| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Weizman, M Carmi, S Tyano, A Apter, M Rehav. High affinity [3H]imipramine binding and serotonin uptake to platelets of adolescent females suffering from anorexia nervosa. Life sciences. vol 38. issue 13. 1986-05-19. PMID:3959752. |
the fact that the decrease in imipramine binding is not accompanied by a parallel reduction in serotonin uptake might indicate that anorexia nervosa is not ultimately related to major depression and that the imipramine binding site is not identical to the serotonin uptake site. |
1986-05-19 |
2023-08-11 |
Not clear |
| M Asberg, B Eriksson, B Mårtensson, L Träskman-Bendz, A Wägne. Therapeutic effects of serotonin uptake inhibitors in depression. The Journal of clinical psychiatry. vol 47 Suppl. 1986-05-14. PMID:2937776. |
therapeutic effects of serotonin uptake inhibitors in depression. |
1986-05-14 |
2023-08-11 |
Not clear |
| M Asberg, B Eriksson, B Mårtensson, L Träskman-Bendz, A Wägne. Therapeutic effects of serotonin uptake inhibitors in depression. The Journal of clinical psychiatry. vol 47 Suppl. 1986-05-14. PMID:2937776. |
depression has been associated with a disturbance in serotonin function as reflected in platelet uptake of the transmitter as well as in csf levels of its major metabolite, 5-hydroxyindoleacetic acid (5-hiaa). |
1986-05-14 |
2023-08-11 |
Not clear |
| M Asberg, B Eriksson, B Mårtensson, L Träskman-Bendz, A Wägne. Therapeutic effects of serotonin uptake inhibitors in depression. The Journal of clinical psychiatry. vol 47 Suppl. 1986-05-14. PMID:2937776. |
the biochemical effects of some serotonin uptake inhibitors and their clinical and research potential in depression are reviewed. |
1986-05-14 |
2023-08-11 |
Not clear |
| R Bluth, R Langnickel, T Ot. Modulation by dopaminergic and serotonergic systems of cholinergic interneurons in nucleus accumbens and striatum. Polish journal of pharmacology and pharmacy. vol 37. issue 6. 1986-05-06. PMID:3832017. |
dopamine and serotonin agonists induced a depression of the enzymatic activity but this effect was less pronounced than the effect on acetylcholine turnover rate. |
1986-05-06 |
2023-08-11 |
Not clear |
| A Roy, D Pickar, M Linnoila, A R Doran, S M Pau. Cerebrospinal fluid monoamine and monoamine metabolite levels and the dexamethasone suppression test in depression. Relationship to life events. Archives of general psychiatry. vol 43. issue 4. 1986-04-24. PMID:2420302. |
however, depressed patients who did not have a life event in the six months before the onset of depression had significantly lower levels of the dopamine metabolite homovanillic acid and the serotonin metabolite 5-hydroxyindoleacetic acid than those with life events. |
1986-04-24 |
2023-08-11 |
Not clear |
| S Consolo, M Sieklucka, F Fiorentini, G Forloni, H Ladinsk. Frontal decortication and adaptive changes in striatal cholinergic neurons in the rat. Brain research. vol 363. issue 1. 1986-03-28. PMID:3004639. |
interruption of the corticostriatal pathway by undercutting the cortex resulted in a reduction of glutamate uptake by 55% and in a depression of acetylcholine (ach) synthesis by 30% in striatum after two postlesion weeks without affecting the content of ach and choline, the specific binding of [3h]dexetimide to muscarinic receptors, the activity of choline acetyltransferase and the levels of noradrenaline, serotonin, dopamine and 3,4-dihydroxyphenylacetic acid. |
1986-03-28 |
2023-08-11 |
rat |
| M F Poirier, C Benkelfat, A M Galzin, S Z Lange. Platelet 3H-imipramine binding and steroid hormones serum concentrations during the menstrual cycle. Psychopharmacology. vol 88. issue 1. 1986-03-10. PMID:3080779. |
this recognition site is associated with the transporter for 5ht, and may be a biological marker in depression. |
1986-03-10 |
2023-08-11 |
human |
| F Owen, D R Chambers, S J Cooper, T J Crow, J A Johnson, R Lofthouse, M Poulte. Serotonergic mechanisms in brains of suicide victims. Brain research. vol 362. issue 1. 1986-02-24. PMID:2417665. |
the results do not provide any evidence of gross alterations in 5-ht mechanisms in suicide or depression. |
1986-02-24 |
2023-08-11 |
Not clear |
| S E Mølle. Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments. Acta psychiatrica Scandinavica. Supplementum. vol 325. 1986-02-21. PMID:2418637. |
these studies strongly indicate that brain serotoninergic function can be disturbed in depressed patients and, thus, lend support to the serotonin deficiency hypothesis in depression. |
1986-02-21 |
2023-08-11 |
Not clear |
| D Healy, P A Carney, A O'Halloran, B E Leonar. Peripheral adrenoceptors and serotonin receptors in depression. Changes associated with response to treatment with trazodone or amitriptyline. Journal of affective disorders. vol 9. issue 3. 1986-02-19. PMID:2934461. |
peripheral adrenoceptors and serotonin receptors in depression. |
1986-02-19 |
2023-08-11 |
Not clear |
| D Healy, P A Carney, A O'Halloran, B E Leonar. Peripheral adrenoceptors and serotonin receptors in depression. Changes associated with response to treatment with trazodone or amitriptyline. Journal of affective disorders. vol 9. issue 3. 1986-02-19. PMID:2934461. |
in addition, female depressives had a slightly lower platelet 5-ht aggregatory response than males irrespective to the type of depression. |
1986-02-19 |
2023-08-11 |
Not clear |
| H A Ei-Fawal, P O Ogunbiyi, V Gordon, P Eyr. Reactivity of the bronchial artery to 5-hydroxytryptamine. Research communications in chemical pathology and pharmacology. vol 50. issue 3. 1986-02-05. PMID:2934778. |
ketanserin on the bronchial artery of the bovine (concentrations: 1.0 x 10(-9) m and 1.0 x 10(-8) m), equine (concentrations: 1.0 x 10(-10) m, 1.0 x 10(-9) m and 1.0 x 10(-8) m) and ovine (concentrations: 1.0 x 10(-10) m, 5.0 x 10(-10) m and 1.0 x 10(-9) m), significantly (p less than 0.05) shifted the concentration response curves to 5-hydroxytryptamine and caused a depression of the maximum at the higher concentrations. |
1986-02-05 |
2023-08-11 |
cattle |
| B E Suranyi-Cadotte, S Gauthier, F Lafaille, S DeFlores, T V Dam, N P Nair, R Quirio. Platelet 3H-imipramine binding distinguishes depression from Alzheimer dementia. Life sciences. vol 37. issue 24. 1986-01-17. PMID:2999549. |
platelet 3h-imipramine binding and serotonin uptake were studied simultaneously in normal subjects and in depressed, parkinsonian and alzheimer's disease patients to investigate the usefulness of these variables in the diagnosis of depression in the elderly. |
1986-01-17 |
2023-08-11 |
human |
| A Roy, D Pickar, M Linnoila, A R Doran, P Ninan, S M Pau. Cerebrospinal fluid monoamine and monoamine metabolite concentrations in melancholia. Psychiatry research. vol 15. issue 4. 1986-01-14. PMID:2415996. |
in patients with major depressive episode with melancholia, levels of hva and of the serotonin metabolite 5-hydroxyindoleacetic acid significantly correlated with the severity of depression. |
1986-01-14 |
2023-08-11 |
Not clear |
| A J Gelenberg, C J Gibso. Tyrosine for the treatment of depression. Nutrition and health. vol 3. issue 3. 1985-12-30. PMID:6443584. |
the two most widely held biochemical models of depression--the catecholamine (ca) and indoleamine (ia) hypotheses--explain depression as a result of deficient transmission of the ca norepinephrine (ne) or the ia serotonin (5-hydroxytryptamine, 5-ht) respectively. |
1985-12-30 |
2023-08-12 |
Not clear |
| E Berry-Kravis, G Dawso. Possible role of gangliosides in regulating an adenylate cyclase-linked 5-hydroxytryptamine (5-HT1) receptor. Journal of neurochemistry. vol 45. issue 6. 1985-12-16. PMID:2997394. |
gangliosides had no effect on the potency of dadle or 3,4-dihydroxyphenylethylamine (dopamine)-mediated depression of cyclic amp levels, suggesting some specificity for 5-ht. |
1985-12-16 |
2023-08-11 |
Not clear |
| N G Ward, J Ang, G Pavinic. A comparison of the acute effects of dextroamphetamine and fenfluramine in depression. Biological psychiatry. vol 20. issue 10. 1985-11-21. PMID:3899198. |
fenfluramine (fen) 40 mg, a selective releaser of serotonin, and dextroamphetamine (dex) 15 mg were administered in a double-blind crossover design to 16 subjects with major affective disorder, depression. |
1985-11-21 |
2023-08-11 |
human |
| S N Young, S E Smith, R O Pihl, F R Ervi. Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology. vol 87. issue 2. 1985-11-19. PMID:3931142. |
although the mood-lowering effect was not as great as that seen in depressed patients, our results suggest that low brain 5ht might be one factor precipitating depression in some patients. |
1985-11-19 |
2023-08-11 |
human |
| O Lingjaerd. From clomipramine to mianserin: therapeutic relevance of interactions with serotonin uptake and storage, as studied in the blood platelet model. Acta psychiatrica Scandinavica. Supplementum. vol 320. 1985-11-15. PMID:3901671. |
serotonin uptake inhibition seems to be one of several mechanisms for obtaining the required normalization of monoamine dysfunction in depression. |
1985-11-15 |
2023-08-11 |
Not clear |