| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Nagayama, J Akiyoshi, M Tob. Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. Pharmacology, biochemistry, and behavior. vol 25. issue 4. 1987-01-13. PMID:3491369. |
the purpose of the present study was to test this theory further by using the model of depression in rats induced by l-5-hydroxytryptophan (5-htp), the precursor of 5-ht. |
1987-01-13 |
2023-08-11 |
human |
| H Nagayama, J Akiyoshi, M Tob. Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. Pharmacology, biochemistry, and behavior. vol 25. issue 4. 1987-01-13. PMID:3491369. |
the drug effects on 5-htp (25 mg/kg) induced behavioral depression were tested by chronic administration using methysergide which is a postsynaptic blocker of 5-ht, or by comparable clinical doses of antidepressant drugs. |
1987-01-13 |
2023-08-11 |
human |
| H Nagayama, J Akiyoshi, M Tob. Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. Pharmacology, biochemistry, and behavior. vol 25. issue 4. 1987-01-13. PMID:3491369. |
considering these results in light of recent data reported on the 5-ht synapse, it was suggested that 5-htp induced depression may be induced by excessive transmission of 5-ht and that some antidepressant drugs may produce their effect by blocking this postsynaptic transmission. |
1987-01-13 |
2023-08-11 |
human |
| G A Kennett, F Chaouloff, M Marcou, G Curzo. Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. Brain research. vol 382. issue 2. 1986-11-18. PMID:3756525. |
female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. |
1986-11-18 |
2023-08-11 |
rat |
| D M Stone, D C Stahl, G R Hanson, J W Gib. The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain. European journal of pharmacology. vol 128. issue 1-2. 1986-11-17. PMID:2875893. |
in all regions examined, the reduction in 5-ht content corresponded to the depression of tph activity. |
1986-11-17 |
2023-08-11 |
rat |
| J K Tews, A E Harpe. Tissue amino acids in rats fed norleucine, norvaline, homoarginine or other amino acid analogues. The Journal of nutrition. vol 116. issue 8. 1986-10-30. PMID:2428957. |
dopamine was not low in brains having low tyrosine levels; serotonin was low in rats receiving alpha-aminooctanoate, the only analogue associated with a significant depression in brain tryptophan. |
1986-10-30 |
2023-08-11 |
rat |
| H M van Praa. Affective disorders and aggression disorders: evidence for a common biological mechanism. Suicide & life-threatening behavior. vol 16. issue 2. 1986-10-20. PMID:2428139. |
this chapter reviews the evidence in favor of a relationship between depression and central 5-ht dysfunctions. |
1986-10-20 |
2023-08-11 |
Not clear |
| H M van Praa. Affective disorders and aggression disorders: evidence for a common biological mechanism. Suicide & life-threatening behavior. vol 16. issue 2. 1986-10-20. PMID:2428139. |
although no single 5-ht-related finding in depression has so far been unequivocally established, the available evidence, in balance, justifies the tentative conclusion that disturbances in 5-ht metabolism can occur in depression. |
1986-10-20 |
2023-08-11 |
Not clear |
| D Paupardin-Tritsch, C Hammond, H M Gerschenfel. Serotonin and cyclic GMP both induce an increase of the calcium current in the same identified molluscan neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 9. 1986-10-17. PMID:2427671. |
however, in a group of identified ventral neurons of the snail helix aspersa in which 5-ht (1-10 microm) also prolonged the duration of the ca2+-dependent action potential, no 5-ht-induced depression of s current or of any other outward current was observed. |
1986-10-17 |
2023-08-11 |
Not clear |
| S Garattini, T Mennini, C Bendotti, R Invernizzi, R Samani. Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system. Appetite. vol 7 Suppl. 1986-09-18. PMID:2427023. |
several studies with drugs affecting different serotonin mechanisms such as release and uptake or mimicking the action of serotonin at post-synaptic receptors suggest that increase serotonin release and direct stimulation of postsynaptic receptors are the most effective mechanisms for causing depression of food intake, although inhibition of serotonin uptake may also contribute in appropriate conditions. |
1986-09-18 |
2023-08-11 |
Not clear |
| J D Leande. Peripheral action of serotonin as a model of depression. Biological psychiatry. vol 21. issue 8-9. 1986-09-16. PMID:3488080. |
peripheral action of serotonin as a model of depression. |
1986-09-16 |
2023-08-11 |
Not clear |
| M E Trulson, T Cris. Do serotonin-containing dorsal raphe neurons possess autoreceptors? Experimental brain research. vol 62. issue 3. 1986-08-06. PMID:2941313. |
similarly, increasing the concentration of serotonin in the tissue slice by adding serotonin directly to the incubation medium resulted in a profound, though transitory, depression of rd neuron activity. |
1986-08-06 |
2023-08-11 |
mouse |
| Y Sugimoto, J Yamada, K Horisak. Effect of tryptamine on the behavior of mice. Journal of pharmacobio-dynamics. vol 9. issue 1. 1986-07-02. PMID:2940357. |
our results show that trm induced both the depression and excitation in the behavior of mice depending on the dosage and trm-induced excitatory behaviors may be attributed to both its direct stimulation of 5-ht receptors and facilitation of 5-ht release. |
1986-07-02 |
2023-08-11 |
mouse |
| C Nyström, S B Ross, T Hällström, D Kelde. Comparison between a serotonin and a noradrenaline reuptake blocker in the treatment of depressed outpatients. Biochemical aspects. Acta psychiatrica Scandinavica. vol 73. issue 2. 1986-06-13. PMID:2939691. |
these findings support the hypothesis of a subgroup of depression characterized by serotonin disturbance. |
1986-06-13 |
2023-08-11 |
rat |
| S Jeftinija, C Raspantini, M Randić, T L Yaksh, V L Go, A A Larso. Altered responsiveness to substance P and 5-hydroxytryptamine in cat dorsal horn neurons after 5-HT depletion with p-chlorophenylalanine. Brain research. vol 368. issue 1. 1986-05-22. PMID:2420413. |
at the same time, depression induced by 5-ht in the dorsal horn cells was virtually absent in p-cpa-pretreated animals. |
1986-05-22 |
2023-08-11 |
cat |
| R Weizman, M Carmi, S Tyano, A Apter, M Rehav. High affinity [3H]imipramine binding and serotonin uptake to platelets of adolescent females suffering from anorexia nervosa. Life sciences. vol 38. issue 13. 1986-05-19. PMID:3959752. |
the fact that the decrease in imipramine binding is not accompanied by a parallel reduction in serotonin uptake might indicate that anorexia nervosa is not ultimately related to major depression and that the imipramine binding site is not identical to the serotonin uptake site. |
1986-05-19 |
2023-08-11 |
Not clear |
| M Asberg, B Eriksson, B Mårtensson, L Träskman-Bendz, A Wägne. Therapeutic effects of serotonin uptake inhibitors in depression. The Journal of clinical psychiatry. vol 47 Suppl. 1986-05-14. PMID:2937776. |
depression has been associated with a disturbance in serotonin function as reflected in platelet uptake of the transmitter as well as in csf levels of its major metabolite, 5-hydroxyindoleacetic acid (5-hiaa). |
1986-05-14 |
2023-08-11 |
Not clear |
| M Asberg, B Eriksson, B Mårtensson, L Träskman-Bendz, A Wägne. Therapeutic effects of serotonin uptake inhibitors in depression. The Journal of clinical psychiatry. vol 47 Suppl. 1986-05-14. PMID:2937776. |
therapeutic effects of serotonin uptake inhibitors in depression. |
1986-05-14 |
2023-08-11 |
Not clear |
| M Asberg, B Eriksson, B Mårtensson, L Träskman-Bendz, A Wägne. Therapeutic effects of serotonin uptake inhibitors in depression. The Journal of clinical psychiatry. vol 47 Suppl. 1986-05-14. PMID:2937776. |
the biochemical effects of some serotonin uptake inhibitors and their clinical and research potential in depression are reviewed. |
1986-05-14 |
2023-08-11 |
Not clear |
| R Bluth, R Langnickel, T Ot. Modulation by dopaminergic and serotonergic systems of cholinergic interneurons in nucleus accumbens and striatum. Polish journal of pharmacology and pharmacy. vol 37. issue 6. 1986-05-06. PMID:3832017. |
dopamine and serotonin agonists induced a depression of the enzymatic activity but this effect was less pronounced than the effect on acetylcholine turnover rate. |
1986-05-06 |
2023-08-11 |
Not clear |