| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K P Lesch, S Mayer, J Disselkamp-Tietze, A Hoh, M Wiesmann, M Osterheider, H M Schult. 5-HT1A receptor responsivity in unipolar depression. Evaluation of ipsapirone-induced ACTH and cortisol secretion in patients and controls. Biological psychiatry. vol 28. issue 7. 1990-12-04. PMID:1977479. |
the impaired hpa response following 5-ht1a receptor challenge in unipolar depression could have resulted from glucocorticoid-dependent subsensitivity of the (post-synaptic) 5-ht1a receptor itself and/or from a defective postreceptor signaling pathway [inhibitory guanine nucleotide-binding protein (gi)-adenylate cyclase complex function], thus supporting the hypothesis that a disintegrated 5-ht and hpa system interaction may be present in depression. |
1990-12-04 |
2023-08-11 |
human |
| A M Mellow, B A Lawlor, T Sunderland, E A Mueller, S E Molchan, D L Murph. Effects of daily oral m-chlorophenylpiperazine in elderly depressed patients. Initial experience with a serotonin agonist. Biological psychiatry. vol 28. issue 7. 1990-12-04. PMID:2223928. |
six patients (mean age 62.5 +/- 7.6 years) with major depression were treated for 2 weeks with the serotonin agonist m-chlorophenylpiperazine (m-cpp), 80 mg/day in a double-blind, placebo-controlled, crossover-design pilot study. |
1990-12-04 |
2023-08-11 |
Not clear |
| S A Montgomery, N A Fineberg, D Montgomer. [Biological treatments in obsessive-compulsive disorder]. L'Encephale. vol 16 Spec No. 1990-11-21. PMID:2209492. |
thirdly the evidence of the efficacy of clomipramine in ocd without concomitant depression reported by montgomery 1980 and supported by other studies suggests that 5-ht uptake inhibitors have a specifically anti-obsessional effect. |
1990-11-21 |
2023-08-11 |
Not clear |
| J B Meagher, A O'Halloran, P A Carney, B E Leonar. Changes in platelet 5-hydroxytryptamine uptake in mania. Journal of affective disorders. vol 19. issue 3. 1990-11-19. PMID:1976659. |
manic patients with no previous history of either mania or depression had highly significant increases in 5ht platelet uptake compared to either schizophrenics, controls or manic patients with a previous history of manic-depression. |
1990-11-19 |
2023-08-11 |
human |
| Serotonin partial agonists in the treatment of anxiety and depression. Proceedings from the VIII World Congress of Psychiatry. Athens, Greece, October 12-19, 1989. The Journal of clinical psychiatry. vol 51 Suppl. 1990-11-06. PMID:1976624. |
serotonin partial agonists in the treatment of anxiety and depression. |
1990-11-06 |
2023-08-11 |
Not clear |
| D C Jimerson, M D Lesem, W H Kaye, A P Hegg, T D Brewerto. Eating disorders and depression: is there a serotonin connection? Biological psychiatry. vol 28. issue 5. 1990-11-06. PMID:2207221. |
eating disorders and depression: is there a serotonin connection? |
1990-11-06 |
2023-08-11 |
Not clear |
| D C Jimerson, M D Lesem, W H Kaye, A P Hegg, T D Brewerto. Eating disorders and depression: is there a serotonin connection? Biological psychiatry. vol 28. issue 5. 1990-11-06. PMID:2207221. |
this review compares evidence for alterations in central serotonin regulation in patients with anorexia nervosa, bulimia nervosa, and depression. |
1990-11-06 |
2023-08-11 |
Not clear |
| D C Jimerson, M D Lesem, W H Kaye, A P Hegg, T D Brewerto. Eating disorders and depression: is there a serotonin connection? Biological psychiatry. vol 28. issue 5. 1990-11-06. PMID:2207221. |
it is proposed that impaired synaptic transmission in functionally distinct serotonin pathways may result in concurrent or sequential periods of binge eating, behavioral impulsivity, and depression in patients with eating disorders. |
1990-11-06 |
2023-08-11 |
Not clear |
| R G Dudle. Serotonin partial agonists in the treatment of anxiety and depression. Introduction. The Journal of clinical psychiatry. vol 51 Suppl. 1990-11-06. PMID:2211563. |
serotonin partial agonists in the treatment of anxiety and depression. |
1990-11-06 |
2023-08-11 |
Not clear |
| E Dimitrio. Serotonin partial agonists in the treatment of depression. The Journal of clinical psychiatry. vol 51 Suppl. 1990-11-06. PMID:2211573. |
serotonin partial agonists in the treatment of depression. |
1990-11-06 |
2023-08-11 |
Not clear |
| R S Nathan, J M Perel, B G Pollock, D J Kupfe. The role of neuropharmacologic selectivity in antidepressant action: fluvoxamine versus desipramine. The Journal of clinical psychiatry. vol 51. issue 9. 1990-11-01. PMID:2120201. |
the authors found a positive relationship between hamilton rating scale for depression scores and norepinephrine uptake inhibition for desipramine but found no such relationship between fluvoxamine and serotonin uptake inhibition. |
1990-11-01 |
2023-08-11 |
Not clear |
| Zh A Kruchenko, V V Sachenk. [The effect of the selective blocking of synaptic transmission in the parafascicular complex on the neuronal activity of the sensorimotor cortex]. Neirofiziologiia = Neurophysiology. vol 22. issue 3. 1990-10-18. PMID:2169030. |
it is shown that an increase in the background activity of neurons of the sensorimotor cortex was caused by microinjections of obsidan, an adrenergic blocker, while depression--by microinjections of lysergoamid, a serotonin blocker. |
1990-10-18 |
2023-08-11 |
Not clear |
| S Barry, O M Phillips, D C Williams, T G Dina. Platelet 5-HT uptake in post-stroke depression. Acta psychiatrica Scandinavica. vol 82. issue 1. 1990-10-12. PMID:2399828. |
platelet 5-ht uptake in post-stroke depression. |
1990-10-12 |
2023-08-11 |
Not clear |
| C J Gouret, R Porsolt, J G Wettstein, A Puech, C Soulard, X Pascaud, J L Junie. Biochemical and pharmacological evaluation of the novel antidepressant and serotonin uptake inhibitor 2-(3,4-Dichlorobenzyl)-2-dimethylamino-1-propanol hydrochloride. Arzneimittel-Forschung. vol 40. issue 6. 1990-10-09. PMID:2168703. |
jo 1017 may have a potential clinical utility both in the treatment of depression and for indications where serotonin transmission is involved, e.g., anxiety, panic attack, obsessive compulsive disorder, obesity and alcohol consumption. |
1990-10-09 |
2023-08-11 |
mouse |
| S B Backman, H Sequeira-Martinho, J L Henr. Adrenal versus nonadrenal sympathetic preganglionic neurones in the lower thoracic intermediolateral nucleus of the cat: effects of serotonin, substance P, and thyrotropin-releasing hormone. Canadian journal of physiology and pharmacology. vol 68. issue 8. 1990-10-04. PMID:1697219. |
depression was never observed and responses were similar whether using serotonin at a ph of 3.3 or 4.5, suggesting that the absence of a depressant effect cannot be accounted for by ph, as has been reported with cortical neurones. |
1990-10-04 |
2023-08-11 |
cat |
| Y Dua. [Thyrotrophin-releasing hormone (TRH) stimulation test in psychiatric patients]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry. vol 23. issue 2. 1990-10-04. PMID:2118064. |
these results seemed to support the view that trh stimulation test can be used as a biological marker to distinguish affective disorder and that both depression and mania is correlated with the decreased function of serotonin. |
1990-10-04 |
2023-08-11 |
Not clear |
| P Elliott, B M Seemungal, D I Walli. Antagonism of the effects of 5-hydroxytryptamine on the rabbit isolated vagus nerve by BRL 43694 and metoclopramide. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 6. 1990-10-04. PMID:2168021. |
at the highest concentration of antagonist, there was some depression of the maximal 5-ht response. |
1990-10-04 |
2023-08-11 |
rabbit |
| A Biegon, N Essar, M Israeli, A Elizur, S Bruch, A A Bar-Natha. Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder. Psychopharmacology. vol 102. issue 1. 1990-10-04. PMID:2392511. |
serotonin receptors of the 5-ht2 type were studied on platelet membranes from 15 patients suffering from major depression. |
1990-10-04 |
2023-08-11 |
Not clear |
| D J Horrigan, J M Horowit. Thermal dependence of serotonergic modulation of neural activity in the hamster. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology. vol 167. issue 1. 1990-09-24. PMID:2388182. |
thus, over the entire temperature range of 35 degrees c to 15 degrees c, serotonin exerted a dual modulatory effect on the spike amplitude, a depression followed by an enhancement. |
1990-09-24 |
2023-08-11 |
Not clear |
| F D Yocc. Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973941. |
these results suggest that the efficacy seen in clinical trials of anxiety and depression may be related to buspirone's and gepirone's complex interaction with presynaptic and postsynaptic 5-ht1a receptors, which initiate long-term changes in central 5-ht neurotransmission. |
1990-09-05 |
2023-08-11 |
Not clear |