| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Palmer, O Tottmar, R A Deitric. Electrophysiological effects of monoamine-derived aldehydes on single neurons in neocortex and cerebellum in rats. Alcoholism, clinical and experimental research. vol 10. issue 6. 1987-03-18. PMID:2433956. |
serotonin and 5-hydroxy-3-acetaldehyde caused pronounced depression of firing rates both of cerebellar purkinje neurons and neurons in prefrontal cortex. |
1987-03-18 |
2023-08-11 |
rat |
| D Healy, A O'Halloran, P A Carney, B E Leonar. Variations in platelet 5-hydroxytryptamine in control and depressed populations. Journal of psychiatric research. vol 20. issue 4. 1987-03-11. PMID:3806429. |
these findings suggest that depression is associated with a disruption of circadian rhythms, that abnormalities of platelet 5-hydroxytryptamine uptake are secondary to such a disruption and that antidepressants may act to correct this disruption. |
1987-03-11 |
2023-08-11 |
human |
| J L Rausch, D S Janowsky, S C Risch, L Y Hue. A kinetic analysis and replication of decreased platelet serotonin uptake in depressed patients. Psychiatry research. vol 19. issue 2. 1987-01-22. PMID:3786602. |
these results are compared with previous studies of platelet serotonin transport in clinically depressed patients and in physostigmine-induced depression. |
1987-01-22 |
2023-08-11 |
Not clear |
| B D Waterhouse, H C Moises, D J Woodwar. Interaction of serotonin with somatosensory cortical neuronal responses to afferent synaptic inputs and putative neurotransmitters. Brain research bulletin. vol 17. issue 4. 1987-01-20. PMID:2877719. |
in some cases evoked spiking was reduced from control levels at doses of 5-ht subthreshold for producing direct depression of baseline firing rate. |
1987-01-20 |
2023-08-11 |
rat |
| H Nagayama, J Akiyoshi, M Tob. Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. Pharmacology, biochemistry, and behavior. vol 25. issue 4. 1987-01-13. PMID:3491369. |
a theory of excessive transmission of serotonin (5-ht) in depression has been previously proposed. |
1987-01-13 |
2023-08-11 |
human |
| H Nagayama, J Akiyoshi, M Tob. Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. Pharmacology, biochemistry, and behavior. vol 25. issue 4. 1987-01-13. PMID:3491369. |
the purpose of the present study was to test this theory further by using the model of depression in rats induced by l-5-hydroxytryptophan (5-htp), the precursor of 5-ht. |
1987-01-13 |
2023-08-11 |
human |
| H Nagayama, J Akiyoshi, M Tob. Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. Pharmacology, biochemistry, and behavior. vol 25. issue 4. 1987-01-13. PMID:3491369. |
the drug effects on 5-htp (25 mg/kg) induced behavioral depression were tested by chronic administration using methysergide which is a postsynaptic blocker of 5-ht, or by comparable clinical doses of antidepressant drugs. |
1987-01-13 |
2023-08-11 |
human |
| H Nagayama, J Akiyoshi, M Tob. Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. Pharmacology, biochemistry, and behavior. vol 25. issue 4. 1987-01-13. PMID:3491369. |
considering these results in light of recent data reported on the 5-ht synapse, it was suggested that 5-htp induced depression may be induced by excessive transmission of 5-ht and that some antidepressant drugs may produce their effect by blocking this postsynaptic transmission. |
1987-01-13 |
2023-08-11 |
human |
| G A Kennett, F Chaouloff, M Marcou, G Curzo. Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. Brain research. vol 382. issue 2. 1986-11-18. PMID:3756525. |
female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. |
1986-11-18 |
2023-08-11 |
rat |
| D M Stone, D C Stahl, G R Hanson, J W Gib. The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain. European journal of pharmacology. vol 128. issue 1-2. 1986-11-17. PMID:2875893. |
in all regions examined, the reduction in 5-ht content corresponded to the depression of tph activity. |
1986-11-17 |
2023-08-11 |
rat |
| J K Tews, A E Harpe. Tissue amino acids in rats fed norleucine, norvaline, homoarginine or other amino acid analogues. The Journal of nutrition. vol 116. issue 8. 1986-10-30. PMID:2428957. |
dopamine was not low in brains having low tyrosine levels; serotonin was low in rats receiving alpha-aminooctanoate, the only analogue associated with a significant depression in brain tryptophan. |
1986-10-30 |
2023-08-11 |
rat |
| H M van Praa. Affective disorders and aggression disorders: evidence for a common biological mechanism. Suicide & life-threatening behavior. vol 16. issue 2. 1986-10-20. PMID:2428139. |
this chapter reviews the evidence in favor of a relationship between depression and central 5-ht dysfunctions. |
1986-10-20 |
2023-08-11 |
Not clear |
| H M van Praa. Affective disorders and aggression disorders: evidence for a common biological mechanism. Suicide & life-threatening behavior. vol 16. issue 2. 1986-10-20. PMID:2428139. |
although no single 5-ht-related finding in depression has so far been unequivocally established, the available evidence, in balance, justifies the tentative conclusion that disturbances in 5-ht metabolism can occur in depression. |
1986-10-20 |
2023-08-11 |
Not clear |
| D Paupardin-Tritsch, C Hammond, H M Gerschenfel. Serotonin and cyclic GMP both induce an increase of the calcium current in the same identified molluscan neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 9. 1986-10-17. PMID:2427671. |
however, in a group of identified ventral neurons of the snail helix aspersa in which 5-ht (1-10 microm) also prolonged the duration of the ca2+-dependent action potential, no 5-ht-induced depression of s current or of any other outward current was observed. |
1986-10-17 |
2023-08-11 |
Not clear |
| S Garattini, T Mennini, C Bendotti, R Invernizzi, R Samani. Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system. Appetite. vol 7 Suppl. 1986-09-18. PMID:2427023. |
several studies with drugs affecting different serotonin mechanisms such as release and uptake or mimicking the action of serotonin at post-synaptic receptors suggest that increase serotonin release and direct stimulation of postsynaptic receptors are the most effective mechanisms for causing depression of food intake, although inhibition of serotonin uptake may also contribute in appropriate conditions. |
1986-09-18 |
2023-08-11 |
Not clear |
| J D Leande. Peripheral action of serotonin as a model of depression. Biological psychiatry. vol 21. issue 8-9. 1986-09-16. PMID:3488080. |
peripheral action of serotonin as a model of depression. |
1986-09-16 |
2023-08-11 |
Not clear |
| M E Trulson, T Cris. Do serotonin-containing dorsal raphe neurons possess autoreceptors? Experimental brain research. vol 62. issue 3. 1986-08-06. PMID:2941313. |
similarly, increasing the concentration of serotonin in the tissue slice by adding serotonin directly to the incubation medium resulted in a profound, though transitory, depression of rd neuron activity. |
1986-08-06 |
2023-08-11 |
mouse |
| Y Sugimoto, J Yamada, K Horisak. Effect of tryptamine on the behavior of mice. Journal of pharmacobio-dynamics. vol 9. issue 1. 1986-07-02. PMID:2940357. |
our results show that trm induced both the depression and excitation in the behavior of mice depending on the dosage and trm-induced excitatory behaviors may be attributed to both its direct stimulation of 5-ht receptors and facilitation of 5-ht release. |
1986-07-02 |
2023-08-11 |
mouse |
| C Nyström, S B Ross, T Hällström, D Kelde. Comparison between a serotonin and a noradrenaline reuptake blocker in the treatment of depressed outpatients. Biochemical aspects. Acta psychiatrica Scandinavica. vol 73. issue 2. 1986-06-13. PMID:2939691. |
these findings support the hypothesis of a subgroup of depression characterized by serotonin disturbance. |
1986-06-13 |
2023-08-11 |
rat |
| S Jeftinija, C Raspantini, M Randić, T L Yaksh, V L Go, A A Larso. Altered responsiveness to substance P and 5-hydroxytryptamine in cat dorsal horn neurons after 5-HT depletion with p-chlorophenylalanine. Brain research. vol 368. issue 1. 1986-05-22. PMID:2420413. |
at the same time, depression induced by 5-ht in the dorsal horn cells was virtually absent in p-cpa-pretreated animals. |
1986-05-22 |
2023-08-11 |
cat |