| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Carrasco, M Díaz-Marsá, J Sáiz-Rui. Sertraline in the treatment of mixed anxiety and depression disorder. Journal of affective disorders. vol 59. issue 1. 2000-08-02. PMID:10814773. |
mad is usually treated as a combination of anxiety and depression, although there are data indicating that selective serotonin reuptake inhibitors (ssris) might be active on both anxiety and depression. |
2000-08-02 |
2023-08-12 |
Not clear |
| S J Wallis, W Marti. Conditions permitting suppression of stretch-induced and vasoconstrictor tone by basal nitric oxide activity in porcine cerebral artery. British journal of pharmacology. vol 130. issue 3. 2000-08-01. PMID:10821784. |
nevertheless, when concentration-response curves were constructed to u46619 and 5-hydroxytryptamine (5-ht), no endothelium-dependent depression of vasoconstriction was observed. |
2000-08-01 |
2023-08-12 |
Not clear |
| A F Schatzber. Clinical efficacy of reboxetine in major depression. The Journal of clinical psychiatry. vol 61 Suppl 10. 2000-07-27. PMID:10910015. |
the past decade has witnessed the advent of selective serotonin reuptake inhibitors (ssris) as first-line treatments for major depression. |
2000-07-27 |
2023-08-12 |
Not clear |
| A Hostetter, Z N Stowe, J R Strader, E McLaughlin, A Llewelly. Dose of selective serotonin uptake inhibitors across pregnancy: clinical implications. Depression and anxiety. vol 11. issue 2. 2000-07-24. PMID:10812529. |
however, there is no data on the dosage of selective serotonin uptake inhibitors (ssris) required to maintain symptom resolution in women treated for major depression during pregnancy. |
2000-07-24 |
2023-08-12 |
human |
| S J Fredman, M Fava, A S Kienke, C N White, A A Nierenberg, J F Rosenbau. Partial response, nonresponse, and relapse with selective serotonin reuptake inhibitors in major depression: a survey of current "next-step" practices. The Journal of clinical psychiatry. vol 61. issue 6. 2000-07-24. PMID:10901336. |
partial response, nonresponse, and relapse with selective serotonin reuptake inhibitors in major depression: a survey of current "next-step" practices. |
2000-07-24 |
2023-08-12 |
Not clear |
| S J Fredman, M Fava, A S Kienke, C N White, A A Nierenberg, J F Rosenbau. Partial response, nonresponse, and relapse with selective serotonin reuptake inhibitors in major depression: a survey of current "next-step" practices. The Journal of clinical psychiatry. vol 61. issue 6. 2000-07-24. PMID:10901336. |
we conducted a survey of psychiatrists and other medical specialists who treat depression to ascertain what clinicians actually do when faced with patients who suboptimally respond to an adequate course of selective serotonin reuptake inhibitor (ssri) therapy. |
2000-07-24 |
2023-08-12 |
Not clear |
| R A Lawrenson, F Tyrer, R B Newson, R D Farme. The treatment of depression in UK general practice: selective serotonin reuptake inhibitors and tricyclic antidepressants compared. Journal of affective disorders. vol 59. issue 2. 2000-07-19. PMID:10837883. |
the treatment of depression in uk general practice: selective serotonin reuptake inhibitors and tricyclic antidepressants compared. |
2000-07-19 |
2023-08-12 |
Not clear |
| P J Goodnick, A M Kuma. Pretreatment platelet 5-HT concentration predicts the short-term response to paroxetine in major depression. Biological psychiatry. vol 47. issue 9. 2000-07-18. PMID:10819459. |
pretreatment platelet 5-ht concentration predicts the short-term response to paroxetine in major depression. |
2000-07-18 |
2023-08-12 |
Not clear |
| W Bligh-Glover, T N Kolli, L Shapiro-Kulnane, G E Dilley, L Friedman, E Balraj, G Rajkowska, C A Stockmeie. The serotonin transporter in the midbrain of suicide victims with major depression. Biological psychiatry. vol 47. issue 12. 2000-07-12. PMID:10862800. |
the serotonin transporter in the midbrain of suicide victims with major depression. |
2000-07-12 |
2023-08-12 |
Not clear |
| W Bligh-Glover, T N Kolli, L Shapiro-Kulnane, G E Dilley, L Friedman, E Balraj, G Rajkowska, C A Stockmeie. The serotonin transporter in the midbrain of suicide victims with major depression. Biological psychiatry. vol 47. issue 12. 2000-07-12. PMID:10862800. |
the involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. |
2000-07-12 |
2023-08-12 |
Not clear |
| J D Matthews, M Fav. Risk of suicidality in depression with serotonergic antidepressants. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 12. issue 1. 2000-07-06. PMID:10798825. |
since depression is a risk factor for suicidal thoughts and behaviors, and since suicidal behaviors are associated with low serotonin activity, are selective serotonin reuptake inhibitors (ssris) more effective than other antidepressants in treating suicidality in depressed patients? |
2000-07-06 |
2023-08-12 |
Not clear |
| A PLETSCHER, H BESENDORF, K F GE. Depression of norepinephrine and 5-hydroxytryptamine in the brain by benzoquinolizine derivatives. Science (New York, N.Y.). vol 129. issue 3352. 2000-07-01. PMID:13635024. |
depression of norepinephrine and 5-hydroxytryptamine in the brain by benzoquinolizine derivatives. |
2000-07-01 |
2023-08-12 |
mouse |
| N H Prins, N P Shankley, N J Welsh, M R Briejer, R A Lefebvre, L M Akkermans, J A Schuurke. An improved in vitro bioassay for the study of 5-HT(4) receptors in the human isolated large intestinal circular muscle. British journal of pharmacology. vol 129. issue 8. 2000-06-30. PMID:10780964. |
sb 204070 (1 nm) produced a rightward shift (pa(2) 10.34) and depression of the 5-ht curve. |
2000-06-30 |
2023-08-12 |
human |
| R T Segraves, R Kavoussi, A R Hughes, S R Batey, J A Johnston, R Donahue, J A Asche. Evaluation of sexual functioning in depressed outpatients: a double-blind comparison of sustained-release bupropion and sertraline treatment. Journal of clinical psychopharmacology. vol 20. issue 2. 2000-06-28. PMID:10770448. |
in a randomized, double-blind, multicenter trial, sustained-release bupropion (bupropion sr) and sertraline, a selective serotonin reuptake inhibitor, were found to be similarly efficacious in the treatment of outpatients with moderate to severe depression. |
2000-06-28 |
2023-08-12 |
Not clear |
| C DeBattista, H B Solvason, J A Breen, A F Schatzber. Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression. Journal of clinical psychopharmacology. vol 20. issue 2. 2000-06-28. PMID:10770475. |
pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression. |
2000-06-28 |
2023-08-12 |
Not clear |
| A Mansilla, H Barajas, R Argüer. Theoretical aspects of the neurobiological integration of memory. Medical hypotheses. vol 54. issue 1. 2000-06-23. PMID:10790724. |
two different processes regulate short-term memory: (1) homosynaptic depression that inhibits neurotransmitter release by means of a decrease in ca++ inflow, and an increase in calmodulin affinity for synaptic vesicles; and (2) heterosynaptic facilitation that triggers neurotransmitter release, whenever serotonin activates a proteinkinase a. |
2000-06-23 |
2023-08-12 |
Not clear |
| R Brys, K Josson, M P Castelli, M Jurzak, P Lijnen, W Gommeren, J E Leyse. Reconstitution of the human 5-HT(1D) receptor-G-protein coupling: evidence for constitutive activity and multiple receptor conformations. Molecular pharmacology. vol 57. issue 6. 2000-06-22. PMID:10825383. |
the 5-hydroxytryptamine (5-ht) 1d/1b receptors have gained particular interest as potential targets for treatment of migraine and depression. |
2000-06-22 |
2023-08-12 |
human |
| A Lin, C Song, G Kenis, E Bosmans, R De Jongh, S Scharpé, M Mae. The in vitro immunosuppressive effects of moclobemide in healthy volunteers. Journal of affective disorders. vol 58. issue 1. 2000-06-21. PMID:10760560. |
it has been shown that tricyclic antidepressants and serotonin reuptake inhibitors suppress the activation of the irs in depression and have negative immunoregulatory effects in vitro. |
2000-06-21 |
2023-08-12 |
human |
| E Schrade. Equivalence of St John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression. International clinical psychopharmacology. vol 15. issue 2. 2000-06-16. PMID:10759336. |
treatment with st john's wort extract tablets (hypericum ze 117) and the commonly used slow serotonin reuptake inhibitor (ssri) fluoxetine was compared in patients with mild-moderate depression with entry hamilton depression scale (ham-d) (21-item) in the range 16-24, in a randomized, double-blind, parallel group comparison in 240 subjects; fluoxetine: 114 (48%), hypericum: 126 (52%). |
2000-06-16 |
2023-08-12 |
human |
| H Plein, M Ber. Changes in the platelet intracellular calcium response to serotonin in patients with major depression treated with electroconvulsive therapy: state or trait marker status. International clinical psychopharmacology. vol 15. issue 2. 2000-06-16. PMID:10759340. |
changes in the platelet intracellular calcium response to serotonin in patients with major depression treated with electroconvulsive therapy: state or trait marker status. |
2000-06-16 |
2023-08-12 |
Not clear |