| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Coppen, D P Dooga. Serotonin and its place in the pathogenesis of depression. The Journal of clinical psychiatry. vol 49 Suppl. 1988-10-13. PMID:3045111. |
serotonin stimulated release of prolactin and growth hormone, although the prolactin response was less marked in depression. |
1988-10-13 |
2023-08-11 |
Not clear |
| J Gerlac. Future treatment of schizophrenia. Psychopharmacology series. vol 5. 1988-10-03. PMID:2901086. |
an incidental discovery of a completely new drug, a new "chlorpromazine" would be the ideal solution, but for the present, one has to continue with the small pragmatic steps, especially within the following areas: (a) the selective antidopaminergic drugs, especially the substituted benzamides, may be further developed in the direction of antipsychotic selectivity with fewer and fewer extrapyramidal side effects; (b) the atypical clozapine ought soon to have successors, hopefully without the risk of bone marrow depression and cardiovascular side effects; (c) the d1 antagonists as well as the d1 agonists may imply therapeutically valuable effects; (d) the dopamine autoreceptor has long been in focus, but until now, no pure agonist has been found, and the drugs available, including (-)3-ppp, appear to have many side effects; (e) serotonin antagonists may be an interesting possibility; and (f) when it may be possible to influence brain peptides more efficiently than up to now, this area will probably provide us with several psychotropic drugs. |
1988-10-03 |
2023-08-11 |
Not clear |
| O J Rafaelsen, A Gjerri. Treating depression in acute stage: biochemical and clinical aspects. Psychopharmacology series. vol 5. 1988-10-03. PMID:3045794. |
drugs like citalopram, fluoxetine, fluvoxamine, and paroxetine are very selective in their 5-ht reuptake inhibition, so that in clinical practice they can be tested for the specific importance of this system in depression. |
1988-10-03 |
2023-08-11 |
Not clear |
| O J Rafaelsen, A Gjerri. Treating depression in acute stage: biochemical and clinical aspects. Psychopharmacology series. vol 5. 1988-10-03. PMID:3045794. |
csf adrenaline was low, noradrenaline normal, and serotonin and dopamine increased in untreated depression. |
1988-10-03 |
2023-08-11 |
Not clear |
| B Woggo. Unsolved problems in the pharmacotherapy of depression. Psychopharmacology series. vol 5. 1988-10-03. PMID:3045799. |
five unsolved problems in the pharmacotherapy of depression are discussed: (a) it is not possible to differentiate endogenous and nonendogenous depression; (b) a selective efficacy of serotonin and noradrenaline reuptake inhibitors cannot be demonstrated; (c) the relationship between plasma levels and antidepressant effect is still unclear: plasma levels are influenced by pharmacogenetic factors, age, route of application, and concomitant treatment with other drugs; (d) evidence is growing for the development of tolerance towards therapeutic effects of antidepressants; (e) no pretreatment variable allows prediction of treatment response: the best predictor is the initial response to treatment. |
1988-10-03 |
2023-08-11 |
Not clear |
| H Y Meltzer, R C Aror. Genetic control of serotonin uptake in blood platelets: a twin study. Psychiatry research. vol 24. issue 3. 1988-09-15. PMID:3406242. |
thus, low platelet 5ht uptake (vmax) in major depression and other disorders may be genetically determined. |
1988-09-15 |
2023-08-11 |
human |
| H S Mayberg, R G Robinson, D F Wong, R Parikh, P Bolduc, S E Starkstein, T Price, R F Dannals, J M Links, A A Wilso. PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression. The American journal of psychiatry. vol 145. issue 8. 1988-08-25. PMID:3394877. |
pet imaging of cortical s2 serotonin receptors after stroke: lateralized changes and relationship to depression. |
1988-08-25 |
2023-08-11 |
human |
| A J Kaumann, M Frenke. ICI 169,369 is both a competitive antagonist and an allosteric activator of the arterial 5-hydroxytryptamine2 receptor system. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:3385635. |
preincubation with ici 169,369 also prevented the methysergide-induced depression of the maximum effects of 5-ht. |
1988-07-29 |
2023-08-11 |
rat |
| W F Byerley, F W Reimherr, D R Wood, B I Grosse. Fluoxetine, a selective serotonin uptake inhibitor, for the treatment of outpatients with major depression. Journal of clinical psychopharmacology. vol 8. issue 2. 1988-07-14. PMID:3286684. |
fluoxetine, a selective serotonin uptake inhibitor, for the treatment of outpatients with major depression. |
1988-07-14 |
2023-08-11 |
Not clear |
| J N Hingtgen, A Shekhar, J A DiMicco, M H Apriso. Response suppression in rats after bilateral microinjection of 5-hydroxytryptophan in lateral hypothalamus. Biological psychiatry. vol 23. issue 7. 1988-06-24. PMID:3259438. |
these data support the important role previously assigned to central 5-ht mechanisms in the 5-htp animal model of depression. |
1988-06-24 |
2023-08-11 |
rat |
| P J Cowe. Prolactin response to tryptophan during mianserin treatment. The American journal of psychiatry. vol 145. issue 6. 1988-06-21. PMID:3369564. |
unlike tricyclic antidepressants and monoamine oxidase inhibitors, mianserin did not increase prolactin response to the 5-hydroxytryptamine (5-ht) precursor tryptophan in nine patients with major depression. |
1988-06-21 |
2023-08-11 |
Not clear |
| H M Pappius, R Dadoun, M McHug. The effect of p-chlorophenylalanine on cerebral metabolism and biogenic amine content of traumatized brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 8. issue 3. 1988-06-20. PMID:2452825. |
doses of pcpa that ameliorated the depression of lcgu in injured brain completely prevented increases in both 5-ht and its metabolite 5-hydroxyindoleacetic acid seen following traumatization in untreated animals. |
1988-06-20 |
2023-08-11 |
rat |
| A Roy, F Karoum, M Linnoila, D Picka. Thyrotropin releasing hormone test in unipolar depressed patients and controls: relationship to clinical and biologic variables. Acta psychiatrica Scandinavica. vol 77. issue 2. 1988-06-09. PMID:3129906. |
these results suggest that the blunted tsh response to trh seen in depression may be associated with dysregulation of the cortisol, noradrenergic and serotonin systems. |
1988-06-09 |
2023-08-11 |
Not clear |
| J Kamei, M Ogawa, Y Kasuy. Monoamines and the mechanisms of action of antitussive drugs in rats. Archives internationales de pharmacodynamie et de therapie. vol 290. issue 1. 1988-04-25. PMID:2965557. |
reserpine (2.5 mg/kg/day, 2 days) produced depression of more than 80% in levels of ne, da and 5-ht in the brain. |
1988-04-25 |
2023-08-11 |
rat |
| J W Gibb, D M Stone, D C Stahl, G R Hanso. The effects of amphetamine-like designer drugs on monoaminergic systems in rat brain. NIDA research monograph. vol 76. 1988-03-29. PMID:2449619. |
the reduction in 5ht content corresponded to the depression of tph activity in all regions examined. |
1988-03-29 |
2023-08-11 |
rat |
| R Gardette, M Krupa, F Crepe. Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices. Neuroscience. vol 23. issue 2. 1988-03-28. PMID:2893990. |
conversely, the monoamine induced a depression of the excitatory responses induced by four agonists tested and the depressant potency of serotonin was in the order quisqualate, glutamate, aspartate, n-methyl-d,l-aspartate. |
1988-03-28 |
2023-08-11 |
rat |
| P Blier, C de Montigny, Y Chapu. Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. Journal of clinical psychopharmacology. vol 7. issue 6 Suppl. 1988-03-18. PMID:3323264. |
serotonin reuptake blockers may relieve depression through an increased efficacy of the presynaptic element resulting from a desensitization of somatodendritic and terminal 5-ht autoreceptors. |
1988-03-18 |
2023-08-11 |
Not clear |
| G Cournoyer, C de Montigny, J Ouellette, R Langlois, R Elie, G Caille, P le Morva. A comparative double-blind controlled study of trimipramine and amitriptyline in major depression: lack of correlation with 5-hydroxytryptamine reuptake blockade. Journal of clinical psychopharmacology. vol 7. issue 6. 1988-03-15. PMID:3323262. |
a comparative double-blind controlled study of trimipramine and amitriptyline in major depression: lack of correlation with 5-hydroxytryptamine reuptake blockade. |
1988-03-15 |
2023-08-11 |
Not clear |
| D W Robertson, N D Jones, J K Swartzendruber, K S Yang, D T Won. Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor. Journal of medicinal chemistry. vol 31. issue 1. 1988-02-17. PMID:3257267. |
fluoxetine, a selective inhibitor of serotonin uptake, is clinically useful in treating depression and may be useful for management of a variety of other psychiatric and metabolic derangements. |
1988-02-17 |
2023-08-11 |
Not clear |
| J F Cloix, M Crabos, M L Grichois, P Meye. An endogenous digitalis-like compound extracted from human urine: biochemical and chemical studies. Canadian journal of physiology and pharmacology. vol 65. issue 8. 1988-02-11. PMID:2825938. |
the main effects of such a compound were the depression of na+-k+ pump activity of human erythrocytes, the inhibition of 5-hydroxytryptamine reuptake by human platelets, and the induction of natriuresis in urethanized rats. |
1988-02-11 |
2023-08-11 |
human |