| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W M Welch, A R Kraska, R Sarges, B K Ko. Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins. Journal of medicinal chemistry. vol 27. issue 11. 1984-12-10. PMID:6492080. |
the potential role of derangements of 5-ht pathways in the etiology of depression has long been suspected and has given impetus to the development of newer compounds that accentuate inhibition of serotonin reuptake. |
1984-12-10 |
2023-08-12 |
Not clear |
| L Branchey, M Branchey, S Shaw, C S Liebe. Depression, suicide, and aggression in alcoholics and their relationship to plasma amino acids. Psychiatry research. vol 12. issue 3. 1984-12-06. PMID:6593754. |
because it has been postulated that altered serotonin metabolism may be a highly significant contributing factor not only to depression but also to aggressive and suicidal behavior, we decided to assess the existence of possible associations between amino acid abnormalities and these behaviors in a population of alcoholics. |
1984-12-06 |
2023-08-12 |
Not clear |
| R A Mueller, E Widerlöv, G R Brees. Attempted antagonism of adenosine analogue induced depression of respiration. Pharmacology, biochemistry, and behavior. vol 21. issue 2. 1984-11-15. PMID:6483940. |
neonatal destruction of brain serotonin or dopamine-containing nerve terminals did not alter the 2ca-induced respiratory depression. |
1984-11-15 |
2023-08-12 |
rat |
| J W Maas, S H Koslow, M M Katz, C L Bowden, R L Gibbons, P E Stokes, E Robins, J M Davi. Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. The American journal of psychiatry. vol 141. issue 10. 1984-11-09. PMID:6207736. |
the authors present hypotheses about the association of alterations in serotonin and norepinephrine systems and definable subtypes of depression. |
1984-11-09 |
2023-08-12 |
Not clear |
| L Branchey, M Branchey, S Shaw, C S Liebe. Relationship between changes in plasma amino acids and depression in alcoholic patients. The American journal of psychiatry. vol 141. issue 10. 1984-11-09. PMID:6486254. |
a decreased tryptophan ratio is known to result in decreased brain tryptophan and may contribute to depression through a deficiency of brain serotonin. |
1984-11-09 |
2023-08-12 |
human |
| N Pomara, K L Coffman, D F Bush, S Gersho. Myalgia and elevation in muscle creatine phosphokinase during zimelidine treatment. Journal of clinical psychopharmacology. vol 4. issue 4. 1984-10-03. PMID:6236235. |
the authors report a case involving a 65-year-old woman with dsm-iii criteria for major unipolar depression in whom the administration of zimelidine, a potent and selective 5-hydroxytryptamine reuptake inhibitor, led to the development of a hypersensitivity reaction characterized by a severe headache, low grade fever, abnormal liver enzymes, and generalized myalgia 10 days after initiation of treatment. |
1984-10-03 |
2023-08-12 |
Not clear |
| H M van Praa. Studies in the mechanism of action of serotonin precursors in depression. Psychopharmacology bulletin. vol 20. issue 3. 1984-10-03. PMID:6473668. |
studies in the mechanism of action of serotonin precursors in depression. |
1984-10-03 |
2023-08-12 |
Not clear |
| A Aberg-Wistedt, S B Ross, K G Jostell, B Sjöquis. A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a norepinephrine uptake inhibitor, in endogenous depression: clinical and biochemical findings. Advances in biochemical psychopharmacology. vol 39. 1984-09-18. PMID:6205564. |
a double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a norepinephrine uptake inhibitor, in endogenous depression: clinical and biochemical findings. |
1984-09-18 |
2023-08-12 |
Not clear |
| S O Ogren, A C Holm, H Hall, U H Lindber. Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia. Journal of neural transmission. vol 59. issue 4. 1984-09-07. PMID:6205120. |
alaproclate, a new selective 5-ht uptake inhibitor with therapeutic potential in depression and senile dementia. |
1984-09-07 |
2023-08-12 |
Not clear |
| I Pietruszewska, M Jasińska, H Lewicka-Wysocka, K Marcjan, K Stenck. [Urinary excretion of 5-hydroxyindoleacetic acid and serum tryptophan and serotonin levels in patients with depression]. Psychiatria polska. vol 18. issue 1. 1984-08-13. PMID:6204348. |
[urinary excretion of 5-hydroxyindoleacetic acid and serum tryptophan and serotonin levels in patients with depression]. |
1984-08-13 |
2023-08-12 |
Not clear |
| R Jouvent, C Rodier, P Baruch, M C Hardy, T Lemperiere, D Widlöche. Indalpine, a specific 5HT uptake inhibitor, in delusional depression. Psychiatry research. vol 11. issue 4. 1984-08-01. PMID:6588397. |
indalpine, a specific 5ht uptake inhibitor, in delusional depression. |
1984-08-01 |
2023-08-12 |
Not clear |
| M A Mena, E G Aguado, J G de Yebene. Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method. Acta neurologica Scandinavica. vol 69. issue 4. 1984-07-31. PMID:6204498. |
patients with depression show a decrease in serotonin turnover expressed by diminished 5-hydroxyindoleacetic acid content in cerebrospinal fluid. |
1984-07-31 |
2023-08-12 |
human |
| G Fontani, F Farabollin. Effect of DSP-4, pCPA, and haloperidol on hippocampal electrical activity and behavior in rabbits. Behavioral and neural biology. vol 40. issue 2. 1984-07-17. PMID:6233963. |
when this noradrenaline depletion was coupled with a serotonin depression by p-chlorophenylalanine (pcpa), the above described effect was potentiated. |
1984-07-17 |
2023-08-12 |
Not clear |
| J N Hingtgen, H C Hendrie, M H Apriso. Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 20. issue 3. 1984-05-24. PMID:6608737. |
the potency of trazodone in relation to other antidepressant drugs in our behavioral model of depression paralleled their potency in displacing radioligand binding to 5-ht receptors, and gives additional support for the new hypersensitive postsynaptic serotonin receptor theory of depression. |
1984-05-24 |
2023-08-12 |
rat |
| K Wood, C Swade, M T Abou-Saleh, A Coppe. Headaches, depression and 5-hydroxytryptamine. The British journal of psychiatry : the journal of mental science. vol 144. 1984-05-24. PMID:6704628. |
headaches, depression and 5-hydroxytryptamine. |
1984-05-24 |
2023-08-12 |
Not clear |
| R Mayeux, Y Stern, L Cote, J B William. Altered serotonin metabolism in depressed patients with parkinson's disease. Neurology. vol 34. issue 5. 1984-05-23. PMID:6200801. |
alterations in serotonin metabolism are found in primary (endogenous) depression. |
1984-05-23 |
2023-08-12 |
Not clear |
| R Mayeux, Y Stern, L Cote, J B William. Altered serotonin metabolism in depressed patients with parkinson's disease. Neurology. vol 34. issue 5. 1984-05-23. PMID:6200801. |
the data suggest that the alterations in serotonin metabolism in parkinson's disease identify a subgroup of patients who are prone to depression. |
1984-05-23 |
2023-08-12 |
Not clear |
| Recent advances with zimeldine, the 5-HT reuptake blocker, in the treatment of depression. Proceedings of a symposium. Laxenburg, Austria, July 9, 1983. Acta psychiatrica Scandinavica. Supplementum. vol 308. 1984-04-17. PMID:6230882. |
recent advances with zimeldine, the 5-ht reuptake blocker, in the treatment of depression. |
1984-04-17 |
2023-08-12 |
Not clear |
| T G Waldrop, F L Eldridge, D E Millhor. Inhibition of breathing after stimulation of muscle is mediated by endogenous opiates and GABA. Respiration physiology. vol 54. issue 2. 1984-03-22. PMID:6665335. |
we conclude that endogenous opiates and possibly gaba, but not serotonin, dopamine or norepinephrine, are involved in the neural mechanism responsible for the prolonged depression of breathing. |
1984-03-22 |
2023-08-12 |
Not clear |
| C de Montign. Electroconvulsive shock treatments enhance responsiveness of forebrain neurons to serotonin. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6319668. |
inasmuch as long-term tricyclic antidepressant drug administration has been shown to produce a similar sensitization to serotonin, the present results suggest that enhancement of serotonergic neurotransmission might mediate the therapeutic effect of both types of treatment in major depression. |
1984-02-29 |
2023-08-12 |
rat |