| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Welner, C De Montigny, J Desroches, P Desjardins, B E Suranyi-Cadott. Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse (New York, N.Y.). vol 4. issue 4. 1990-01-31. PMID:2532423. |
there is growing evidence that the serotonergic (5-ht) system is involved in the pathogenesis and treatment of major depression. |
1990-01-31 |
2023-08-11 |
rat |
| H Ono, Y Hasebe, T Mori, H Fukuda, M Kohno, S Ohta, M Hirob. Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats. Journal of pharmacobio-dynamics. vol 12. issue 7. 1990-01-25. PMID:2593080. |
depressions of msr produced by pea, s(+)-methamphetamine and r(+)-2-aminotetralin were antagonized by ketanserin and haloperidol which have 5-hydroxytryptamine (5-ht) antagonistic activity, and the msr depression caused by s(+)-methamphetamine but not pea and r(+)-2-aminotetralin was abolished by intracisternal 5,6-dihydroxytryptamine treatment or chronic spinal transection. |
1990-01-25 |
2023-08-11 |
rat |
| H Ono, Y Hasebe, T Mori, H Fukuda, M Kohno, S Ohta, M Hirob. Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats. Journal of pharmacobio-dynamics. vol 12. issue 7. 1990-01-25. PMID:2593080. |
these results suggest that pea-related compounds cause msr depression by direct and indirect 5-ht agonistic mechanisms, and support the proposal that the pea moiety which exists in r(+)-2-aminotetralin is important for the direct 5-ht agonistic activity of some hallucinogens. |
1990-01-25 |
2023-08-11 |
rat |
| D M Bowen, A Najlerahim, A W Procter, P T Francis, E Murph. Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 23. 1990-01-19. PMID:2574463. |
results for depression expressed per entire area indicate additionally reduced somatostatin content and serotonin 1a sites in the pars opercularis and serotonin 1a sites in the temporal pole. |
1990-01-19 |
2023-08-11 |
Not clear |
| W Bugge, C J Ribbegren, T Gerner, J Haffne. Serotonin--a possible transmitter for the gastric adaptive relaxation. Interaction with histamine and prostaglandin F2 alpha on pressure responses in the isolated stomach. Scandinavian journal of gastroenterology. vol 24. issue 9. 1990-01-17. PMID:2595269. |
to test whether the relaxation response to serotonin is compatible with a putative role as transmitter in gastric adaptive relaxation, we wanted to evaluate whether serotonin acts by crude muscle depression and whether it selectively inhibits histamine or prostaglandin f2 alpha (pgf2 alpha). |
1990-01-17 |
2023-08-11 |
Not clear |
| W Bugge, C J Ribbegren, T Gerner, J Haffne. Serotonin--a possible transmitter for the gastric adaptive relaxation. Interaction with histamine and prostaglandin F2 alpha on pressure responses in the isolated stomach. Scandinavian journal of gastroenterology. vol 24. issue 9. 1990-01-17. PMID:2595269. |
it is then concluded that the relaxatory effect of 5-ht is provided through other mechanisms than crude muscle depression and that selective inhibition of intramural agonists, like histamine, is a possible effect mechanism. |
1990-01-17 |
2023-08-11 |
Not clear |
| S C Cheetham, M R Crompton, C Czudek, R W Horton, C L Katona, G P Reynold. Serotonin concentrations and turnover in brains of depressed suicides. Brain research. vol 502. issue 2. 1990-01-08. PMID:2479456. |
5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) concentrations and 5-ht turnover (5-hiaa/5-ht) were determined in 6 brain regions from 19 suicide victims in whom a retrospective diagnosis of depression was established, and 19 age- and sex-matched control subjects. |
1990-01-08 |
2023-08-11 |
human |
| L M Tremaine, W M Welch, R A Ronfel. Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog. Drug metabolism and disposition: the biological fate of chemicals. vol 17. issue 5. 1989-12-29. PMID:2573498. |
sertaline [1s,4s-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1- naphthalenamine] is a potent and selective inhibitor of neuronal serotonin uptake and is currently under development for the treatment of depression and of obesity. |
1989-12-29 |
2023-08-11 |
rat |
| R H Cox, K S Haas, D M Moisey, T N Tulenk. Effects of endothelium regeneration on canine coronary artery function. The American journal of physiology. vol 257. issue 5 Pt 2. 1989-12-28. PMID:2589521. |
the results of this study suggest a "chronic" depression of relaxation responses mediated by the guanosine 3',5'-cyclic monophosphate pathway and increased serotonin vasoconstriction sensitivity in arteries 5 wk after an endothelial denudation injury. |
1989-12-28 |
2023-08-11 |
Not clear |
| S A Montgomer. New antidepressants and 5-HT uptake inhibitors. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2530760. |
moreover, the evidence for efficacy in the prophylaxis of depression is better established for 5-ht uptake inhibitors than for reference antidepressants. |
1989-12-18 |
2023-08-11 |
Not clear |
| D G Grahame-Smit. Serotonin function in affective disorders. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2683591. |
biochemical studies have indicated that low plasma levels of tryptophan are unlikely to be the primary 'cause' of depression or of abnormal brain 5-ht function in depression. |
1989-12-18 |
2023-08-11 |
Not clear |
| D G Grahame-Smit. Serotonin function in affective disorders. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2683591. |
clinical studies have provided further evidence that 5-ht is implicated in the causation and treatment of depression, as both 5-ht precursors and selective inhibitors of 5-ht uptake are effective in the treatment of depression. |
1989-12-18 |
2023-08-11 |
Not clear |
| W Kostowski, A Płaźni. [The serotonin concept of depression in light of the mechanism of action of antidepressant drugs]. Psychiatria polska. vol 23. issue 2. 1989-11-30. PMID:2682712. |
[the serotonin concept of depression in light of the mechanism of action of antidepressant drugs]. |
1989-11-30 |
2023-08-11 |
Not clear |
| S N Young, A M Ghadiria. Folic acid and psychopathology. Progress in neuro-psychopharmacology & biological psychiatry. vol 13. issue 6. 1989-11-28. PMID:2682787. |
thus, depression associated with folate deficiency is probably related to low brain 5ht. |
1989-11-28 |
2023-08-11 |
Not clear |
| M J Norde. Fluoxetine in borderline personality disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 13. issue 6. 1989-11-28. PMID:2813806. |
twelve patients with borderline personality disorder and not suffering a major depression were treated with fluoxetine, a selective serotonin reuptake inhibitor, in an open label trial. |
1989-11-28 |
2023-08-11 |
Not clear |
| S L McCance, P R Cohen, P J Cowe. Lithium increases 5-HT-mediated prolactin release. Psychopharmacology. vol 99. issue 2. 1989-11-15. PMID:2508166. |
these data are consistent with the hypothesis that synergistic effects of lithium and clomipramine on brain 5-ht function may be involved in their therapeutic effect in resistant depression. |
1989-11-15 |
2023-08-11 |
human |
| K Nakamura, Y Ikoma, K Kimura, Y Nakada, S Kobayashi, M Yamaguchi, H Nakagaw. [Effects in animal models of depression of lisuride alone and upon coadministration with antidepressants]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 94. issue 1. 1989-11-07. PMID:2792964. |
effects of lisuride, a central dopamine and serotonin agonist of the ergot type, in animal models of depression were investigated in comparison with those of desipramine, mianserin and rolipram. |
1989-11-07 |
2023-08-11 |
mouse |
| J P Feighner, W F Boyer, C H Meredith, G G Hendrickso. A placebo-controlled inpatient comparison of fluvoxamine maleate and imipramine in major depression. International clinical psychopharmacology. vol 4. issue 3. 1989-11-06. PMID:2507630. |
fluvoxamine, a selective serotonin reuptake inhibitor, was investigated in a 6-week double-blind study among severely ill inpatients with dsm-iii major depression. |
1989-11-06 |
2023-08-11 |
Not clear |
| A Plaznik, W Kostowski, T Arche. Serotonin and depression: old problems and new data. Progress in neuro-psychopharmacology & biological psychiatry. vol 13. issue 5. 1989-10-26. PMID:2675193. |
serotonin and depression: old problems and new data. |
1989-10-26 |
2023-08-11 |
Not clear |
| H Shimokawa, N A Flavahan, P M Vanhoutt. Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein. Circulation research. vol 65. issue 3. 1989-10-03. PMID:2504508. |
in quiescent rings, the presence of normal endothelium inhibited the contractions caused by serotonin and aggregating platelets; this endothelium-dependent depression was markedly impaired in the previously denuded arteries throughout the study. |
1989-10-03 |
2023-08-11 |
Not clear |