| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J F Deakin, I Pennell, A J Upadhyaya, R Lofthous. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343077. |
blunted gh and prl responses to ltp appear to be distinct abnormalities in depression which may relate to two processes; (1), an endogenous mechanism indicated by reduced gh responses, and (2), an impairment in 5ht systems, indicated by blunted prl responses and perhaps caused by raised circulating cortisol or reduced tryptophan concentrations. |
1990-06-27 |
2023-08-11 |
Not clear |
| S Kasper, A Vieira, R Schmidt, P Richte. Multiple hormone responses to stimulation with dl-fenfluramine in patients with major depression before and after antidepressive treatment. Pharmacopsychiatry. vol 23. issue 2. 1990-06-20. PMID:2339181. |
the authors investigated 31 drug-free inpatients with major depression using dl-fenfluramine (dl-fen) as a serotonin probe (fenfluramine stimulation test, fft). |
1990-06-20 |
2023-08-11 |
Not clear |
| M Maes, M P Jacobs, E Suy, B Minner, C Leclercq, F Christiaens, J Rau. Suppressant effects of dexamethasone on the availability of plasma L-tryptophan and tyrosine in healthy controls and in depressed patients. Acta psychiatrica Scandinavica. vol 81. issue 1. 1990-05-29. PMID:2330824. |
formation in the brain of serotonin from l-tryptophan (l-trp) and noradrenaline from tyrosine are pathways related to the pathophysiology of major depression and to the regulation of the hypothalamic-pituitary-adrenal (hpa) axis. |
1990-05-29 |
2023-08-11 |
Not clear |
| J Hallman, E Sakurai, L Orelan. Blood platelet monoamine oxidase activity, serotonin uptake and release rates in anorexia and bulimia patients and in healthy controls. Acta psychiatrica Scandinavica. vol 81. issue 1. 1990-05-29. PMID:2330833. |
low platelet serotonin uptake rate has been connected to unipolar depression and the rate of efflux, in the presence of the atp uncoupler ccp, higher in bipolar depressives than in controls. |
1990-05-29 |
2023-08-11 |
Not clear |
| A B Katasonov, B S Beliaev, O S Brusov, G P Zlobina, M I Fakto. [Activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 89. issue 12. 1990-05-18. PMID:2633575. |
[activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents]. |
1990-05-18 |
2023-08-11 |
Not clear |
| D Laws, J J Ashford, J A Anste. A multicentre double-blind comparative trial of fluvoxamine versus lorazepam in mixed anxiety and depression treated in general practice. Acta psychiatrica Scandinavica. vol 81. issue 2. 1990-05-14. PMID:2109498. |
fluvoxamine, a selective serotonin reuptake inhibitor, was compared with lorazepam in a multicentre double-blind, parallel group study in 112 general practice patients with mixed anxiety and depression. |
1990-05-14 |
2023-08-11 |
Not clear |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
the putative 5-ht1a autoreceptor antagonist spiperone reversed the cocaine-induced depression of firing rate in 64% of 5-ht neurons tested whereas receptor antagonists for dopamine d2 (haloperidol), 5-ht2 (ketanserin), gamma-aminobutyric acid (picrotoxin) and 5-ht1/beta-adrenergic (propranolol) were ineffective. |
1990-04-05 |
2023-08-11 |
rat |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
following treatment with the 5-ht synthesis inhibitor p-chlorophenylalanine (100 mg/kg/day of the base for 3 days), impulse depression induced by cocaine was significantly attenuated as compared to control, which suggests that the effects of cocaine may be dependent on endogenous 5-ht stores. |
1990-04-05 |
2023-08-11 |
rat |
| A Biegon, A Grinspoon, B Blumenfeld, A Bleich, A Apter, R Meste. Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men. Psychopharmacology. vol 100. issue 2. 1990-03-27. PMID:2305006. |
in search of a physiological marker of depression and suicidal behavior, serotonin receptors of the 5-ht2 type were studied on platelet membranes from 19 control and 22 suicidal subjects. |
1990-03-27 |
2023-08-11 |
human |
| J Kamei, T Mori, M Ogawa, Y Kasuy. Subsensitivity to the cough-depressant effects of opioid and nonopioid antitussives in morphine-dependent rats: relationship to central serotonin function. Pharmacology, biochemistry, and behavior. vol 34. issue 3. 1990-03-26. PMID:2637700. |
it is possible that the decreased sensitivity to both opioid and nonopioid antitussive drugs, in terms of the depression of the cough reflex, in morphine-dependent rats may be due to changes in the number of serotonin receptors. |
1990-03-26 |
2023-08-11 |
rat |
| L C Ricci, M M Wellma. Monoamines: biochemical markers of suicide? Journal of clinical psychology. vol 46. issue 1. 1990-03-19. PMID:1689324. |
this literature review reports the current findings on serotonin (5-ht), dopamine (da), and norepinephrine (ne) as possible biochemical markers of depression and suicide. |
1990-03-19 |
2023-08-11 |
Not clear |
| H Meltze. Serotonergic dysfunction in depression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692637. |
interference with 5-ht synthesis or storage has been shown to induce depression in vulnerable individuals. |
1990-03-15 |
2023-08-11 |
Not clear |
| H Meltze. Serotonergic dysfunction in depression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692637. |
concentrations of 5-hiaa, the major metabolite of 5-ht in plasma, were found to be significantly negatively correlated with severity of depression as measured by the hamilton rating scale for depression score and specific depressive symptoms, despite the fact that plasma 5-hiaa is largely peripheral in origin. |
1990-03-15 |
2023-08-11 |
Not clear |
| Y Ohno, J E Warnic. Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-methyl-D-aspartate receptors. The Journal of pharmacology and experimental therapeutics. vol 252. issue 1. 1990-03-12. PMID:1967645. |
furthermore, the depression of the reflexes by pcp was unaffected by haloperidol and methiothepin precluding the involvement of sigma and serotonin receptors in pcp-induced depression of the polysynaptic reflex. |
1990-03-12 |
2023-08-11 |
rat |
| G Berkenboom, P Unger, Z Y Fang, S Degre, J Fontain. Comparison of responses to acetylcholine and serotonin on isolated canine and human coronary arteries. Cardiovascular research. vol 23. issue 9. 1990-02-27. PMID:2482133. |
acetylcholine (0.1-10 mumol.litre-1) and serotonin (0.1-100 mumol.litre-1) relaxed canine preparations dose dependently, the maximum responses (expressed as % of depression of pgf2 alpha response) being 84 (sem 6)% (n = 9) and 51(5)% (n = 6) respectively. |
1990-02-27 |
2023-08-11 |
human |
| L D Van de Ka. Neuroendocrine aspects of the serotonergic hypothesis of depression. Neuroscience and biobehavioral reviews. vol 13. issue 4. 1990-02-14. PMID:2691929. |
this review examines the role of serotonin (5-ht) in depression. |
1990-02-14 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
lithium and serotonin function: implications for the serotonin hypothesis of depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
a large body of independent evidence suggests that 5-ht function is abnormal in depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
these actions of lithium may serve to correct as-yet unspecified abnormalities of 5-ht function involved in the pathogenesis of depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| R G Robinson, S E Starkstei. Mood disorders following stroke: new findings and future directions. Journal of geriatric psychiatry. vol 22. issue 1. 1990-02-13. PMID:2607085. |
within the left hemisphere, the lower the serotonin binding, the more severe the depression. |
1990-02-13 |
2023-08-11 |
Not clear |