old woman with dsm-iii criteria for major unipolar depression in whom the administration of zimelidine, a potent and selective 5-hydroxytryptamine reuptake inhibitor, led to the development of a hypersensitivity reaction characterized by a severe headache, low grade fever, abnormal liver enzymes, and generalized myalgia 10 days after initiation of treatment. |
1984-10-03 |
2023-08-12 |
Not clear |
| H M van Praa. Studies in the mechanism of action of serotonin precursors in depression. Psychopharmacology bulletin. vol 20. issue 3. 1984-10-03. PMID:6473668. |
studies in the mechanism of action of serotonin precursors in depression. |
1984-10-03 |
2023-08-12 |
Not clear |
| A Aberg-Wistedt, S B Ross, K G Jostell, B Sjöquis. A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a norepinephrine uptake inhibitor, in endogenous depression: clinical and biochemical findings. Advances in biochemical psychopharmacology. vol 39. 1984-09-18. PMID:6205564. |
a double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a norepinephrine uptake inhibitor, in endogenous depression: clinical and biochemical findings. |
1984-09-18 |
2023-08-12 |
Not clear |