| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Oquendo, J J Man. The biology of impulsivity and suicidality. The Psychiatric clinics of North America. vol 23. issue 1. 2000-04-20. PMID:10729928. |
for example, the presence of lower levels of 5-ht and abnormalities in the da system are related to sib in patients with bpd and depression. |
2000-04-20 |
2023-08-12 |
human |
| L J Sim-Selley, L J Vogt, R Xiao, S R Childers, D E Selle. Region-specific changes in 5-HT(1A) receptor-activated G-proteins in rat brain following chronic buspirone. European journal of pharmacology. vol 389. issue 2-3. 2000-04-18. PMID:10688978. |
5-hydroxytryptamine(1a) (5-ht(1a)) receptors, which activate inhibitory g-proteins, are implicated in psychiatric disorders including anxiety and depression. |
2000-04-18 |
2023-08-12 |
rat |
| R G Robinson, E Chemerinski, R Jorg. Pathophysiology of secondary depressions in the elderly. Journal of geriatric psychiatry and neurology. vol 12. issue 3. 2000-04-11. PMID:10593701. |
studies in stroke have also noted depletions of serotonin receptors in left temporal cortex associated with depression. |
2000-04-11 |
2023-08-12 |
Not clear |
| S Meyer. Use of neurotransmitter precursors for treatment of depression. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 1. 2000-03-28. PMID:10696120. |
insufficient activity of the neurotransmitters serotonin and norepinephrine is a central element of the model of depression most widely held by neurobiologists today. |
2000-03-28 |
2023-08-12 |
Not clear |
| C H van Dyck, P Z Tan, R M Baldwin, L A Amici, P K Garg, C K Ng, R Soufer, D S Charney, R B Inni. PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 41. issue 2. 2000-03-22. PMID:10688105. |
[18f]altanserin has been used to label serotonin 5-ht2a receptors, which are believed to be important in the pathophysiology of schizophrenia and depression. |
2000-03-22 |
2023-08-12 |
human |
| Y Zhang, D K Raap, F Garcia, F Serres, Q Ma, G Battaglia, L D Van de Ka. Long-term fluoxetine produces behavioral anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats. Brain research. vol 855. issue 1. 2000-03-17. PMID:10650130. |
selective serotonin reuptake inhibitors (ssris), such as fluoxetine, are used to treat anxiety and panic disorders, in addition to treating depression. |
2000-03-17 |
2023-08-12 |
rat |
| R Zanardi, F Benedetti, D Di Bella, M Catalano, E Smerald. Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Journal of clinical psychopharmacology. vol 20. issue 1. 2000-03-15. PMID:10653220. |
efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. |
2000-03-15 |
2023-08-12 |
Not clear |
| F Serres, J M Azorin, M Valli, R Jeanningro. Evidence for an increase in functional platelet 5-HT2A receptors in depressed patients using the new ligand [125I]-DOI. European psychiatry : the journal of the Association of European Psychiatrists. vol 14. issue 8. 2000-03-14. PMID:10683631. |
we determined the density (bmax) and the affinity (kd) of 5-ht(2a) receptors labeled by [(125)i]-doi in platelets from 21 untreated patients with major depression and 21 healthy volunteers. |
2000-03-14 |
2023-08-12 |
human |
| F Serres, J M Azorin, M Valli, R Jeanningro. Evidence for an increase in functional platelet 5-HT2A receptors in depressed patients using the new ligand [125I]-DOI. European psychiatry : the journal of the Association of European Psychiatrists. vol 14. issue 8. 2000-03-14. PMID:10683631. |
our results show that the number of coupled platelet 5-ht(2a) receptors is increased in depressed patients, indicating that platelet 5-ht(2a) receptor function is enhanced in depression. |
2000-03-14 |
2023-08-12 |
human |
| P J McGrath, J W Stewart, M N Janal, E Petkova, F M Quitkin, D F Klei. A placebo-controlled study of fluoxetine versus imipramine in the acute treatment of atypical depression. The American journal of psychiatry. vol 157. issue 3. 2000-03-14. PMID:10698808. |
the objective of this study was to estimate the efficacy of the selective serotonin reuptake inhibitor (ssri) fluoxetine in the treatment of major depression with atypical features. |
2000-03-14 |
2023-08-12 |
Not clear |
| P L Delgado, F A Moren. Role of norepinephrine in depression. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703757. |
this article reviews the role of norepinephrine (ne) and serotonin (5-ht) in depression and the therapeutic effects of antidepressant drugs from the perspective of human neurotransmitter depletion studies. |
2000-03-09 |
2023-08-12 |
human |
| P L Delgado, F A Moren. Role of norepinephrine in depression. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703757. |
neither 5-ht nor ne depletion induced clinical depression in healthy subjects or worsened depression in unmedicated symptomatic patients with major depression. |
2000-03-09 |
2023-08-12 |
human |
| P L Delgado, F A Moren. Role of norepinephrine in depression. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703757. |
this finding suggests that the cause of depression is more complex than just an alteration in the levels of 5-ht and/or ne. |
2000-03-09 |
2023-08-12 |
human |
| J M Gorman, G Sulliva. Noradrenergic approaches to antidepressant therapy. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703758. |
this increased understanding of the interrelationship between neurotransmitter systems has renewed interest in the role of neurotransmitters other than serotonin in the treatment of depression. |
2000-03-09 |
2023-08-12 |
Not clear |
| R Zanardi, L Franchini, A Serretti, J Perez, E Smerald. Venlafaxine versus fluvoxamine in the treatment of delusional depression: a pilot double-blind controlled study. The Journal of clinical psychiatry. vol 61. issue 1. 2000-03-07. PMID:10695642. |
previous studies have reported the efficacy of selective serotonin reuptake inhibitors as monotherapy in the treatment of delusional depression. |
2000-03-07 |
2023-08-12 |
Not clear |
| Y Akagawa, Y Masuda, A Maruyama, T Shimizu, Y Hishikaw. Effects of repeated selective serotonin reuptake inhibitor paroxetine treatments on mouse forced swimming. Methods and findings in experimental and clinical pharmacology. vol 21. issue 9. 2000-02-28. PMID:10669904. |
studies were performed in the mouse forced swimming model, a well known experimental depression model, in order to detect the mechanism of the antidepressive effects induced by repeated serotonin reuptake inhibitor (ssri) dosing. |
2000-02-28 |
2023-08-12 |
mouse |
| N Sahibzada, M Ferreira, A M Wasserman, A M Taveira-DaSilva, R A Gilli. Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640309. |
the purpose of our study was to test the hypothesis that 5-hydroxytryptamine (5-ht)(1a) receptor agonists counteract morphine-induced respiratory depression. |
2000-02-22 |
2023-08-12 |
rat |
| N Sahibzada, M Ferreira, A M Wasserman, A M Taveira-DaSilva, R A Gilli. Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640309. |
these results indicate that activation of central nervous system 5-ht(1a) receptors is an effective way of reversing morphine-induced respiratory depression. |
2000-02-22 |
2023-08-12 |
rat |
| H Plein, M Berk, S Eppel, N Butko. Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and 45Ca2+ uptake. Life sciences. vol 66. issue 5. 2000-02-17. PMID:10670830. |
augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using mn2+ influx and 45ca2+ uptake. |
2000-02-17 |
2023-08-12 |
Not clear |
| H Plein, M Berk, S Eppel, N Butko. Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and 45Ca2+ uptake. Life sciences. vol 66. issue 5. 2000-02-17. PMID:10670830. |
there is an augmented platelet intracellular calcium response to serotonin stimulation in major depression. |
2000-02-17 |
2023-08-12 |
Not clear |