| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Ohno, J E Warnic. Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-methyl-D-aspartate receptors. The Journal of pharmacology and experimental therapeutics. vol 252. issue 1. 1990-03-12. PMID:1967645. |
furthermore, the depression of the reflexes by pcp was unaffected by haloperidol and methiothepin precluding the involvement of sigma and serotonin receptors in pcp-induced depression of the polysynaptic reflex. |
1990-03-12 |
2023-08-11 |
rat |
| G Berkenboom, P Unger, Z Y Fang, S Degre, J Fontain. Comparison of responses to acetylcholine and serotonin on isolated canine and human coronary arteries. Cardiovascular research. vol 23. issue 9. 1990-02-27. PMID:2482133. |
acetylcholine (0.1-10 mumol.litre-1) and serotonin (0.1-100 mumol.litre-1) relaxed canine preparations dose dependently, the maximum responses (expressed as % of depression of pgf2 alpha response) being 84 (sem 6)% (n = 9) and 51(5)% (n = 6) respectively. |
1990-02-27 |
2023-08-11 |
human |
| L D Van de Ka. Neuroendocrine aspects of the serotonergic hypothesis of depression. Neuroscience and biobehavioral reviews. vol 13. issue 4. 1990-02-14. PMID:2691929. |
this review examines the role of serotonin (5-ht) in depression. |
1990-02-14 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
lithium and serotonin function: implications for the serotonin hypothesis of depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
a large body of independent evidence suggests that 5-ht function is abnormal in depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2404294. |
these actions of lithium may serve to correct as-yet unspecified abnormalities of 5-ht function involved in the pathogenesis of depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| R G Robinson, S E Starkstei. Mood disorders following stroke: new findings and future directions. Journal of geriatric psychiatry. vol 22. issue 1. 1990-02-13. PMID:2607085. |
within the left hemisphere, the lower the serotonin binding, the more severe the depression. |
1990-02-13 |
2023-08-11 |
Not clear |
| S A Welner, C De Montigny, J Desroches, P Desjardins, B E Suranyi-Cadott. Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse (New York, N.Y.). vol 4. issue 4. 1990-01-31. PMID:2532423. |
there is growing evidence that the serotonergic (5-ht) system is involved in the pathogenesis and treatment of major depression. |
1990-01-31 |
2023-08-11 |
rat |
| H Ono, Y Hasebe, T Mori, H Fukuda, M Kohno, S Ohta, M Hirob. Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats. Journal of pharmacobio-dynamics. vol 12. issue 7. 1990-01-25. PMID:2593080. |
depressions of msr produced by pea, s(+)-methamphetamine and r(+)-2-aminotetralin were antagonized by ketanserin and haloperidol which have 5-hydroxytryptamine (5-ht) antagonistic activity, and the msr depression caused by s(+)-methamphetamine but not pea and r(+)-2-aminotetralin was abolished by intracisternal 5,6-dihydroxytryptamine treatment or chronic spinal transection. |
1990-01-25 |
2023-08-11 |
rat |
| H Ono, Y Hasebe, T Mori, H Fukuda, M Kohno, S Ohta, M Hirob. Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats. Journal of pharmacobio-dynamics. vol 12. issue 7. 1990-01-25. PMID:2593080. |
these results suggest that pea-related compounds cause msr depression by direct and indirect 5-ht agonistic mechanisms, and support the proposal that the pea moiety which exists in r(+)-2-aminotetralin is important for the direct 5-ht agonistic activity of some hallucinogens. |
1990-01-25 |
2023-08-11 |
rat |
| D M Bowen, A Najlerahim, A W Procter, P T Francis, E Murph. Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 23. 1990-01-19. PMID:2574463. |
results for depression expressed per entire area indicate additionally reduced somatostatin content and serotonin 1a sites in the pars opercularis and serotonin 1a sites in the temporal pole. |
1990-01-19 |
2023-08-11 |
Not clear |
| W Bugge, C J Ribbegren, T Gerner, J Haffne. Serotonin--a possible transmitter for the gastric adaptive relaxation. Interaction with histamine and prostaglandin F2 alpha on pressure responses in the isolated stomach. Scandinavian journal of gastroenterology. vol 24. issue 9. 1990-01-17. PMID:2595269. |
to test whether the relaxation response to serotonin is compatible with a putative role as transmitter in gastric adaptive relaxation, we wanted to evaluate whether serotonin acts by crude muscle depression and whether it selectively inhibits histamine or prostaglandin f2 alpha (pgf2 alpha). |
1990-01-17 |
2023-08-11 |
Not clear |
| W Bugge, C J Ribbegren, T Gerner, J Haffne. Serotonin--a possible transmitter for the gastric adaptive relaxation. Interaction with histamine and prostaglandin F2 alpha on pressure responses in the isolated stomach. Scandinavian journal of gastroenterology. vol 24. issue 9. 1990-01-17. PMID:2595269. |
it is then concluded that the relaxatory effect of 5-ht is provided through other mechanisms than crude muscle depression and that selective inhibition of intramural agonists, like histamine, is a possible effect mechanism. |
1990-01-17 |
2023-08-11 |
Not clear |
| S C Cheetham, M R Crompton, C Czudek, R W Horton, C L Katona, G P Reynold. Serotonin concentrations and turnover in brains of depressed suicides. Brain research. vol 502. issue 2. 1990-01-08. PMID:2479456. |
5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) concentrations and 5-ht turnover (5-hiaa/5-ht) were determined in 6 brain regions from 19 suicide victims in whom a retrospective diagnosis of depression was established, and 19 age- and sex-matched control subjects. |
1990-01-08 |
2023-08-11 |
human |
| L M Tremaine, W M Welch, R A Ronfel. Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog. Drug metabolism and disposition: the biological fate of chemicals. vol 17. issue 5. 1989-12-29. PMID:2573498. |
sertaline [1s,4s-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1- naphthalenamine] is a potent and selective inhibitor of neuronal serotonin uptake and is currently under development for the treatment of depression and of obesity. |
1989-12-29 |
2023-08-11 |
rat |
| R H Cox, K S Haas, D M Moisey, T N Tulenk. Effects of endothelium regeneration on canine coronary artery function. The American journal of physiology. vol 257. issue 5 Pt 2. 1989-12-28. PMID:2589521. |
the results of this study suggest a "chronic" depression of relaxation responses mediated by the guanosine 3',5'-cyclic monophosphate pathway and increased serotonin vasoconstriction sensitivity in arteries 5 wk after an endothelial denudation injury. |
1989-12-28 |
2023-08-11 |
Not clear |
| S A Montgomer. New antidepressants and 5-HT uptake inhibitors. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2530760. |
moreover, the evidence for efficacy in the prophylaxis of depression is better established for 5-ht uptake inhibitors than for reference antidepressants. |
1989-12-18 |
2023-08-11 |
Not clear |
| D G Grahame-Smit. Serotonin function in affective disorders. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2683591. |
biochemical studies have indicated that low plasma levels of tryptophan are unlikely to be the primary 'cause' of depression or of abnormal brain 5-ht function in depression. |
1989-12-18 |
2023-08-11 |
Not clear |
| D G Grahame-Smit. Serotonin function in affective disorders. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2683591. |
clinical studies have provided further evidence that 5-ht is implicated in the causation and treatment of depression, as both 5-ht precursors and selective inhibitors of 5-ht uptake are effective in the treatment of depression. |
1989-12-18 |
2023-08-11 |
Not clear |
| W Kostowski, A Płaźni. [The serotonin concept of depression in light of the mechanism of action of antidepressant drugs]. Psychiatria polska. vol 23. issue 2. 1989-11-30. PMID:2682712. |
[the serotonin concept of depression in light of the mechanism of action of antidepressant drugs]. |
1989-11-30 |
2023-08-11 |
Not clear |