| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E Molchan, B A Lawlor, J L Hill, R A Martinez, C L Davis, A M Mellow, D R Rubinow, T Sunderlan. CSF monoamine metabolites and somatostatin in Alzheimer's disease and major depression. Biological psychiatry. vol 29. issue 11. 1991-09-26. PMID:1714776. |
further exploration of the relationship between the somatostatin and serotonin systems may provide clues as to how neuropeptides interact with monoamine neurotransmitters and what role they have in depression. |
1991-09-26 |
2023-08-11 |
Not clear |
| D Heal. The marketing of 5-hydroxytryptamine: depression or anxiety? The British journal of psychiatry : the journal of mental science. vol 158. 1991-09-26. PMID:1873625. |
the marketing of 5-hydroxytryptamine: depression or anxiety? |
1991-09-26 |
2023-08-11 |
Not clear |
| L Staner, J Mendlewic. [Biological psychiatry and current classifications of depressive disorders]. L'Encephale. vol 17. issue 3. 1991-09-11. PMID:1864251. |
for example, catecholamines and serotonin metabolism seem to reflect respectively psychomotor status and aggressiveness in depression. |
1991-09-11 |
2023-08-11 |
Not clear |
| V O'Keane, T G Dina. Prolactin and cortisol responses to d-fenfluramine in major depression: evidence for diminished responsivity of central serotonergic function. The American journal of psychiatry. vol 148. issue 8. 1991-08-20. PMID:1853948. |
the authors' goal, therefore, was to look at 5-ht function in depression using the d isomer of fenfluramine as a probe. |
1991-08-20 |
2023-08-11 |
Not clear |
| D H Bobker, J T William. Cocaine and amphetamine interact at 5-HT synapses through distinct mechanisms in guinea-pig prepositus hypoglossi. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 7. 1991-08-12. PMID:2066779. |
the depression of the ipsp is most likely due to a presynaptic effect, because cocaine augmented the response to applied 5-ht. |
1991-08-12 |
2023-08-11 |
Not clear |
| J L Rausch, F G Moelle. Kinetic effects of desmethylimipramine treatment on platelet serotonin uptake in depressed patients: a comparison with imipramine. Psychiatry research. vol 36. issue 3. 1991-08-08. PMID:2062971. |
although dmi is considered a preferential norepinephrine uptake inhibitor, the results suggest the following: (1) significant decreases in the apparent platelet 5ht affinity are achieved with dmi; (2) the inhibition kinetics in depressed patients are competitive; (3) there was a significant relationship between km change and depression outcome with dmi discontinuation; and (4) dmi, as a metabolite, appears to contribute to the 5ht uptake inhibition of imi in vivo. |
1991-08-08 |
2023-08-11 |
Not clear |
| J T Buchanan, S Grillne. 5-Hydroxytryptamine depresses reticulospinal excitatory postsynaptic potentials in motoneurons of the lamprey. Neuroscience letters. vol 122. issue 1. 1991-08-01. PMID:1676146. |
the depression could be produced either by local application of small volumes of 10 mm 5-ht to the surface of the spinal cord or by bath-application of 1 or 10 microm 5-ht. |
1991-08-01 |
2023-08-11 |
Not clear |
| E Richelso. Biological basis of depression and therapeutic relevance. The Journal of clinical psychiatry. vol 52 Suppl. 1991-07-25. PMID:1646793. |
these effects, derived from neurochemical studies with laboratory animals, have implicated catecholamines and serotonin in depression. |
1991-07-25 |
2023-08-11 |
Not clear |
| P Valeri, G Pimpinella, L A Morrone, L Romanell. Antinociceptive effects of trazodone and m-chlorophenylpiperazine (mCPP) in mice: interaction with morphine. General pharmacology. vol 22. issue 1. 1991-07-24. PMID:2050281. |
the results further support the suggested role played by opioid and 5-ht systems on depression. |
1991-07-24 |
2023-08-11 |
mouse |
| L Barrelet, B Blajev, L Bolzani, C de Saussure, A Kasas, H Van, J P Gachou. [Multicenter study comparing efficacy and tolerance of moclobemide and fluvoxamine in hospitalized and ambulatory patients with severe depressive episodes]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis. vol 80. issue 19. 1991-07-18. PMID:1904620. |
61 patients with major depression (according to dsm-iii) were either treated with moclobemide or fluvoxamine, a selective reuptake-inhibitor of 5-ht. |
1991-07-18 |
2023-08-11 |
Not clear |
| R W Fulle. Role of serotonin in therapy of depression and related disorders. The Journal of clinical psychiatry. vol 52 Suppl. 1991-06-20. PMID:1674251. |
role of serotonin in therapy of depression and related disorders. |
1991-06-20 |
2023-08-11 |
Not clear |
| R W Fulle. Role of serotonin in therapy of depression and related disorders. The Journal of clinical psychiatry. vol 52 Suppl. 1991-06-20. PMID:1674251. |
selective inhibitors of serotonin uptake, which enhance serotonergic function by preventing the removal of serotonin from the synaptic cleft via the membrane transporter, have been introduced for the treatment of depression and may be effective in other disorders. |
1991-06-20 |
2023-08-11 |
Not clear |
| P L Bonat. Serotonin receptor subtypes: functional, physiological, and clinical correlates. Clinical neuropharmacology. vol 14. issue 1. 1991-06-18. PMID:2029690. |
novel treatments for hypertension, migraine headaches, anxiety, and depression using 5-ht are just the beginning. |
1991-06-18 |
2023-08-11 |
human |
| A M Montgomery, I C Rose, L J Herber. 5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward. Journal of neural transmission. General section. vol 83. issue 1-2. 1991-05-28. PMID:1826841. |
depression of self-stimulation by higher doses of 8-oh-dpat may reflect the activity of 8-oh-dpat at postsynaptic 5-ht receptors, with consequent inhibition of da transmission. |
1991-05-28 |
2023-08-11 |
rat |
| E Edwards, K Harkins, G Wright, F Hen. Modulation of [3H]paroxetine binding to the 5-hydroxytryptamine uptake site in an animal model of depression. Journal of neurochemistry. vol 56. issue 5. 1991-05-16. PMID:1826517. |
modulation of [3h]paroxetine binding to the 5-hydroxytryptamine uptake site in an animal model of depression. |
1991-05-16 |
2023-08-11 |
rat |
| I Lucki, S Wielan. 5-Hydroxytryptamine1A receptors and behavioral responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078281. |
these studies have helped define important neuropharmacologic actions on 5-ht receptors that may contribute to therapeutic effects in anxiety and depression. |
1991-04-29 |
2023-08-11 |
Not clear |
| F Licata, G Li Volsi, G Maugeri, L Ciranna, F Santangel. Effects of glutamate on the serotonin-induced responses of vestibular neurons. Bollettino della Societa italiana di biologia sperimentale. vol 66. issue 8. 1991-04-11. PMID:1981315. |
the trend to a depression of the response to 5-ht in function of the background discharge was observed when either the enhancement of firing occurred spontaneously and it was induced by an application of glu, no significant difference (f-test) being found between the two cases. |
1991-04-11 |
2023-08-11 |
rat |
| J Sagen, C E Sortwell, G D Pappa. Monoaminergic neural transplants prevent learned helplessness in a rat depression model. Biological psychiatry. vol 28. issue 12. 1991-04-03. PMID:1963093. |
current theories of the etiology of depression implicate disturbances and imbalances in the function of monoaminergic systems, particularly involving serotonin and norepinephrine. |
1991-04-03 |
2023-08-11 |
rat |
| K P Lesch, H Beckman. [The serotonin hypothesis of depression]. Fortschritte der Neurologie-Psychiatrie. vol 58. issue 11. 1991-03-13. PMID:2177721. |
[the serotonin hypothesis of depression]. |
1991-03-13 |
2023-08-11 |
Not clear |
| F Westwic. Depression and selective serotonin reuptake inhibitors. British journal of hospital medicine. vol 44. issue 5. 1991-03-07. PMID:2148896. |
depression and selective serotonin reuptake inhibitors. |
1991-03-07 |
2023-08-11 |
Not clear |