| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Paul, M Rehavi, P Skolnick, J C Ballenger, F K Goodwi. Depressed patients have decreased binding of tritiated imipramine to platelet serotonin "transporter". Archives of general psychiatry. vol 38. issue 12. 1982-02-25. PMID:7316676. |
these results, coupled with previous studies showing a significant decrease in the maximal uptake of serotonin in platelets from depressed patients, suggest that an inherited or acquired deficiency of the serotonin transport protein or proteins may be involved in the pathogenesis of depression. |
1982-02-25 |
2023-08-12 |
human |
| H Y Meltzer, R C Arora, R Baber, B J Trico. Serotonin uptake in blood platelets of psychiatric patients. Archives of general psychiatry. vol 38. issue 12. 1982-02-25. PMID:7316677. |
decreased 5-ht uptake in platelets provides additional evidence for the role of 5-ht in the pathophysiologic process of some forms of depression. |
1982-02-25 |
2023-08-12 |
Not clear |
| R Takahashi, T Tateishi, H Yoshida, H Nagayama, K H Tachik. Serotonin metabolism of animal model of depression. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6172020. |
serotonin metabolism of animal model of depression. |
1982-02-12 |
2023-08-12 |
human |
| R Takahashi, T Tateishi, H Yoshida, H Nagayama, K H Tachik. Serotonin metabolism of animal model of depression. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6172020. |
all results presented here would indicate that serotonin plays an important role in animal behavior such as locomotor depression and that, taking into consideration the effects of antidepressants on 5-ht receptor activity as well as recent biochemical findings of human depression, some forms of human depression could be induced by a cerebral serotonergic receptor hyperactivity contrary to a conventional theory of serotonin deficiency in the synaptic cleft in the brain. |
1982-02-12 |
2023-08-12 |
human |
| J Mendlewicz, J E Vanderheyden, G Noe. Serotonin and dopamine disturbances in patients with unipolar depression and Parkinsonism. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6172024. |
serotonin and dopamine disturbances in patients with unipolar depression and parkinsonism. |
1982-02-12 |
2023-08-12 |
Not clear |
| R C Murthy, S Lal, D K Saxena, G S Shukla, M M Ali, S V Chandr. Effect of manganese and copper interaction on behavior and biogenic amines in rats fed a 10% casein diet. Chemico-biological interactions. vol 37. issue 3. 1982-01-20. PMID:7296699. |
combined exposure of mn and cu also produced a greater elevation in the levels of dopamine (da) and norepinephrine (ne) and a depression of 5-hydroxytryptamine (5-ht) in the brain of animals fed with a 10% casein diet compared to the animals receiving the 21% casein diet. |
1982-01-20 |
2023-08-12 |
rat |
| H R Olpe, R Ortmann, B Fehr, P C Waldmeie. Experimentally induced supersensitivity of neocortical neurons to microiontophoretically administered serotonin. Brain research. vol 224. issue 2. 1981-12-22. PMID:6169411. |
the depressant action of 5-ht on neuronal firing was potentiated with regard to both maximal firing depression and duration of the firing inhibition. |
1981-12-22 |
2023-08-12 |
rat |
| C De Montign. Enhancement of the 5-HT neurotransmission by antidepressant treatments. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:6270317. |
little unequivocal evidence exists for a 5-ht deficit in depression. |
1981-12-22 |
2023-08-12 |
human |
| A Ferron, T A Reader, L Descarrie. Responsiveness of cortical neurons to serotonin after 5,7-DHT denervation or PCPA depletion. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:6457141. |
in adult rats under urethane anesthesia, a vast majority of spontaneously active neurons in the frontoparietal cortex undergo a prolonged depression of their firing rate upon microiontophoretic application of 5-ht. |
1981-12-22 |
2023-08-12 |
rat |
| A Ferron, T A Reader, L Descarrie. Responsiveness of cortical neurons to serotonin after 5,7-DHT denervation or PCPA depletion. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:6457141. |
moreover, small ejection currents of 5-ht are sufficient to induce a prolonged depression of the firing rate. |
1981-12-22 |
2023-08-12 |
rat |
| V Bhargava, A Salamy, S Sha. Role of serotonin in the nicotine-induced depression of the brainstem auditory evoked response. Pharmacology, biochemistry, and behavior. vol 15. issue 4. 1981-12-22. PMID:6457306. |
role of serotonin in the nicotine-induced depression of the brainstem auditory evoked response. |
1981-12-22 |
2023-08-12 |
Not clear |
| G M Asnis, E J Sachar, U Halbreich, R S Nathan, L Ostrow, M Soloman, F S Halper. Endocrine responses to thyrotropin-releasing hormone in major depressive disorders. Psychiatry research. vol 5. issue 2. 1981-12-21. PMID:6117098. |
the role of possible abnormalities in dopamine and/or serotonin in depression contributing to these endocrine disturbances is discussed. |
1981-12-21 |
2023-08-12 |
Not clear |
| A Aberg-Wistedt, K G Jostell, S B Ross, D Westerlun. Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression. Psychopharmacology. vol 74. issue 4. 1981-12-15. PMID:6457309. |
effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression. |
1981-12-15 |
2023-08-12 |
rat |
| A Aberg-Wistedt, K G Jostell, S B Ross, D Westerlun. Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression. Psychopharmacology. vol 74. issue 4. 1981-12-15. PMID:6457309. |
the selective inhibitors of neuronal 5-hydroxytryptamine (5-ht) and noradrenaline (na) uptake, zimelidine and desipramine, were compared in a double blind crossover study of 40 inpatients with endogenous depression. |
1981-12-15 |
2023-08-12 |
rat |
| H Nagayama, J N Hingtgen, M H Apriso. Postsynaptic action by four antidepressive drugs in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 15. issue 1. 1981-12-15. PMID:6974869. |
to further test the new hypersensitive postsynaptic serotonin (5-ht) receptor theory of depression bases on or animal model, it was necessary to demonstrate that some of the currently used antidepressive drugs can block d,l-5-hydroxytryptophan (5-htp) induced depression acting through postsynaptic rather than presynaptic mechanisms. |
1981-12-15 |
2023-08-12 |
rat |
| H Nagayama, J N Hingtgen, M H Apriso. Postsynaptic action by four antidepressive drugs in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 15. issue 1. 1981-12-15. PMID:6974869. |
since acute pretreatment with comparable clinical doses of the antidepressive drugs, mianserin, amitriptyline, imipramine, or iprindole, resulted in blockade of the 5-htp induced depression by 70, 50, 40, and 20% respectively, these drugs can act as antagonists of 5-ht at the postsynaptic serotonin receptor. |
1981-12-15 |
2023-08-12 |
rat |
| E R Block, S A Stalcu. Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 50. issue 6. 1981-10-25. PMID:7263381. |
depression of serotonin uptake by cultured endothelial cells exposed to high o2 tension. |
1981-10-25 |
2023-08-12 |
Not clear |
| E R Block, S A Stalcu. Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 50. issue 6. 1981-10-25. PMID:7263381. |
to characterized the cellular basis and mechanism for hyperoxic depression of lung 5-ht uptake, we evaluated the effect of high po2 on 5-ht uptake by calf aortic endothelial cells in primary confluent monolayer. |
1981-10-25 |
2023-08-12 |
Not clear |
| E R Block, S A Stalcu. Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 50. issue 6. 1981-10-25. PMID:7263381. |
exposure to 95% o2 for 20 h or 42 h resulted in significant depression of 5-ht uptake by cultured endothelial cells, and uptakes remained significantly depressed 48 h after exposure to 95% o2 had ended. |
1981-10-25 |
2023-08-12 |
Not clear |
| E R Block, S A Stalcu. Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 50. issue 6. 1981-10-25. PMID:7263381. |
these results indicate that 1) high po2 levels depress 5-ht uptake in endothelial cells by direct inhibition of the transcellular transport of 5-ht and 2) hyperoxic depression of 5-ht uptake in cultured endothelial cells is not readily reversible. |
1981-10-25 |
2023-08-12 |
Not clear |