| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Menza, B Palermo, R DiPaola, J I Sage, M H Rickett. Depression and anxiety in Parkinson's disease: possible effect of genetic variation in the serotonin transporter. Journal of geriatric psychiatry and neurology. vol 12. issue 2. 1999-10-15. PMID:10483924. |
patients with the short allele of the serotonin transporter promotor scored significantly higher on both the depression and anxiety measures. |
1999-10-15 |
2023-08-12 |
Not clear |
| M A Menza, B Palermo, R DiPaola, J I Sage, M H Rickett. Depression and anxiety in Parkinson's disease: possible effect of genetic variation in the serotonin transporter. Journal of geriatric psychiatry and neurology. vol 12. issue 2. 1999-10-15. PMID:10483924. |
this study suggests that the short allele of the serotonin transporter gene may represent a significant risk factor for the development of anxiety and depression in parkinson's disease patients. |
1999-10-15 |
2023-08-12 |
Not clear |
| P Räsänen, H Hakko, J Tiihone. Mitchell B. Balter Award--1998. Pindolol and major affective disorders: a three-year follow-up study of 30,485 patients. Journal of clinical psychopharmacology. vol 19. issue 4. 1999-10-14. PMID:10440455. |
the role of serotonin autoreceptor antagonism in major depression has been a matter of intense debate in recent years. |
1999-10-14 |
2023-08-12 |
human |
| G Figueras, V Pérez, O San Martino, E Alvarez, F Artiga. Pretreatment platelet 5-HT concentration predicts the short-term response to paroxetine in major depression. Grupo de Trastornos Afectivos. Biological psychiatry. vol 46. issue 4. 1999-10-14. PMID:10459402. |
pretreatment platelet 5-ht concentration predicts the short-term response to paroxetine in major depression. |
1999-10-14 |
2023-08-12 |
Not clear |
| B H Mulsant, B G Pollock, R D Nebes, M D Miller, J T Little, J Stack, P R Houck, S Bensasi, S Mazumdar, C F Reynold. A double-blind randomized comparison of nortriptyline and paroxetine in the treatment of late-life depression: 6-week outcome. The Journal of clinical psychiatry. vol 60 Suppl 20. 1999-10-08. PMID:10513853. |
some studies have suggested that selective serotonin reuptake inhibitors may be less efficacious than tricyclic antidepressants in the treatment of severe depression in older patients. |
1999-10-08 |
2023-08-12 |
Not clear |
| L M Hurley, G D Polla. Serotonin differentially modulates responses to tones and frequency-modulated sweeps in the inferior colliculus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 18. 1999-10-04. PMID:10479707. |
although serotonin depressed tone-evoked responses in most neurons, its effects on responses to fm sweeps were evenly mixed between depression and facilitation. |
1999-10-04 |
2023-08-12 |
Not clear |
| F Benedetti, A Serretti, C Colombo, E Campori, B Barbini, D di Bella, E Smerald. Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression. The American journal of psychiatry. vol 156. issue 9. 1999-09-27. PMID:10484962. |
influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression. |
1999-09-27 |
2023-08-12 |
Not clear |
| A J Claxton, A J Chawla, S Kenned. Absenteeism among employees treated for depression. Journal of occupational and environmental medicine. vol 41. issue 7. 1999-09-21. PMID:10412102. |
monthly absenteeism counts from employers were summed in the 6 months before and after the initiation of antidepressant therapy in 630 workers treated for depression with a tricyclic antidepressant or a selective serotonin reuptake inhibitor (fluoxetine, sertraline, paroxetine). |
1999-09-21 |
2023-08-12 |
Not clear |
| M T Silva, C R Alves, E M Santare. Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 32. issue 3. 1999-09-09. PMID:10347793. |
the selective serotonin reuptake inhibitor fluoxetine (flx) is widely prescribed for depression and anxiety-related disorders. |
1999-09-09 |
2023-08-12 |
human |
| C Scorza, R Silveira, D E Nichols, M Reyes-Parad. Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428424. |
based on evidence showing that an acute enhancement of 5-ht neurotransmission might result in the rapid appearance of therapeutic effects of serotonergic antidepressants, we suggest that mta and mmai might serve as leads for a novel family of compounds with a short onset of action useful for treating depression. |
1999-09-03 |
2023-08-12 |
rat |
| B Andrée, S O Thorberg, C Halldin, L Fard. Pindolol binding to 5-HT1A receptors in the human brain confirmed with positron emission tomography. Psychopharmacology. vol 144. issue 3. 1999-09-02. PMID:10435400. |
the augmentation effect of (-)pindolol as used in combination with ssri to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-ht autoreceptors. |
1999-09-02 |
2023-08-12 |
human |
| P J Schwartz, E H Turner, D Garcia-Borreguero, J Sedway, R G Vetticad, T A Wehr, D L Murphy, N E Rosentha. Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects. Psychiatry research. vol 86. issue 1. 1999-08-30. PMID:10359479. |
serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-ht(1a) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects. |
1999-08-30 |
2023-08-12 |
human |
| K E Heslop, G Curzo. Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. Neuropharmacology. vol 38. issue 6. 1999-08-25. PMID:10465692. |
the results are discussed with particular reference to altered 5-ht function in depression. |
1999-08-25 |
2023-08-12 |
rat |
| D A Ruggiero, M D Underwood, P M Rice, J J Mann, V Arang. Corticotropic-releasing hormone and serotonin interact in the human brainstem: behavioral implications. Neuroscience. vol 91. issue 4. 1999-08-24. PMID:10391441. |
the objective of this human post mortem study was to determine whether neurons which synthesize corticotropic-releasing hormone and serotonin form circuits implicated in the pathophysiology of major depression and suicide. |
1999-08-24 |
2023-08-12 |
mouse |
| H G Westenber. Pharmacology of antidepressants: selectivity or multiplicity? The Journal of clinical psychiatry. vol 60 Suppl 17. 1999-08-17. PMID:10446734. |
the strong antidepressant activity of the tricyclic antidepressants (tcas) has supported the role of both norepinephrine and serotonin (5-ht) in depression and the mechanism involved in antidepressant action. |
1999-08-17 |
2023-08-12 |
Not clear |
| D Ma, M K Chakrabarti, J G Whitwa. Propofol, bradycardia and the Bezold-Jarisch reflex in rabbits. British journal of anaesthesia. vol 82. issue 3. 1999-08-12. PMID:10434826. |
5-ht and veratridine produced an acute, rapid, dose-dependent decrease in mean heart rate (delta hr) and a decrease in mean arterial pressure (delta map) together with transient but severe depression and abolition of renal sympathetic nerve activity (rsna). |
1999-08-12 |
2023-08-12 |
Not clear |
| L N Yatham, P F Liddle, J Dennie, I S Shiah, M J Adam, C J Lane, R W Lam, T J Rut. Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone. Archives of general psychiatry. vol 56. issue 8. 1999-08-11. PMID:10435604. |
decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone. |
1999-08-11 |
2023-08-12 |
Not clear |
| K K Fitzgerald, D H Sane. Serotonergic modulation of synapses in the developing gerbil lateral superior olive. Journal of neurophysiology. vol 81. issue 6. 1999-08-05. PMID:10368394. |
a 5-ht2 agonist, alpha-me-5-ht, reproduced all the observed effects of 5-ht (psc depression as well as induction of spontaneous ipscs), whereas a 5-ht2 antagonist, ketanserin, blocked the induction of spontaneous ipscs. |
1999-08-05 |
2023-08-12 |
Not clear |
| J H Meyer, S Kapur, S Houle, J DaSilva, B Owczarek, G M Brown, A A Wilson, S H Kenned. Prefrontal cortex 5-HT2 receptors in depression: an [18F]setoperone PET imaging study. The American journal of psychiatry. vol 156. issue 7. 1999-07-30. PMID:10401447. |
widespread disturbances of serotonin (5-ht) are implicated in the pathophysiology of depression. |
1999-07-30 |
2023-08-12 |
Not clear |
| R W Teasell, H Merskey, S Deshpand. Antidepressants in rehabilitation. Physical medicine and rehabilitation clinics of North America. vol 10. issue 2. 1999-07-28. PMID:10370930. |
this article focuses on the two most widely used categories of antidepressants, tricyclic antidepressants (tcas) and the newer selective serotonin reuptake inhibitors (ssris), and highlights their use in post-stroke depression and chronic pain. |
1999-07-28 |
2023-08-12 |
Not clear |