| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yayoi Miyamatsu, Ryutaro Tanizak. Serotonin Syndrome Triggered by Increasing the Dose of Quetiapine. Clinical practice and cases in emergency medicine. vol 5. issue 3. 2021-08-29. PMID:34437050. |
an 85-year-old woman with a history of depression treated with polypharmacy including selective serotonin reuptake inhibitor presented to the emergency department with head, and upper and lower limb tremors four hours after increasing the dose of quetiapine from 12.5 milligrams (mg) per day to 25 mg/day. |
2021-08-29 |
2023-08-13 |
Not clear |
| Sharon A Smith, Paula D Trotter, Francis P McGlone, Susannah C Walke. Effects of Acute Tryptophan Depletion on Human Taste Perception. Chemical senses. vol 46. 2021-08-26. PMID:33277648. |
serotonin is a key neurotransmitter implicated in the etiology of anxiety and depression; systemic and peripheral manipulations of serotonin signaling have previously been shown to modulate taste detection. |
2021-08-26 |
2023-08-13 |
human |
| Lijun Liu, Xiaozhen Lv, Shuzhe Zhou, Qi Liu, Jing Wang, Hongjun Tian, Kerang Zhang, Jing Wei, Chuanyue Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Nan Zhang, Yu Huang, Tianmei Si, Xin Y. The effect of selective serotonin reuptake inhibitors on cognitive impairment in patients with depression: A prospective, multicenter, observational study. Journal of psychiatric research. vol 141. 2021-08-25. PMID:34171760. |
the effect of selective serotonin reuptake inhibitors on cognitive impairment in patients with depression: a prospective, multicenter, observational study. |
2021-08-25 |
2023-08-13 |
Not clear |
| Ning Liu, Shiqiang Sun, Pengjie Wang, Yanan Sun, Qingjuan Hu, Xiaoyu Wan. The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine. International journal of molecular sciences. vol 22. issue 15. 2021-08-25. PMID:34360695. |
apart from being an important neurotransmitter and a paracrine signaling molecule in the gut, gut-derived 5-ht was also shown to exert other biological functions (in autism and depression) far beyond the gut. |
2021-08-25 |
2023-08-13 |
Not clear |
| Lierni Ugartemendia, Rafael Bravo, Martin Reuter, M Yolanda Castaño, Thomas Plieger, Vera Zamoscik, Peter Kirsch, Ana B Rodrígue. SLC6A4 polymorphisms modulate the efficacy of a tryptophan-enriched diet on age-related depression and social cognition. Clinical nutrition (Edinburgh, Scotland). vol 40. issue 4. 2021-08-24. PMID:33743283. |
in a placebo controlled study we sought to determine if a four-weeks tryptophan-enriched diet is able to improve age-related depression or social cognitive impairment, depending on polymorphisms located in the promoter region of solute carrier family 6 member 4 (slc6a4), also known as serotonin transporter (sert1) gene. |
2021-08-24 |
2023-08-13 |
Not clear |
| Caixia Yuan, Yucen Yao, Tao Liu, Ying Jin, Chunrong Yang, Xian Jun Loh, Zibiao L. Research Progress on Natural Compounds Exerting an Antidepressant Effect through Anti-inflammatory. Current medicinal chemistry. 2021-08-23. PMID:34420503. |
hence, this review aims to systematically sort the literature related to the mechanism of exerting an antidepressant effect through anti-inflammatory actions, and to summarize the related natural products in the past 20 years, in terms of a number of inflammatory related pathways (i.e., the protein kinase b (akt) pathway, monoamine neurotransmitters (5-hydroxytryptamine and norepinephrine) (5-ht and ne), the nod-like receptor protein-3 (nlrp3) inflammasome, proinflammatory cytokines, neurotrophins, or cytokine-signaling pathways), which might provide a useful reference for the potential treatment of depression. |
2021-08-23 |
2023-08-13 |
Not clear |
| Cheryl S Rosenfel. Placental serotonin signaling, pregnancy outcomes, and regulation of fetal brain development†. Biology of reproduction. vol 102. issue 3. 2021-08-20. PMID:31711155. |
increasing number of pregnant women at risk of depression are being treated with selective serotonin-reuptake inhibitors (ssris) that bind to serotonin transporters (sert), which prevents 5-ht binding and cellular internalization, allowing for accumulation of extracellular 5-ht available to bind to 5-ht(2a) receptor (5-ht(2a)r). |
2021-08-20 |
2023-08-13 |
mouse |
| C R Yang, L Ning, F H Zhou, Q Sun, H P Meng, Z Han, Y Liu, W Huang, S Liu, X H Li, B Zheng, Dong Ming, Xin-Fu Zho. Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress. Neurotoxicity research. vol 38. issue 4. 2021-08-20. PMID:32557322. |
although genome-wide expression profiling of human lymphoblastoid cell lines (lcls) reported neural cell adhesion molecule (ncam) l1 as a tentative biomarker for selective serotonin reuptake inhibitor (ssri) antidepressant response, the involvement of chl1 in depression is unclear. |
2021-08-20 |
2023-08-13 |
mouse |
| Kyounghoon Park, Seonji Kim, Young-Jin Ko, Byung-Joo Par. Comparison of risk of cardiovascular disease related adverse events between selective serotonin reuptake inhibitor users and serotonin norepinephrine reuptake inhibitor users in Korean adult patients with depression: retrospective cohort study. Psychiatry research. vol 298. 2021-08-19. PMID:33578063. |
comparison of risk of cardiovascular disease related adverse events between selective serotonin reuptake inhibitor users and serotonin norepinephrine reuptake inhibitor users in korean adult patients with depression: retrospective cohort study. |
2021-08-19 |
2023-08-13 |
Not clear |
| Hui-Qin Wang, Zhen-Zhen Wang, Nai-Hong Che. The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates. Pharmacological research. vol 167. 2021-08-19. PMID:33711432. |
this review summarizes the pathogenesis of depression from six of the most related receptors and their associated genes, including n-methyl-d-aspartate receptor, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, glucocorticoid receptor, 5-hydroxytryptamine receptor, gaba |
2021-08-19 |
2023-08-13 |
human |
| Joana Perez-Tejada, Ainitze Labaka, Oscar Vegas, Aitziber Larraioz, Ane Pescador, Amaia Arreg. Anxiety and depression after breast cancer: The predictive role of monoamine levels. European journal of oncology nursing : the official journal of European Oncology Nursing Society. vol 52. 2021-08-19. PMID:33813184. |
we aimed to examine the predictive role of peripheral dopamine (da), noradrenaline (na), serotonin (5-ht) and kynurenine (kyn) in anxiety and depression among breast cancer survivors. |
2021-08-19 |
2023-08-13 |
Not clear |
| O V Kotova, V E Medvedev, E S Akarachkova, A A Belyae. [COVID-19 and stress-related disorders]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 121. issue 5. Vyp. 2. 2021-08-19. PMID:34405668. |
current first choice agents for the treatment of both pathological anxiety and depression are selective serotonin reuptake inhibitors (ssris). |
2021-08-19 |
2023-08-13 |
Not clear |
| Hui-Hua Li, Xiao-Yan Yao, Sheng Tao, Xue Sun, Pan-Pan Li, Xi-Xin Li, Zhu-Li Liu, Chao Re. Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease. Behavioural neurology. vol 2021. 2021-08-18. PMID:33859767. |
studies have shown that reduction of serotonin receptors can increase depression and mental symptoms in ad patients. |
2021-08-18 |
2023-08-13 |
Not clear |
| Hui-Hua Li, Xiao-Yan Yao, Sheng Tao, Xue Sun, Pan-Pan Li, Xi-Xin Li, Zhu-Li Liu, Chao Re. Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease. Behavioural neurology. vol 2021. 2021-08-18. PMID:33859767. |
among them, agomelatine, as a new type of antidepressant, can act on serotonin 2 receptors to improve symptoms such as depression and anxiety. |
2021-08-18 |
2023-08-13 |
Not clear |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| Kostas Iakovou, Kleopatra Schulpi. The significant role of educational status in PKU patients: the beneficial effect of psychological support in depression. International journal of adolescent medicine and health. vol 33. issue 4. 2021-08-18. PMID:30888965. |
high phe levels minimize brain tryptophan concentration, the pressure of serotonin, which is responsible for the appearance of depression symptoms. |
2021-08-18 |
2023-08-13 |
Not clear |
| Mohsen Ghaffari Darab, Arvin Hedayati, Elahe Khorasani, Mohsen Bayati, Khosro Keshavar. Selective serotonin reuptake inhibitors in major depression disorder treatment: an umbrella review on systematic reviews. International journal of psychiatry in clinical practice. vol 24. issue 4. 2021-08-16. PMID:32667275. |
selective serotonin reuptake inhibitors in major depression disorder treatment: an umbrella review on systematic reviews. |
2021-08-16 |
2023-08-13 |
Not clear |
| Shuanghui Lu, Zhiyuan Ma, Yong Gu, Ping Li, Yingchun Chen, Mengru Bai, Hui Zhou, Xi Yang, Huidi Jian. Downregulation of glucose-6-phosphatase expression contributes to fluoxetine-induced hepatic steatosis. Journal of applied toxicology : JAT. vol 41. issue 8. 2021-08-16. PMID:33179799. |
fluoxetine is a first-line selective serotonin reuptake inhibitor widely applied for the treatment of depression; however, it induces abnormal hepatic lipid metabolism. |
2021-08-16 |
2023-08-13 |
mouse |
| Yejin Ahn, Sung Hee Han, Min Guk Kim, Ki-Bae Hong, Woo Jung Kim, Hyung Joo Suh, Kyungae J. Anti-depressant effects of ethanol extract from Pharmaceutical biology. vol 59. issue 1. 2021-08-14. PMID:34362287. |
anti-depressant effects of ethanol extract from depression is a severe mental illness caused by a deficiency of dopamine and serotonin. |
2021-08-14 |
2023-08-13 |
Not clear |
| Burak Yaman, Ramazan Ba. Serotonin hyperpolarizes the dorsal raphe nucleus neurons of mice by activating G protein-coupled inward rectifier potassium channels. Neuroreport. vol 31. issue 12. 2021-08-13. PMID:32576771. |
serotonin (5-ht) has an important role in the pathophysiology of the mood disorders like major depression and anxiety disorders in central nervous system. |
2021-08-13 |
2023-08-13 |
mouse |