| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Boismare, J P Lhuintre, M Daoust, N Moore, C Saligaut, B Hilleman. Platelet affinity for serotonin is increased in alcoholics and former alcoholics: a biological marker for dependence? Alcohol and alcoholism (Oxford, Oxfordshire). vol 22. issue 2. 1987-11-09. PMID:2888469. |
we believe that this increased platelet affinity for serotonin, in the absence of cirrhosis of the liver and/or depression could be a marker for alcohol dependence, enabling the therapeutic effort to be focussed on these patients. |
1987-11-09 |
2023-08-11 |
rat |
| A J Rapkin, E Edelmuth, L C Chang, A E Reading, M T McGuire, T P S. Whole-blood serotonin in premenstrual syndrome. Obstetrics and gynecology. vol 70. issue 4. 1987-10-22. PMID:3627623. |
decreased serotonin is known to be associated with depression in humans, and nonhuman primates have exhibited abnormal behavioral profiles when given serotonin antagonists. |
1987-10-22 |
2023-08-11 |
human |
| M B Weinger, E J Cline, N T Smith, G F Koo. Ketanserin pretreatment reverses alfentanil-induced muscle rigidity. Anesthesiology. vol 67. issue 3. 1987-10-09. PMID:3115150. |
pretreatment with type-2 serotonin antagonists may be clinically useful in attenuating opiate-induced rigidity, although further studies will be necessary to assess the interaction of possibly enhanced cns, cardiovascular, and respiratory depression. |
1987-10-09 |
2023-08-11 |
rat |
| T Ishii, Y Shim. Effect of cooling on ovalbumin-induced contraction of the tracheal muscle isolated from actively sensitized rat. Archives internationales de pharmacodynamie et de therapie. vol 287. issue 1. 1987-10-07. PMID:3632137. |
on the other hand, 5-ht-induced contractile responses of the trachea which was incubated with normal and ca2+-free krebs bicarbonate solution containing atropine (1 microm) were both augmented by 20 degrees c. in the presence of atropine (1 microm), diltiazem in a concentration of 10 microm, which almost abolished the potassium chloride (kcl, 20-40 mm) induced contraction, caused partial depression of the contractile response to 5-ht at 20 degrees c but not at 37 degrees c. the present results demonstrate that the cooling-induced augmentation of the sensitized rat trachea to oa is due to the increase of tissue responsiveness to 5-ht which is an important chemical mediator in the anaphylactic response. |
1987-10-07 |
2023-08-11 |
rat |
| R P Sharma, R A Coulomb. Effects of repeated doses of aspartame on serotonin and its metabolite in various regions of the mouse brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 25. issue 8. 1987-10-01. PMID:2442082. |
an increased supply of phenylalanine may be responsible for a decrease in tryptophan uptake by the brain tissue or for a depression in tryptophan conversion to serotonin. |
1987-10-01 |
2023-08-11 |
mouse |
| G K Pike, D I Ker. The influence of temperature upon depolarizing responses of rat isolated vagal nerve to 5-hydroxytryptamine. Brain research. vol 413. issue 2. 1987-09-18. PMID:3607489. |
in isolated cervical segments of rat vagus nerve, over the temperature range 5-45 degrees c, reversible depolarizations to 5-hydroxytryptamine (5-ht) were maximal at 10 degrees c and negligible at 45 degrees c. dose-response curves for this depolarization were compared at 20 degrees c and 37 degrees c, with a similar sensitivity but marked proportionate reduction at 37 degrees c vs 20 degrees c, whilst the 5-ht-induced depression of vagal compound action potentials seen at 20 degrees c was abolished at 37 degrees c; such changes at 20 degrees c or 37 degrees c were insensitive to inhibitors of 5-ht-uptake (zimelidine) or mao (pargyline). |
1987-09-18 |
2023-08-11 |
rat |
| C Vindreau, D Gineste. [Sweet bulimia, salty bulimia. 2 syndromes]. L'Encephale. vol 13. issue 3. 1987-08-26. PMID:3109875. |
these results are consistent with literature data on carbohydrate metabolism, impulsivity disorders, depression and cerebral serotonin. |
1987-08-26 |
2023-08-11 |
human |
| J Zohar, T R Inse. Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology. Biological psychiatry. vol 22. issue 6. 1987-08-11. PMID:3036259. |
putative biological markers previously reported in depression were studied in this disorder and revealed that on some measures [dexamethasone suppression test and rapid eye movement (rem) latency on sleep electroencephalogram (eeg)], ocd patients resemble those with major depressive disorder (mdd), whereas on others [rem density, platelet serotonin uptake, probably platelet 3h-imipramine binding, and 5-hydroxy-indoleacetic acid (5-hiaa) in cerebral spinal fluid (csf)] they do not. |
1987-08-11 |
2023-08-11 |
human |
| R B Innis, D S Charney, G R Heninge. Differential 3H-imipramine platelet binding in patients with panic disorder and depression. Psychiatry research. vol 21. issue 1. 1987-08-10. PMID:3037580. |
because 3h-imi binding is associated with the serotonin reuptake site in platelet and brain membranes, these findings give further support to abnormalities in serotonergic function in patients with major depression. |
1987-08-10 |
2023-08-11 |
human |
| R Malmgren, A Aberg-Wistedt, L Bertilsso. Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. Psychopharmacology. vol 92. issue 2. 1987-08-04. PMID:2440073. |
serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. |
1987-08-04 |
2023-08-11 |
Not clear |
| W F Byerley, L L Judd, F W Reimherr, B I Grosse. 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. Journal of clinical psychopharmacology. vol 7. issue 3. 1987-07-31. PMID:3298325. |
alterations in serotonin metabolism may be an important factor in the etiology and treatment of depression. |
1987-07-31 |
2023-08-11 |
human |
| W F Byerley, L L Judd, F W Reimherr, B I Grosse. 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. Journal of clinical psychopharmacology. vol 7. issue 3. 1987-07-31. PMID:3298325. |
in this regard, 5-hydroxytryptophan (5-htp), a serotonin precursor, has been given to patients with depression. |
1987-07-31 |
2023-08-11 |
human |
| G M Bressa, S Marini, S Gregor. Serotonin S2 receptors blockage and generalized anxiety disorders. A double-blind study on ritanserin and lorazepam. International journal of clinical pharmacology research. vol 7. issue 2. 1987-07-10. PMID:3108171. |
serotonin (5-ht) and 5-ht receptors are involved in mood disturbances, such as anxiety and depression. |
1987-07-10 |
2023-08-11 |
Not clear |
| H M Emrich, M Berger, D Riemann, D von Zersse. Serotonin reuptake inhibition vs. norepinephrine reuptake inhibition: a double-blind differential-therapeutic study with fluvoxamine and oxaprotiline in endogenous and neurotic depressives. Pharmacopsychiatry. vol 20. issue 2. 1987-07-01. PMID:3108909. |
the antidepressive properties of the specific serotonin reuptake inhibitor fluvoxamine and the specific norepinephrine reuptake inhibitor oxaprotiline were investigated in a sequential design with the aim of evaluating the hypothesis that two distinct biochemical subtypes of depression exist. |
1987-07-01 |
2023-08-11 |
Not clear |
| S E Smith, R O Pihl, S N Young, F R Ervi. A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males. Psychopharmacology. vol 91. issue 4. 1987-06-30. PMID:3108925. |
our data strongly support the idea that 5ht exerts an effect on mood and that low 5ht may, in some patients, be an important factor contributing to the etiology of clinical depression. |
1987-06-30 |
2023-08-11 |
human |
| A Gjerris, A S Sørensen, O J Rafaelsen, L Werdelin, C Alling, M Linnoil. 5-HT and 5-HIAA in cerebrospinal fluid in depression. Journal of affective disorders. vol 12. issue 1. 1987-06-11. PMID:2437171. |
5-ht and 5-hiaa in cerebrospinal fluid in depression. |
1987-06-11 |
2023-08-11 |
Not clear |
| M E Trulson, C J Frederickso. A comparison of the electrophysiological and pharmacological properties of serotonin-containing neurons in the nucleus raphe dorsalis, raphe medianus and raphe pallidus recorded from mouse brain slices in vitro: role of autoreceptors. Brain research bulletin. vol 18. issue 2. 1987-06-05. PMID:2436725. |
similarly, increasing the concentration of serotonin in the tissue slice by adding serotonin directly to the incubation medium resulted in a profound, though transitory, depression of unit activity. |
1987-06-05 |
2023-08-11 |
mouse |
| K L Brugge, J N Hingtgen, M H Apriso. Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. Pharmacology, biochemistry, and behavior. vol 26. issue 2. 1987-06-02. PMID:3495008. |
model of depression involving the serotonergic system, we predicted the development of receptor supersensitivity of postsynaptic serotonin (5-ht) receptors due to the decreased release of this neurotransmitter as a consequence of chronic reserpine treatment. |
1987-06-02 |
2023-08-11 |
human |
| K L Brugge, J N Hingtgen, M H Apriso. Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. Pharmacology, biochemistry, and behavior. vol 26. issue 2. 1987-06-02. PMID:3495008. |
we found that 5-htp induced behavioral depression was potentiated in rats chronically treated with reserpine, thus suggesting the development of supersensitive 5-ht receptors. |
1987-06-02 |
2023-08-11 |
human |
| K L Brugge, J N Hingtgen, M H Apriso. Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. Pharmacology, biochemistry, and behavior. vol 26. issue 2. 1987-06-02. PMID:3495008. |
these results support the hypothesis that in some types of human depression a decreased release of 5-ht occurs of sufficient duration to permit the subsequent development of supersensitive 5-ht receptors. |
1987-06-02 |
2023-08-11 |
human |