| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Monro, C Swade, A Coppe. Mianserin in the prophylaxis of migraine: a double-blind study. Acta psychiatrica Scandinavica. Supplementum. vol 320. 1985-11-15. PMID:3901676. |
the rationale is discussed for selecting mianserin as a potentially effective migraine prophylactic based on: (i) its ability to restore to normal platelet 5-hydroxytryptamine uptake when this is decreased in depression; (ii) its effect on the central nervous system; and particularly (iii) its antiserotonergic activity. |
1985-11-15 |
2023-08-11 |
Not clear |
| M Joëls, I J Urba. Monoamine-induced responses in lateral septal neurons: influence of iontophoretically applied vasopressin. Brain research. vol 344. issue 1. 1985-11-12. PMID:2864107. |
na, da and 5-ht induced a depression of the spontaneous activity in 70% of the spontaneously active neurons on which they were tested. |
1985-11-12 |
2023-08-11 |
rat |
| M Baudouin-Legros, K H Le Quan-Bui, P Guicheney, L A Kamal, P Meye. Platelet serotonin in essential hypertension and in mental depression. Journal of cardiovascular pharmacology. vol 7 Suppl 7. 1985-10-17. PMID:2412030. |
platelet serotonin in essential hypertension and in mental depression. |
1985-10-17 |
2023-08-11 |
Not clear |
| M Baudouin-Legros, K H Le Quan-Bui, P Guicheney, L A Kamal, P Meye. Platelet serotonin in essential hypertension and in mental depression. Journal of cardiovascular pharmacology. vol 7 Suppl 7. 1985-10-17. PMID:2412030. |
the turnover of serotonin was therefore investigated in two diseases: hypertension (as central serotoninergic neurones appear to modulate central sympathetic nervous activity) and depression (as a central 5-ht-deficiency and a low 3h-imipramine binding on platelets have been described in patients with endogenous depression). |
1985-10-17 |
2023-08-11 |
Not clear |
| M Baudouin-Legros, K H Le Quan-Bui, P Guicheney, L A Kamal, P Meye. Platelet serotonin in essential hypertension and in mental depression. Journal of cardiovascular pharmacology. vol 7 Suppl 7. 1985-10-17. PMID:2412030. |
a reduction in platelet 5-ht level was also observed in depression and was more marked in women than in men. |
1985-10-17 |
2023-08-11 |
Not clear |
| b' V A Pastukhov, V K Bolondinski\\xc4\\xa. [Participation of serotoninergic mechanisms in the regulation of visceral functions during conditioned reflex activity]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 71. issue 6. 1985-10-07. PMID:2993041.' |
an increased level of serotonin in the blood was revealed in neuroses peculiar by a prolonged depression of conditioning. |
1985-10-07 |
2023-08-11 |
Not clear |
| J J Grome, A M Harpe. Serotonin depression of local cerebral glucose utilisation after monoamine oxidase inhibition. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 5. issue 3. 1985-10-04. PMID:4030926. |
serotonin depression of local cerebral glucose utilisation after monoamine oxidase inhibition. |
1985-10-04 |
2023-08-11 |
rat |
| L H Price, D S Charney, G R Heninge. Effects of tranylcypromine treatment on neuroendocrine, behavioral, and autonomic responses to tryptophan in depressed patients. Life sciences. vol 37. issue 9. 1985-10-04. PMID:4033356. |
these results suggest that tranylcypromine treatment may enhance serotonin function in depression. |
1985-10-04 |
2023-08-11 |
Not clear |
| W F Byerley, S C Risc. Depression and serotonin metabolism: rationale for neurotransmitter precursor treatment. Journal of clinical psychopharmacology. vol 5. issue 4. 1985-09-19. PMID:2410463. |
depression and serotonin metabolism: rationale for neurotransmitter precursor treatment. |
1985-09-19 |
2023-08-11 |
Not clear |
| G R Breese, S Coyle, G D Frye, R A Muelle. Effects of TRH, ethanol, and TRH-ethanol combination on activity in rats with altered monoamine content. Pharmacology, biochemistry, and behavior. vol 22. issue 6. 1985-09-16. PMID:3927322. |
while reduction of brain serotonin did not affect the ethanol-induced changes in activity, preferential reduction of dopamine as well as reduction of both norepinephrine and dopamine significantly antagonized this measure of ethanol-induced depression. |
1985-09-16 |
2023-08-11 |
rat |
| C Dreux, J M Launa. [Blood platelets: neuronal model in psychiatric disorders]. L'Encephale. vol 11. issue 2. 1985-09-06. PMID:2862006. |
for example: serotonin uptake, bioamine storage, enzymatic activities are modified in different types of depression and schizophrenia, infantile autism, neurologic diseases (migraine, chorea, down syndrom). |
1985-09-06 |
2023-08-11 |
Not clear |
| N J Rusch, D Chyatte, T M Sundt, P M Vanhoutt. 5-hydroxytryptamine: source of activator calcium in human basilar arteries. Stroke. vol 16. issue 4. 1985-09-04. PMID:4024184. |
in both cases, the depression of the response to 5-hydroxytryptamine was comparable to that seen when kcl was used to contract the vessels. |
1985-09-04 |
2023-08-11 |
human |
| P Bauman. Transport systems and enzymes involved in the metamorphosis of tryptophan into serotonin. Pharmacopsychiatry. vol 18. issue 2. 1985-09-03. PMID:3875108. |
tryptophan (trp), as the precursor of serotonin, has been introduced in the treatment of depression and isomnia, but its clinical effectiveness must be considered with caution. |
1985-09-03 |
2023-08-11 |
Not clear |
| B Müller-Oerlinghause. Lithium long-term treatment--does it act via serotonin? Pharmacopsychiatry. vol 18. issue 2. 1985-09-03. PMID:3927331. |
taking into account that, firstly, lithium possesses antiaggressive effects in animals and men, and secondly, that (auto-)aggression seems to be related to a low concentration of 5-hiaa in csf, and thirdly, that a close relationship exists between depression and aggressive behavior, the proof of 5-ht agonistic effects in humans may enable us to formulate an integrative theory on the mode of action of lithium salts. |
1985-09-03 |
2023-08-11 |
Not clear |
| C J Schmidt, J W Gib. Role of the serotonin uptake carrier in the neurochemical response to methamphetamine: effects of citalopram and chlorimipramine. Neurochemical research. vol 10. issue 5. 1985-08-22. PMID:3859754. |
the role of the serotonin uptake carrier in the methamphetamine-induced depression of serotonin synthesis was examined. |
1985-08-22 |
2023-08-11 |
Not clear |
| C J Schmidt, J W Gib. Role of the serotonin uptake carrier in the neurochemical response to methamphetamine: effects of citalopram and chlorimipramine. Neurochemical research. vol 10. issue 5. 1985-08-22. PMID:3859754. |
furthermore, the methamphetamine-induced depression of serotonin synthesis is dependent upon a functional serotonin uptake system. |
1985-08-22 |
2023-08-11 |
Not clear |
| S W Cadde. The digastric reflex evoked by tooth-pulp stimulation in the cat and its modulation by stimuli applied to the limbs. Brain research. vol 336. issue 1. 1985-08-20. PMID:4005575. |
the serotonin antagonists, methysergide and cinanserin, strongly depressed the digastric reflex but it was not clear whether these drugs also affected the depression of the reflex by the conditioning stimuli. |
1985-08-20 |
2023-08-11 |
cat |
| Y Take, S Narumi, E Kurihara, M Shibota, Y Saji, Y Nagaw. [Pharmacological study of the temporary cerebral ischemic rats produced by bilateral vertebral and carotid artery occlusion. Effects of DN-1417]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 85. issue 3. 1985-08-12. PMID:2861149. |
in addition, dn-1417 (10 mg/kg) recovered the various changes such as decrease of 5-hydroxytryptamine (5-ht) levels, increase of cyclic amp (camp) levels, inhibition of [3h]-choline uptake, depression of choline acetyltransferase (cat) and acetylcholine esterase (ache) activities, and shortened the durations of hyperperfusion and hypoperfusion of rcbf. |
1985-08-12 |
2023-08-11 |
rat |
| B B Domangue, C G Margolis, D Lieberman, H Kaj. Biochemical correlates of hypnoanalgesia in arthritic pain patients. The Journal of clinical psychiatry. vol 46. issue 6. 1985-07-18. PMID:3158643. |
dopamine levels were positively correlated with both depression and epinephrine levels and negatively correlated with levels of serotonin. |
1985-07-18 |
2023-08-11 |
Not clear |
| P Riederer, H Beckmann, T Brück. [Current biochemical hypotheses of endogenous depression]. Wiener klinische Wochenschrift. vol 97. issue 4. 1985-05-23. PMID:2580396. |
anticholinergic properties, co-modulation of various transmitters by different neuropeptides, great variations in the influence on the "re-uptake" mechanism for noradrenaline and serotonin with no effect by novel antidepressants like iprindole, mianserin and clenbuterol and variability to either stimulate or block receptor systems (alpha 1-, alpha 2-, beta-, serotonin-, dopamine-, adenylate cyclase dependent-, histaminergic receptors and possibly others) might further indicate a complex pathobiochemical background to depression. |
1985-05-23 |
2023-08-11 |
Not clear |