| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Gardette, M Krupa, F Crepe. Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices. Neuroscience. vol 23. issue 2. 1988-03-28. PMID:2893990. |
conversely, the monoamine induced a depression of the excitatory responses induced by four agonists tested and the depressant potency of serotonin was in the order quisqualate, glutamate, aspartate, n-methyl-d,l-aspartate. |
1988-03-28 |
2023-08-11 |
rat |
| P Blier, C de Montigny, Y Chapu. Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. Journal of clinical psychopharmacology. vol 7. issue 6 Suppl. 1988-03-18. PMID:3323264. |
serotonin reuptake blockers may relieve depression through an increased efficacy of the presynaptic element resulting from a desensitization of somatodendritic and terminal 5-ht autoreceptors. |
1988-03-18 |
2023-08-11 |
Not clear |
| G Cournoyer, C de Montigny, J Ouellette, R Langlois, R Elie, G Caille, P le Morva. A comparative double-blind controlled study of trimipramine and amitriptyline in major depression: lack of correlation with 5-hydroxytryptamine reuptake blockade. Journal of clinical psychopharmacology. vol 7. issue 6. 1988-03-15. PMID:3323262. |
a comparative double-blind controlled study of trimipramine and amitriptyline in major depression: lack of correlation with 5-hydroxytryptamine reuptake blockade. |
1988-03-15 |
2023-08-11 |
Not clear |
| D W Robertson, N D Jones, J K Swartzendruber, K S Yang, D T Won. Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor. Journal of medicinal chemistry. vol 31. issue 1. 1988-02-17. PMID:3257267. |
fluoxetine, a selective inhibitor of serotonin uptake, is clinically useful in treating depression and may be useful for management of a variety of other psychiatric and metabolic derangements. |
1988-02-17 |
2023-08-11 |
Not clear |
| J F Cloix, M Crabos, M L Grichois, P Meye. An endogenous digitalis-like compound extracted from human urine: biochemical and chemical studies. Canadian journal of physiology and pharmacology. vol 65. issue 8. 1988-02-11. PMID:2825938. |
the main effects of such a compound were the depression of na+-k+ pump activity of human erythrocytes, the inhibition of 5-hydroxytryptamine reuptake by human platelets, and the induction of natriuresis in urethanized rats. |
1988-02-11 |
2023-08-11 |
human |
| P Kruzik, E Sofic, P Riederer, E Gabrie. Biochemical aspects of dysphoria: case study for hypothesis generation. Psychopathology. vol 20. issue 2. 1988-02-05. PMID:2892224. |
comparing the pattern of serotonin, 5-hydroxyindole acetic acid, 3,4-dihydroxyphenyl acetic acid and homovanillic acid in five brain areas of one dysphoric patient to those of 3 depressed patients it seems that dysphoria biochemically is a state between depression and mania. |
1988-02-05 |
2023-08-11 |
Not clear |
| D W Gietzen, Q R Rogers, P M Leung, B Semon, T Piechot. Serotonin and feeding responses of rats to amino acid imbalance: initial phase. The American journal of physiology. vol 253. issue 5 Pt 2. 1988-01-12. PMID:2446514. |
pcpa and dht may have caused receptor supersensitivity, such that the food intake depression after serotonin depletion was similar to that seen with the quip and trp treatments. |
1988-01-12 |
2023-08-11 |
rat |
| M J Sarrias, F Artigas, E Martínez, E Gelpí, E Alvarez, C Udina, M Casa. Decreased plasma serotonin in melancholic patients: a study with clomipramine. Biological psychiatry. vol 22. issue 12. 1988-01-12. PMID:3676370. |
the very marked decrease in plasma 5-ht levels may be in accord with the central nervous system changes reported in depression and suggests the possibility of using plasma 5-ht as a peripheral indicator of abnormal serotonin function in melancholia. |
1988-01-12 |
2023-08-11 |
Not clear |
| A Biegon, A Weizman, L Karp, A Ram, S Tiano, M Wolf. Serotonin 5-HT2 receptor binding on blood platelets--a peripheral marker for depression? Life sciences. vol 41. issue 22. 1987-12-23. PMID:3683087. |
serotonin 5-ht2 receptor binding on blood platelets--a peripheral marker for depression? |
1987-12-23 |
2023-08-11 |
human |
| A Biegon, A Weizman, L Karp, A Ram, S Tiano, M Wolf. Serotonin 5-HT2 receptor binding on blood platelets--a peripheral marker for depression? Life sciences. vol 41. issue 22. 1987-12-23. PMID:3683087. |
thus, ketanserin can be used to monitor changes in platelet serotonin 5-ht2 receptors which may be a relevant marker for the state of depression. |
1987-12-23 |
2023-08-11 |
human |
| S A Montgomer. The psychopharmacology of borderline personality disorders. Acta psychiatrica Belgica. vol 87. issue 3. 1987-12-15. PMID:3673629. |
a substantial body of research has established an association between disturbance of serotonin and also dopamine and suicidal behaviour in depression. |
1987-12-15 |
2023-08-11 |
Not clear |
| T J Feuerstein, A Lupp, G Herttin. The serotonin (5-HT) autoreceptor in the hippocampus of the rabbit: role of 5-HT biophase concentration. Neuropharmacology. vol 26. issue 8. 1987-11-18. PMID:2958718. |
the inhibitor of the uptake of 5-ht, 6-nitroquipazine diminished the autoreceptor-mediated depression of release of 5-ht. |
1987-11-18 |
2023-08-11 |
rat |
| F Boismare, J P Lhuintre, M Daoust, N Moore, C Saligaut, B Hilleman. Platelet affinity for serotonin is increased in alcoholics and former alcoholics: a biological marker for dependence? Alcohol and alcoholism (Oxford, Oxfordshire). vol 22. issue 2. 1987-11-09. PMID:2888469. |
we believe that this increased platelet affinity for serotonin, in the absence of cirrhosis of the liver and/or depression could be a marker for alcohol dependence, enabling the therapeutic effort to be focussed on these patients. |
1987-11-09 |
2023-08-11 |
rat |
| A J Rapkin, E Edelmuth, L C Chang, A E Reading, M T McGuire, T P S. Whole-blood serotonin in premenstrual syndrome. Obstetrics and gynecology. vol 70. issue 4. 1987-10-22. PMID:3627623. |
decreased serotonin is known to be associated with depression in humans, and nonhuman primates have exhibited abnormal behavioral profiles when given serotonin antagonists. |
1987-10-22 |
2023-08-11 |
human |
| M B Weinger, E J Cline, N T Smith, G F Koo. Ketanserin pretreatment reverses alfentanil-induced muscle rigidity. Anesthesiology. vol 67. issue 3. 1987-10-09. PMID:3115150. |
pretreatment with type-2 serotonin antagonists may be clinically useful in attenuating opiate-induced rigidity, although further studies will be necessary to assess the interaction of possibly enhanced cns, cardiovascular, and respiratory depression. |
1987-10-09 |
2023-08-11 |
rat |
| T Ishii, Y Shim. Effect of cooling on ovalbumin-induced contraction of the tracheal muscle isolated from actively sensitized rat. Archives internationales de pharmacodynamie et de therapie. vol 287. issue 1. 1987-10-07. PMID:3632137. |
on the other hand, 5-ht-induced contractile responses of the trachea which was incubated with normal and ca2+-free krebs bicarbonate solution containing atropine (1 microm) were both augmented by 20 degrees c. in the presence of atropine (1 microm), diltiazem in a concentration of 10 microm, which almost abolished the potassium chloride (kcl, 20-40 mm) induced contraction, caused partial depression of the contractile response to 5-ht at 20 degrees c but not at 37 degrees c. the present results demonstrate that the cooling-induced augmentation of the sensitized rat trachea to oa is due to the increase of tissue responsiveness to 5-ht which is an important chemical mediator in the anaphylactic response. |
1987-10-07 |
2023-08-11 |
rat |
| R P Sharma, R A Coulomb. Effects of repeated doses of aspartame on serotonin and its metabolite in various regions of the mouse brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 25. issue 8. 1987-10-01. PMID:2442082. |
an increased supply of phenylalanine may be responsible for a decrease in tryptophan uptake by the brain tissue or for a depression in tryptophan conversion to serotonin. |
1987-10-01 |
2023-08-11 |
mouse |
| G K Pike, D I Ker. The influence of temperature upon depolarizing responses of rat isolated vagal nerve to 5-hydroxytryptamine. Brain research. vol 413. issue 2. 1987-09-18. PMID:3607489. |
in isolated cervical segments of rat vagus nerve, over the temperature range 5-45 degrees c, reversible depolarizations to 5-hydroxytryptamine (5-ht) were maximal at 10 degrees c and negligible at 45 degrees c. dose-response curves for this depolarization were compared at 20 degrees c and 37 degrees c, with a similar sensitivity but marked proportionate reduction at 37 degrees c vs 20 degrees c, whilst the 5-ht-induced depression of vagal compound action potentials seen at 20 degrees c was abolished at 37 degrees c; such changes at 20 degrees c or 37 degrees c were insensitive to inhibitors of 5-ht-uptake (zimelidine) or mao (pargyline). |
1987-09-18 |
2023-08-11 |
rat |
| C Vindreau, D Gineste. [Sweet bulimia, salty bulimia. 2 syndromes]. L'Encephale. vol 13. issue 3. 1987-08-26. PMID:3109875. |
these results are consistent with literature data on carbohydrate metabolism, impulsivity disorders, depression and cerebral serotonin. |
1987-08-26 |
2023-08-11 |
human |
| J Zohar, T R Inse. Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology. Biological psychiatry. vol 22. issue 6. 1987-08-11. PMID:3036259. |
putative biological markers previously reported in depression were studied in this disorder and revealed that on some measures [dexamethasone suppression test and rapid eye movement (rem) latency on sleep electroencephalogram (eeg)], ocd patients resemble those with major depressive disorder (mdd), whereas on others [rem density, platelet serotonin uptake, probably platelet 3h-imipramine binding, and 5-hydroxy-indoleacetic acid (5-hiaa) in cerebral spinal fluid (csf)] they do not. |
1987-08-11 |
2023-08-11 |
human |