| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A A Brzezinski, J J Wurtman, R J Wurtman, R Gleason, J Greenfield, T Nade. d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. Obstetrics and gynecology. vol 76. issue 2. 1990-08-21. PMID:2371034. |
the ability of d-fenfluramine, a drug that releases brain serotonin and blocks its reuptake, to relieve premenstrual depression and excessive calorie and carbohydrate intakes was examined in 17 women with premenstrual syndrome. |
1990-08-21 |
2023-08-11 |
human |
| R Mayeu. Depression in the patient with Parkinson's disease. The Journal of clinical psychiatry. vol 51 Suppl. 1990-08-13. PMID:2195009. |
attempts to alleviate depression with serotonin agonists have proven successful. |
1990-08-13 |
2023-08-11 |
Not clear |
| P Martin, P Soubrié, A J Puec. Reversal of helpless behavior by serotonin uptake blockers in rats. Psychopharmacology. vol 101. issue 3. 1990-08-08. PMID:2362957. |
there is little evidence, however, to suggest that serotonin uptake blockers are efficacious in animal models of depression. |
1990-08-08 |
2023-08-11 |
rat |
| J E Humphries, M S Wheby, S R VandenBer. Fluoxetine and the bleeding time. Archives of pathology & laboratory medicine. vol 114. issue 7. 1990-08-06. PMID:2363631. |
fluoxetine (prozac) is a nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitor commonly prescribed for the treatment of depression. |
1990-08-06 |
2023-08-11 |
Not clear |
| S H Wong, C H Cho, C W Ogl. The role of serotonin in ethanol-induced gastric glandular damage in rats. Digestion. vol 45. issue 1. 1990-06-27. PMID:2340964. |
this depression of gastric mucosal blood flow was further reduced by 5-ht, but was reversed by methysergide. |
1990-06-27 |
2023-08-11 |
rat |
| J F Deakin, I Pennell, A J Upadhyaya, R Lofthous. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343077. |
a neuroendocrine study of 5ht function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. |
1990-06-27 |
2023-08-11 |
Not clear |
| J F Deakin, I Pennell, A J Upadhyaya, R Lofthous. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343077. |
to investigate whether depression is a consequence of disturbed function in 5ht systems, neuroendocrine responses to infusions of the 5ht precursor l-tryptophan (ltp) were studied in patients and controls. |
1990-06-27 |
2023-08-11 |
Not clear |
| J F Deakin, I Pennell, A J Upadhyaya, R Lofthous. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343077. |
blunted gh and prl responses to ltp appear to be distinct abnormalities in depression which may relate to two processes; (1), an endogenous mechanism indicated by reduced gh responses, and (2), an impairment in 5ht systems, indicated by blunted prl responses and perhaps caused by raised circulating cortisol or reduced tryptophan concentrations. |
1990-06-27 |
2023-08-11 |
Not clear |
| S Kasper, A Vieira, R Schmidt, P Richte. Multiple hormone responses to stimulation with dl-fenfluramine in patients with major depression before and after antidepressive treatment. Pharmacopsychiatry. vol 23. issue 2. 1990-06-20. PMID:2339181. |
the authors investigated 31 drug-free inpatients with major depression using dl-fenfluramine (dl-fen) as a serotonin probe (fenfluramine stimulation test, fft). |
1990-06-20 |
2023-08-11 |
Not clear |
| M Maes, M P Jacobs, E Suy, B Minner, C Leclercq, F Christiaens, J Rau. Suppressant effects of dexamethasone on the availability of plasma L-tryptophan and tyrosine in healthy controls and in depressed patients. Acta psychiatrica Scandinavica. vol 81. issue 1. 1990-05-29. PMID:2330824. |
formation in the brain of serotonin from l-tryptophan (l-trp) and noradrenaline from tyrosine are pathways related to the pathophysiology of major depression and to the regulation of the hypothalamic-pituitary-adrenal (hpa) axis. |
1990-05-29 |
2023-08-11 |
Not clear |
| J Hallman, E Sakurai, L Orelan. Blood platelet monoamine oxidase activity, serotonin uptake and release rates in anorexia and bulimia patients and in healthy controls. Acta psychiatrica Scandinavica. vol 81. issue 1. 1990-05-29. PMID:2330833. |
low platelet serotonin uptake rate has been connected to unipolar depression and the rate of efflux, in the presence of the atp uncoupler ccp, higher in bipolar depressives than in controls. |
1990-05-29 |
2023-08-11 |
Not clear |
| A B Katasonov, B S Beliaev, O S Brusov, G P Zlobina, M I Fakto. [Activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 89. issue 12. 1990-05-18. PMID:2633575. |
[activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents]. |
1990-05-18 |
2023-08-11 |
Not clear |
| D Laws, J J Ashford, J A Anste. A multicentre double-blind comparative trial of fluvoxamine versus lorazepam in mixed anxiety and depression treated in general practice. Acta psychiatrica Scandinavica. vol 81. issue 2. 1990-05-14. PMID:2109498. |
fluvoxamine, a selective serotonin reuptake inhibitor, was compared with lorazepam in a multicentre double-blind, parallel group study in 112 general practice patients with mixed anxiety and depression. |
1990-05-14 |
2023-08-11 |
Not clear |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
the putative 5-ht1a autoreceptor antagonist spiperone reversed the cocaine-induced depression of firing rate in 64% of 5-ht neurons tested whereas receptor antagonists for dopamine d2 (haloperidol), 5-ht2 (ketanserin), gamma-aminobutyric acid (picrotoxin) and 5-ht1/beta-adrenergic (propranolol) were ineffective. |
1990-04-05 |
2023-08-11 |
rat |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
following treatment with the 5-ht synthesis inhibitor p-chlorophenylalanine (100 mg/kg/day of the base for 3 days), impulse depression induced by cocaine was significantly attenuated as compared to control, which suggests that the effects of cocaine may be dependent on endogenous 5-ht stores. |
1990-04-05 |
2023-08-11 |
rat |
| A Biegon, A Grinspoon, B Blumenfeld, A Bleich, A Apter, R Meste. Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men. Psychopharmacology. vol 100. issue 2. 1990-03-27. PMID:2305006. |
in search of a physiological marker of depression and suicidal behavior, serotonin receptors of the 5-ht2 type were studied on platelet membranes from 19 control and 22 suicidal subjects. |
1990-03-27 |
2023-08-11 |
human |
| J Kamei, T Mori, M Ogawa, Y Kasuy. Subsensitivity to the cough-depressant effects of opioid and nonopioid antitussives in morphine-dependent rats: relationship to central serotonin function. Pharmacology, biochemistry, and behavior. vol 34. issue 3. 1990-03-26. PMID:2637700. |
it is possible that the decreased sensitivity to both opioid and nonopioid antitussive drugs, in terms of the depression of the cough reflex, in morphine-dependent rats may be due to changes in the number of serotonin receptors. |
1990-03-26 |
2023-08-11 |
rat |
| L C Ricci, M M Wellma. Monoamines: biochemical markers of suicide? Journal of clinical psychology. vol 46. issue 1. 1990-03-19. PMID:1689324. |
this literature review reports the current findings on serotonin (5-ht), dopamine (da), and norepinephrine (ne) as possible biochemical markers of depression and suicide. |
1990-03-19 |
2023-08-11 |
Not clear |
| H Meltze. Serotonergic dysfunction in depression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692637. |
interference with 5-ht synthesis or storage has been shown to induce depression in vulnerable individuals. |
1990-03-15 |
2023-08-11 |
Not clear |
| H Meltze. Serotonergic dysfunction in depression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692637. |
concentrations of 5-hiaa, the major metabolite of 5-ht in plasma, were found to be significantly negatively correlated with severity of depression as measured by the hamilton rating scale for depression score and specific depressive symptoms, despite the fact that plasma 5-hiaa is largely peripheral in origin. |
1990-03-15 |
2023-08-11 |
Not clear |