| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Plein, M Berk, S Eppel, N Butko. Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and 45Ca2+ uptake. Life sciences. vol 66. issue 5. 2000-02-17. PMID:10670830. |
the objective of this study was to determine platelet calcium influx in response to serotonin by two methods, mn2+ influx and 45ca2+ uptake, in order to observe if the uptake response to serotonin was augmented in major depression by comparing the response to normal controls. |
2000-02-17 |
2023-08-12 |
Not clear |
| H Plein, M Berk, S Eppel, N Butko. Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and 45Ca2+ uptake. Life sciences. vol 66. issue 5. 2000-02-17. PMID:10670830. |
furthermore, patients with major depression have significantly augmented platelet calcium uptake in response to serotonin. |
2000-02-17 |
2023-08-12 |
Not clear |
| E McCance-Katz, K Sevarino, P C Gottschalk, T Koste. Pharmacotherapy of stimulant dependence: one of Japan's greatest public health challenges. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 19. issue 4. 2000-02-16. PMID:10637824. |
this abnormality in dopamine and serotonin neurotransmission appears to be associated with depression and has supported antidepressant treatments to re-normalize neurotransmission. |
2000-02-16 |
2023-08-12 |
human |
| M K Osterlund, D H Overstreet, Y L Hur. The flinders sensitive line rats, a genetic model of depression, show abnormal serotonin receptor mRNA expression in the brain that is reversed by 17beta-estradiol. Brain research. Molecular brain research. vol 74. issue 1-2. 2000-02-15. PMID:10640686. |
the possible link between estrogen and serotonin (5-ht) in depression was investigated using a genetic animal model of depression, the flinders sensitive line (fsl) rats, in comparison to control flinders resistant line rats. |
2000-02-15 |
2023-08-12 |
rat |
| M K Osterlund, D H Overstreet, Y L Hur. The flinders sensitive line rats, a genetic model of depression, show abnormal serotonin receptor mRNA expression in the brain that is reversed by 17beta-estradiol. Brain research. Molecular brain research. vol 74. issue 1-2. 2000-02-15. PMID:10640686. |
moreover, the ability of estradiol to regulate the expression of the 5-ht(1a) and 5-ht(2a) receptor genes might account for the reported influence of gonadal hormones in mood and depression. |
2000-02-15 |
2023-08-12 |
rat |
| K P Lesch, S Jatzke, J Meyer, G Stöber, O Okladnova, R Mössner, P Riedere. Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651116. |
mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression. |
2000-02-15 |
2023-08-12 |
human |
| A S New, A Woo-Ming, V Mitropoulou, J Silverman, D Reynolds, F Schopick, R L Trestman, L J Sieve. Serotonin and the prediction of response time to fluoxetine in patients with mild depression. Psychiatry research. vol 88. issue 2. 2000-02-08. PMID:10622345. |
serotonin and the prediction of response time to fluoxetine in patients with mild depression. |
2000-02-08 |
2023-08-12 |
Not clear |
| A S New, A Woo-Ming, V Mitropoulou, J Silverman, D Reynolds, F Schopick, R L Trestman, L J Sieve. Serotonin and the prediction of response time to fluoxetine in patients with mild depression. Psychiatry research. vol 88. issue 2. 2000-02-08. PMID:10622345. |
pharmacologic manipulation of the serotonin system with a selective serotonin reuptake inhibitor (ssri) is effective in the treatment of depression. |
2000-02-08 |
2023-08-12 |
Not clear |
| A S New, A Woo-Ming, V Mitropoulou, J Silverman, D Reynolds, F Schopick, R L Trestman, L J Sieve. Serotonin and the prediction of response time to fluoxetine in patients with mild depression. Psychiatry research. vol 88. issue 2. 2000-02-08. PMID:10622345. |
although preliminary, this study suggests that low baseline serotonin activity may be associated with a slower response to flu in depression. |
2000-02-08 |
2023-08-12 |
Not clear |
| M Leboyer, P Quintin, P Manivet, O Varoquaux, J F Allilaire, J M Launa. Decreased serotonin transporter binding in unaffected relatives of manic depressive patients. Biological psychiatry. vol 46. issue 12. 2000-02-08. PMID:10624553. |
there are numerous reports of decreased binding to platelet serotonin transporter (5-htt) in depression, suggesting that it might be considered a trait marker of depression. |
2000-02-08 |
2023-08-12 |
human |
| M Bos. Assessment of social functioning in depression. Comprehensive psychiatry. vol 41. issue 1. 2000-02-08. PMID:10646621. |
recently, the sass was used to demonstrate the greater efficacy of reboxetine, a new selective noradrenaline reuptake inhibitor (selective nri), compared with the selective serotonin reuptake inhibitor (ssri) fluoxetine, in improving social functioning in patients with depression. |
2000-02-08 |
2023-08-12 |
Not clear |
| A Heinz, H Weingartner, D George, D Hommer, O M Wolkowitz, M Linnoil. Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations. Psychiatry research. vol 89. issue 2. 2000-02-08. PMID:10646828. |
we measured severity of depression with beck's depression inventory (bdi) and hamilton's depression rating scale (hdrs), plasma concentrations of cortisol, dhea and dhea-s, and csf concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-hiaa), the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (mhpg) and the dopamine metabolite homovanillic acid (hva) in 21 abstinent alcoholics after 4 weeks of abstinence and in 11 age-matched healthy control subjects. |
2000-02-08 |
2023-08-12 |
human |
| D A Sclar, B Pharm, T L Skaer, D Pharm, L M Robinso. [Antidepressant pharmacotherapy: a review of pharmaco-economic research]. L'Encephale. vol 25. issue 5. 2000-02-01. PMID:10598299. |
recent pharmacotherapeutic advances in the treatment of depression have included the development of selective serotonin reuptake inhibitors (ssris), thereby providing an alternative to tricyclic antidepressants (tcas). |
2000-02-01 |
2023-08-12 |
Not clear |
| C Gury, F Cousi. [Pharmacokinetics of SSRI antidepressants: half-life and clinical applicability]. L'Encephale. vol 25. issue 5. 2000-02-01. PMID:10598311. |
the selective serotonin reuptake inhibitors (ssris) antidepressants are at present time the most useful for the treatment of depression. |
2000-02-01 |
2023-08-12 |
Not clear |
| G J Marek, R A Wright, D D Schoepp, J A Monn, G K Aghajania. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604933. |
these findings suggest a close coupling between mglu2/3 and 5-ht(2a) receptors in the prefrontal cortex that may be relevant for novel therapeutic approaches in the treatment of neuropsychiatric syndromes such as depression and schizophrenia. |
2000-01-27 |
2023-08-12 |
Not clear |
| D Aizenberg, S Naor, Z Zemishlany, A Weizma. The serotonin antagonist mianserin for treatment of serotonin reuptake inhibitor-induced sexual dysfunction in women: an open-label add-on study. Clinical neuropharmacology. vol 22. issue 6. 2000-01-27. PMID:10626096. |
the study population included 16 women aged 20-65 years undergoing treatment at a psychiatric outpatient clinic, who presented with sexual dysfunction subsequent to intake of a serotonin reuptake inhibitor (sri) for depression. |
2000-01-27 |
2023-08-12 |
Not clear |
| P T Nina. The functional anatomy, neurochemistry, and pharmacology of anxiety. The Journal of clinical psychiatry. vol 60 Suppl 22. 2000-01-19. PMID:10634350. |
potent serotonin reuptake inhibitors appear to have superior efficacy in many of the anxiety disorders, with indications that norepinephrine reuptake inhibitors have an advantage in severe forms of major depression. |
2000-01-19 |
2023-08-12 |
Not clear |
| P T Nina. The functional anatomy, neurochemistry, and pharmacology of anxiety. The Journal of clinical psychiatry. vol 60 Suppl 22. 2000-01-19. PMID:10634350. |
medications with dual effects--blocking reuptake of both serotonin and norepinephrine (e.g., clomipramine and venlafaxine xr)--have superior benefits in achieving remission in major depression and gad. |
2000-01-19 |
2023-08-12 |
Not clear |
| E Haffen, P Vandel, F Broly, S Vandel, D Sechter, P Bizouard, P R Bechte. Citalopram: an interaction study with clomipramine in a patient heterozygous for CYP2D6 genotype. Pharmacopsychiatry. vol 32. issue 6. 2000-01-12. PMID:10599932. |
a pharmacokinetic interaction between the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine, was noted in a patient treated for major depression and obsessive-compulsive disorder. |
2000-01-12 |
2023-08-12 |
Not clear |
| A Degl'Innocenti, H Agren, M Sjögren, O Zachrisson, L Bäckma. [Executive functions and serotonin activity in patients with depression. A connection mirrors the influence of serotonin on prefrontal cortex]. Lakartidningen. vol 96. issue 45. 2000-01-11. PMID:10596531. |
[executive functions and serotonin activity in patients with depression. |
2000-01-11 |
2023-08-12 |
Not clear |