| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Eiso. Serotonin: a common neurobiologic substrate in anxiety and depression. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:2198299. |
serotonin: a common neurobiologic substrate in anxiety and depression. |
1990-09-05 |
2023-08-11 |
Not clear |
| M S Eiso. Serotonin: a common neurobiologic substrate in anxiety and depression. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:2198299. |
it is proposed that imbalances in serotonergic neurotransmission may contribute significantly to both pathologies and that agents that act as serotonin partial agonists may normalize neurotransmission in both serotonin deficit (depression) and excess (anxiety) diseases. |
1990-09-05 |
2023-08-11 |
Not clear |
| D S Robinson, K Rickels, J Feighner, L F Fabre, R E Gammans, R C Shrotriya, D R Alms, J J Andary, M E Messin. Clinical effects of the 5-HT1A partial agonists in depression: a composite analysis of buspirone in the treatment of depression. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:2198303. |
buspirone, a serotonin (5-hydroxytryptamine, 5-ht) partial agonist active at the 5-ht1a receptor subtype, was evaluated in the treatment of depression in a series of five placebo-controlled, parallel group studies involving 382 patients with dsm-iii major depression and significant associated anxiety symptoms (both hamilton depression [ham-d] and hamilton anxiety [ham-a] scales greater than or equal to 18). |
1990-09-05 |
2023-08-11 |
Not clear |
| M L Rao, B Müller-Oerlinghausen, A Mackert, R D Stieglitz, B Strebel, H P Vol. The influence of phototherapy on serotonin and melatonin in non-seasonal depression. Pharmacopsychiatry. vol 23. issue 3. 1990-08-29. PMID:2374773. |
the influence of phototherapy on serotonin and melatonin in non-seasonal depression. |
1990-08-29 |
2023-08-11 |
human |
| M L Rao, B Müller-Oerlinghausen, A Mackert, R D Stieglitz, B Strebel, H P Vol. The influence of phototherapy on serotonin and melatonin in non-seasonal depression. Pharmacopsychiatry. vol 23. issue 3. 1990-08-29. PMID:2374773. |
circadian profiles of melatonin in serum and serotonin in blood were assessed before and after 7 days of artificial light treatment in 30 patients with non-seasonal depression and 12 healthy subjects. |
1990-08-29 |
2023-08-11 |
human |
| A A Brzezinski, J J Wurtman, R J Wurtman, R Gleason, J Greenfield, T Nade. d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. Obstetrics and gynecology. vol 76. issue 2. 1990-08-21. PMID:2371034. |
the ability of d-fenfluramine, a drug that releases brain serotonin and blocks its reuptake, to relieve premenstrual depression and excessive calorie and carbohydrate intakes was examined in 17 women with premenstrual syndrome. |
1990-08-21 |
2023-08-11 |
human |
| R Mayeu. Depression in the patient with Parkinson's disease. The Journal of clinical psychiatry. vol 51 Suppl. 1990-08-13. PMID:2195009. |
attempts to alleviate depression with serotonin agonists have proven successful. |
1990-08-13 |
2023-08-11 |
Not clear |
| P Martin, P Soubrié, A J Puec. Reversal of helpless behavior by serotonin uptake blockers in rats. Psychopharmacology. vol 101. issue 3. 1990-08-08. PMID:2362957. |
there is little evidence, however, to suggest that serotonin uptake blockers are efficacious in animal models of depression. |
1990-08-08 |
2023-08-11 |
rat |
| J E Humphries, M S Wheby, S R VandenBer. Fluoxetine and the bleeding time. Archives of pathology & laboratory medicine. vol 114. issue 7. 1990-08-06. PMID:2363631. |
fluoxetine (prozac) is a nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitor commonly prescribed for the treatment of depression. |
1990-08-06 |
2023-08-11 |
Not clear |
| S H Wong, C H Cho, C W Ogl. The role of serotonin in ethanol-induced gastric glandular damage in rats. Digestion. vol 45. issue 1. 1990-06-27. PMID:2340964. |
this depression of gastric mucosal blood flow was further reduced by 5-ht, but was reversed by methysergide. |
1990-06-27 |
2023-08-11 |
rat |
| J F Deakin, I Pennell, A J Upadhyaya, R Lofthous. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343077. |
a neuroendocrine study of 5ht function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. |
1990-06-27 |
2023-08-11 |
Not clear |
| J F Deakin, I Pennell, A J Upadhyaya, R Lofthous. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343077. |
to investigate whether depression is a consequence of disturbed function in 5ht systems, neuroendocrine responses to infusions of the 5ht precursor l-tryptophan (ltp) were studied in patients and controls. |
1990-06-27 |
2023-08-11 |
Not clear |
| J F Deakin, I Pennell, A J Upadhyaya, R Lofthous. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343077. |
blunted gh and prl responses to ltp appear to be distinct abnormalities in depression which may relate to two processes; (1), an endogenous mechanism indicated by reduced gh responses, and (2), an impairment in 5ht systems, indicated by blunted prl responses and perhaps caused by raised circulating cortisol or reduced tryptophan concentrations. |
1990-06-27 |
2023-08-11 |
Not clear |
| S Kasper, A Vieira, R Schmidt, P Richte. Multiple hormone responses to stimulation with dl-fenfluramine in patients with major depression before and after antidepressive treatment. Pharmacopsychiatry. vol 23. issue 2. 1990-06-20. PMID:2339181. |
the authors investigated 31 drug-free inpatients with major depression using dl-fenfluramine (dl-fen) as a serotonin probe (fenfluramine stimulation test, fft). |
1990-06-20 |
2023-08-11 |
Not clear |
| M Maes, M P Jacobs, E Suy, B Minner, C Leclercq, F Christiaens, J Rau. Suppressant effects of dexamethasone on the availability of plasma L-tryptophan and tyrosine in healthy controls and in depressed patients. Acta psychiatrica Scandinavica. vol 81. issue 1. 1990-05-29. PMID:2330824. |
formation in the brain of serotonin from l-tryptophan (l-trp) and noradrenaline from tyrosine are pathways related to the pathophysiology of major depression and to the regulation of the hypothalamic-pituitary-adrenal (hpa) axis. |
1990-05-29 |
2023-08-11 |
Not clear |
| J Hallman, E Sakurai, L Orelan. Blood platelet monoamine oxidase activity, serotonin uptake and release rates in anorexia and bulimia patients and in healthy controls. Acta psychiatrica Scandinavica. vol 81. issue 1. 1990-05-29. PMID:2330833. |
low platelet serotonin uptake rate has been connected to unipolar depression and the rate of efflux, in the presence of the atp uncoupler ccp, higher in bipolar depressives than in controls. |
1990-05-29 |
2023-08-11 |
Not clear |
| A B Katasonov, B S Beliaev, O S Brusov, G P Zlobina, M I Fakto. [Activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 89. issue 12. 1990-05-18. PMID:2633575. |
[activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents]. |
1990-05-18 |
2023-08-11 |
Not clear |
| D Laws, J J Ashford, J A Anste. A multicentre double-blind comparative trial of fluvoxamine versus lorazepam in mixed anxiety and depression treated in general practice. Acta psychiatrica Scandinavica. vol 81. issue 2. 1990-05-14. PMID:2109498. |
fluvoxamine, a selective serotonin reuptake inhibitor, was compared with lorazepam in a multicentre double-blind, parallel group study in 112 general practice patients with mixed anxiety and depression. |
1990-05-14 |
2023-08-11 |
Not clear |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
the putative 5-ht1a autoreceptor antagonist spiperone reversed the cocaine-induced depression of firing rate in 64% of 5-ht neurons tested whereas receptor antagonists for dopamine d2 (haloperidol), 5-ht2 (ketanserin), gamma-aminobutyric acid (picrotoxin) and 5-ht1/beta-adrenergic (propranolol) were ineffective. |
1990-04-05 |
2023-08-11 |
rat |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
following treatment with the 5-ht synthesis inhibitor p-chlorophenylalanine (100 mg/kg/day of the base for 3 days), impulse depression induced by cocaine was significantly attenuated as compared to control, which suggests that the effects of cocaine may be dependent on endogenous 5-ht stores. |
1990-04-05 |
2023-08-11 |
rat |