| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Chouinard, W Goodman, J Greist, M Jenike, S Rasmussen, K White, E Hackett, M Gaffney, P A Bic. Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder. Psychopharmacology bulletin. vol 26. issue 3. 1991-02-26. PMID:2274626. |
eighty-seven patients with a dsm-iii diagnosis of obsessive-compulsive disorder (ocd) without depression were entered into a double-blind, placebo-controlled study of the efficacy of sertraline, a new serotonin uptake inhibitor. |
1991-02-26 |
2023-08-11 |
Not clear |
| Serotonin reuptake inhibition in the management of depression. Proceedings of a satellite symposium in connection with the VIII World Congress of Psychiatry. October 18, 1989, Athens, Greece. The Journal of clinical psychiatry. vol 51 Suppl B. 1991-01-30. PMID:1979557. |
serotonin reuptake inhibition in the management of depression. |
1991-01-30 |
2023-08-11 |
Not clear |
| K Rickels, E Schweize. Clinical overview of serotonin reuptake inhibitors. The Journal of clinical psychiatry. vol 51 Suppl B. 1991-01-30. PMID:2147922. |
although serotonin reuptake inhibitors have not replaced the tricyclics, they are a useful addition to the variety of drugs currently used for the treatment of depression. |
1991-01-30 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Fenfluramine augmentation in tricyclic-refractory depression. Journal of clinical psychopharmacology. vol 10. issue 5. 1991-01-28. PMID:2258448. |
the clinical efficacy of lithium augmentation in refractory depression is hypothesized to depend on the ability of lithium to enhance presynaptic 5-hydroxytryptamine (5-ht) function. |
1991-01-28 |
2023-08-11 |
Not clear |
| L H Price, D S Charney, P L Delgado, G R Heninge. Fenfluramine augmentation in tricyclic-refractory depression. Journal of clinical psychopharmacology. vol 10. issue 5. 1991-01-28. PMID:2258448. |
since fenfluramine promotes release and inhibits reuptake of presynaptic 5-ht, we assessed its efficacy in augmenting ongoing tricyclic antidepressant treatment of refractory depression. |
1991-01-28 |
2023-08-11 |
Not clear |
| H Y Meltze. Role of serotonin in depression. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252328. |
role of serotonin in depression. |
1991-01-14 |
2023-08-11 |
Not clear |
| R W Fuller, D T Won. Serotonin uptake and serotonin uptake inhibition. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252338. |
some serotonin uptake inhibitors are finding therapeutic uses in mental depression and other psychiatric disorders and in treating obesity and bulimia; other therapeutic applications continue to be evaluated. |
1991-01-14 |
2023-08-11 |
Not clear |
| J Quintan. Platelet imipramine binding in endogenous depressed patients and controls: relationship to platelet MAO and 5HT uptake during successful imipramine treatment. Psychiatry research. vol 33. issue 3. 1991-01-03. PMID:2173840. |
however, such changes accompany changes in other biological parameters, such as platelet monoamine oxidase and serotonin uptake, seen in the same patients throughout imipramine treatment, suggesting that the drug acts on a wide range of normal or altered serotonin-related cellular mechanisms while it accelerates the clinical recovery from depression. |
1991-01-03 |
2023-08-11 |
Not clear |
| R S Kahn, O Kalus, S Wetzler, W Cahn, G M Asnis, H M van Praa. Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects. Psychiatry research. vol 33. issue 2. 1991-01-03. PMID:2243896. |
the serotonin (5ht) agonist, m-chlorophenylpiperazine (mcpp), has been used as a challenge agent to assess central 5ht receptor sensitivity in normal subjects and patients with panic disorder, obsessive-compulsive disorder, and major depression. |
1991-01-03 |
2023-08-11 |
human |
| R Mayeu. The "serotonin hypothesis" for depression in Parkinson's disease. Advances in neurology. vol 53. 1990-12-13. PMID:2239456. |
the "serotonin hypothesis" for depression in parkinson's disease. |
1990-12-13 |
2023-08-11 |
Not clear |
| F P Zemlan, D L Garve. Depression and antidepressant therapy: receptor dynamics. Progress in neuro-psychopharmacology & biological psychiatry. vol 14. issue 4. 1990-12-07. PMID:2173022. |
the classical norepinephrine (ne) and serotonin (5-ht) theories of depression have been abandoned in light of recent chronic antidepressant drug studies. |
1990-12-07 |
2023-08-11 |
rat |
| F P Zemlan, D L Garve. Depression and antidepressant therapy: receptor dynamics. Progress in neuro-psychopharmacology & biological psychiatry. vol 14. issue 4. 1990-12-07. PMID:2173022. |
the new ne and 5-ht theories of depression focus on the dynamics of receptor subtypes in depression and chronic antidepressant treatments. |
1990-12-07 |
2023-08-11 |
rat |
| L H Price, D S Charney, P L Delgado, W K Goodman, J H Krystal, S W Woods, G R Heninge. Clinical studies of 5-HT function using i.v. L-tryptophan. Progress in neuro-psychopharmacology & biological psychiatry. vol 14. issue 4. 1990-12-07. PMID:2236580. |
similarly, clinical studies suggest that brain 5-ht function is abnormal in depression. |
1990-12-07 |
2023-08-11 |
Not clear |
| F J Arnold, L R Meyerso. Olfactory bulbectomy alters alpha-1 acid glycoprotein levels in rat plasma. Brain research bulletin. vol 25. issue 2. 1990-12-05. PMID:2121313. |
in humans, depression was shown to be accompanied by increases in plasma cortisol, inability to decrease cortisol in the dexamethasone suppression test and increases in plasma alpha-1 acid glycoprotein (agp), an endogenous modulator for the serotonin uptake site. |
1990-12-05 |
2023-08-11 |
human |
| J J Williams, R Moalli, C Calista, J H Herndo. Pulmonary endothelial injury and altered fibrinolysis after femur fracture in rabbits. Journal of orthopaedic trauma. vol 4. issue 3. 1990-12-05. PMID:2172494. |
prolonged depression of 5-ht uptake suggests that musculoskeletal trauma is associated with pulmonary endothelial damage. |
1990-12-05 |
2023-08-11 |
rabbit |
| K P Lesch, S Mayer, J Disselkamp-Tietze, A Hoh, M Wiesmann, M Osterheider, H M Schult. 5-HT1A receptor responsivity in unipolar depression. Evaluation of ipsapirone-induced ACTH and cortisol secretion in patients and controls. Biological psychiatry. vol 28. issue 7. 1990-12-04. PMID:1977479. |
the impaired hpa response following 5-ht1a receptor challenge in unipolar depression could have resulted from glucocorticoid-dependent subsensitivity of the (post-synaptic) 5-ht1a receptor itself and/or from a defective postreceptor signaling pathway [inhibitory guanine nucleotide-binding protein (gi)-adenylate cyclase complex function], thus supporting the hypothesis that a disintegrated 5-ht and hpa system interaction may be present in depression. |
1990-12-04 |
2023-08-11 |
human |
| A M Mellow, B A Lawlor, T Sunderland, E A Mueller, S E Molchan, D L Murph. Effects of daily oral m-chlorophenylpiperazine in elderly depressed patients. Initial experience with a serotonin agonist. Biological psychiatry. vol 28. issue 7. 1990-12-04. PMID:2223928. |
six patients (mean age 62.5 +/- 7.6 years) with major depression were treated for 2 weeks with the serotonin agonist m-chlorophenylpiperazine (m-cpp), 80 mg/day in a double-blind, placebo-controlled, crossover-design pilot study. |
1990-12-04 |
2023-08-11 |
Not clear |
| S A Montgomery, N A Fineberg, D Montgomer. [Biological treatments in obsessive-compulsive disorder]. L'Encephale. vol 16 Spec No. 1990-11-21. PMID:2209492. |
thirdly the evidence of the efficacy of clomipramine in ocd without concomitant depression reported by montgomery 1980 and supported by other studies suggests that 5-ht uptake inhibitors have a specifically anti-obsessional effect. |
1990-11-21 |
2023-08-11 |
Not clear |
| J B Meagher, A O'Halloran, P A Carney, B E Leonar. Changes in platelet 5-hydroxytryptamine uptake in mania. Journal of affective disorders. vol 19. issue 3. 1990-11-19. PMID:1976659. |
manic patients with no previous history of either mania or depression had highly significant increases in 5ht platelet uptake compared to either schizophrenics, controls or manic patients with a previous history of manic-depression. |
1990-11-19 |
2023-08-11 |
human |
| Serotonin partial agonists in the treatment of anxiety and depression. Proceedings from the VIII World Congress of Psychiatry. Athens, Greece, October 12-19, 1989. The Journal of clinical psychiatry. vol 51 Suppl. 1990-11-06. PMID:1976624. |
serotonin partial agonists in the treatment of anxiety and depression. |
1990-11-06 |
2023-08-11 |
Not clear |