| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R B Innis, D S Charney, G R Heninge. Differential 3H-imipramine platelet binding in patients with panic disorder and depression. Psychiatry research. vol 21. issue 1. 1987-08-10. PMID:3037580. |
because 3h-imi binding is associated with the serotonin reuptake site in platelet and brain membranes, these findings give further support to abnormalities in serotonergic function in patients with major depression. |
1987-08-10 |
2023-08-11 |
human |
| R Malmgren, A Aberg-Wistedt, L Bertilsso. Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. Psychopharmacology. vol 92. issue 2. 1987-08-04. PMID:2440073. |
serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. |
1987-08-04 |
2023-08-11 |
Not clear |
| W F Byerley, L L Judd, F W Reimherr, B I Grosse. 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. Journal of clinical psychopharmacology. vol 7. issue 3. 1987-07-31. PMID:3298325. |
alterations in serotonin metabolism may be an important factor in the etiology and treatment of depression. |
1987-07-31 |
2023-08-11 |
human |
| W F Byerley, L L Judd, F W Reimherr, B I Grosse. 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. Journal of clinical psychopharmacology. vol 7. issue 3. 1987-07-31. PMID:3298325. |
in this regard, 5-hydroxytryptophan (5-htp), a serotonin precursor, has been given to patients with depression. |
1987-07-31 |
2023-08-11 |
human |
| G M Bressa, S Marini, S Gregor. Serotonin S2 receptors blockage and generalized anxiety disorders. A double-blind study on ritanserin and lorazepam. International journal of clinical pharmacology research. vol 7. issue 2. 1987-07-10. PMID:3108171. |
serotonin (5-ht) and 5-ht receptors are involved in mood disturbances, such as anxiety and depression. |
1987-07-10 |
2023-08-11 |
Not clear |
| H M Emrich, M Berger, D Riemann, D von Zersse. Serotonin reuptake inhibition vs. norepinephrine reuptake inhibition: a double-blind differential-therapeutic study with fluvoxamine and oxaprotiline in endogenous and neurotic depressives. Pharmacopsychiatry. vol 20. issue 2. 1987-07-01. PMID:3108909. |
the antidepressive properties of the specific serotonin reuptake inhibitor fluvoxamine and the specific norepinephrine reuptake inhibitor oxaprotiline were investigated in a sequential design with the aim of evaluating the hypothesis that two distinct biochemical subtypes of depression exist. |
1987-07-01 |
2023-08-11 |
Not clear |
| S E Smith, R O Pihl, S N Young, F R Ervi. A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males. Psychopharmacology. vol 91. issue 4. 1987-06-30. PMID:3108925. |
our data strongly support the idea that 5ht exerts an effect on mood and that low 5ht may, in some patients, be an important factor contributing to the etiology of clinical depression. |
1987-06-30 |
2023-08-11 |
human |
| A Gjerris, A S Sørensen, O J Rafaelsen, L Werdelin, C Alling, M Linnoil. 5-HT and 5-HIAA in cerebrospinal fluid in depression. Journal of affective disorders. vol 12. issue 1. 1987-06-11. PMID:2437171. |
5-ht and 5-hiaa in cerebrospinal fluid in depression. |
1987-06-11 |
2023-08-11 |
Not clear |
| M E Trulson, C J Frederickso. A comparison of the electrophysiological and pharmacological properties of serotonin-containing neurons in the nucleus raphe dorsalis, raphe medianus and raphe pallidus recorded from mouse brain slices in vitro: role of autoreceptors. Brain research bulletin. vol 18. issue 2. 1987-06-05. PMID:2436725. |
similarly, increasing the concentration of serotonin in the tissue slice by adding serotonin directly to the incubation medium resulted in a profound, though transitory, depression of unit activity. |
1987-06-05 |
2023-08-11 |
mouse |
| K L Brugge, J N Hingtgen, M H Apriso. Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. Pharmacology, biochemistry, and behavior. vol 26. issue 2. 1987-06-02. PMID:3495008. |
model of depression involving the serotonergic system, we predicted the development of receptor supersensitivity of postsynaptic serotonin (5-ht) receptors due to the decreased release of this neurotransmitter as a consequence of chronic reserpine treatment. |
1987-06-02 |
2023-08-11 |
human |
| K L Brugge, J N Hingtgen, M H Apriso. Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. Pharmacology, biochemistry, and behavior. vol 26. issue 2. 1987-06-02. PMID:3495008. |
we found that 5-htp induced behavioral depression was potentiated in rats chronically treated with reserpine, thus suggesting the development of supersensitive 5-ht receptors. |
1987-06-02 |
2023-08-11 |
human |
| K L Brugge, J N Hingtgen, M H Apriso. Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. Pharmacology, biochemistry, and behavior. vol 26. issue 2. 1987-06-02. PMID:3495008. |
these results support the hypothesis that in some types of human depression a decreased release of 5-ht occurs of sufficient duration to permit the subsequent development of supersensitive 5-ht receptors. |
1987-06-02 |
2023-08-11 |
human |
| V S Kostić, B M Djuricić, N Covicković-Sternić, L Bumbasirević, M Nikolić, B B Mrsulj. Depression and Parkinson's disease: possible role of serotonergic mechanisms. Journal of neurology. vol 234. issue 2. 1987-05-12. PMID:2435855. |
the results indicate that disturbed 5-ht metabolism may possibly play a role in parkinson's disease as a predisposing factor in the development of depression. |
1987-05-12 |
2023-08-11 |
Not clear |
| H M Van Praag, R Plutchik, H Cont. The serotonin hypothesis of (auto)aggression. Critical appraisal of the evidence. Annals of the New York Academy of Sciences. vol 487. 1987-05-01. PMID:2436530. |
based on the relation found to exist between low csf 5-hiaa and suicide attempt, in particular violent suicide attempt, both in depressed and in so-called nondepressed suicide attempters, the conclusion was drawn that decreased central 5-ht metabolism is related to (auto)aggression, rather than to depression. |
1987-05-01 |
2023-08-11 |
Not clear |
| H Y Meltzer, R C Aror. Platelet markers of suicidality. Annals of the New York Academy of Sciences. vol 487. 1987-05-01. PMID:3471162. |
six serotonergic measures in blood platelets, km and vmax of serotonin (5-ht) uptake, kd and bmax of 3h-imipramine binding, 5-ht content, and mao activity, were measured in depressed and other psychiatric patients and related to hamilton depression scale suicide ratings. |
1987-05-01 |
2023-08-11 |
Not clear |
| R W Fulle. Pharmacologic properties of serotonergic agents and antidepressant drugs. The Journal of clinical psychiatry. vol 48 Suppl. 1987-04-17. PMID:3493240. |
the ways in which pharmacologic intervention is possible in the synthesis, storage, release, inactivation, and actions of serotonin as a brain neurotransmitter are outlined, and the effects on serotonergic neuron function of the drugs used in the treatment of depression are discussed. |
1987-04-17 |
2023-08-11 |
Not clear |
| R W Fulle. Pharmacologic properties of serotonergic agents and antidepressant drugs. The Journal of clinical psychiatry. vol 48 Suppl. 1987-04-17. PMID:3493240. |
recently, selective inhibitors of serotonin uptake have been shown to be effective in the treatment of depression. |
1987-04-17 |
2023-08-11 |
Not clear |
| R W Fulle. Pharmacologic properties of serotonergic agents and antidepressant drugs. The Journal of clinical psychiatry. vol 48 Suppl. 1987-04-17. PMID:3493240. |
selective drugs for modulating serotonergic function will facilitate understanding of the role of serotonin and of specific subtypes of serotonin receptors in depression. |
1987-04-17 |
2023-08-11 |
Not clear |
| K J Kella. Effects of electroconvulsive shock on noradrenergic and serotonergic receptors in rat brain. Pharmacopsychiatry. vol 20. issue 1. 1987-04-17. PMID:3547420. |
it is likely that both noradrenalin and serotonin neurotransmission are important in the pathophysiology of depression and to its treatment. |
1987-04-17 |
2023-08-11 |
rat |
| S J Flora, S K Tando. Effect of combined exposure to lead and ethanol on some biochemical indices in the rat. Biochemical pharmacology. vol 36. issue 4. 1987-03-30. PMID:3827940. |
simultaneous exposure to lead and ethanol produced a greater depression of dopamine (da) and 5-hydroxytryptamine (5-ht) levels in the whole brain of rats, compared to rats treated with lead alone. |
1987-03-30 |
2023-08-11 |
rat |