| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T A Slotkin, W L Whitmore, G A Barnes, K R Krishnan, D G Blazer, D L Knight, C B Nemerof. Reduced inhibitory effect of imipramine on radiolabeled serotonin uptake into platelets in geriatric depression. Biological psychiatry. vol 25. issue 6. 1989-05-05. PMID:2538161. |
tritiated imipramine binding, uptake of radiolabeled serotonin, and inhibition of uptake by imipramine in vitro were studied in platelets obtained from four groups of subjects: (1) normal controls 50 years of age or younger, (2) patients with major depression 50 years of age or younger, (3) normal controls 60 years of age or older, and (4) patients with major depression 60 years of age or older. |
1989-05-05 |
2023-08-11 |
human |
| T A Slotkin, W L Whitmore, G A Barnes, K R Krishnan, D G Blazer, D L Knight, C B Nemerof. Reduced inhibitory effect of imipramine on radiolabeled serotonin uptake into platelets in geriatric depression. Biological psychiatry. vol 25. issue 6. 1989-05-05. PMID:2538161. |
depression in both age groups was associated with a substantial decrease in the number of [3h]imipramine binding sites; the elderly depressed patients exhibited a small but significant (p less than 0.05) reduction in platelet [3h]serotonin uptake. |
1989-05-05 |
2023-08-11 |
human |
| H E Connor, W Feniuk, P P Humphre. Characterization of 5-HT receptors mediating contraction of canine and primate basilar artery by use of GR43175, a selective 5-HT1-like receptor agonist. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2538191. |
in canine basilar artery, ketanserin (0.1-1 microm) caused some depression of the maximum effect of 5-ht but produced little or no shift of the concentration-effect curve. |
1989-05-05 |
2023-08-11 |
Not clear |
| H E Connor, W Feniuk, P P Humphre. Characterization of 5-HT receptors mediating contraction of canine and primate basilar artery by use of GR43175, a selective 5-HT1-like receptor agonist. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2538191. |
in primate basilar artery, ketanserin (1 microm) again caused a small depression of the 5-ht maximum response but had not effect against gr43175-induced contractions. |
1989-05-05 |
2023-08-11 |
Not clear |
| G A Higgins, A J Bradbury, B J Jones, N R Oakle. Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the rat. Neuropharmacology. vol 27. issue 10. 1989-05-02. PMID:2467224. |
these findings, together with available electrophysiological data suggest that these behavioural responses are a consequence of a depression of the firing of cells in the dorsal raphé nucleus, with a corresponding decrease in functional activity of 5-ht in the forebrain. |
1989-05-02 |
2023-08-11 |
rat |
| J Butler, B E Leonar. The platelet serotonergic system in depression and following sertraline treatment. International clinical psychopharmacology. vol 3. issue 4. 1989-05-02. PMID:3235819. |
this preliminary study examined the effect of 8 weeks' treatment with the serotonin (5ht) uptake inhibitor, sertraline, on the platelet serotonergic system in depression. |
1989-05-02 |
2023-08-11 |
Not clear |
| B M Baron, A M Ogden, B W Siegel, J Stegeman, R C Ursillo, M W Dudle. Rapid down regulation of beta-adrenoceptors by co-administration of desipramine and fluoxetine. European journal of pharmacology. vol 154. issue 2. 1989-04-20. PMID:2465908. |
consequently, the combination of a norepinephrine and serotonin uptake inhibitor may be an advantageous and rapid treatment for the alleviation of certain forms of depression. |
1989-04-20 |
2023-08-11 |
rat |
| O S Brusov, B S Beliaev, A B Katasonov, G P Zlobina, M I Fakto. [Development of subsensitivity to imipramine in the system of reverse serotonin uptake by thrombocytes in patients with endogenous depression]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 88. issue 9. 1989-04-20. PMID:3232463. |
[development of subsensitivity to imipramine in the system of reverse serotonin uptake by thrombocytes in patients with endogenous depression]. |
1989-04-20 |
2023-08-11 |
Not clear |
| J C Wanstall, S R O'Donnel. Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent. European journal of pharmacology. vol 159. issue 3. 1989-04-19. PMID:2920774. |
accordingly, the depression in the maximum responses to other spasmogens (5-ht or k+) by 1 microm diltiazem was not increased by age (5-ht, young 59%, aged 49% reduction; k+, young 65%, aged 70% reduction). |
1989-04-19 |
2023-08-11 |
rat |
| J Quintan. Platelet serotonin uptake dynamic changes in depression: effects of long-term imipramine treatment and clinical recovery. Journal of affective disorders. vol 16. issue 2-3. 1989-04-14. PMID:2522122. |
platelet serotonin uptake dynamic changes in depression: effects of long-term imipramine treatment and clinical recovery. |
1989-04-14 |
2023-08-11 |
human |
| A Gjerri. Do concentrations of neurotransmitters in lumbar CSF reflect cerebral dysfunction in depression? Acta psychiatrica Scandinavica. Supplementum. vol 345. 1989-04-04. PMID:2906516. |
concentrations of the amines and amine metabolites dopamine (da), noradrenaline (na), adrenaline (a), serotonin (5-ht), homovanillic acid (hva), 3-methoxy-4-hydroxyphenylglycol (mhpg), 5-hydroxyindoleacetic acid (5-hiaa) and of the peptides, vasopressin (avp), vasoactive intestinal polypeptide (vip), thyrotropin releasing hormone (trh) and cholecystokinin (cck) were measured in lumbar cerebrospinal fluid (csf) in patients with depression and compared with that of controls. |
1989-04-04 |
2023-08-11 |
Not clear |
| R S Kahn, G M Asnis, S Wetzler, H M van Praa. Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder. Psychopharmacology. vol 96. issue 3. 1989-03-23. PMID:2906153. |
normal controls (nc) (n = 15), patients with panic disorder (pd) (n = 13) and patients with major depression (md) (n = 17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5ht agonist m-chlorophenyl-piperazine (mcpp) or placebo. |
1989-03-23 |
2023-08-11 |
human |
| R S Kahn, S Wetzler, H M van Praag, G M Asnis, T Strauma. Behavioral indications for serotonin receptor hypersensitivity in panic disorder. Psychiatry research. vol 25. issue 1. 1989-03-08. PMID:3217461. |
immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (mcpp), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. |
1989-03-08 |
2023-08-11 |
Not clear |
| R Mayeux, Y Stern, M Sano, J B Williams, L J Cot. The relationship of serotonin to depression in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 3. issue 3. 1989-01-05. PMID:2461509. |
the relationship of serotonin to depression in parkinson's disease. |
1989-01-05 |
2023-08-11 |
Not clear |
| R Mayeux, Y Stern, M Sano, J B Williams, L J Cot. The relationship of serotonin to depression in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 3. issue 3. 1989-01-05. PMID:2461509. |
we have previously reported a correlation between depression in patients with idiopathic parkinson's disease and decreased concentrations of the cerebrospinal fluid content of the serotonin metabolite, 5-hiaa. |
1989-01-05 |
2023-08-11 |
Not clear |
| R Mayeux, Y Stern, M Sano, J B Williams, L J Cot. The relationship of serotonin to depression in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 3. issue 3. 1989-01-05. PMID:2461509. |
to further examine this relationship, we repeated the study in a new cohort of patients while they remained on dopaminergic medications, conducted follow-up interviews and examinations in our original cohort, and conducted an open trial of the serotonin precursor, 5-hydroxytryptophan in a group of new patients with depression. |
1989-01-05 |
2023-08-11 |
Not clear |
| R Mayeux, Y Stern, M Sano, J B Williams, L J Cot. The relationship of serotonin to depression in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 3. issue 3. 1989-01-05. PMID:2461509. |
these three studies support our hypothesis that depression in idiopathic parkinson's disease is associated with a reduction in brain serotonin. |
1989-01-05 |
2023-08-11 |
Not clear |
| G Curzo. Serotonergic mechanisms of depression. Clinical neuropharmacology. vol 11 Suppl 2. 1988-12-20. PMID:3052824. |
second, data provided by studies of humans and by animal models suggest that vulnerability to depression depends on disturbances of both 5-ht and the hypothalamohypophysial axis. |
1988-12-20 |
2023-08-11 |
human |
| Serotonin and depression. International Symposium on Tianeptine. Satellite of Symposium on Affect and Emotion, World Psychiatric Association. Vienna, Austria, October 10, 1987. Proceedings. Clinical neuropharmacology. vol 11 Suppl 2. 1988-12-20. PMID:3180114. |
serotonin and depression. |
1988-12-20 |
2023-08-11 |
Not clear |
| S N Young, R O Pihl, F R Ervi. The effect of altered tryptophan levels on mood and behavior in normal human males. Clinical neuropharmacology. vol 11 Suppl 1. 1988-11-28. PMID:3052819. |
tryptophan depletion also caused an acute lowering of mood, suggesting that low serotonin (5-ht) may be involved in the etiology of clinical depression in some patients. |
1988-11-28 |
2023-08-11 |
human |