| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Richelso. Biological basis of depression and therapeutic relevance. The Journal of clinical psychiatry. vol 52 Suppl. 1991-07-25. PMID:1646793. |
these effects, derived from neurochemical studies with laboratory animals, have implicated catecholamines and serotonin in depression. |
1991-07-25 |
2023-08-11 |
Not clear |
| P Valeri, G Pimpinella, L A Morrone, L Romanell. Antinociceptive effects of trazodone and m-chlorophenylpiperazine (mCPP) in mice: interaction with morphine. General pharmacology. vol 22. issue 1. 1991-07-24. PMID:2050281. |
the results further support the suggested role played by opioid and 5-ht systems on depression. |
1991-07-24 |
2023-08-11 |
mouse |
| L Barrelet, B Blajev, L Bolzani, C de Saussure, A Kasas, H Van, J P Gachou. [Multicenter study comparing efficacy and tolerance of moclobemide and fluvoxamine in hospitalized and ambulatory patients with severe depressive episodes]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis. vol 80. issue 19. 1991-07-18. PMID:1904620. |
61 patients with major depression (according to dsm-iii) were either treated with moclobemide or fluvoxamine, a selective reuptake-inhibitor of 5-ht. |
1991-07-18 |
2023-08-11 |
Not clear |
| R W Fulle. Role of serotonin in therapy of depression and related disorders. The Journal of clinical psychiatry. vol 52 Suppl. 1991-06-20. PMID:1674251. |
role of serotonin in therapy of depression and related disorders. |
1991-06-20 |
2023-08-11 |
Not clear |
| R W Fulle. Role of serotonin in therapy of depression and related disorders. The Journal of clinical psychiatry. vol 52 Suppl. 1991-06-20. PMID:1674251. |
selective inhibitors of serotonin uptake, which enhance serotonergic function by preventing the removal of serotonin from the synaptic cleft via the membrane transporter, have been introduced for the treatment of depression and may be effective in other disorders. |
1991-06-20 |
2023-08-11 |
Not clear |
| P L Bonat. Serotonin receptor subtypes: functional, physiological, and clinical correlates. Clinical neuropharmacology. vol 14. issue 1. 1991-06-18. PMID:2029690. |
novel treatments for hypertension, migraine headaches, anxiety, and depression using 5-ht are just the beginning. |
1991-06-18 |
2023-08-11 |
human |
| A M Montgomery, I C Rose, L J Herber. 5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward. Journal of neural transmission. General section. vol 83. issue 1-2. 1991-05-28. PMID:1826841. |
depression of self-stimulation by higher doses of 8-oh-dpat may reflect the activity of 8-oh-dpat at postsynaptic 5-ht receptors, with consequent inhibition of da transmission. |
1991-05-28 |
2023-08-11 |
rat |
| E Edwards, K Harkins, G Wright, F Hen. Modulation of [3H]paroxetine binding to the 5-hydroxytryptamine uptake site in an animal model of depression. Journal of neurochemistry. vol 56. issue 5. 1991-05-16. PMID:1826517. |
modulation of [3h]paroxetine binding to the 5-hydroxytryptamine uptake site in an animal model of depression. |
1991-05-16 |
2023-08-11 |
rat |
| I Lucki, S Wielan. 5-Hydroxytryptamine1A receptors and behavioral responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078281. |
these studies have helped define important neuropharmacologic actions on 5-ht receptors that may contribute to therapeutic effects in anxiety and depression. |
1991-04-29 |
2023-08-11 |
Not clear |
| F Licata, G Li Volsi, G Maugeri, L Ciranna, F Santangel. Effects of glutamate on the serotonin-induced responses of vestibular neurons. Bollettino della Societa italiana di biologia sperimentale. vol 66. issue 8. 1991-04-11. PMID:1981315. |
the trend to a depression of the response to 5-ht in function of the background discharge was observed when either the enhancement of firing occurred spontaneously and it was induced by an application of glu, no significant difference (f-test) being found between the two cases. |
1991-04-11 |
2023-08-11 |
rat |
| J Sagen, C E Sortwell, G D Pappa. Monoaminergic neural transplants prevent learned helplessness in a rat depression model. Biological psychiatry. vol 28. issue 12. 1991-04-03. PMID:1963093. |
current theories of the etiology of depression implicate disturbances and imbalances in the function of monoaminergic systems, particularly involving serotonin and norepinephrine. |
1991-04-03 |
2023-08-11 |
rat |
| K P Lesch, H Beckman. [The serotonin hypothesis of depression]. Fortschritte der Neurologie-Psychiatrie. vol 58. issue 11. 1991-03-13. PMID:2177721. |
[the serotonin hypothesis of depression]. |
1991-03-13 |
2023-08-11 |
Not clear |
| F Westwic. Depression and selective serotonin reuptake inhibitors. British journal of hospital medicine. vol 44. issue 5. 1991-03-07. PMID:2148896. |
depression and selective serotonin reuptake inhibitors. |
1991-03-07 |
2023-08-11 |
Not clear |
| G Chouinard, W Goodman, J Greist, M Jenike, S Rasmussen, K White, E Hackett, M Gaffney, P A Bic. Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder. Psychopharmacology bulletin. vol 26. issue 3. 1991-02-26. PMID:2274626. |
eighty-seven patients with a dsm-iii diagnosis of obsessive-compulsive disorder (ocd) without depression were entered into a double-blind, placebo-controlled study of the efficacy of sertraline, a new serotonin uptake inhibitor. |
1991-02-26 |
2023-08-11 |
Not clear |
| Serotonin reuptake inhibition in the management of depression. Proceedings of a satellite symposium in connection with the VIII World Congress of Psychiatry. October 18, 1989, Athens, Greece. The Journal of clinical psychiatry. vol 51 Suppl B. 1991-01-30. PMID:1979557. |
serotonin reuptake inhibition in the management of depression. |
1991-01-30 |
2023-08-11 |
Not clear |
| K Rickels, E Schweize. Clinical overview of serotonin reuptake inhibitors. The Journal of clinical psychiatry. vol 51 Suppl B. 1991-01-30. PMID:2147922. |
although serotonin reuptake inhibitors have not replaced the tricyclics, they are a useful addition to the variety of drugs currently used for the treatment of depression. |
1991-01-30 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Fenfluramine augmentation in tricyclic-refractory depression. Journal of clinical psychopharmacology. vol 10. issue 5. 1991-01-28. PMID:2258448. |
the clinical efficacy of lithium augmentation in refractory depression is hypothesized to depend on the ability of lithium to enhance presynaptic 5-hydroxytryptamine (5-ht) function. |
1991-01-28 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Fenfluramine augmentation in tricyclic-refractory depression. Journal of clinical psychopharmacology. vol 10. issue 5. 1991-01-28. PMID:2258448. |
since fenfluramine promotes release and inhibits reuptake of presynaptic 5-ht, we assessed its efficacy in augmenting ongoing tricyclic antidepressant treatment of refractory depression. |
1991-01-28 |
2023-08-11 |
Not clear |
| H Y Meltze. Role of serotonin in depression. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252328. |
role of serotonin in depression. |
1991-01-14 |
2023-08-11 |
Not clear |
| R W Fuller, D T Won. Serotonin uptake and serotonin uptake inhibition. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252338. |
some serotonin uptake inhibitors are finding therapeutic uses in mental depression and other psychiatric disorders and in treating obesity and bulimia; other therapeutic applications continue to be evaluated. |
1991-01-14 |
2023-08-11 |
Not clear |