| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Biegon, A Grinspoon, B Blumenfeld, A Bleich, A Apter, R Meste. Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men. Psychopharmacology. vol 100. issue 2. 1990-03-27. PMID:2305006. |
in search of a physiological marker of depression and suicidal behavior, serotonin receptors of the 5-ht2 type were studied on platelet membranes from 19 control and 22 suicidal subjects. |
1990-03-27 |
2023-08-11 |
human |
| J Kamei, T Mori, M Ogawa, Y Kasuy. Subsensitivity to the cough-depressant effects of opioid and nonopioid antitussives in morphine-dependent rats: relationship to central serotonin function. Pharmacology, biochemistry, and behavior. vol 34. issue 3. 1990-03-26. PMID:2637700. |
it is possible that the decreased sensitivity to both opioid and nonopioid antitussive drugs, in terms of the depression of the cough reflex, in morphine-dependent rats may be due to changes in the number of serotonin receptors. |
1990-03-26 |
2023-08-11 |
rat |
| L C Ricci, M M Wellma. Monoamines: biochemical markers of suicide? Journal of clinical psychology. vol 46. issue 1. 1990-03-19. PMID:1689324. |
this literature review reports the current findings on serotonin (5-ht), dopamine (da), and norepinephrine (ne) as possible biochemical markers of depression and suicide. |
1990-03-19 |
2023-08-11 |
Not clear |
| H Meltze. Serotonergic dysfunction in depression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692637. |
interference with 5-ht synthesis or storage has been shown to induce depression in vulnerable individuals. |
1990-03-15 |
2023-08-11 |
Not clear |
| H Meltze. Serotonergic dysfunction in depression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692637. |
concentrations of 5-hiaa, the major metabolite of 5-ht in plasma, were found to be significantly negatively correlated with severity of depression as measured by the hamilton rating scale for depression score and specific depressive symptoms, despite the fact that plasma 5-hiaa is largely peripheral in origin. |
1990-03-15 |
2023-08-11 |
Not clear |
| Y Ohno, J E Warnic. Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-methyl-D-aspartate receptors. The Journal of pharmacology and experimental therapeutics. vol 252. issue 1. 1990-03-12. PMID:1967645. |
furthermore, the depression of the reflexes by pcp was unaffected by haloperidol and methiothepin precluding the involvement of sigma and serotonin receptors in pcp-induced depression of the polysynaptic reflex. |
1990-03-12 |
2023-08-11 |
rat |
| G Berkenboom, P Unger, Z Y Fang, S Degre, J Fontain. Comparison of responses to acetylcholine and serotonin on isolated canine and human coronary arteries. Cardiovascular research. vol 23. issue 9. 1990-02-27. PMID:2482133. |
acetylcholine (0.1-10 mumol.litre-1) and serotonin (0.1-100 mumol.litre-1) relaxed canine preparations dose dependently, the maximum responses (expressed as % of depression of pgf2 alpha response) being 84 (sem 6)% (n = 9) and 51(5)% (n = 6) respectively. |
1990-02-27 |
2023-08-11 |
human |
| L D Van de Ka. Neuroendocrine aspects of the serotonergic hypothesis of depression. Neuroscience and biobehavioral reviews. vol 13. issue 4. 1990-02-14. PMID:2691929. |
this review examines the role of serotonin (5-ht) in depression. |
1990-02-14 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
lithium and serotonin function: implications for the serotonin hypothesis of depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
a large body of independent evidence suggests that 5-ht function is abnormal in depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
these actions of lithium may serve to correct as-yet unspecified abnormalities of 5-ht function involved in the pathogenesis of depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| R G Robinson, S E Starkstei. Mood disorders following stroke: new findings and future directions. Journal of geriatric psychiatry. vol 22. issue 1. 1990-02-13. PMID:2607085. |
within the left hemisphere, the lower the serotonin binding, the more severe the depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| S A Welner, C De Montigny, J Desroches, P Desjardins, B E Suranyi-Cadott. Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse (New York, N.Y.). vol 4. issue 4. 1990-01-31. PMID:2532423. |
there is growing evidence that the serotonergic (5-ht) system is involved in the pathogenesis and treatment of major depression. |
1990-01-31 |
2023-08-11 |
rat |
| H Ono, Y Hasebe, T Mori, H Fukuda, M Kohno, S Ohta, M Hirob. Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats. Journal of pharmacobio-dynamics. vol 12. issue 7. 1990-01-25. PMID:2593080. |
depressions of msr produced by pea, s(+)-methamphetamine and r(+)-2-aminotetralin were antagonized by ketanserin and haloperidol which have 5-hydroxytryptamine (5-ht) antagonistic activity, and the msr depression caused by s(+)-methamphetamine but not pea and r(+)-2-aminotetralin was abolished by intracisternal 5,6-dihydroxytryptamine treatment or chronic spinal transection. |
1990-01-25 |
2023-08-11 |
rat |
| H Ono, Y Hasebe, T Mori, H Fukuda, M Kohno, S Ohta, M Hirob. Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats. Journal of pharmacobio-dynamics. vol 12. issue 7. 1990-01-25. PMID:2593080. |
these results suggest that pea-related compounds cause msr depression by direct and indirect 5-ht agonistic mechanisms, and support the proposal that the pea moiety which exists in r(+)-2-aminotetralin is important for the direct 5-ht agonistic activity of some hallucinogens. |
1990-01-25 |
2023-08-11 |
rat |
| D M Bowen, A Najlerahim, A W Procter, P T Francis, E Murph. Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 23. 1990-01-19. PMID:2574463. |
results for depression expressed per entire area indicate additionally reduced somatostatin content and serotonin 1a sites in the pars opercularis and serotonin 1a sites in the temporal pole. |
1990-01-19 |
2023-08-11 |
Not clear |
| W Bugge, C J Ribbegren, T Gerner, J Haffne. Serotonin--a possible transmitter for the gastric adaptive relaxation. Interaction with histamine and prostaglandin F2 alpha on pressure responses in the isolated stomach. Scandinavian journal of gastroenterology. vol 24. issue 9. 1990-01-17. PMID:2595269. |
to test whether the relaxation response to serotonin is compatible with a putative role as transmitter in gastric adaptive relaxation, we wanted to evaluate whether serotonin acts by crude muscle depression and whether it selectively inhibits histamine or prostaglandin f2 alpha (pgf2 alpha). |
1990-01-17 |
2023-08-11 |
Not clear |
| W Bugge, C J Ribbegren, T Gerner, J Haffne. Serotonin--a possible transmitter for the gastric adaptive relaxation. Interaction with histamine and prostaglandin F2 alpha on pressure responses in the isolated stomach. Scandinavian journal of gastroenterology. vol 24. issue 9. 1990-01-17. PMID:2595269. |
it is then concluded that the relaxatory effect of 5-ht is provided through other mechanisms than crude muscle depression and that selective inhibition of intramural agonists, like histamine, is a possible effect mechanism. |
1990-01-17 |
2023-08-11 |
Not clear |
| S C Cheetham, M R Crompton, C Czudek, R W Horton, C L Katona, G P Reynold. Serotonin concentrations and turnover in brains of depressed suicides. Brain research. vol 502. issue 2. 1990-01-08. PMID:2479456. |
5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) concentrations and 5-ht turnover (5-hiaa/5-ht) were determined in 6 brain regions from 19 suicide victims in whom a retrospective diagnosis of depression was established, and 19 age- and sex-matched control subjects. |
1990-01-08 |
2023-08-11 |
human |
| L M Tremaine, W M Welch, R A Ronfel. Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog. Drug metabolism and disposition: the biological fate of chemicals. vol 17. issue 5. 1989-12-29. PMID:2573498. |
sertaline [1s,4s-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1- naphthalenamine] is a potent and selective inhibitor of neuronal serotonin uptake and is currently under development for the treatment of depression and of obesity. |
1989-12-29 |
2023-08-11 |
rat |